Target (4)
Compound (960)
Article Title (29)
Assay (6)
Tanini, D; Carradori, S; Capperucci, A; Lupori, L; Zara, S; Ferraroni, M; Ghelardini, C; Mannelli, L; Micheli, L; Lucarini, E; Carta, F; Angeli, A; Supuran, CT Chalcogenides-incorporating carbonic anhydrase inhibitors concomitantly reverted oxaliplatin-induced neuropathy and enhanced antiproliferative action. Eur J Med Chem 225: (2021) Angeli, A; Micheli, L; Carta, F; Ferraroni, M; Pirali, T; Fernandez Carvajal, A; Ferrer Montiel, A; Di Cesare Mannelli, L; Ghelardini, C; Supuran, CT First-in-Class Dual Hybrid Carbonic Anhydrase Inhibitors and Transient Receptor Potential Vanilloid 1 Agonists Revert Oxaliplatin-Induced Neuropathy. 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Eur J Med Chem 161: 456 -467 (2019) Nocentini, A; Alterio, V; Bua, S; Micheli, L; Esposito, D; Buonanno, M; Bartolucci, G; Osman, SM; ALOthman, ZA; Cirilli, R; Pierini, M; Monti, SM; Di Cesare Mannelli, L; Gratteri, P; Ghelardini, C; De Simone, G; Supuran, CT Phenyl(thio)phosphon(amid)ate Benzenesulfonamides as Potent and Selective Inhibitors of Human Carbonic Anhydrases II and VII Counteract Allodynia in a Mouse Model of Oxaliplatin-Induced Neuropathy. J Med Chem 63: 5185 -5200 (2020) Ho, TC; Tius, MA; Nikas, SP; Tran, NK; Tong, F; Zhou, H; Zvonok, N; Makriyannis, A Oxa-adamantyl cannabinoids. Bioorg Med Chem Lett 38: (2021) Virgili-Bernado, M; Almansa-Rosales, C; Alegret-Molina, C OXA-Diazaspiro compounds having activity against pain US Patent US10689398 (2020) Cecere, G; Galley, G; Hu, Y; Norcross, R; Pflieger, P; Shen, H 5-oxa-2-azabicyclo[2.2.2]OCTAN-4-yl and 5-oxa-2-azabicyclo[2.2.1]heptan-4-yl derivatives US Patent US9663530 (2017) Cecere, G; Galley, G; Hu, Y; Norcross, R; Pflieger, P; Shen, H 2-oxa-5-azabicyclo[2.2.1]heptan-3-yl derivatives US Patent US9790230 (2017) Sames, D; Havel, V; Hemby, S OXA-IBOGAINE ANALOGUES FOR TREATMENT OF SUBSTANCE USE DISORDERS US Patent US20240150372 (2024) Che, T; Bethel, CR; Pusztai-Carey, M; Bonomo, RA; Carey, PR The different inhibition mechanisms of OXA-1 and OXA-24 ß-lactamases are determined by the stability of active site carboxylated lysine. J Biol Chem 289: 6152 -64 (2014) Clark, RD; Caroon, JM; Repke, DB; Strosberg, AM; Bitter, SM; Okada, MD; Michel, AD; Whiting, RL Antihypertensive 9-substituted 1-oxa-4,9-diazaspiro[5.5]undecan-3-ones. J Med Chem 26: 855 -61 (1983) Sames, D; Havel, V; Bechond, B; Lankri, D OXA- IBOGAINE INSPIRED ANALOGUES FOR TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS US Patent US20230382919 (2023) Kang, FA; Allan, G; Guan, J; Jain, N; Linton, O; Tannenbaum, P; Xu, J; Zhu, P; Gunnet, J; Chen, X; Demarest, K; Lundeen, S; Sui, Z Synthesis and identification of novel oxa-steroids as progesterone receptor antagonists. Bioorg Med Chem Lett 17: 907 -10 (2007) Feng, Z; Hellberg, MR; Sharif, NA; McLaughlin, MA; Williams, GW; Scott, D; Wallace, T Discovery of 13-oxa prostaglandin analogs as antiglaucoma agents: synthesis and biological activity. Bioorg Med Chem 17: 576 -84 (2009) Kozikowski, AP; Simoni, D; Roberti, M; Rondanin, R; Wang, S; Du, P; Johnson, KM Synthesis of 8-Oxa analogues of norcocaine endowed with interesting cocaine-like activity. Bioorg Med Chem Lett 9: 1831 -6 (1999) Wrobel, J; Li, Z; Sredy, J; Sawicki, DR; Seestaller, L; Sullivan, D Synthesis and PTP1B inhibition of novel 4-aryl-1-oxa-9-thiacyclopenta[b]fluorenes. Bioorg Med Chem Lett 10: 1535 -8 (2000) Vlattas, I; Dellureficio, J; Cohen, DS; Lee, W; Clarke, F; Dotson, R; Mathis, J; Zoganas, H Oxa-prostanoid analogs. Identification of an orally effective, dual thromboxane receptor antagonist /thromboxane synthase inhibitor Bioorg Med Chem Lett 4: 2073 -2076 (1994) Cheng, Y; Huang, Y; Zhou, J; Wang, Y; Chen, WW 8-OXA-3-AZABICYCLO[3.2.1]OCTANE COMPOUNDS OR SALT THEREOF, AND PREPARATION METHOD AND USE THEREOF US Patent US20240294550 (2024) Selliah, RD; Hellberg, MR; Sharif, NA; McLaughlin, MA; Williams, GW; Scott, DA; Earnest, D; Haggard, KS; Dean, WD; Delgado, P; Gaines, MS; Conrow, RE; Klimko, PG AL-12182, a novel 11-oxa prostaglandin analog with topical ocular hypotensive activity in the monkey. Bioorg Med Chem Lett 14: 4525 -8 (2004) Verma, V; Testero, SA; Amini, K; Wei, W; Liu, J; Balachandran, N; Monoharan, T; Stynes, S; Kotra, LP; Golemi-Kotra, D Hydrolytic mechanism of OXA-58 enzyme, a carbapenem-hydrolyzing class D β-lactamase from Acinetobacter baumannii. J Biol Chem 286: 37292 -303 (2011) Kang, FA; Guan, J; Jain, N; Allan, G; Linton, O; Tannenbaum, P; Chen, X; Xu, J; Zhu, P; Gunnet, J; Demarest, K; Lundeen, S; Sui, Z Parallel synthesis and SAR study of novel oxa-steroids as potent and selective progesterone receptor antagonists. Bioorg Med Chem Lett 17: 2531 -4 (2007) Stupple, PA 3-oxa-8-azabicyclo[3.2.1]octane derivatives and their use in the treatment of cancer and hemoglobinopathies US Patent US10519167 (2019) García, M; Virgili, M; Alonso, M; Alegret, C; Fernández, B; Port, A; Pascual, R; Monroy, X; Vidal-Torres, A; Serafini, MT; Vela, JM; Almansa, C 4-Aryl-1-oxa-4,9-diazaspiro[5.5]undecane Derivatives as Dual μ-Opioid Receptor Agonists and σ J Med Chem 63: 2434 -2454 (2020) René, O; Fauber, BP; Barnard, A; Chapman, K; Deng, Y; Eidenschenk, C; Everett, C; Gobbi, A; Johnson, AR; La, H; Norman, M; Salmon, G; Summerhill, S; Wong, H Discovery of oxa-sultams as RORc inverse agonists showing reduced lipophilicity, improved selectivity and favorable ADME properties. Bioorg Med Chem Lett 26: 4455 -4461 (2016) Meziane-Cherif, D; Lambert, T; Dupêchez, M; Courvalin, P; Galimand, M Genetic and biochemical characterization of OXA-63, a new class D beta-lactamase from Brachyspira pilosicoli BM4442. Antimicrob Agents Chemother 52: 1264 -8 (2008) Knappmann, I; Schepmann, D; Wünsch, B Oxa-Pictet-Spengler reaction as key step in the synthesis of novels receptor ligands with 2-benzopyran structure. Bioorg Med Chem 24: 4045 -4055 (2016) Kam, ST; Portoghese, PS; Gerrard, JM; Dunham, EW Synthesis and biological evaluation of 9,11-azo-13-oxa-15-hydroxyprostanoic acid, a potent inhibitor of platelet aggregation. J Med Chem 22: 1402 -8 (1980) Lund, BA; Christopeit, T; Guttormsen, Y; Bayer, A; Leiros, HK Screening and Design of Inhibitor Scaffolds for the Antibiotic Resistance Oxacillinase-48 (OXA-48) through Surface Plasmon Resonance Screening. J Med Chem 59: 5542 -54 (2016)
BDBM92388 Oxaliplatin, 3
8-Oxa-norcocaine BDBM86700
US20240150372, Compound Oxa-noribogaine BDBM674461
BDBM674462 US20240150372, Compound (16S)-Oxa-noribogaine
BDBM674463 US20240150372, Compound (16R)-Oxa-noribogaine
3-oxa-6,9,12,15-octadecatetraenoic acid BDBM50242354 CHEMBL460445
8-oxa-10,14,19,20-tetraazatetracyclo US20230357269, Example 141 BDBM634456
8-oxa-10,19,20-triazatetracyclo US20230357269, Example 142 BDBM634457
2,3-dihydro-1H-4-oxa-2,5-diazaphenanthrenes, 3.0 BDBM59199
2,3-dihydro-1H-4-oxa-2,5-diazaphenanthrenes, 3.1 BDBM59200
2,3-dihydro-1H-4-oxa-2,5-diazaphenanthrenes, 3.2 BDBM59201
3-Benzhydryloxy-8-oxa-bicyclo[3.2.1]octane CHEMBL3084972 BDBM50097923
BDBM50059269 10-Oxa-9-thia-1-aza-anthracene CHEMBL81472
US20230357269, Example 163 14-methyl-8-oxa-10,14,19,20- BDBM634478
3,4-Dihydro-2H-1-oxa-9-aza-anthracen-10-ylamine 10-Amino-3,4-dihydro-2H-1-oxa-9-azonia-anthracene BDBM50279988 CHEMBL132260
CHEMBL170741 6,6a-Dihydro-1aH-1-oxa-cyclopropa[a]indene BDBM50286812
2-{[(3- cyclopropyl- 1,2,4-oxa- diazol-5- yl)oxy] methyl}-5- [5-(trifluoro- methyl)- 1,2,4-oxa- diazol-3- yl]pyridine US11066396, Example 296 BDBM504888
3,4-Dihydro-2H-1-oxa-8,9-diaza-anthracen-10-ylamine BDBM50279991 CHEMBL133441 10-Amino-3,4-dihydro-2H-1-oxa-8-aza-9-azonia-anthracene
CHEMBL130373 3,4-Dihydro-2H-1-oxa-7,9-diaza-anthracen-10-ylamine BDBM50279990 10-Amino-3,4-dihydro-2H-1-oxa-7-aza-9-azonia-anthracene
CHEMBL507701 (-)-7,9-difluoro-5-(6-methyl-7-oxa-bicyclo[4.1.0]hept-2-yl)-2,2,4-trimethyl 2,5-dihydro-(1H)-6-oxa-1-aza-chrysen BDBM50243440
BDBM504928 (4R)-3-{3- fluoro-4-[5- (trifluoro- methyl)- 1,2,4-oxa- diazol-3- yl]phenyl}- 4-phenyl- 1,3-oxa- zolidin- 2-one US11066396, Example 332
(3S,5S)-7-Methyl-1-oxa-7- BDBM598107 US11612606, Compound 467a
1,1'-prop-2-oxa-1,3-diyl-bis(quinolinium)dichloride CHEMBL1761996 BDBM50339950
10-Oxa-9-thia-1-aza-anthracene 9,9-dioxide BDBM50059258 CHEMBL82051
BDBM598109 US11612606, Compound 467c (3S,5R)-7-Methyl-1-oxa-7-
(1R,4S)-7-Oxa-bicyclo[2.2.1]heptane-2,3-dicarboxylic acid monopropyl ester (1S,4R)-7-Oxa-bicyclo[2.2.1]heptane-2,3-dicarboxylic acid monopropyl ester CHEMBL48010 BDBM50090501
(1S,4R)-7-Oxa-bicyclo[2.2.1]heptane-2,3-dicarboxylic acid monoethyl ester BDBM50090509 CHEMBL48076 (1R,4S)-7-Oxa-bicyclo[2.2.1]heptane-2,3-dicarboxylic acid monoethyl ester
(3-methylol-1-oxa-4-azaspiro[4.4]nonan-3-yl)methanol BDBM55218 cid_266964 [3-(hydroxymethyl)-1-oxa-4-azaspiro[4.4]nonan-3-yl]methanol SMR000036973 MLS000079275
BDBM50090502 (1R,4S)-7-Oxa-bicyclo[2.2.1]heptane-2,3-dicarboxylic acid monomethyl ester CHEMBL47665 (1S,4R)-7-Oxa-bicyclo[2.2.1]heptane-2,3-dicarboxylic acid monomethyl ester
BDBM50279989 10-Amino-6-chloro-3,4-dihydro-2H-1-oxa-9-azonia-anthracene 6-Chloro-3,4-dihydro-2H-1-oxa-9-aza-anthracen-10-ylamine CHEMBL134240
2,3-Dimethyl-7-oxa-bicyclo[2.2.1]heptane-2,3-dicarboxylic acid BDBM50110677 CHEMBL17457
3,4,5,6,7,8-Hexahydro-2H-1-oxa-9-aza-anthracen-10-ylamine CHEMBL436367 BDBM50279980
5H-6-Oxa-12-aza-benzo[a]anthracen-7-ylamine CHEMBL89011 BDBM50290517
7,12-dibenzyl-4-oxa-7,12- diazadispiro[2.1.5.3] tridecane(*) BDBM448176 US10689398, Example 78
7-Oxa-bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid CHEMBL8157 BDBM50289213
7-Oxa-bicyclo[2.2.1]heptane-2,3-dicarboxylic acid monopropyl ester CHEMBL17154 BDBM50110698
BDBM448180 US10689398, Example 82 8,13-dibenzyl-4-oxa-8,13- diazadispiro[2.1.6.3] tetradecane(*)
BDBM50018736 1,3,4,5,6,11b-Hexahydro-2H-11-oxa-4a-aza-benzo[a]fluorene CHEMBL158371
BDBM50110692 CHEMBL16701 7-Oxa-bicyclo[2.2.1]heptane-2,3-dicarboxylic acid monoethyl ester
BDBM50110695 CHEMBL278014 7-Oxa-bicyclo[2.2.1]heptane-2,3-dicarboxylic acid monomethyl ester
BDBM50174170 7-oxa-5,13-diazatetracyclo[9.3.1.02,10.04,8]pentadeca-2(10),3,5,8-tetraene CHEMBL194268
BDBM50199052 11-cyclohexyl-5-oxa-6a-azabenzo[a]fluorene-8-carboxylicacid CHEMBL425286
BDBM50286811 3-Methoxy-6,6a-dihydro-1aH-1-oxa-cyclopropa[a]indene CHEMBL174285
BDBM50321013 CHEMBL1163244 3-bromo-5-oxa-4,10-diazatricyclo[6.3.1.0'2,6]dodec-3-ene
BDBM598078 US11612606, Compound 439a (1R,5S,9s)-7-Methyl-3-oxa-7-
BDBM598144 US11612606, Compound 506a (1R,5S,9s)-7-isopropyl-3-oxa-7-
CHEMBL115174 2,2,4,5-Tetramethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene BDBM50072719
CHEMBL163803 1-Propyl-2,3,10,10a-tetrahydro-1H-9-oxa-1-aza-phenanthrene BDBM50016881
CHEMBL371276 5,6-Dimethoxy-7H-8-oxa-1-aza-phenalen-9-one BDBM50166812
trisodium (2S,3R)-2-(carboxylatomethoxy)-3-hydroxybutanedioate Homoisocitrate oxa analogue, 2 BDBM23213
8-ethylsulfonyl-4-(4-methoxyphenyl)sulfonyl-1-oxa-4,8-diazaspiro[4.5]decane SMR000811998 BDBM64471 cid_7384392 MLS001237371 8-esyl-4-(4-methoxyphenyl)sulfonyl-1-oxa-4,8-diazaspiro[4.5]decane
LY379268 (1R,4R,5S,6R)-4-Amino-2-oxa-bicyclo[3.1.0]hexane-4,6-dicarboxylic acid CHEMBL275079 BDBM50074749 LY-379268 4-Amino-2-oxa-bicyclo[3.1.0]hexane-4,6-dicarboxylic acid
US11066396, Example 396 BDBM504998 N-(3-fluoro- phenyl)-2- (3-methyl- 1,2,4-oxa- diazol-5- yl)-N- ({5-[5- (trifluoro- methyl)- 1,2,4-oxa- diazol-3- yl]pyridin- 2-yl}
BDBM113996 4-hydroxy-4-methyl-3-(phenylmethyl)-1-oxa-3-azaspiro[4.5]decan-2-one MLS000107807 cid_3872332 3-benzyl-4-hydroxy-4-methyl-1-oxa-3-azaspiro[4.5]decan-2-one 4-methyl-4-oxidanyl-3-(phenylmethyl)-1-oxa-3-azaspiro[4.5]decan-2-one SMR000103771
2,8-Dimethyl-1-oxa-8-aza-spiro[4.5]decan-3-one BDBM50034651 CHEMBL40121
4-Phenyl-5H-6-oxa-1-thia-s-indacen-7-one CHEMBL65329 BDBM50280977
4-Trifluoromethyl-5,6,7,8-tetrahydro-1-oxa-8-aza-anthracen-2-one CHEMBL268098 BDBM50076697
7,9-Dimethyl-1,4,5,6-tetrahydro-8-oxa-1,2-diaza-cyclopenta[e]azulene BDBM50135718 CHEMBL329503
7-Hydroxy-5-oxa-11-thia-benzo[b]fluoren-10-one CHEMBL78254 BDBM50130188
BDBM50016898 CHEMBL163532 1-Propyl-2,3,4,4a,10,10a-hexahydro-1H-9-oxa-1-aza-phenanthrene
BDBM50130189 CHEMBL310972 7,9-Dihydroxy-5-oxa-11-thia-benzo[b]fluoren-10-one
BDBM50135732 1,7,9-Trimethyl-1,4,5,6-tetrahydro-8-oxa-1,2-diaza-cyclopenta[e]azulene CHEMBL433376
BDBM50166813 9-Allyl-5,6,9-trimethoxy-7H,9H-8-oxa-1-aza-phenalene CHEMBL196116
BDBM50279986 1,2,3,6,7,8-Hexahydro-5-oxa-4-aza-cyclopenta[b]naphthalen-9-ylamine CHEMBL335922
BDBM50280539 CHEMBL424360 2,8-Dimethyl-1-oxa-3-thia-8-aza-spiro[4.5]decane
BDBM50309831 CHEMBL596657 10-Phenyl-7-oxa-8,10-diaza-benzo[a]anthracene-9,11-dione
BDBM598145 US11612606, Compound 507a (1R,5S,9s)-7-(2,2-difluoroethyl)-3-oxa-7-
CHEMBL168897 2,8-Dimethyl-3-oxa-1-thia-8-aza-spiro[4.5]decane BDBM50280542
CHEMBL3084973 3-[Bis-(4-fluoro-phenyl)-methoxy]-8-oxa-bicyclo[3.2.1]octane BDBM50097920
CHEMBL327869 5-Phenyl-6-oxa-10b-aza-benzo[e]azulen-4-one BDBM50052061
CHEMBL330735 5-Ethyl-6-oxa-10b-aza-benzo[e]azulen-4-one BDBM50052042
CHEMBL430566 6-Piperazin-1-yl-7-oxa-5-aza-benzo[c]fluorene BDBM50031933
CHEMBL89000 BDBM50089890 4-Amino-2-oxa-bicyclo[3.1.0]hexane-4,6-dicarboxylic acid(LY379268)
CHEMBL94169 4-Ethoxy-5-phenyl-6-oxa-10b-aza-benzo[e]azulene BDBM50052047
CHEMBL95018 8,9,10-Trihydroxy-6-oxa-1,3-diaza-spiro[4.5]decane-2,4-dione BDBM50102883
CHEMBL95888 BDBM50102886 8,9,10-Trihydroxy-6-oxa-1,3-diaza-spiro[4.5]decane-2,4-dione
methyl 3-(phenylimino)-2-oxa-4-azaspiro[5.5]undecane-4-carbodithioate BDBM50256222 CHEMBL475611
(+/-)-5-ethyl-5-m-tolyl-6-oxa-10b-aza-benzo[e]azulen-4-one 5-Ethyl-5-m-tolyl-6-oxa-10b-aza-benzo[e]azulen-4-one CHEMBL139532 BDBM50082057
3-(4-morpholinyl)-1-oxa-3-azonia-2-azanidacyclopent-3-en-5-imine;hydrochloride (3-morpholino-1-oxa-3-azonia-2-azanidacyclopent-3-en-5-ylidene)amine;hydrochloride BDBM83470 3-morpholin-4-yl-1-oxa-3-azonia-2-azanidacyclopent-3-en-5-imine;hydrochloride MLS000028691 3-MORPHOLINOSYDNONIMINE cid_9859122 SMR000058925
8-(4-chlorophenyl)sulfonyl-4-(2-thienylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane cid_18577943 MLS001237344 SMR000812025 BDBM73133 8-(4-chlorophenyl)sulfonyl-4-thiophen-2-ylsulfonyl-1-oxa-4,8-diazaspiro[4.5]decane
BDBM448191 US10689398, Example 93 (R)-8-benzyl-13-ethyl-4-oxa-8,13-diazadispiro[2.1.3]tetradecan-14-one and (S)-8-benzyl-13-ethyl-4-oxa-8,13-diazadispiro[2.1.6.3]tetradecan-14-one
(1R,2S,3R,5R,6S)-7-Oxa-bicyclo[4.1.0]heptane-2,3,5-triol CHEMBL285910 BDBM50078112
(1S,2R,3S,4R,6R)-7-Oxa-bicyclo[4.1.0]heptane-2,3,4-triol BDBM50078113 CHEMBL35833
(1S,4R)-7-Oxa-bicyclo[2.2.1]heptane-2,3-dicarboxylic acid monobenzyl ester BDBM50143511 CHEMBL369584
(R)-2,8-Dimethyl-1-oxa-8-aza-spiro[4.5]decan-3-one BDBM50284962 CHEMBL50831
(S)-2,8-Dimethyl-1-oxa-8-aza-spiro[4.5]decan-3-one BDBM50284961 CHEMBL50898
(S)-methyl 3,11-dioxo-1,13-diphenyl-12-oxa-2,4,10-triazatridecane-5-carboxylate CHEMBL1643410 BDBM50333674
(S)-methyl 3,11-dioxo-1,14-diphenyl-2-oxa-4,10,12-triazatetradecane-9-carboxylate BDBM50333675 CHEMBL1643411
1,2,8,9,10,11-Hexahydro-7H-3-oxa-9,11b-diaza-cyclohepta[a]acenaphthylene CHEMBL76494 PHA-57378 BDBM50130081
1,2-dihydro-11H-3-oxa-5,11-diaza-benzo[a]trindene-4,6-dione BDBM50177474 CHEMBL202537
1-Propyl-2,3,12,12a-tetrahydro-1H-7-oxa-1-aza-pleiaden-10-ol BDBM50202304 CHEMBL345240
1-ethyl-2,3,12,12a-tetrahydro-1H-7-oxa-1-aza-pleiaden-10-ol BDBM50202316 CHEMBL154468
12-benzyl-7-phenethyl-4- oxa-7,12- diazadispiro[2.1.5.3] tridecane(*) BDBM448177 US10689398, Example 79
13-benzyl-8-isopentyl-4- oxa-8,13- diazadispiro[2.1.6.3] tetradecane(*) US10689398, Example 84 BDBM448182
13-benzyl-8-phenethyl-4- oxa-8,13- diazadispiro[2.1.6.3] tetradecane(*) BDBM448181 US10689398, Example 83
2,2,4-Trimethyl-9-phenyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene CHEMBL65307 BDBM50129172
5-Butyl-2,2,4,9-tetramethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene BDBM50072705 CHEMBL114941
5-Chloro-3,4-dihydro-2H-1-oxa-9-aza-anthracen-10-ylamine BDBM50279981 CHEMBL337453
5-Hydroxymethyl-7-isopropoxy-6-oxa-bicyclo[3.2.2]nonane-1,8,9-triol, 16 CID24752824 BDBM36391
5-Methoxy-1-propyl-2,3,10,10a-tetrahydro-1H-9-oxa-1-aza-phenanthrene BDBM50016895 CHEMBL349824
5-Methoxy-3,4-dihydro-2H-1-oxa-9-aza-anthracen-10-ylamine BDBM50279994 CHEMBL134154
6-benzyl-7-oxa-5,13-diazatetracyclo[9.3.1.02,10.04,8]pentadeca-2(10),3,5,8-tetraene BDBM50174165 CHEMBL196201
6-isopropyl-7-oxa-5,13-diazatetracyclo[9.3.1.02,10.04,8]pentadeca-2(10),3,5,8-tetraene CHEMBL196150 BDBM50174178
6-methyl-7-oxa-5,13-diazatetracyclo[9.3.1.02,10.04,8]pentadeca-2(10),3,5,8-tetraene BDBM50174190 CHEMBL194475
7-Hydroxy-10H-11-oxa-10-aza-benzo[b]fluoren-5-one CHEMBL318416 BDBM50105766
7-Piperazin-1-yl-6H-5-oxa-8-aza-benzo[c]phenanthrene CHEMBL64879 BDBM50031937
7-benzyl-12-ethyl-4-oxa-7,12-diazadispiro[2.1.5.3]tridecane US10689398, Example 17 BDBM448111
7-isopentyl-12-phenyl-4-oxa-7,12- diazadispiro[2.1.5.3]tridecane BDBM448114 US10689398, Example 20
8-phenethyl-13-phenyl-4-oxa-8,13- diazadispiro[2.1.6.3]tetradecane BDBM448116 US10689398, Example 22
9-(4-(2-oxa-5-azaspiro[3.4]octane-5- BDBM522853 US11161848, Compound I-411
BDBM434843 7-{3-Oxa-10,11,17-triazatetracyclo[16.2.2.14,8.110,13]tetracosa-4,6,8(24),11,13 US10577383, Example 18
BDBM434859 US10577383, Example 17 7-{14-Oxa-3,4,10-triazatricyclo[13.3.1.13,6]icosa-1(19),4,6
BDBM448110 US10689398, Example 16 13-Ethyl-8-phenethyl-4-oxa-8,13- diazadispiro[2.1.6.3]tetradecane
BDBM448115 US10689398, Example 21 8-benzyl-13-phenyl-4-oxa-8,13- diazadispiro[2.1.6.3]tetradecane
BDBM448117 US10689398, Example 23 7-benzyl-12-phenyl-4-oxa- 7,12- diazadispiro[2.1.5.3] tridecane
BDBM50015846 1,2,3,4,6,7,8,9-Octafluoro-5,11-dihydro-10-oxa-5,11-diaza-dibenzo[a,d]cycloheptene CHEMBL78395
BDBM50044703 CHEMBL542886 8-Methyl-1-oxa-3,8-diaza-spiro[4.5]decane-2,4-dione; hydrochloride
BDBM50044707 CHEMBL542404 3,8-Dimethyl-1-oxa-3,8-diaza-spiro[4.5]decane-2,4-dione; hydrochloride
BDBM50044708 3-Ethyl-1-oxa-3,8-diaza-spiro[4.5]decane-2,4-dione; hydrochloride CHEMBL555730
BDBM50052060 5-Phenyl-6-oxa-12b-aza-naphtho[2,3-e]azulen-4-one CHEMBL314882
BDBM50059479 3-Phenyl-8-oxa-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester CHEMBL314402
BDBM50072698 CHEMBL113099 2,2,4-Trimethyl-5-propoxy-2,5-dihydro-1H-6-oxa-1-aza-chrysene
BDBM50072701 CHEMBL286446 9-Chloro-2,2,4,5-tetramethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
BDBM50072707 CHEMBL8639 5-Allyl-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
BDBM50072710 CHEMBL114611 2,2,4-Trimethyl-5-propylsulfanyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
BDBM50072714 CHEMBL325221 5-Butyl-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
BDBM50072718 5-Hexyl-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene CHEMBL115173
BDBM50105770 2-Hydroxy-5H-11-oxa-5-aza-benzo[a]fluoren-6-one CHEMBL95917
BDBM50107357 10-Methoxy-2,2,4,5-tetramethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene CHEMBL141836
BDBM50111084 2-Phenyl-4,5-dihydro-3H-6-oxa-1,3-diaza-benzo[e]azulene CHEMBL6985
BDBM50129167 2,2,4-Trimethyl-9-nitro-2,3,4,5-tetrahydro-1H-6-oxa-1-aza-chrysene CHEMBL293409
BDBM50129176 9-Fluoro-2,2,4,7-tetramethyl-2,3,4,5-tetrahydro-1H-6-oxa-1-aza-chrysene CHEMBL65054
BDBM50129177 CHEMBL62872 2,2,4-Trimethyl-8-trifluoromethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
BDBM50144784 10a,11-Dihydro-10-oxa-5-aza-benzo[b]fluorene-2,8-diol CHEMBL73989
BDBM50202302 CHEMBL439639 1-ethyl-2,3,12,12a-tetrahydro-1H-7-oxa-1-aza-pleiaden-5-ol
BDBM50202327 1-methyl-2,3,12,12a-tetrahydro-1H-7-oxa-1-aza-pleiaden-10-ol CHEMBL155352
BDBM50202339 1-propyl-2,3,12,12a-tetrahydro-1H-7-oxa-1-aza-pleiaden-5-ol CHEMBL155066
BDBM50256315 CHEMBL469895 methyl 3-(2-methoxyphenylimino)-2-oxa-4-azaspiro[5.5]undecane-4-carbodithioate
BDBM50279993 CHEMBL132619 5-Methyl-3,4-dihydro-2H-1-oxa-9-aza-anthracen-10-ylamine
BDBM50286819 CHEMBL367463 Pranoprofen i2-(10H-9-Oxa-1-aza-anthracen-6-yl)-propionic acid
BDBM50288162 (3E)-2,8-dimethyl-1-oxa-8-azaspiro[4.5]decan-3-one semicarbazone CHEMBL312200
BDBM50321015 4-Methyl-3-oxa-4,10-diazatricyclo[6.3.1.0'2,6]dodecan-5-one fumaric acid CHEMBL1164456
BDBM50321016 4-Methyl-5-oxa-4,10-diazatricyclo[6.3.1.0'2,6]dodecan-3-one fumaric acid CHEMBL1163515
BDBM50321017 CHEMBL1164404 3-Bromo-5-oxa-4,11-diazatricyclo[6.2.1.0'2,6]undec-3-ene fumaric acid
BDBM50321019 3-Methoxy-5-oxa-4,11-diazatricyclo[6.2.1.0'2,6]undec-3-ene fumaric acid CHEMBL1163517
BDBM522835 US11161848, Compound I-393 9-(4-(5-oxa-2-azaspiro[3.4]octane-2-
BDBM522836 US11161848, Compound I-394 9-(4-(6-oxa-2-azaspiro[3.4]octane-2-
BDBM598257 (1R,5S,9s)-7-(Oxetan-3-yl)-3-oxa-7- US11612606, Compound 575a
BDBM677240 N4-ethyl-N2-(9-oxa-1,2-diazatriyclo[6.4.1.04,13]trideca-2,4,6,8 US20240174647, Example 161
CHEMBL101914 2,2,4-Trimethyl-5-phenyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene BDBM50062410
CHEMBL1083970 BDBM50318618 8-Imidazol-1-ylmethyl-5-nitro-9-oxa-1-azaanthracen-10-one
CHEMBL112058 BDBM50072708 5-Methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
CHEMBL116007 9-Fluoro-2,2,4,5-tetramethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene BDBM50072709
CHEMBL1163249 BDBM50321020 5-Methoxy-3-oxa-4,11-diazatricyclo[6.2.1.0'2,6]undec-4-ene fumaric acid
CHEMBL1164458 BDBM50321021 4-Methyl-5-oxa-4,11-diazatricyclo[6.2.1.0'2,6]undecan-3-one fumaric acid
CHEMBL1164459 4-Methyl-3-oxa-4,11-diazatricyclo[6.2.1.0'2,6]undecan-5-one fumaric acid BDBM50321022
CHEMBL133520 5-Fluoro-3,4-dihydro-2H-1-oxa-9-aza-anthracen-10-ylamine BDBM50279982
CHEMBL138283 5-Benzyl-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene BDBM50067679
CHEMBL140553 10-Methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene BDBM50107349
CHEMBL155208 BDBM50202296 1-Methyl-2,3,12,12a-tetrahydro-1H-7-oxa-1-aza-pleiaden-5-ol
CHEMBL163061 BDBM50016894 1-Propyl-2,3,10,10a-tetrahydro-1H-9-oxa-1-aza-phenanthren-6-ol
CHEMBL197129 BDBM50174148 5-methyl-7-oxa-6,13-diazatetracyclo[9.3.1.02,10.04,8]pentadeca-2(10),3,5,8-tetraene
CHEMBL267270 4,5-Bis-trifluoromethyl-5,6,7,8-tetrahydro-1-oxa-8-aza-anthracen-2-one BDBM50076684
CHEMBL371651 7-Bromo-5,6-dimethoxy-7H-8-oxa-1-aza-phenalen-9-one BDBM50166807
CHEMBL381460 2,3-dihydro-1H-11-oxa-5-aza-benzo[a]trindene-4,6-dione BDBM50177473
CHEMBL603077 BDBM50307091 4-Nitrophenyl 2,2-Diphenyl-1-oxa-6-azaspiro[2.5]octane-6-carboxylate
CHEMBL63788 7,9-Difluoro-2,2,4-trimethyl-2,3,4,5-tetrahydro-1H-6-oxa-1-aza-chrysene BDBM50129173
CHEMBL66198 7,9-Dibromo-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene BDBM50129174
MLS000565038 2-methyl-2,6-diphenyl-7-oxa-1-azabicyclo[2.2.1]heptane BDBM72006 cid_4367643 SMR000152278
N4-cyclopropyl-N2-(9-oxa-1,2-diazatricyclo[6.4.1.04,13]trideca-2,4,6,8 US20240174647, Example 160 BDBM677239
SMR000011536 cid_650321 5-Phenyl-2-oxa-1,3,4,5a,10-pentaaza-cyclopenta[a]fluorene MLS000028260 BDBM38279
US10689398, Example 18 BDBM448112 13-ethyl-8-phenethyl-4-oxa-8,13- diazadispiro[2.1.6.3]tetradecane
US10689398, Example 19 BDBM448113 7-phenethyl-12-phenyl-4-oxa-7,12- diazadispiro[2.1.5.3]tridecane
US10689398, Example 80 12-benzyl-7-isopentyl-4- oxa-7,12- diazadispiro[2.1.5.3] tridecane(*) BDBM448178
US10689398, Example 81 12-benzyl-7-isobutyl-4- oxa-7,12- diazadispiro[2.1.5.3] tridecane(*) BDBM448179
US10689398, Example 85 13-benzyl-8-isobutyl-4- oxa-8,13- diazadispiro[2.1.6.3] tetradecane(*) BDBM448183
US10689398, Example 90 10-benzyl-7-phenethyl-4- oxa-7,10- diazadispiro[2.1.3.3] undecane BDBM448188
US20240174647, Example 178 BDBM677257 N4-methyl-N2-(9-oxa-1,2-diazatricyclo[6.3.1.04,12]dodeca-2,4,6,8
US20240174647, Example 18 BDBM677097 N4-isopropyl-N2-(9-oxa-1,2-diazatricyclo[6.3.1.04,12]dodeca-2,4,6,8
BDBM50107347 5-Allyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene (+)5-Allyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene (-)5-Allyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene (+/-)5-Allyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene 5-allyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]quinoline CHEMBL266282
CHEMBL169429 3-(3,4-Dichloro-phenyl)-8-oxa-bicyclo[3.2.1]oct-2-ene-2-carboxylic acid methyl ester (1R/1S)-methyl 3-(3,4-dichlorophenyl)-8-oxa-bicyclo[3.2.1]oct-2-ene-2-carboxylate BDBM50076047
Preparation of 3-(2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-4-((8-oxa-3-azabicyclo[3.2.1]octan-3-yl)pyrido[2,3-d]pyrimidin-7-yl)-N-methylbenzamide US9796732, Compound 52 BDBM351980
Preparation of 5-(2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-4-((3-oxa-8-azabicyclo[3.2.1]octan-8-yl)pyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenylmethanol US9796732, Compound 7 BDBM351931
(1R,2S)-2-isobutoxy-7-oxa-5-aza-bicyclo[3.2.1]octan-6-one BDBM50201699 CHEMBL230478
(1R,2S)-2-phenoxy-7-oxa-5-aza-bicyclo[3.2.1]octan-6-one CHEMBL230474 BDBM50201700
(1R,2S)-2-phenoxy-7-oxa-5-aza-bicyclo[3.2.1]octane-6-thione BDBM50201702 CHEMBL390643
(1S,2S)-2-bromo-7-oxa-5-aza-bicyclo[3.2.1]octan-6-one CHEMBL397972 BDBM50201703
(2-Oxaadamant-1-yl)amine 2-Oxa-tricyclo[3.3.1.1(3,7)]dec-1-ylamine BDBM50343547 CHEMBL472275
(2S,3S)-methyl 3-(3,4-dichlorophenyl)-8-oxa-bicyclo[3.2.1]octane-2-carboxylate CHEMBL390929 BDBM50197486
1,10a-Dihydro-2-oxa-9-thia-3a-aza-benzo[f]azulene-4,10-dione BDBM50079915 CHEMBL113539
1,5-Dimethyl-2,3,4,4a,10,10a-hexahydro-1H-9-oxa-1-aza-phenanthren-8-ol BDBM50016886 CHEMBL422024
1-(5-Phenyl-6-oxa-10b-aza-benzo[e]azulen-4-yl)-ethanone BDBM50052758 CHEMBL323793
1-Benzyl-2,3-dimethyl-1,7-dihydro-5-oxa-1,7-diaza-indene-4,6-dione CHEMBL176449 BDBM50284207
1-Butyl-2,3,4,4a,10,10a-hexahydro-1H-9-oxa-1-aza-phenanthren-8-ol CHEMBL263574 BDBM50016882
1-Butyl-2,3-dimethyl-1,7-dihydro-5-oxa-1,7-diaza-indene-4,6-dione CHEMBL174114 BDBM50284209
1-Propyl-2,3,4,4a,10,10a-hexahydro-1H-9-oxa-1-aza-phenanthren-6-ol BDBM50016888 CHEMBL162955
1-Propyl-2,3,4,4a,10,10a-hexahydro-1H-9-oxa-1-aza-phenanthren-8-ol CHEMBL162170 BDBM50016884
11,12-Dihydro-3H-1-oxa-benzo[4,5]cyclohepta[1,2-e]indene-2,6-dione CHEMBL311679 BDBM50022260
2-(2-Methyl-10H-9-oxa-1-aza-anthracen-6-yl)-propionic acid BDBM50286822 CHEMBL176477
2-(2-Propyl-10H-9-oxa-1-aza-anthracen-6-yl)-propionic acid BDBM50286820 CHEMBL368207
3-(2-Methoxy-phenyl)-6-phenyl-1-oxa-7-aza-spiro[4.5]decane CHEMBL327928 BDBM50118662
3-Allyl-8-methyl-1-oxa-3,8-diaza-spiro[4.5]decane-2,4-dione CHEMBL419451 BDBM50044695
4,5a,6,7,8,9a-Hexahydro-5H-9-oxa-3-thia-6-aza-cyclopenta[a]naphthalene BDBM50115284 CHEMBL319051
5-Allyl-5-ethyl-6-oxa-10b-aza-benzo[e]azulen-4-one BDBM50052064 CHEMBL327832
5-Allyl-5-phenyl-6-oxa-10b-aza-benzo[e]azulen-4-one CHEMBL328235 BDBM50052048
5-Cyclopropylmethyl-5-phenyl-6-oxa-10b-aza-benzo[e]azulen-4-one BDBM50052055 CHEMBL92308
5-Ethyl-5-phenyl-6-oxa-10b-aza-benzo[e]azulen-4-one BDBM50052046 CHEMBL329653
5-Methyl-4-trifluoromethyl-5,6,7,8-tetrahydro-1-oxa-8-aza-anthracen-2-one BDBM50076687 CHEMBL415289
5-Methyl-5-phenyl-6-oxa-10b-aza-benzo[e]azulen-4-one BDBM50052052 CHEMBL91318
5-Naphthalen-2-yl-6-oxa-10b-aza-benzo[e]azulen-4-one CHEMBL94074 BDBM50052065
5-Phenyl-5-propyl-6-oxa-10b-aza-benzo[e]azulen-4-one BDBM50052057 CHEMBL91491
5-Propyl-4-trifluoromethyl-5,6,7,8-tetrahydro-1-oxa-8-aza-anthracen-2-one CHEMBL6855 BDBM50076692
8,9,10-Trihydroxy-2-thioxo-6-oxa-1,3-diaza-spiro[4.5]decan-4-one CHEMBL98177 BDBM50102892
BDBM50016899 CHEMBL162215 8-Methoxy-1,5-dimethyl-2,3,4,4a,10,10a-hexahydro-1H-9-oxa-1-aza-phenanthrene
BDBM50062411 2,2,4-Trimethyl-5-p-tolyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene CHEMBL102403
BDBM50076694 CHEMBL266928 5-Pentafluoroethyl-4-trifluoromethyl-5,6,7,8-tetrahydro-1-oxa-8-aza-anthracen-2-one
BDBM50166810 CHEMBL196401 9-Allyl-5,6-dimethoxy-7H,9H-8-oxa-1-aza-phenalen-9-ol
BDBM50201705 CHEMBL390475 (1R,2S)-2-(benzyloxy)-7-oxa-5-aza-bicyclo[3.2.1]octan-6-one
BDBM50216901 2-cyclooctylamino-1-oxa-3-aza-spiro[4.4]non-2-en-4-one CHEMBL396187
BDBM50216921 CHEMBL235016 2-(1-adamantylamino)-1-oxa-3-azaspiro[4.4]non-2-en-4-one
BDBM50284221 CHEMBL367233 1-Cyclohexyl-2,3-dimethyl-1,7-dihydro-5-oxa-1,7-diaza-indene-4,6-dione
BDBM50284222 2,3-Dimethyl-1-phenethyl-1,7-dihydro-5-oxa-1,7-diaza-indene-4,6-dione CHEMBL177213
BDBM50286821 CHEMBL175027 2-(2-Ethyl-10H-9-oxa-1-aza-anthracen-6-yl)-propionic acid
BDBM50290403 (1-Methoxy-8-methyl-2-oxa-tricyclo[5.3.1.0*3,8*]undec-3-yl)-methanol CHEMBL55922
BDBM50320683 11-isopropyl-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazadodecan-12-oic acid CHEMBL1164333
CHEMBL137838 5-Ethyl-5-phenyl-6-oxa-10,10b-diaza-benzo[e]azulen-4-one BDBM50082060
CHEMBL161947 1-Propyl-2,3,4,4a,10,10a-hexahydro-1H-9-oxa-1-aza-phenanthren-5-ol BDBM50016883
CHEMBL162282 1-Propyl-2,3,4,4a,10,10a-hexahydro-1H-9-oxa-1-aza-phenanthren-7-ol BDBM50016885
CHEMBL162449 5-Methoxy-1,7-dimethyl-2,3,4,4a,10,10a-hexahydro-1H-9-oxa-1-aza-phenanthrene BDBM50016892
CHEMBL163281 5-Methoxy-1-propyl-2,3,4,4a,10,10a-hexahydro-1H-9-oxa-1-aza-phenanthrene BDBM50016890
CHEMBL173194 2-(2-Isopropyl-10H-9-oxa-1-aza-anthracen-6-yl)-propionic acid BDBM50286824
CHEMBL174602 BDBM50286823 2-(4-Methyl-10H-9-oxa-1-aza-anthracen-6-yl)-propionic acid
CHEMBL174736 BDBM50286825 2-(3-Methyl-10H-9-oxa-1-aza-anthracen-6-yl)-propionic acid
CHEMBL287432 8,9,10-Trihydroxy-7-hydroxymethyl-6-oxa-1,3-diaza-spiro[4.5]decane-2,4-dione BDBM50057754
CHEMBL293866 6-(4-Methyl-piperazin-1-yl)-7-oxa-5-aza-benzo[c]fluorene BDBM50031936
CHEMBL317592 8,9,10-Trihydroxy-7-hydroxymethyl-6-oxa-1,3-diaza-spiro[4.5]decane-2,4-dione BDBM50102884
CHEMBL349776 BDBM50016887 8-Methoxy-1-methyl-2,3,4,4a,10,10a-hexahydro-1H-9-oxa-1-aza-phenanthrene
CHEMBL353345 (1R,2S,5S)-6-Oxa-3-aza-bicyclo[3.1.0]hexane-2-carboxylic acid BDBM50069058
CHEMBL390392 BDBM50197457 (2S,3R)-methyl 3-(3,4-dichlorophenyl)-8-oxa-bicyclo[3.2.1]octane-2-carboxylate
CHEMBL390474 BDBM50201701 cis-4-(2,3-dimethylphenoxy)-6-oxa-1-aza-bicyclo[3.2.1]octan-7-one
CHEMBL516406 methyl 3-(naphthalen-1-ylimino)-2-oxa-4-azaspiro[5.5]undecane-4-carbodithioate BDBM50256218
CHEMBL64145 BDBM50031943 Dimethyl-[2-(7-oxa-5-aza-benzo[c]fluoren-6-ylsulfanyl)-ethyl]-amine
CHEMBL64146 BDBM50031921 6-(4-Ethyl-piperazin-1-yl)-7-oxa-5-aza-benzo[c]fluorene
CHEMBL6441 5,7,7-Trimethyl-4-trifluoromethyl-7,8-dihydro-1-oxa-8-aza-anthracen-2-one BDBM50076695
CHEMBL6843 BDBM50076693 5-Ethyl-4-trifluoromethyl-5,6,7,8-tetrahydro-1-oxa-8-aza-anthracen-2-one
CHEMBL72539 9-Benzyloxy-3-phenyl-1-oxa-spiro[5.5]undec-2-en-4-one BDBM50281456
CHEMBL7289 BDBM50076691 7,7-Dimethyl-4-trifluoromethyl-5,6,7,8-tetrahydro-1-oxa-8-aza-anthracen-2-one
CHEMBL88213 BDBM50052053 5-Ethyl-5-propyl-6-oxa-10b-aza-benzo[e]azulen-4-one
CHEMBL91013 BDBM50059509 3-Benzyl-7-methoxy-1,2,3,4-tetrahydro-9-oxa-3-aza-phenanthren-10-one
CHEMBL97548 BDBM50102880 8,9,10-Trihydroxy-7-hydroxymethyl-6-oxa-1,3-diaza-spiro[4.5]decane-2,4-dione
SMR000225039 BDBM46936 cid_11834987 MLS000700355 5-mesityl-3-oxa-4-azatricyclo[5.2.1.0~2,6~]dec-4-ene
US9790230, Example 6 BDBM348644 (1R,3S,4R)-3-Phenyl-2-oxa-5-azabicyclo[2.2.1]heptane
US9790230, Example 9 BDBM348647 (1S,3R,4S)-3-Phenyl-2-oxa-5-azabicyclo[2.2.1]heptane
and 5-bromo-3-oxa-4,11-diazatricyclo[6.2.1.0'2,6]undec-4-ene fumaric acid BDBM50321018 CHEMBL1163516
rac-trans4-(2,3-dimethylphenoxy)-6-oxa-1-aza-bicyclo[3.2.1]octan-7-one CHEMBL230473 BDBM50201698
BDBM448190 US10689398, Example 92 US10689398, Example 93 (R)-8-benzyl-13-ethyl-4-oxa-8,13-diazadispiro[2.1.3]tetradecan-14-one and (S)-8-benzyl-13-ethyl-4-oxa-8,13-diazadispiro[2.1.6.3]tetradecan-14-one
BDBM50123273 19-cyclopropylmethyl-11-oxa-8,19-diazahexacyclo[10.9.1.01,10.02,18.04,9.016,22]docosa-4(9),5,7,12,14,16(22)-hexaene-2,13-diol CHEMBL346173 19-cyclopropylmethyl-(2S,10R)-11-oxa-8,19-diazahexacyclo[10.9.1.01,10.02,18.04,9.016,22]docosa-4(9),5,7,12,14,16(22)-hexaene-2,13-diol
(R)-2,2-dimethyl-9-phenethyl-1-oxa-4,9-diazaspiro[5.6]dodecan-4-yl)(phenyl)methanone and (S)-(2,2-dimethyl-9-phenethyl-1-oxa-4,9-diazaspiro[5.6]dodecane-4-yl)(phenyl)methanone US10689398, Example 95 BDBM448193
CHEMBL1088974 BDBM50315212 1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-6-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-1,3,5-triazin-2-yl)phenyl)-3-(4-(4-methylpiperazin-1-yl)phenyl)urea
(1R,2S,3R)-methyl 3-(3,4-dichlorophenyl)-8-oxa-bicyclo[3.2.1]octane-2-carboxylate BDBM50197456 CHEMBL390712
(1R,2S,3S)-methyl 3-(3,4-dichlorophenyl)-8-oxa-bicyclo[3.2.1]octane-2-carboxylate BDBM50197443 CHEMBL227526
(1R,3S,4R)-3-(2-Fluorophenyl)-2-oxa-5-azabicyclo[2.2.1]heptane BDBM348744 US9790230, Example 106
(1R,3S,4R)-3-(4-Bromophenyl)-2-oxa-5-azabicyclo[2.2.1]heptane US9790230, Example 54 BDBM348692
(1S,2S,3R)-methyl 3-(3,4-dichlorophenyl)-8-oxa-bicyclo[3.2.1]octane-2-carboxylate CHEMBL226974 BDBM50197485
(1S,2S,3S)-methyl 3-(3,4-dichlorophenyl)-8-oxa-bicyclo[3.2.1]octane-2-carboxylate CHEMBL390764 BDBM50197463
(1S,4R)-3-(3-Methoxycarbonyl-phenylcarbamoyl)-7-oxa-bicyclo[2.2.1]heptane-2-carboxylic acid CHEMBL177853 BDBM50143517
(1S,4R)-3-(4-Ethoxycarbonyl-phenylcarbamoyl)-7-oxa-bicyclo[2.2.1]heptane-2-carboxylic acid CHEMBL425851 BDBM50143516
(2R,3R)-3-Benzoyloxy-8-oxa-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester BDBM50078778 CHEMBL299297
(2R,3S)-3-Benzoyloxy-8-oxa-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester CHEMBL301941 BDBM50078779
(2S,3R)-3-Benzoyloxy-8-oxa-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester BDBM50078781 CHEMBL50518
(7-benzyl-4-oxa-7,12- diazadispiro[2.1.5.3] tridecan-12-yl)(phenyl) methanone US10689398, Example 55 BDBM448145
(8-phenethyl-4-oxa- 8,13- diazadispiro[2.1.6.3] tetradecan-13-yl)(phenyl) methanone BDBM448121 US10689398, Example 27
(S)-methyl 13,13-dimethyl-3,11-dioxo-1-phenyl-2-oxa-4,10,12-triazatetradecane-9-carboxylate CHEMBL1643412 BDBM50333676
10-ethyl-7-isopentyl-4-oxa-7,10-diazadispiro[2.1.3.3]undecan- 11-one US10689398, Example 6 BDBM448100
12-Ethyl-7-phenethyl-4-oxa-7,12-diazadispiro[2.1.5.3]tridecan- 13-one US10689398, Example 2 BDBM448096
12-cyclohexyl-6,7-dihydro-5-oxa-7a-azadibenzo[a,e]azulene-9-carboxylic acid BDBM50199058 CHEMBL386726
13-ethyl-8-phenethyl-4-oxa-8,13- diazadispiro[2.1.6.3]tetradecan-14-one BDBM448097 US10689398, Example 3
2,4-diamino-6,7-dihydroxy-10H-9-oxa-1-aza-anthracene-3-carbonitrile; TFA CHEMBL1185204 CHEMBL397819 BDBM50225787
2-Phenyl-1-oxa-8-aza-spiro[4.5]dec-2-en-4-one; hydrochloride CHEMBL543111 BDBM50281426
3-(4-Bromo-phenyl)-8-oxa-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester CHEMBL88792 BDBM50059481
3-(4-Chloro-phenyl)-8-oxa-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester CHEMBL90903 BDBM50059483
3-Ethyl-8-methyl-1-oxa-3,8-diaza-spiro[4.5]decane-2,4-dione; hydrochloride CHEMBL553520 BDBM50044696
3-Phenyl-1-oxa-7-aza-spiro[4.5]dec-2-en-4-one; hydrochloride CHEMBL553288 BDBM50281437
3-Phenyl-1-oxa-8-aza-spiro[4.5]dec-2-en-4-one; hydrochloride BDBM50281431 CHEMBL541817
4-(4,5-Dihydro-1H-imidazol-2-yl)-3,4-dihydro-5-oxa-2a-aza-acenaphthylene CHEMBL60186 BDBM50127590
4-ethyl-9-isobutyl-2,2- dimethyl-1-oxa-4,9- diazaspiro[5.6]dodecane BDBM448187 US10689398, Example 89
4-ethyl-9-isopentyl-2,2- dimethyl-1-oxa-4,9- diazaspiro[5.6]dodecane BDBM448186 US10689398, Example 88
5-(3-Fluoro-phenyl)-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene BDBM50062419 CHEMBL103237
5-(4-Chloro-phenyl)-2,2-dimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene BDBM50076304 CHEMBL33909
5-(4-Methoxy-phenyl)-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene BDBM50062412 CHEMBL103468
5-Allyl-10-allyloxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene CHEMBL8139 BDBM50124598
5-Allyl-10-benzyloxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene BDBM50124622 CHEMBL8131
5-Allyl-10-cyclopropylmethoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene CHEMBL8359 BDBM50124623
5-Allyl-10-difluoromethoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene BDBM50124597 CHEMBL267231
5-Allyl-10-methoxymethyl-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene BDBM50124601 CHEMBL267670
5-Benzyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene CHEMBL337112 BDBM50107350
5-Butyl-9-chloro-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene BDBM50072704 CHEMBL112987
5-Cyclohexyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene BDBM50107365 CHEMBL141524
5-Ethyl-5-phenyl-6-oxa-12b-aza-naphtho[2,3-e]azulen-4-one BDBM50052049 CHEMBL88836
5-Isopropyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene BDBM50107364 CHEMBL141282
7-(4-Methyl-piperazin-1-yl)-6H-5-oxa-8-aza-benzo[c]phenanthrene CHEMBL304193 BDBM50031932
7-(6-Hexylaminomethyl-2-oxa-bicyclo[2.2.1]hept-5-yl)-hept-5-enoic acid BDBM50004558 CHEMBL102584
7-benzyl-12-phenyl-4-oxa-7,12-diazadispiro[2.1.5.3]tridecan- 13-one BDBM448109 US10689398, Example 15
7-{18-Oxa-3,4,10-triazatetracyclo[18.3.1.13,6.113,17]hexacosa-1(24),4,6(26),13 US10577383, Example 16 BDBM434858
8-Benzyl-3-ethyl-1-oxa-3,8-diaza-spiro[4.5]decane-2,4-dione; hydrochloride CHEMBL540543 BDBM50044699
8-benzyl-13-methyl-4-oxa- 8,13- diazadispiro[2.1.6.3] tetradecan-14-one US10689398, Example 71 BDBM448167
8-isopentyl-13-phenyl-4-oxa-8,13- diazadispiro[2.1.6.3]tetradecan-14-one BDBM448104 US10689398, Example 10
8-phenethyl-13-phenyl-4-oxa-8,13- diazadispiro[2.1.6.3]tetradecan-14-one BDBM448103 US10689398, Example 9
9-Chloro-2,2,4-trimethyl-5-phenyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene BDBM50062433 CHEMBL318409
9-Fluoro-2,2,4-trimethyl-7-nitro-2,3,4,5-tetrahydro-1H-6-oxa-1-aza-chrysene CHEMBL65380 BDBM50129175
9-benzyl-4-ethyl-2,2- dimethyl-1-oxa-4,9- diazaspiro[5.6]dodecane US10689398, Example 86 BDBM448184
Acetic acid 5-ethyl-6-oxa-10b-aza-benzo[e]azulen-4-yl ester BDBM50052755 CHEMBL119905
Acetic acid [2,8-dimethyl-1-oxa-8-aza-spiro[4.5]dec-(3E)-ylidene]-hydrazide CHEMBL83874 BDBM50288166
BDBM348743 (1S,3S,4S)-3-(2-Pyridyl)-2-oxa-5-azabicyclo[2.2.1]heptane US9790230, Example 105
BDBM434851 7-{17-Oxa-3,4,10-triazatetracyclo[17.3.1.13,6.112,16]pentacosa-1(23),4,6(25),12,14,16 US10577383, Example 9
BDBM448098 US10689398, Example 4 13-ethyl-8-isopentyl-4-oxa-8,13- diazadispiro[2.1.6.3]tetradecan-14-one
BDBM448099 7-benzyl-10-ethyl-4-oxa-7,10-diazadispiro[2.1.3.3]undecan- 11-one US10689398, Example 5
BDBM448101 US10689398, Example 7 7-phenethyl-12-phenyl-4-oxa-7,12- diazadispiro[2.1.5.3]tridecan-13-one
BDBM448102 US10689398, Example 8 7-isopentyl-12-phenyl-4-oxa-7,12- diazadispiro[2.1.5.3]tridecan-13-one
BDBM448105 US10689398, Example 11 7-Benzyl-12-ethyl-4-oxa-7,12-diazadispiro[2.1.5.3]tridecan-13- one
BDBM448106 US10689398, Example 12 8-benzyl-13-ethyl-4-oxa-8,13-diazadispiro[2.1.6.3]tetradecan- 14-one
BDBM448107 7-benzyl-10-ethyl-4-oxa-7,10-diazadispiro[2.1.3.3]undecan- 11-one US10689398, Example 13
BDBM448108 8-benzyl-13-phenyl-4-oxa-8,13- diazadispiro[2.1.6.3]tetradecan-14-one US10689398, Example 14
BDBM448118 (7-phenethyl-4-oxa- 7,12- diazadispiro[2.1.5.3] tridecan-12-yl)(phenyl) methanone US10689398, Example 24
BDBM448119 US10689398, Example 25 (7-isopentyl-4-oxa- 7,12- diazadispiro[2.1.5.3] tridecan-12-yl)(phenyl) methanone
BDBM448120 US10689398, Example 26 (7-isobutyl-4-oxa-7,12- diazadispiro[2.1.5.3] tridecan-12-yl)(phenyl) methanone
BDBM448127 10-benzyl-7-phenethyl- 4-oxa-7,10- diazadispiro[2.1.3.3] undecan-11-one US10689398, Example 33
BDBM448146 US10689398, Example 56 (8-benzyl-4-oxa-8,13- diazadispiro[2.1.6.3] tetradecan-13-yl)(phenyl) methanone
BDBM50014325 10a,12a-Dimethyl-3,4,4a,5,6,10a,10b,11,12,12a-decahydro-4bH-1-oxa-chrysene-2,8-dione CHEMBL99370
BDBM50016779 7-(3-Propylsulfanylmethyl-7-oxa-bicyclo[2.2.1]hept-2-yl)-hept-5-enoic acid CHEMBL175303
BDBM50031931 7-(4-Ethyl-piperazin-1-yl)-6H-5-oxa-8-aza-benzo[c]phenanthrene CHEMBL62449
BDBM50044690 8-Methyl-2-thioxo-1-oxa-3,8-diaza-spiro[4.5]decan-4-one; hydrochloride CHEMBL553123
BDBM50044706 CHEMBL542406 3-Ethyl-7-methyl-1-oxa-3,7-diaza-spiro[4.5]decane-2,4-dione; hydrochloride
BDBM50052743 CHEMBL332933 5-Phenyl-6-oxa-10b-aza-benzo[e]azulene-4-carboxylic acid methyl ester
BDBM50052746 Acetic acid 5-phenyl-6-oxa-10b-aza-benzo[e]azulen-4-ylmethyl ester CHEMBL115004
BDBM50052759 CHEMBL325471 Cyclohexanecarboxylic acid 5-phenyl-6-oxa-10b-aza-benzo[e]azulen-4-yl ester
BDBM50059478 CHEMBL329454 3-(4-Fluoro-phenyl)-8-oxa-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester
BDBM50059480 CHEMBL316342 3-(3,4-Dichloro-phenyl)-8-oxa-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester
BDBM50062403 CHEMBL323324 5-(4-Fluoro-phenyl)-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
BDBM50062405 CHEMBL318513 2,2,4-Trimethyl-5-(3-trifluoromethyl-phenyl)-2,5-dihydro-1H-6-oxa-1-aza-chrysene
BDBM50062406 CHEMBL320690 5-(3-Chloro-phenyl)-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
BDBM50062407 CHEMBL430855 5-(3-Bromo-phenyl)-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
BDBM50062423 5-(3,4-Dichloro-phenyl)-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene CHEMBL317921
BDBM50072696 CHEMBL114435 9-Fluoro-5-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
BDBM50072697 CHEMBL326092 5-Butyl-9-fluoro-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
BDBM50072699 5-Butyl-9-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene CHEMBL322108
BDBM50072720 9-Fluoro-2,2,4-trimethyl-5-propylsulfanyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene CHEMBL325213
BDBM50072722 CHEMBL114553 9-Chloro-5-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
BDBM50078782 (2S,3S)-3-Benzoyloxy-8-oxa-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester CHEMBL53436
BDBM50082055 CHEMBL336441 5-Ethyl-5-m-tolyl-6-oxa-10,10b-diaza-benzo[e]azulen-4-one
BDBM50103245 9-Methoxy-2,2,4-trimethyl-5-phenyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene CHEMBL317983
BDBM50103252 8-Methoxy-2,2,4-trimethyl-5-phenyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene CHEMBL99128
BDBM50107344 CHEMBL137982 5-Isobutyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
BDBM50107346 10-Methoxy-2,2,4-trimethyl-5-propyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene CHEMBL336041
BDBM50107352 CHEMBL138197 10-Methoxy-2,2,4-trimethyl-5-propenyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
BDBM50107354 5-Benzyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene CHEMBL343135
BDBM50107358 10-Methoxy-2,2,4-trimethyl-5-propenyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene CHEMBL137890
BDBM50107359 CHEMBL140336 5-Butyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
BDBM50124593 5-Allyl-2,2,4-trimethyl-10-methylsulfanyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene CHEMBL8394
BDBM50124596 CHEMBL266709 5-Allyl-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysen-10-ol
BDBM50124600 CHEMBL8209 5-Allyl-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene-10-carbonitrile
BDBM50124606 CHEMBL267940 5-Allyl-2,2,4-trimethyl-10-vinyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
BDBM50124618 CHEMBL8026 5-Allyl-10-ethoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
BDBM50129147 CHEMBL418670 5-Cyclohexylmethylene-9-fluoro-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
BDBM50129148 [9-Fluoro-2,2,4-trimethyl-1,2-dihydro-6-oxa-1-aza-chrysen-(5Z)-ylidene]-acetaldehyde CHEMBL65689
BDBM50163592 (3,4-Dihydro-2H-1-oxa-9-aza-anthracen-6-yl)-(4-methoxy-cyclohexyl)-methanone CHEMBL174588
BDBM50170601 CHEMBL187927 SSR591813 (1R,10S)-9-oxa-4,13-diazatetracyclo[11.2.1.0^{1,10}.0^{3,8}]hexadeca-3,5,7-triene
BDBM50197487 (1S)-methyl 3-(3,4-dichlorophenyl)-8-oxa-bicyclo[3.2.1]oct-2-ene-2-carboxylate CHEMBL449654
BDBM50256220 CHEMBL475610 S-methyl 3-(naphthalen-1-ylimino)-2-oxa-4-azaspiro[5.5]undecane-4-carbothioate
BDBM50256380 methyl 3-(4-cyanonaphthalen-1-ylimino)-2-oxa-4-azaspiro[5.5]undecane-4-carbodithioate CHEMBL482357
BDBM50256381 CHEMBL519635 methyl 3-(4-nitronaphthalen-1-ylimino)-2-oxa-4-azaspiro[5.5]undecane-4-carbodithioate
BDBM50281419 2-Phenyl-1-oxa-7-aza-spiro[4.5]dec-2-en-4-one; hydrochloride CHEMBL545457
BDBM50288147 CHEMBL314796 Decanoic acid [2,8-dimethyl-1-oxa-8-aza-spiro[4.5]dec-(3E)-ylidene]-hydrazide
BDBM50288149 Benzoic acid [2,8-dimethyl-1-oxa-8-aza-spiro[4.5]dec-(3E)-ylidene]-hydrazide CHEMBL421531
BDBM50288157 Heptanoic acid [2,8-dimethyl-1-oxa-8-aza-spiro[4.5]dec-(3E)-ylidene]-hydrazide CHEMBL314421
BDBM50288160 CHEMBL315347 Acetic acid [2-methyl-1-oxa-8-aza-spiro[4.5]dec-(3E)-ylidene]-hydrazide
BDBM50288167 CHEMBL84985 Octanoic acid [2,8-dimethyl-1-oxa-8-aza-spiro[4.5]dec-(3E)-ylidene]-hydrazide
BDBM50288168 CHEMBL84222 Cyclohexanecarboxylic acid [2,8-dimethyl-1-oxa-8-aza-spiro[4.5]dec-(3E)-ylidene]-hydrazide
Butyric acid [2,8-dimethyl-1-oxa-8-aza-spiro[4.5]dec-(3E)-ylidene]-hydrazide CHEMBL83905 BDBM50288164
CHEMBL102541 5-(3,5-Dichloro-phenyl)-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene BDBM50062421
CHEMBL103232 BDBM50062409 5-(4-Bromo-phenyl)-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
CHEMBL104037 9-Fluoro-2,2,4-trimethyl-5-phenyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene BDBM50062441
CHEMBL113098 9-Fluoro-2,2,4-trimethyl-5-propoxy-2,5-dihydro-1H-6-oxa-1-aza-chrysene BDBM50072717
CHEMBL114607 BDBM50072713 2,2,4-Trimethyl-5-(3-methyl-butyl)-2,5-dihydro-1H-6-oxa-1-aza-chrysene
CHEMBL116221 9-Chloro-2,2,4-trimethyl-5-propoxy-2,5-dihydro-1H-6-oxa-1-aza-chrysene BDBM50072716
CHEMBL126291 (1S,4R)-7-Oxa-bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid dimethyl ester BDBM50109195
CHEMBL13955 BDBM50127578 4-(4,5-Dihydro-1H-imidazol-2-yl)-1,2,3,4-tetrahydro-5-oxa-2a-aza-acenaphthylene
CHEMBL141344 5-Ethyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene BDBM50107355
CHEMBL177949 7-(3-Allylsulfanylmethyl-7-oxa-bicyclo[2.2.1]hept-2-yl)-hept-5-enoic acid BDBM50016783
CHEMBL178022 1-(3,4-Dihydro-2H-1-oxa-9-aza-anthracen-7-yl)-2-phenyl-ethanone BDBM50163612
CHEMBL184867 3-Phenyl-8-oxa-bicyclo[3.2.1]oct-2-ene-2-carboxylic acid methyl ester BDBM50156396
CHEMBL206781 BDBM50179949 1-(6,11-dihydro-5-oxa-12-aza-dibenzo[a,e]cycloocten-12-yl)-ethanone
CHEMBL227654 BDBM50197458 (1R)-methyl 3-(3,4-dichlorophenyl)-8-oxa-bicyclo[3.2.1]oct-2-ene-2-carboxylate
CHEMBL250599 BDBM50223063 2,4-dimethyl-9-phenethyl-3-oxa-9-aza-6-azonia-spiro[5.5]undecane chloride
CHEMBL266473 trans-7-Ethyl-4-trifluoromethyl-5,6,7,8-tetrahydro-1-oxa-8-aza-anthracen-2-one BDBM50076688
CHEMBL274208 5-Allyl-9,10-dimethoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene BDBM50124613
CHEMBL286595 5-(4-Chloro-phenyl)-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene BDBM50062417
CHEMBL313664 BDBM50059485 3-(4-Iodo-phenyl)-8-oxa-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester
CHEMBL321243 5-Butyl-8-fluoro-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene BDBM50072706
CHEMBL321584 2,2,4-Trimethyl-5-(4-trifluoromethyl-phenyl)-2,5-dihydro-1H-6-oxa-1-aza-chrysene BDBM50062408
CHEMBL326943 BDBM50052748 Acetic acid 5-phenyl-6-oxa-10b-aza-benzo[e]azulen-4-yl ester
CHEMBL332264 5-(4-Chloro-butyl)-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene BDBM50072711
CHEMBL333167 8-Fluoro-5-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene BDBM50072712
CHEMBL368311 (1S,4R)-3-Dimethylcarbamoyl-7-oxa-bicyclo[2.2.1]hept-5-ene-2-carboxylatedimethyl-ammonium; BDBM50143509
CHEMBL369464 BDBM50143513 (1S,4R)-3-Methylcarbamoyl-7-oxa-bicyclo[2.2.1]hept-5-ene-2-carboxylatemethyl-ammonium;
CHEMBL432186 Pentanoic acid [2,8-dimethyl-1-oxa-8-aza-spiro[4.5]dec-(3E)-ylidene]-hydrazide BDBM50288165
CHEMBL52344 7-(3-Pyridin-3-yl-7-oxa-bicyclo[2.2.1]hept-2-yl)-heptanoic acid BDBM50008791
CHEMBL544767 3-Ethyl-7-methyl-1-oxa-3,7-diaza-spiro[4.4]nonane-2,4-dione; hydrochloride BDBM50044693
CHEMBL7655 BDBM50124621 5-Allyl-10-methoxy-2,2,4,7-tetramethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
CHEMBL7671 5-Allyl-10-ethynyl-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene BDBM50124615
CHEMBL8007 5-Allyl-10-chloro-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene BDBM50124603
CHEMBL84825 BDBM50288146 Propionic acid [2,8-dimethyl-1-oxa-8-aza-spiro[4.5]dec-(3E)-ylidene]-hydrazide
CHEMBL85729 Isobutyric acid [2,8-dimethyl-1-oxa-8-aza-spiro[4.5]dec-(3E)-ylidene]-hydrazide BDBM50288154
CHEMBL99046 10-Methoxy-2,2,4-trimethyl-5-phenyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene BDBM50103246
Dimethyl-[2-(6H-5-oxa-8-aza-benzo[c]phenanthren-7-ylsulfanyl)-ethyl]-amine CHEMBL63024 BDBM50031930
Hexanoic acid [2,8-dimethyl-1-oxa-8-aza-spiro[4.5]dec-(3E)-ylidene]-hydrazide CHEMBL418933 BDBM50288152
Nonanoic acid [2,8-dimethyl-1-oxa-8-aza-spiro[4.5]dec-(3E)-ylidene]-hydrazide CHEMBL420596 BDBM50288153
US10577383, Example 1 BDBM434845 7-{17-oxa-3,4,10-triazatetracyclo[16.3.1.13,6.112,16]tetracosa-1(22),4,6(24),12,14,16
US10577383, Example 3 7-{18-oxa-3,4,10-triazatetracyclo[17.3.1.13,6.113,17]pentacosa-1(23),4,6(25),13,15,17 BDBM434846
US10577383, Example 32 7-[(11S,14R)-16-Oxa-3,4,10-triazatetracyclo[15.3.1.13,6.111,14]tricosa-1(21),4,6 BDBM434872
US10689398, Example 1 12-Ethyl-7-isopentyl-4-oxa-7,12-diazadispiro[2.1.5.3]tridecan- 13-one BDBM448095
US10689398, Example 28 BDBM448122 (8-isopentyl-4-oxa- 8,13- diazadispiro[2.1.6.3] tetradecan-13-yl)(phenyl) methanone
US10689398, Example 29 (8-isobutyl-4-oxa-8,13- diazadispiro[2.1.6.3] tetradecan-13-yl)(phenyl) methanone BDBM448123
US10689398, Example 87 4-ethyl-2,2-dimethyl-9- phenethyl-1-oxa-4,9- diazaspiro[5.6]dodecane BDBM448185
US10927128, Example 112 BDBM484191 4-Ethyl-2-methyl-9- phenethyl-1-oxa-4,9- diazaspiro[5.5]undecane
US11649248, Example 112 4-Ethyl-2-methyl-9- phenethyl-1-oxa-4,9- diazaspiro[5.5]undecane BDBM603131
US9790230, Example 104 BDBM348742 (1R,3R,4R)-3-(2-Pyridyl)-2-oxa-5-azabicyclo[2.2.1]heptane
US9790230, Example 53 (1S,3R,4S)-3-(4-Bromophenyl)-2-oxa-5-azabicyclo[2.2.1]heptane BDBM348691
methyl 3-(4-chloronaphthalen-1-ylimino)-2-oxa-4-azaspiro[5.5]undecane-4-carbodithioate BDBM50256379 CHEMBL482356
methyl 3-(4-fluoronaphthalen-1-ylimino)-2-oxa-4-azaspiro[5.5]undecane-4-carbodithioate BDBM50256378 CHEMBL482355
methyl 3-(5,6,7,8-tetrahydronaphthalen-1-ylimino)-2-oxa-4-azaspiro[5.5]undecane-4-carbodithioate CHEMBL480578 BDBM50256431
trans-5,7-Diethyl-4-trifluoromethyl-5,6,7,8-tetrahydro-1-oxa-8-aza-anthracen-2-one CHEMBL6721 BDBM50076696
8-Benzyl-3-(4-fluoro-phenyl)-3-methyl-1-oxa-8-aza-spiro[4.5]decan-4-one; hydrochloride CHEMBL543344 8-Benzyl-3-(4-fluoro-phenyl)-1-oxa-8-aza-spiro[4.5]decan-4-one; hydrochloride BDBM50281411
BDBM351939 Preparation of 5-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-2-((1R,5S)-3-oxa-8-azabicyclo[3.2.1]octan-8-yl)pyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphen ylmethanol US9796732, Compound 11
(5S,7R,8S,9S,10R)-8,9,10-trihydroxy-7-(hydroxymethyl)-2-thioxo-6-oxa-1,3-diazaspiro[4.5]decan-4-one (5S,7R,8S,9S,10R)-8,9,10-Trihydroxy-7-hydroxymethyl-2-thioxo-6-oxa-1,3-diaza-spiro[4.5]decan-4-one 8,9,10-TRIHYDROXY-7-HYDROXYMETHYL-2-THIOXO-6-OXA-1,3-DIAZA-SPIRO[4.5]DECAN-4-ONE CHEMBL489798 BDBM50263769
4-[(Z)-2,6-Dimethyl-phenylimino]-7,7-dimethyl-1-phenyl-8-oxa-1,3-diaza-spiro[4.5]decane-2-thione BDBM41820 4-(2,6-dimethylanilino)-7,7-dimethyl-1-phenyl-8-oxa-1,3-diazaspiro[4.5]dec-3-ene-2-thione cid_4005418 4-[(2,6-dimethylphenyl)amino]-7,7-dimethyl-1-phenyl-8-oxa-1,3-diazaspiro[4.5]dec-3-ene-2-thione MLS000552149 SMR000145863
MLS000562067 SMR000390761 (8S)-7-caproyl-3-(3-propionamidophenyl)-1-oxa-2,7-diazaspiro[4.4]non-2-ene-8-carboxamide (8S)-7-(1-oxohexyl)-3-[3-(1-oxopropylamino)phenyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene-8-carboxamide (8S)-7-hexanoyl-3-[3-(propanoylamino)phenyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene-8-carboxamide cid_16681906 BDBM90666
(8S)-3-[3-(caproylamino)phenyl]-7-p-anisoyl-1-oxa-2,7-diazaspiro[4.4]non-2-ene-8-carboxamide cid_16745480 SMR000390668 (8S)-3-[3-(hexanoylamino)phenyl]-7-(4-methoxyphenyl)carbonyl-1-oxa-2,7-diazaspiro[4.4]non-2-ene-8-carboxamide (8S)-7-[(4-methoxyphenyl)-oxomethyl]-3-[3-(1-oxohexylamino)phenyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene-8-carboxamide MLS000561965 (8S)-3-[3-(hexanoylamino)phenyl]-7-(4-methoxybenzoyl)-1-oxa-2,7-diazaspiro[4.4]non-2-ene-8-carboxamide BDBM79503
CHEMBL13030 Benzotropine3-Hydroxy-2-phenyl-propionic acid 9-methyl-3-oxa-9-aza-tricyclo[3.3.1.0*2,4*]non-7-yl ester 9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl 3-hydroxy-2-phenylpropanoate BDBM50015720 3-hydroxy-2-phenyl-propionic acid 9-methyl-3-oxa-9-aza-tricyclo[3.3.1.0*2,4*]non-7-yl ester ChEMBL_11434 SCOPOLAMINE (hyoscine)3-Hydroxy-2-phenyl-propionic acid 9-methyl-3-oxa-9-aza-tricyclo[3.3.1.0*2,4*]non-7-yl ester
CHEMBL553080 NALORPHINE - HCI BDBM50021560 4-allyl-(13R,14S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraene-10,14-diol:hydrocholride(Nalorphine) 4-allyl-(5R)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraene-10,14-diol ; hydrochloride(Nalorphine hydrochloride) 4-allyl-(1S,13R,14S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraene-10,14-diolhydrochloride(Nalorphine hydrochloride) 4-allyl-(1S,13R,14S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraene-10,14-diol; Hydrochloride(Nalorphine)
(+)-1-Propyl-2,3,10,10a-tetrahydro-1H,4aH-4-oxa-9-thia-1-aza-phenanthren-6-ol CHEMBL98197 BDBM50090830
(-)-1-Propyl-2,3,10,10a-tetrahydro-1H,4aH-4-oxa-9-thia-1-aza-phenanthren-6-ol BDBM50090828 CHEMBL98305
(1R,3R)-1,5-Diphenyl-6-oxa-4-aza-spiro[2.4]hept-4-en-7-one BDBM50288106 CHEMBL79805
(3R,11R)-6-fluoro-3,11-dimethyl-10-oxa-2,13,17,21,22-pentaazapentacyclo[13.5.2.18,11.04,9.018,22]tricosa-1 US12410191, Example 26 BDBM769510
(4R,5S)-2,2,4-Trimethyl-5-phenyl-1,2,4,5-tetrahydro-6-oxa-1-aza-chrysen-3-one BDBM50076298 CHEMBL285705
(5-Allyl-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysen-10-yl)-methanol BDBM50124594 CHEMBL268239
(9S,13S)-dimethyl 15-methyl-3,11-dioxo-1-phenyl-2-oxa-4,10,12-triazahexadecane-9,13-dicarboxylate BDBM50333683 CHEMBL1643396
(9S,13S)-dimethyl 3,11-dioxo-1-phenyl-2-oxa-16-thia-4,10,12-triazaheptadecane-9,13-dicarboxylate BDBM50333686 CHEMBL1643399
(R)-21-(4-Hydroxybenzylcarbamoyl)-3,7,14,23-tetraoxo-24,24-diphenyl-2-oxa-6,15,17,22-tetraazatetracosan-16-iminium2,2,2-trifluoroacetate BDBM50325607 CHEMBL1223995
12-ethyl-8-(2-phenoxyethyl)-4-oxa-8,12- diazadispiro[2.1.5.3]tridecan-13-one BDBM603030 US11649248, Example 11
18-methyl-10-oxa-6,7,18-triazahexacyclo[9.9.1.01,9.02,17.04,8.015,21]henicosa-4(8),5,11,13,15(21)-pentaene-2,12-diol BDBM50083672 CHEMBL112035
19-methyl-11-oxa-6,8,19-triazahexacyclo[10.9.1.01,10.02,18.04,9.016,22]docosa-4(9),5,7,12,14,16(22)-hexaene-2,7,13-triol BDBM50083671 CHEMBL114803
2,3-Dimethyl-1-(3-phenyl-propyl)-1,7-dihydro-5-oxa-1,7-diaza-indene-4,6-dione CHEMBL174956 BDBM50284205
2,3-Dimethyl-1-pyridin-2-ylmethyl-1,7-dihydro-5-oxa-1,7-diaza-indene-4,6-dione BDBM50284223 CHEMBL173644
2-({4-[5- (trifluoro- methyl)- 1,2,4-oxa- diazol-3- yl]benzyl} oxy) pyrimidine BDBM505060 US11066396, Example 457
2-[9-Fluoro-2,2,4-trimethyl-1,2-dihydro-6-oxa-1-aza-chrysen-(5Z)-ylidenemethyl]-benzonitrile BDBM50133145 CHEMBL334747
3-(3-Chloro-phenyl)-8-methyl-1-oxa-3,8-diaza-spiro[4.5]decane-2,4-dione BDBM50044694 CHEMBL74823
3-(5,6,9-Trimethoxy-7H,9H-8-oxa-1-aza-phenalen-9-yl)-propane-1,2-diol BDBM50166811 CHEMBL371006
3-({4-[5- (trifluoro- methyl)- 1,2,4-oxa- diazol-3- yl]benzyl} amino) benzonitrile US11066396, Example 412 BDBM505015
3-Amino-2-chloro-11-ethyl-6,7,8,9,10,11,12,13,14,15-decahydro-5-oxa-11,15-diaza-benzocyclotetradecen-16-one CHEMBL432681 BDBM50023801
3-Ethyl-8-methyl-2-thioxo-1-oxa-3,8-diaza-spiro[4.5]decan-4-one BDBM50044702 CHEMBL75380
3-[4-(4-Fluoro-phenoxy)-benzenesulfonylamino]-8-oxa-bicyclo[3.2.1]octane-3-carboxylic acid hydroxyamide BDBM50148208 CHEMBL321633
4-({4-[5- (trifluoro- methyl)- 1,2,4-oxa- diazol-3- yl]benzyl} amino) benzonitrile US11066396, Example 410 BDBM505013
4-Hydroxy-3-(1-phenyl-allyl)-1-oxa-spiro[5.6]dodec-3-en-2-one BDBM50054620 CHEMBL343637
4-cyclopropyl-9-(2- isopropoxyethyl)-1-oxa-4,9- diazaspiro[5.5]undecan-3- one BDBM603078 US11649248, Example 59
5-(1-benzylpiperidin-4-yl)-7-ethyl-4- oxa-7-azaspiro[2.5]octane US10421750, Example 14 BDBM413882
5-(3,5-Difluoro-phenyl)-5-ethyl-6-oxa-10b-aza-benzo[e]azulen-4-one BDBM50082058 CHEMBL141371
5-Ethyl-5-(3-fluoro-phenyl)-6-oxa-10b-aza-benzo[e]azulen-4-one CHEMBL344257 BDBM50082059
5-Ethyl-5-naphthalen-2-yl-6-oxa-10b-aza-benzo[e]azulen-4-one BDBM50052051 CHEMBL91891
5-Methoxy-7-methyl-1-propyl-2,3,4,4a,10,10a-hexahydro-1H-9-oxa-1-aza-phenanthrene CHEMBL162510 BDBM50016891
6-Propyl-4,5a,6,7,8,9a-hexahydro-5H-9-oxa-3-thia-6-aza-cyclopenta[a]naphthalene CHEMBL102632 BDBM50115281
7,7-Bis-(4-hydroxy-phenyl)-2,7-dihydro-1H-6-oxa-cyclopenta[cd]phenalen-5-one BDBM50077836 CHEMBL67851
7-(4-benzylpiperidin-1-carbonyl)-1,6-dihydro-3-oxa-1,6,8-triaza-as-indacen-2-one CHEMBL373907 BDBM50204892
7-Amino-3,3a,4,5-tetrahydro-8H-2-oxa-5,6,8,9b-tetraaza-cyclopenta[a]naphthalene-1,9-dione BDBM50115155 CHEMBL101885
7-Bromo-5,6-dimethoxy-1-methyl-9-oxo-7H,9H-8-oxa-1-azonia-phenalene CHEMBL370561 BDBM50166808
7-[(17R)-18-Phenyl-16-oxa-2,8,9-triazapentacyclo[16.2.2.11,17.16,9.111,15]pentacosa-6(25),7,11 US10577383, Example 28 BDBM434868
7-[(18S)-19-Phenyl-17-oxa-2,8,9-triazapentacyclo[17.2.2.11,18.16,9.112,16]hexacosa-6(26),7,12 US10577383, Example 29 BDBM434869
8-(2,4-Difluoro-phenylamino)-11H-10-oxa-1-aza-dibenzo[a,d]cyclohepten-5-one BDBM50248941 CHEMBL515758
8-(2-Amino-phenylamino)-11H-10-oxa-1-aza-dibenzo[a,d]cyclohepten-5-one BDBM50248939 CHEMBL475360
8-(3,4-difluorobenzyl)-12-ethyl-4-oxa- 8,12-diazadispiro[2.1.5.3]tridecan-13-one US11649248, Example 24 BDBM603043
8-Methyl-3-phenyl-2-thioxo-1-oxa-3,8-diaza-spiro[4.5]decan-4-one CHEMBL75045 BDBM50044701
8-benzyl-2-cycloheptylamino-1-oxa-3,8-diaza-spiro[4.5]dec-2-en-4-one CHEMBL236727 BDBM50216930
9-Hydroxy-8-(1-phenyl-allyl)-6-oxa-spiro[4.5]dec-8-en-7-one BDBM50054617 CHEMBL356524
9-Methyl-3-p-tolyl-6-oxa-9-aza-tricyclo[5.2.1.0*4,8*]decan-5-one CHEMBL113410 BDBM50091310
Acetic acid 1,1-diacetoxy-3-oxo-1lambda*5*-ioda-2-oxa-indan-1-yl ester CHEMBL116656 BDBM50075026
Acetic acid 5-m-tolyl-6-oxa-10b-aza-benzo[e]azulen-4-yl ester BDBM50118540 CHEMBL135484
BDBM413879 7-ethyl-5-(1-phenethylpiperidin-4-yl)- 4-oxa-7-azaspiro[2.5]octane US10421750, Example 11
BDBM413912 US10421750, Example 48 7-ethyl-5-(1-isopentylpiperidin-4- yl)-4-oxa-7-azaspiro[2.5]actane
BDBM448129 10-ethyl-7-(2- isopropoxyethyl)-4-oxa- 7,10- diazadispiro[2.1.3.3] undecan-11-one US10689398, Example 35
BDBM448168 US10689398, Example 72 8-(4-fluorobenzyl)-13- methyl-4-oxa-8,13- diazadispiro[2.1.6.3] tetradecan-14-one
BDBM484090 US10927128, Example 11 12-ethyl-8-(2-phenoxyethyl)-4-oxa-8,12- diazadispiro[2.1.5.3]tridecan-13-one
BDBM484103 8-(3,4-difluorobenzyl)-12-ethyl-4-oxa-8,12- diazadispiro[2.1.5.3]tridecan-13-one US10927128, Example 24
BDBM484138 4-cyclopropyl-9-(2- isopropoxyethyl)-1-oxa-4,9- diazaspiro[5.5]undecan-3- one US10927128, Example 59
BDBM484190 US10927128, Example 111 US11649248, Example 111 4-(cyclopropylmethyl)-9- phenethyl-1-oxa-4,9- diazaspiro[5.5]undecane
BDBM50009127 bis(4-cyclopropylmethyl-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,14-tetraene-10,17-diol)thiphene
BDBM50012860 1-Oxo-1,2-dihydro-6-oxa-10b-aza-aceanthrylene-2-carboxylic acid thiazol-2-ylamide CHEMBL61422
BDBM50012875 1-Oxo-1,2-dihydro-6-oxa-10b-aza-aceanthrylene-2-carboxylic acid pyridin-2-ylamide CHEMBL64490
BDBM50025436 1,4a,6a-Trimethyl-2-oxo-hexadecahydro-3-oxa-1-aza-chrysene-7-carboxylic acid diethylamide CHEMBL3349166
BDBM50027091 19-isothiocyanato-15-methoxy-3-methyl-13-oxa-3-azahexacyclo[13.2.2.12,8.01,6.06,14.07,12]icosa-7,9,11,16-tetraen-11-ol
BDBM50044704 CHEMBL552656 3-tert-Butyl-8-methyl-1-oxa-3,8-diaza-spiro[4.5]decane-2,4-dione; hydrochloride
BDBM50052744 Acetic acid 5-p-tolyl-6-oxa-10b-aza-benzo[e]azulen-4-yl ester CHEMBL326772
BDBM50052754 CHEMBL115740 Diethyl-carbamic acid 5-phenyl-6-oxa-10b-aza-benzo[e]azulen-4-yl ester
BDBM50052757 Diethyl-thiocarbamic acid 5-phenyl-6-oxa-10b-aza-benzo[e]azulen-4-yl ester CHEMBL326302
BDBM50054607 CHEMBL141176 4-Hydroxy-3-(1-phenyl-propyl)-1-oxa-spiro[5.7]tridec-3-en-2-one
BDBM50054623 CHEMBL143401 4-Hydroxy-3-(1-phenyl-propyl)-1-oxa-spiro[5.5]undec-3-en-2-one
BDBM50069969 Sodium; 9-fluoro-3-phenyl-5H-6-oxa-12-aza-benzo[a]anthracene-7-carboxylate CHEMBL318798
BDBM50076310 5-(4-Chloro-phenyl)-2,2,4,4-tetramethyl-1,2,4,5-tetrahydro-6-oxa-1-aza-chrysen-3-one CHEMBL34589
BDBM50076689 CHEMBL6530 5-Ethyl-8-methyl-4-trifluoromethyl-5,6,7,8-tetrahydro-1-oxa-8-aza-anthracen-2-one
BDBM50082056 CHEMBL138969 5-Ethyl-5-thiophen-2-yl-6-oxa-10,10b-diaza-benzo[e]azulen-4-one
BDBM50082062 CHEMBL141223 5-Ethyl-5-thiophen-2-yl-6-oxa-10b-aza-benzo[e]azulen-4-one
BDBM50118532 Acetic acid 5-p-tolyl-6-oxa-10,10b-diaza-benzo[e]azulen-4-yl ester CHEMBL137600
BDBM50118663 3-(2-Methoxy-phenyl)-6-phenyl-1-oxa-7-aza-spiro[4.5]dec-3-ene CHEMBL93184
BDBM50133130 CHEMBL422268 2-[9-Fluoro-2,2,4-trimethyl-1,2-dihydro-6-oxa-1-aza-chrysen-(5Z)-ylidenemethyl]-benzaldehyde
BDBM50133226 15-methoxy-3-methyl-19-(1-methylbutyl)-13-oxa-3-azahexacyclo[13.2.2.12,8.01,6.06,14.07,12]icosa-7,9,11,16-tetraene CHEMBL133836
BDBM50192675 CHEMBL376272 (7r,9r)-9-(2-(4-chlorophenoxy)-2-methylpropanamido)-3-oxa-bicyclo[3.3.1]nonane-7-carboxamide
BDBM50216911 CHEMBL396387 2-(adamantan-2-ylamino)-1-oxa-3-aza-spiro[4.4]non-2-en-4-one
BDBM50256430 CHEMBL481716 methyl 3-(4-(dimethylamino)naphthalen-1-ylimino)-2-oxa-4-azaspiro[5.5]undecane-4-carbodithioate
BDBM50262454 CHEMBL478000 11-Amino-3,3-dimethyl-12-phenyl-2,3,4,7,8,9,10,12-octahydro-5-oxa-6-aza-naphthacen-1-one
BDBM50288148 Phenyl-acetic acid [2,8-dimethyl-1-oxa-8-aza-spiro[4.5]dec-(3E)-ylidene]-hydrazide CHEMBL85999
BDBM50288150 CHEMBL85953 Cyclohexyl-acetic acid [2,8-dimethyl-1-oxa-8-aza-spiro[4.5]dec-(3E)-ylidene]-hydrazide
BDBM50333682 CHEMBL1643395 (9S,13S)-dimethyl 14-methyl-3,11-dioxo-1-phenyl-2-oxa-4,10,12-triazapentadecane-9,13-dicarboxylate
BDBM50333689 (9S,13S)-14-methyl-3,11-dioxo-1-phenyl-2-oxa-4,10,12-triazapentadecane-9,13-dicarboxylic acid CHEMBL1643402
BDBM50333690 (9S,13S)-15-methyl-3,11-dioxo-1-phenyl-2-oxa-4,10,12-triazahexadecane-9,13-dicarboxylic acid CHEMBL1643403
BDBM50333693 (9S,13S)-3,11-dioxo-1-phenyl-2-oxa-16-thia-4,10,12-triazaheptadecane-9,13-dicarboxylic acid CHEMBL1643406
BDBM50339307 (15R)-10,6-Dibenzyl 15-Ethyl-2,2-dimethyl-4,12,17-trioxo-3-oxa-5,11,16-triazaoctacosane-6,10,15-tricarboxylate CHEMBL1689705
BDBM603129 US11649248, Example 110 4-(2-cyclopropylethyl)-2- methyl-9-phenethyl-1-oxa- 4,9-diazaspiro[5.5]undecane
CHEMBL114706 3-[4-(4-Chloro-phenoxy)-benzenesulfonylamino]-8-oxa-bicyclo[3.2.1]octane-3-carboxylic acid hydroxyamide BDBM50148204
CHEMBL117025 Acetic acid 5-phenyl-6-oxa-12b-aza-naphtho[2,3-e]azulen-4-yl ester BDBM50052756
CHEMBL135327 Diethyl-carbamic acid 5-phenyl-6-oxa-10,10b-diaza-benzo[e]azulen-4-yl ester BDBM50118531
CHEMBL135514 Ethyl-carbamic acid 5-phenyl-6-oxa-10b-aza-benzo[e]azulen-4-yl ester BDBM50118528
CHEMBL135801 Propyl-carbamic acid 5-phenyl-6-oxa-10b-aza-benzo[e]azulen-4-yl ester BDBM50118535
CHEMBL196177 3-(5,6,9-Trimethoxy-7H,9H-8-oxa-1-aza-phenalen-9-yl)-propan-1-ol BDBM50166815
CHEMBL213332 4,4-dimethyl-2-pyridin-4-yl-1,9b-dihydro-5-oxa-3,3a-diaza-cyclopenta[a]naphthalene BDBM50191184
CHEMBL274784 BDBM50127600 2-(4,5-Dihydro-1H-imidazol-2-yl)-2,3,5,6-tetrahydro-4H-1-oxa-3a-aza-phenalene
CHEMBL284475 BDBM50076309 (4S,5S)-2,2,4-Trimethyl-5-phenyl-1,2,4,5-tetrahydro-6-oxa-1-aza-chrysen-3-one
CHEMBL285764 BDBM50057745 3-Amino-8,9,10-trihydroxy-7-hydroxymethyl-6-oxa-1,3-diaza-spiro[4.5]decane-2,4-dione
CHEMBL298513 [1-(3-Bromo-benzyloxy)-8-methyl-2-oxa-tricyclo[5.3.1.0*3,8*]undec-3-yl]-methanol BDBM50290408
CHEMBL306839 2-(8-Methyl-2,4-dioxo-1-oxa-3,8-diaza-spiro[4.5]dec-3-yl)-acetamide BDBM50044689
CHEMBL319915 BDBM50062438 9-Chloro-2,2,4-trimethyl-5-m-tolyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
CHEMBL320164 BDBM50062427 9-Fluoro-2,2,4-trimethyl-5-m-tolyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
CHEMBL336774 Methyl-carbamic acid 5-phenyl-6-oxa-10b-aza-benzo[e]azulen-4-yl ester BDBM50118527
CHEMBL353264 PD-146884 2-Oxa-7,10-diaza-bicyclo[11.3.1]heptadeca-1(17),13,15-trien-11-one BDBM50281661
CHEMBL431074 BDBM50083668 7,19-dimethyl-11-oxa-6,8,19-triazahexacyclo[10.9.1.01,10.02,18.04,9.016,22]docosa-4(9),5,7,12,14,16(22)-hexaene-2,13-diol
CHEMBL6654 7-Ethyl-6-methyl-4-trifluoromethyl-5,6,7,8-tetrahydro-1-oxa-8-aza-anthracen-2-one BDBM50076685
Cyclopropyl-carbamic acid 5-phenyl-6-oxa-10b-aza-benzo[e]azulen-4-yl ester BDBM50118541 CHEMBL445583
Dimethyl-carbamic acid 5-ethyl-6-oxa-10b-aza-benzo[e]azulen-4-yl ester BDBM50052752 CHEMBL115704
Dimethyl-carbamic acid 5-phenyl-6-oxa-10b-aza-benzo[e]azulen-4-yl ester BDBM50052751 CHEMBL325169
MLS000762738 SMR000439740 BDBM58111 8-Chloro-5-propyl-1,2,3,4-tetrahydro-7-oxa-6,9,11-triaza-benzo[c]fluorene cid_1953598
SMR000439900 MLS000763219 BDBM96022 cid_1862923 8-Chloro-5-isobutyl-1,2,3,4-tetrahydro-7-oxa-6,9,11-triaza-benzo[c]fluorene
US10577383, Example 27 7-[(17S)-18-Phenyl-16-oxa-2,8,9-triazapentacyclo[16.2.2.11,17.16,9.111,15]pentacosa-6(25),7,11 BDBM434867
US10927128, Example 110 4-(2-cyclopropylethyl)-2- methyl-9-phenethyl-1-oxa- 4,9-diazaspiro[5.5]undecane BDBM484189
US10927128, Example 21 US11649248, Example 21 BDBM484100 8,12-diethyl-4-oxa-8,12- diazadispiro[2.1.5.3]tridecan-13-one
US11066396, Example 250 2-[(2- fluoro- phenoxy) methyl]- 4-[5- (trifluoro- methyl)- 1,2,4-oxa- diazol-3- BDBM504841
US11066396, Example 408 4-({4-[5- (trifluoro- methyl)- 1,2,4-oxa- diazol-3- yl]benzyl} amino) benzamide BDBM505011
US11066396, Example 409 2-({4-[5- (trifluoro- methyl)- 1,2,4-oxa- diazol-3- yl]benzyl} amino) benzamide BDBM505012
methyl 3-(3-tert-butylisoxazol-5-ylimino)-2-oxa-4-azaspiro[5.5]undecane-4-carbodithioate CHEMBL481508 BDBM50256318
methyl 3-(4-tert-butylthiazol-2-ylimino)-2-oxa-4-azaspiro[5.5]undecane-4-carbodithioate CHEMBL511790 BDBM50256317
methyl 3-(5-tert-butylisoxazol-3-ylimino)-2-oxa-4-azaspiro[5.5]undecane-4-carbodithioate BDBM50256377 CHEMBL449624
12-Isobutyl-3,11-dioxo-1-oxa-4,10-diaza-cyclotridecane-9,13-dicarboxylic acid 13-hydroxyamide 9-methylamide (SC903) (9S,12R,13S)-12-Isobutyl-3,11-dioxo-1-oxa-4,10-diaza-cyclotridecane-9,13-dicarboxylic acid 13-hydroxyamide 9-methylamide BDBM50064339 CHEMBL48258
BDBM448192 (R)-2,2-dimethyl-9-phenethyl-1-oxa-4,9-diazaspiro[5.6]dodecan-4-yl)(phenyl)methanone and (S)-(2,2-dimethyl-9-phenethyl-1-oxa-4,9-diazaspiro[5.6]dodecane-4-yl)(phenyl)methanone US10689398, Example 95 US10689398, Example 94
CHEMBL93068 (20S)-4-Ethyl-4,10-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione (20RS)-4-Ethyl-4,10-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione BDBM50045372
(8R)-7-benzoyl-3-(3-methacrylamidophenyl)-1-oxa-2,7-diazaspiro[4.4]non-2-ene-8-carboxamide BDBM79500 cid_16681845 SMR000390636 (8R)-3-[3-(2-methylprop-2-enoylamino)phenyl]-7-(phenylcarbonyl)-1-oxa-2,7-diazaspiro[4.4]non-2-ene-8-carboxamide MLS000561979 (8R)-7-benzoyl-3-[3-(2-methylprop-2-enoylamino)phenyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene-8-carboxamide (8R)-7-benzoyl-3-[3-[(2-methyl-1-oxoprop-2-enyl)amino]phenyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene-8-carboxamide
4-Ethyl-4,9-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione (10-hydroxycamptothecin) 10-hydroxy-camptothecin CHEMBL273862 (20S)-4-Ethyl-4,9-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione 10-hydroxycamptothecin 4-Ethyl-4,9-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione 10-Hydroxycamptothecine BDBM50008922 4-Ethyl-4,10-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione
(20RS)-10-Amino-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione BDBM50045367 (20S)-10-Amino-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione 10-Amino-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione 9-Aminocamptothecin CHEMBL315269
BDBM50089903 (+/-)1aRS,7aRS -2-Hydroxyimino-1a,2-dihydro-1H-7-oxa-cyclopropa[b]naphthalene-7a-carboxylic acid ethyl ester 2-[(E)-Hydroxyimino]-1a,2-dihydro-1H-7-oxa-cyclopropa[b]naphthalene-7a-carboxylic acid ethyl ester 2-Hydroxyimino-1a,2-dihydro-1H-7-oxa-cyclopropa[b]naphthalene-7a-carboxylic acid ethyl ester(CPCCOEt) CHEMBL327783 7-hydroxyiminocyclopropan[b]chromene-1a-carboxylic acid ethyl ester
MLS000877349 N-benzyl-4-[3-(4-chlorophenyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-en-8-yl]-3-nitro-benzamide BDBM94100 4-[3-(4-chlorophenyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-en-8-yl]-3-nitro-N-(phenylmethyl)benzamide SMR000673526 cid_24789307 N-benzyl-4-[3-(4-chlorophenyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-en-8-yl]-3-nitrobenzamide
(1S,4R)-3-(3-Methoxycarbonyl-phenylcarbamoyl)-7-oxa-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid CHEMBL175576 BDBM50143514
(2s,4S)-N-((1r,3S)-3-Benzylcyclobutyl)-N-methyl-6-oxo-7-oxa-5- BDBM581700 US11512059, Example 34
(2s,4S)-N-((1s,3R)-3-Benzylcyclobutyl)-N-methyl-6-oxo-7-oxa-5- BDBM581701 US11512059, Example 35
(2s,4S)-N-Methyl-6-oxo-N-((1r,3R)-3-phenylcyclobutyl)-7-oxa-5- BDBM581666 US11512059, Example 2
(3R)-6-chloro-3,11-dimethyl-10-oxa-2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11.04,9.011,22]tricosa-1(21),4,6,8,15 US12410191, Example 22 BDBM769507
(5-Allyl-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysen-10-yl)-methyl-amine BDBM50124611 CHEMBL440454
(7aR,10aS)-8-Propyl-7,7a,8,9,10,10a-hexahydro-6H-1-oxa-8-aza-dicyclopenta[a,h]naphthalene BDBM50290663 CHEMBL328107
(8-Methoxy-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-yl)-phenyl-amine CHEMBL383121 BDBM50180434
(9R,12R,15S)-9,12-diisopropyl-15-propyl-6,7,8,9,11,12,14,15,17,18-decahydro-5-oxa-8,11,14,17-tetraaza-benzocyclooctadecene-10,13,16-trione CHEMBL214703 BDBM50199388
1-(3,4-Dihydro-2H-1-oxa-9-aza-anthracen-6-yl)-2-phenyl-ethanone CHEMBL369459 R 214127 BDBM50163606
1-Oxo-1,2-dihydro-6-oxa-10b-aza-aceanthrylene-2-carboxylic acid (4-fluoro-phenyl)-amide BDBM50012839 CHEMBL61952
1-{8-[(2,3-Diphenyl-cycloprop-2-enecarbonyl)-methyl-amino]-1-oxa-spiro[4.5]dec-7-yl}-pyrrolidinium BDBM50088375
10-Methoxy-2,2,4-trimethyl-5-(3-trifluoromethyl-phenyl)-2,5-dihydro-1H-6-oxa-1-aza-chrysene CHEMBL95644 BDBM50103247
11-Isobutyl-2,10-dioxo-1-oxa-3,9-diaza-cyclopentadecane-8,12-dicarboxylic acid 12-hydroxyamide 8-methylamide CHEMBL313199 BDBM50102604
17-Hydroxy-2-methanesulfonyl-10,13-dimethyl-tetradecahydro-20-oxa-cyclopropa[4,5]cyclopenta[a]phenanthren-3-one BDBM50045401 CHEMBL3137862
19-methyl-(2R,10R)-11-oxa-8,19-diazahexacyclo[10.9.1.01,10.02,18.04,9.016,22]docosa-4(9),5,7,12,14,16(22)-hexaen-13-ol BDBM50140910
19-methyl-(2S,10R)-11-oxa-8,19-diazahexacyclo[10.9.1.01,10.02,18.04,9.016,22]docosa-4(9),5,7,12,14,16(22)-hexaene-2,13-diol BDBM50140899
2-(isoxazol- 5-ylmethoxy)- 4-[5- (trifluoro- methyl)- 1,2,4-oxa- diazol-3- yl]pyridine US11066396, Example 207 BDBM504793
2-Diethylamino-6,7,8,9-tetrahydro-5H-3-oxa-10-thia-1-aza-benzo[a]azulen-4-one CHEMBL356390 BDBM50084234
2-fluoro- N-{4-[5- (trifluoro- methyl)- 1,2,4-oxa- diazol-3- yl]benzyl} aniline US11066396, Example 384 BDBM504986
3-(4-Chloro-phenyl)-8-oxa-bicyclo[3.2.1]oct-2-ene-2-carboxylic acid methyl ester CHEMBL185792 BDBM50156394
3-Chloro-N-[4-(5-oxa-2-azabicyclo[2.2.2]octan-4-yl)phenyl]benzamide BDBM330162 US9663530, Example 6
3-benzyloxy-12-cyclohexyl-6,7-dihydro-5-oxa-7a-azadibenzo[a,e]azulene-9-carboxylic acid BDBM50199051 CHEMBL386319
4-Ethoxy-N-[4-(5-oxa-2-azabicyclo[2.2.2]octan-4-yl)phenyl]benzamide US9663530, Example 53 BDBM330209
4-ethyl-9-isobutyl-2,2- dimethyl-1-oxa-4,9- diazaspiro[5.6]dodecan-3- one BDBM448126 US10689398, Example 32
4-fluoro- N-{4-[5- (trifluoro- methyl)- 1,2,4-oxa- diazol-3- yl]benzyl} aniline US11066396, Example 385 BDBM504987
5-(3,5-Dimethyl-phenyl)-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene CHEMBL330638 BDBM50103248
5-(3-Bromo-5-methyl-phenyl)-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene BDBM50062413 CHEMBL101907
5-(4-Chloro-3-fluoro-phenyl)-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene BDBM50062415 CHEMBL102754
5-(4-Chloro-phenyl)-2,2-dimethyl-4-methylene-2,3,4,5-tetrahydro-1H-6-oxa-1-aza-chrysene CHEMBL286130 BDBM50076313
5-(6-Bromo-pyridin-2-yl)-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene CHEMBL101852 BDBM50062420
5-[8-(6-Oxa-3-azabicyclo[3;1;1]heptan-3-yl)-2-phenyl-imidazo[1,2- US10513523, Example 79 BDBM426140
5Z-(9S,11R,15R)-13-Oxa-16-phenoxy-propoxy]-9,11,15-trihydroxy-17,18,19,20-tetranor-5-prostadienoic acid CHEMBL523143 BDBM50247915
5Z-(9S,11R,15S)-13-Oxa-16-phenoxy-propoxy]-9,11,15-trihydroxy-17,18,19,20-tetranor-5-prostadienoic acid BDBM50247917 CHEMBL491475
6-Methoxy-12-methyl-9-oxa-12-aza-tricyclo[13.4.0.0*3,8*]nonadeca-1(15),3,5,7,16,18-hexaene BDBM50151049 CHEMBL184049
7,16-dihydroxy-5,14-dimethyl-(1S,13S,16R)-2-oxa-14-azatetracyclo[11.2.1.01,10.03,8]hexadeca-3,5,7,10-tetraene-9,15-dione BDBM50081431
7-(3-But-3-enylsulfanylmethyl-7-oxa-bicyclo[2.2.1]hept-2-yl)-hept-5-enoic acid BDBM50016780 CHEMBL175751
7-(3-Pyridin-3-yl-7-oxa-bicyclo[2.2.1]hept-2-yl)-hept-5-enoic acid CHEMBL51618 BDBM50008803
7-{14-Chloro-17-oxa-3,4,10-triazatetracyclo[17.3.1.13,6.112,16]pentacosa-1(23),4,6(25),12 US10577383, Example 15 BDBM434857
7-{15-Fluoro-17-oxa-3,4,10-triazatetracyclo[17.3.1.13,6.112,16]pentacosa-1(23),4,6(25),12 BDBM434856 US10577383, Example 14
7-{15-Methoxy-17-oxa-3,4,10-triazatetracyclo[17.3.1.13,6.112,16]pentacosa-1(23),4,6(25),12 BDBM434855 US10577383, Example 13
8-(2,5-difluorophenethyl)-12- isobutyl-4-oxa-8,12- diazadispiro[2.1.5.3]tridecane BDBM484125 US10927128, Example 46 US11649248, Example 46
8-(2-Dimethylamino-ethyl)-6-methyl-7,8-dihydro-6H-9-oxa-1,6-diaza-benzocycloheptene-5-thione CHEMBL24031 BDBM50007539
8-(2-Dimethylamino-ethyl)-6-methyl-7,8-dihydro-6H-9-oxa-1,6-diaza-benzocycloheptene-5-thione CHEMBL25622 BDBM50007537
8-(3-Oxa-tricyclo[3.2.1.0*2,4*]oct-6-yl)-1,3-dipropyl-3,7-dihydro-purine-2,6-dione BDBM50058235 CHEMBL298474
8-Benzyl-2-phenyl-1-oxa-8-aza-spiro[4.5]dec-2-en-4-one; hydrochloride CHEMBL553500 BDBM50281406
8-Cyclohexylmethyl-3-phenyl-1-oxa-8-aza-spiro[4.5]dec-2-en-4-one; hydrochloride BDBM50281418 CHEMBL544996
8-Methyl-3-phenyl-1-oxa-8-aza-spiro[4.5]dec-2-en-4-one; hydrochloride CHEMBL552631 BDBM50281432
8-Phenethyl-2-phenyl-1-oxa-8-aza-spiro[4.5]dec-2-en-4-one; hydrochloride BDBM50281423 CHEMBL545222
8-Phenethyl-3-phenyl-1-oxa-8-aza-spiro[4.5]dec-2-en-4-one; hydrochloride BDBM50281413 CHEMBL553372
9-Benzyl-3-phenyl-1-oxa-9-aza-spiro[5.5]undec-2-en-4-one; hydrochloride CHEMBL544533 BDBM50281459
9-Methyl-3-phenyl-1-oxa-9-aza-spiro[5.5]undec-2-en-4-one; hydrochloride CHEMBL539518 BDBM50281446
9-benzyl-4-ethyl-2,2- dimethyl-1-oxa-4,9- diazaspiro[5.6]dodecan-3- one BDBM448147 US10689398, Example 57
9-ethyl-2-oxa-9-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3,5,7,11,13-hexaen-10-one BDBM1971 Dibenzoxazepinone 10
9-propyl-2-oxa-9-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3,5,7,11,13-hexaene-10-thione Dibenzoxazepinone 13 BDBM1975
Acetic acid 5-naphthalen-2-yl-6-oxa-10b-aza-benzo[e]azulen-4-yl ester BDBM50052742 CHEMBL325858
BDBM1973 9-propyl-2-oxa-9-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3,5,7,11,13-hexaen-10-one Dibenzoxazepinone 1
BDBM1991 Dibenzoxazepinone 42 5,7,9-trimethyl-2-oxa-9-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3,5,7,11,13-hexaen-10-one
BDBM413880 US10421750, Example 12 5-(1-benzylpiperidin-4-yl)-7-(4- methoxybenzyl)-4-oxa-7- azaspiro[2.5]octane
BDBM413911 US10421750, Example 47 5-(1-isopentylpiperidin-4-yl)-7-(4- methoxybenzyl)-4-oxa-7- azaspiro[2.5]octane
BDBM434854 US10577383, Example 12 7-{14-Fluoro-17-oxa-3,4,10-triazatetracyclo[17.3.1.13,6.112,16]pentacosa-1(23),4,6(25),12
BDBM434863 7-[14-(Trifluoromethoxy)-18-oxa-3,4,10-triazatetracyclo[17.3.1.13,6.112,16]pentacosa-1(23),4,6(25),12,14,16 US10577383, Example 23
BDBM434864 7-{15,22-Difluoro-18-oxa-3,4,10-triazatetracyclo[17.3.1.13,6.112,16]pentacosa-1(23),4,6(25),12,14,16 US10577383, Example 24
BDBM434874 7-[(12S,13R)-12-Phenyl-15-oxa-3,4,10-triazatetracyclo[14.3.1.13,6.110,13]docosa-1(20),4,6 US10577383, Example 34
BDBM434876 7-{12,12-Difluoro-18-oxa-3,4,10-triazatetracyclo[17.3.1.13,6.113,17]pentacosa-1(23),4,6(25),13,15,17 US10577383, Example 36
BDBM435985 5-[2-Methyl-3-(6-oxa-3-azabicyclo[3;1;1]heptan-3-ylmethyl)phenyl]-1,3- US10611730, Example 158
BDBM448125 4-ethyl-9-isopentyl-2,2- dimethyl-1-oxa-4,9- diazaspiro[5.6]dodecan-3- one US10689398, Example 31
BDBM448128 (2,2-dimethyl-9- phenethyl-1-oxa-4,9- diazaspiro[5.6]dodecan-4- yl)(phenyl)methanone US10689398, Example 34
BDBM50012822 CHEMBL62572 1-Oxo-1,2-dihydro-6-oxa-10b-aza-aceanthrylene-2-carboxylic acid (4-chloro-phenyl)-amide
BDBM50031938 CHEMBL59871 6-Piperazin-1-yl-7,8-dihydro-9-oxa-5-aza-benzo[6,7]cyclohepta[1,2-a]naphthalene
BDBM50042716 8-(2-Methyl-imidazol-1-ylmethyl)-1,2,9,10-tetrahydro-8H-3-oxa-10b-aza-fluoranthen-7-one CHEMBL123010
BDBM50052747 CHEMBL117444 Dimethyl-carbamic acid 5-p-tolyl-6-oxa-10b-aza-benzo[e]azulen-4-yl ester
BDBM50052749 CHEMBL325025 Diethyl-carbamic acid 5-p-tolyl-6-oxa-10b-aza-benzo[e]azulen-4-yl ester
BDBM50055481 16-(Isoxazol-3-yloxymethyl)-5,9,12,13-tetramethyl-4-oxa-tricyclo[10.3.1.0*3,5*]hexadec-8-en-2-ol CHEMBL358635
BDBM50062414 CHEMBL102720 5-(4-Chloro-3-methyl-phenyl)-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
BDBM50062416 5-(3-Fluoro-4-methyl-phenyl)-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene CHEMBL103092
BDBM50062418 CHEMBL102179 5-(6-Bromo-pyridin-3-yl)-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
BDBM50062422 CHEMBL102602 5-(3-Bromo-5-fluoro-phenyl)-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
BDBM50062424 1-[4-(2,2,4-Trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysen-5-yl)-phenyl]-ethanone CHEMBL320411
BDBM50062425 5-(4-Fluoro-3-trifluoromethyl-phenyl)-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene CHEMBL320423
BDBM50062428 9-Chloro-2,2,4-trimethyl-5-(3-trifluoromethyl-phenyl)-2,5-dihydro-1H-6-oxa-1-aza-chrysene CHEMBL431807
BDBM50062436 9-Fluoro-2,2,4-trimethyl-5-(3-trifluoromethyl-phenyl)-2,5-dihydro-1H-6-oxa-1-aza-chrysene CHEMBL418990
BDBM50062437 9-Chloro-5-(4-methoxy-phenyl)-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene CHEMBL322312
BDBM50062445 5-(4-Bromo-phenyl)-9-chloro-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene CHEMBL322576
BDBM50076307 CHEMBL36076 (4R,5S)-5-(4-Chloro-phenyl)-2,2,4-trimethyl-2,3,4,5-tetrahydro-1H-6-oxa-1-aza-chrysene
BDBM50076315 CHEMBL286822 (4S,5S)-5-(4-Chloro-phenyl)-2,2,4-trimethyl-2,3,4,5-tetrahydro-1H-6-oxa-1-aza-chrysene
BDBM50076327 isobutyl 12-methoxy-5,18-dimethyl-10-oxa-7,18-diazahexacyclo[9.9.1.01,9.02,17.04,8.015,21]henicosa-5,11,13,15(21)-tetraene-6-carboxylate CHEMBL34663
BDBM50089779 4-cyclopropylmethyl-14-(3,4-diformylphenylcarboxamidomethylcarboxamido)-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-triene
BDBM50090832 CHEMBL98836 (cis)1-Propyl-2,3,10,10a-tetrahydro-1H,4aH-4-oxa-9-thia-1-aza-phenanthren-6-ol
BDBM50096420 7-Chloro-5-cyclopropyl-3a-trifluoromethyl-3,3a-dihydro-1H-6-oxa-1,3-diaza-phenalen-2-one CHEMBL303446
BDBM50096739 (R)-7-methyl-6a,7,8,9-tetrahydro-6H-1-oxa-7-aza-benzo[cd]pyren-2-one CHEMBL124419
BDBM50096740 (R)-7-Methyl-6a,7,8,9-tetrahydro-6H-2-oxa-7-aza-benzo[cd]pyren-1-one CHEMBL122485
BDBM50103250 CHEMBL99123 5-(3,5-Difluoro-phenyl)-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
BDBM50103251 5-(3,5-Dichloro-phenyl)-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene CHEMBL419158
BDBM50107006 CHEMBL106942 9,9'-Dihydroxy-2,2'-dimethyl-1,2,1',2'-tetrahydro-[7,7']bi[3-oxa-phenanthrenyl]-4,5,8,4',5',8'-hexaone
BDBM50107348 CHEMBL138737 (10-Methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysen-5-yl)-acetic acid
BDBM50107353 5-But-3-enyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene CHEMBL141915
BDBM50107356 10-Methoxy-2,2,4-trimethyl-5-prop-2-ynyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene CHEMBL138098
BDBM50118530 CHEMBL132915 Azetidine-1-carboxylic acid 5-phenyl-6-oxa-10b-aza-benzo[e]azulen-4-yl ester
BDBM50118534 Dimethyl-carbamic acid 5-p-tolyl-6-oxa-10,10b-diaza-benzo[e]azulen-4-yl ester CHEMBL136926
BDBM50118543 Ethyl-methyl-carbamic acid 5-phenyl-6-oxa-10b-aza-benzo[e]azulen-4-yl ester CHEMBL341455
BDBM50118544 CHEMBL335085 Methyl-propyl-carbamic acid 5-phenyl-6-oxa-10b-aza-benzo[e]azulen-4-yl ester
BDBM50118545 CHEMBL133144 Ethyl-carbamic acid 5-p-tolyl-6-oxa-10b-aza-benzo[e]azulen-4-yl ester
BDBM50124595 CHEMBL273658 5-Allyl-10-chloro-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysen-9-ol
BDBM50124605 5-Allyl-7-bromo-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene CHEMBL7817
BDBM50124607 CHEMBL8329 5-Allyl-9-allyloxy-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
BDBM50124609 5-Allyl-2,2,4-trimethyl-10-prop-2-ynyloxy-2,5-dihydro-1H-6-oxa-1-aza-chrysene CHEMBL8360
BDBM50124616 CHEMBL415309 5-Allyl-10-methoxy-2,2,4-trimethyl-7-vinyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
BDBM50124617 5-Allyl-9-ethoxy-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene CHEMBL7966
BDBM50124619 5-Allyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysen-9-ol CHEMBL8140
BDBM50127581 2-(4,5-Dihydro-1H-imidazol-2-yl)-1,2,7,8,9,10-hexahydro-3-oxa-10a-aza-cyclohepta[de]naphthalene CHEMBL418716
BDBM50133227 10,17-dimethoxy-4,13-dimethyl-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-one CHEMBL133454
BDBM50143512 CHEMBL175996 (1S,4R)-3-(4-Chloro-phenylcarbamoyl)-7-oxa-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid
BDBM50143522 (1S,4R)-3-(3-Carboxy-phenylcarbamoyl)-7-oxa-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid CHEMBL175630
BDBM50151041 CHEMBL184050 12-Methyl-9-oxa-12-aza-tricyclo[13.4.0.0*3,8*]nonadeca-1(15),3,5,7,16,18-hexaen-6-ol
BDBM50156389 3-(4-Iodo-phenyl)-8-oxa-bicyclo[3.2.1]oct-2-ene-2-carboxylic acid methyl ester CHEMBL187211
BDBM50156392 CHEMBL185169 3-Naphthalen-2-yl-8-oxa-bicyclo[3.2.1]oct-2-ene-2-carboxylic acid methyl ester
BDBM50156399 3-(4-Bromo-phenyl)-8-oxa-bicyclo[3.2.1]oct-2-ene-2-carboxylic acid methyl ester CHEMBL186488
BDBM50161596 CHEMBL178734 4-((1R,2R,5R)-4,4,8-Trimethyl-3-oxa-bicyclo[3.3.1]non-7-en-2-yl)-phenol
BDBM50163611 1-(3,4-Dihydro-2H-1-oxa-9-aza-anthracen-6-yl)-2-thiophen-3-yl-ethanone CHEMBL178742
BDBM50180430 (3-Bromo-phenyl)-(10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-yl)-amine CHEMBL203219
BDBM50180446 Benzyl-(8-bromo-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-yl)-amine CHEMBL381306
BDBM50192478 1-(3-bromo-phenoxy)-7,8-dimethoxy-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cycloheptene CHEMBL216048
BDBM50192489 1-(3-bromo-phenylsulfanyl)-7,8-dimethoxy-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cycloheptene CHEMBL214853
BDBM50262456 CHEMBL478001 11-Amino-3,3-dimethyl-12-p-tolyl-2,3,4,7,8,9,10,12-octahydro-5-oxa-6-aza-naphthacen-1-one
BDBM50281407 7-Benzyl-2-phenyl-1-oxa-7-aza-spiro[4.5]dec-2-en-4-one; hydrochloride CHEMBL544761
BDBM50281420 8-Methyl-2-phenyl-1-oxa-8-aza-spiro[4.5]dec-2-en-4-one; hydrochloride CHEMBL556133
BDBM50281451 CHEMBL552910 8-Benzyl-3-phenyl-1-oxa-8-aza-spiro[5.5]undec-2-en-4-one; hydrochloride
BDBM50288145 CHEMBL86224 3-Methyl-butyric acid [2,8-dimethyl-1-oxa-8-aza-spiro[4.5]dec-(3E)-ylidene]-hydrazide
BDBM50288158 CHEMBL82012 2,2-Dimethyl-propionic acid [2,8-dimethyl-1-oxa-8-aza-spiro[4.5]dec-(3E)-ylidene]-hydrazide
BDBM50288159 5-Cyclohexyl-pentanoic acid [2,8-dimethyl-1-oxa-8-aza-spiro[4.5]dec-(3E)-ylidene]-hydrazide CHEMBL313565
BDBM50288169 CHEMBL83410 N'-[2,8-Dimethyl-1-oxa-8-aza-spiro[4.5]dec-(3E)-ylidene]-hydrazinecarboxylic acid methyl ester
BDBM50291347 Piperidin-1-yl-[3-(3,4,10,10a-tetrahydro-1H-9-oxa-2,4a-diaza-phenanthren-2-ylmethyl)-phenyl]-methanone CHEMBL164330
BDBM50333691 CHEMBL1643404 (9S,13S,14R)-14-methyl-3,11-dioxo-1-phenyl-2-oxa-4,10,12-triazahexadecane-9,13-dicarboxylic acid
BDBM50343395 10-(cyclohexylamino)-12-[(2-hydroxyethyl)amino]-15-oxa-14-azatetracyclohexadeca-1(16),2,4,6,9,11,13-heptaen-8-one CHEMBL1774936
BDBM504790 3-hydroxy- N-{4-[5- (trifluoro- methyl)- 1,2,4-oxa- diazol-3- yl]benzyl} benzamide US11066396, Example 205
BDBM505016 [3-({4-[5- (trifluoro- methyl)- 1,2,4-oxa- diazol-3- yl]benzyl} amino) phenyl] methanol US11066396, Example 413
BDBM505017 3-fluoro- N-{4-[5- (trifluoro- methyl)- 1,2,4-oxa- diazol-3- yl]benzyl} aniline US11066396, Example 414
BDBM571387 US11440918, Compound 2 N-(4-((2-oxa-6-azaspiro[3.3]heptan-6-yl)methyl)phenyl)-4-chlorobenzamide 
BDBM571390 N-(4-((7-oxa-2-azaspiro[3.5]nonan-2-yl)methyl)phenyl)-4-chlorobenzamide US11440918, Compound 4
BDBM571391 US11440918, Compound 6 N-(4-((1-oxa-7-azaspiro[4.4]nonan-7-yl)methyl)phenyl)-4-chlorobenzamide 
BDBM579867 4-(3-oxa-8- azabicyclo [3.2.1] octane- 8- carbonyl)- N-(3-(3,4- dihydro- isoquinolin- US11485731, Example 1R
BDBM581665 (2s,4S)-N-Methyl-6-oxo-N-((1s,3S)-3-phenylcyclobutyl)-7-oxa-5- US11512059, Example 1
BDBM700876 US20240342186, Example 9.01 (2S,4S)-1-[4-(difluoromethyl)-8-oxa-3,5-diazatricyclo[7.4.0.02,7]trideca-1(9),2
Benzyl-(8-fluoro-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-yl)-amine BDBM50180436 CHEMBL379041
Butyl-methyl-carbamic acid 5-phenyl-6-oxa-10b-aza-benzo[e]azulen-4-yl ester BDBM50118529 CHEMBL134282
C-(5-Allyl-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysen-10-yl)-methylamine BDBM50124610 CHEMBL8340
CHEMBL104183 9-Chloro-5-(3-chloro-phenyl)-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene BDBM50062430
CHEMBL104451 BDBM50062435 9-Fluoro-5-(4-methoxy-phenyl)-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
CHEMBL106994 BDBM50062443 5-(4-Chloro-phenyl)-9-fluoro-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
CHEMBL107998 BDBM50062426 5-(4-Chloro-phenyl)-9-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
CHEMBL108230 5-(4-Chloro-phenyl)-8-fluoro-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene BDBM50062431
CHEMBL114508 BDBM50052745 Dimethyl-carbamic acid 5-phenyl-6-oxa-12b-aza-naphtho[2,3-e]azulen-4-yl ester
CHEMBL134421 BDBM50067668 2,2,4-Trimethyl-5-[1-phenyl-meth-(Z)-ylidene]-2,5-dihydro-1H-6-oxa-1-aza-chrysene
CHEMBL138957 BDBM50107351 2-(10-Methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysen-5-yl)-ethanol
CHEMBL150968 16-(Isoxazol-3-yloxymethyl)-5,9,12,13-tetramethyl-4-oxa-tricyclo[10.3.1.0*3,5*]hexadec-8-en-2-ol BDBM50055485
CHEMBL1650518 3-[5-(2,6-Difluorophenyl)-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene BDBM50335169
CHEMBL203529 (8-Fluoro-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-yl)-phenyl-amine BDBM50180451
CHEMBL204335 BDBM50180427 Benzyl-(8-methoxy-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-yl)-amine
CHEMBL215210 1-(3-chloro-phenylsulfanyl)-7,8-dimethoxy-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cycloheptene BDBM50192496
CHEMBL269305 cis-7-Ethyl-5-methyl-4-trifluoromethyl-5,6,7,8-tetrahydro-1-oxa-8-aza-anthracen-2-one BDBM50076699
CHEMBL280181 19-oxa-2,5,10,12-tetraazahexacyclo[18.6.2.22,5.114,18.08,12.023,27]hentriaconta-1(27),8,10,14(31),15,17,20(28),21,23,25-decaen-3-one BDBM50112388
CHEMBL285563 BDBM50001675 14-oxa-11,22-diazaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5(10),6,8,15(25),16,18-heptaene-2,16-diol
CHEMBL293617 1-Oxo-1,2-dihydro-6-oxa-10b-aza-aceanthrylene-2-carboxylic acid (2,4-difluoro-phenyl)-amide BDBM50012883
CHEMBL312957 4-Cyclohexyl-benzoic acid [2,8-dimethyl-1-oxa-8-aza-spiro[4.5]dec-(3E)-ylidene]-hydrazide BDBM50288143
CHEMBL322485 BDBM50062444 9-Chloro-5-(3-fluoro-phenyl)-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
CHEMBL322575 9-Chloro-5-(4-chloro-phenyl)-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene BDBM50062442
CHEMBL327757 BDBM50103255 10-Methoxy-5-(3-methoxymethoxy-phenyl)-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
CHEMBL330216 BDBM50090829 (trans)1-Propyl-2,3,10,10a-tetrahydro-1H,4aH-4-oxa-9-thia-1-aza-phenanthren-6-ol
CHEMBL335300 Diethyl-carbamic acid 5-m-tolyl-6-oxa-10,10b-diaza-benzo[e]azulen-4-yl ester BDBM50118542
CHEMBL342819 10-Methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene-5-carboxylic acid amide BDBM50107361
CHEMBL344000 14-oxa-11,22-diazaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5(10),6,8,15(25),16,18-heptaen-16-ol BDBM50001674
CHEMBL361493 3-(4-Fluoro-phenyl)-8-oxa-bicyclo[3.2.1]oct-2-ene-2-carboxylic acid methyl ester BDBM50156397
CHEMBL382862 (8-Bromo-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-yl)-phenyl-amine BDBM50180428
CHEMBL416411 5-(3-Chloro-phenyl)-9-fluoro-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene BDBM50062432
CHEMBL481888 methyl 3-(4-cyano-5,6,7,8-tetrahydronaphthalen-1-ylimino)-2-oxa-4-azaspiro[5.5]undecane-4-carbodithioate BDBM50256433
CHEMBL538755 BDBM50281453 9-Phenethyl-3-phenyl-1-oxa-9-aza-spiro[5.5]undec-2-en-4-one; hydrochloride
CHEMBL539007 BDBM50281447 3-(4-Fluoro-phenyl)-9-phenethyl-1-oxa-9-aza-spiro[5.5]undecan-4-one; hydrochloride
CHEMBL539526 BDBM50281454 9-Phenethyl-2-phenyl-1-oxa-9-aza-spiro[5.5]undec-2-en-4-one; hydrochloride
CHEMBL540028 BDBM50281410 7-Benzyl-3-phenyl-1-oxa-7-aza-spiro[4.5]dec-2-en-4-one; hydrochloride
CHEMBL542877 7-Benzyl-3-phenyl-1-oxa-7-aza-spiro[4.4]non-2-en-4-one; hydrochloride BDBM50281434
CHEMBL552687 BDBM50281433 8-Benzyl-3-phenyl-1-oxa-8-aza-spiro[4.5]dec-2-en-4-one; hydrochloride
CHEMBL555614 8-Allyl-3-phenyl-1-oxa-8-aza-spiro[4.5]dec-2-en-4-one; hydrochloride BDBM50281415
CHEMBL68353 BDBM50096415 7-Chloro-5-phenyl-3a-trifluoromethyl-3,3a-dihydro-1H-6-oxa-1,3-diaza-phenalen-2-one
CHEMBL7987 5-Allyl-9-chloro-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene BDBM50124612
CHEMBL7988 5-Allyl-9-fluoro-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene BDBM50124604
CHEMBL8027 BDBM50124620 5-Allyl-9-bromo-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
CHEMBL84135 4-Phenyl-butyric acid [2,8-dimethyl-1-oxa-8-aza-spiro[4.5]dec-(3E)-ylidene]-hydrazide BDBM50288155
CHEMBL85952 BDBM50288144 4-Cyclohexyl-butyric acid [2,8-dimethyl-1-oxa-8-aza-spiro[4.5]dec-(3E)-ylidene]-hydrazide
CHEMBL97206 10-Methoxy-2,2,4-trimethyl-5-(3-methylsulfanylmethoxy-phenyl)-2,5-dihydro-1H-6-oxa-1-aza-chrysene BDBM50103249
Dibenzoxazepinone 25 5,9-dimethyl-2-oxa-9-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3,5,7,11,13-hexaen-10-one BDBM1978
Diethyl-carbamic acid 5-m-tolyl-6-oxa-10b-aza-benzo[e]azulen-4-yl ester BDBM50118546 CHEMBL134781
Dimethyl-(11-methyl-3,3a,8,12b-tetrahydro-2H-1-oxa-dibenzo[e,h]azulen-2-ylmethyl)-amine CHEMBL371352 BDBM50162956
N-((1r,4r)-4-(3-aminopropanamido)cyclohexyl)benzo[c][1,2,5]oxa-diazole-5-carboxamide US10266526, Compound 332 BDBM378202
N-[4-(7,8-Dihydro-6H-5-oxa-9-aza-benzocycloheptene-9-carbonyl)-phenyl]-2-methyl-benzamide BDBM50052919 CHEMBL332060
N-{4-[5- (trifluoro- methyl)- 1,2,4-oxa- diazol-3- yl]benzyl} pyridin-2- amine US11066396, Example 382 BDBM504983
N-{4-[5- (trifluoro- methyl)- 1,2,4-oxa- diazol-3- yl]benzyl} pyridin-3- amine US11066396, Example 383 BDBM504984
SMR000149442 7-Chloro-4-isobutyl-2,3-dihydro-1H-6-oxa-5,8,10-triaza-cyclopenta[c]fluorene cid_2027229 BDBM67173 MLS000559126
SMR000440129 BDBM72702 cid_4885948 MLS000333811 2-Butyl-6,7,8,9-tetrahydro-2H-11-oxa-2,4,10-triaza-benzo[b]fluoren-1-one
US10421750, Example 13 7-(4-methoxybenzyl)-5-(1- phenethylpiperidin-4-yl)-4-oxa-7- azaspiro[2.5]octane BDBM413881
US10421750, Example 46 5-(1-isobutylpiperidin-4-yl)-7-(4- methoxybenzyl)-4-oxa-7- azaspiro[2.5]octane BDBM413910
US10577383, Example 6 BDBM434848 7-{10-methyl-17-oxa-3,4,10-triazatetracyclo[16.3.1.13,6.112,16]tetracosa-1(22),4,6(24),12,14,16
US10689398, Example 30 BDBM448124 4-ethyl-2,2-dimethyl-9- phenethyl-1-oxa-4,9- diazaspiro[5.6]dodecan- 3-one
US10858373, Example 1 1,1,1,3,3,3-Hexafluoropropan-2-yl 4-(phenylsulfonyl)-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate BDBM474403
US11066396, Example 386 BDBM504988 N-{4-[5- (trifluoro- methyl)- 1,2,4-oxa- diazol-3- yl]benzyl} pyrimidin- 2-amine
US11066396, Example 407 3-methoxy- N-{4-[5- (trifluoro- methyl)- 1,2,4-oxa- diazol-3- yl]benzyl} aniline BDBM505010
US11066396, Example 417 BDBM505020 N-{4-[5- (trifluoro- methyl)- 1,2,4-oxa- diazol-3- yl]benzyl} pyrazin-2- amine
US11066396, Example 419 N-{4-[5- (trifluoro- methyl)- 1,2,4-oxa- diazol-3- yl]benzyl} pyrimidin- 5-amine BDBM505022
US11485731, Example 1BE 4-(3- oxa-8- azabicyclo [3.2.1] octane- 8- carbonyl)- N-((R)-3- (3,4- dihydro- BDBM579904
US11485731, Example 1X BDBM579873 3-(3-oxa-8- azabicyclo [3.2.1] octane- 8- carbonyl)- N-(3-(3,4- dihydro- isoquinolin-
US11512059, Example 38 (2s,4S)-N-((1s,3S)-3-Cyclohexylcyclobutyl)-N-methyl-6-oxo-7-oxa-5- BDBM581704
US11512059, Example 39 BDBM581705 (2s,4S)-N-((1r,3R)-3-Cyclohexylcyclobutyl)-N-methyl-6-oxo-7-oxa-5-
US12410191, Example 1 (3R)-6-fluoro-3-methyl-10-oxa-2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11.04,9.018,22]tricosa-1(21),4,6,8,15 BDBM769494
US12410191, Example 5 (3R)-6-fluoro-3,11-dimethyl-10-oxa-2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11.04,9.018,22]tricosa-1(21),4,6,8,15 BDBM769496
cid_1946605 SMR000145756 5-Propyl-1,2,3,4-tetrahydro-9H-7-oxa-6,9,11-triaza-benzo[c]fluoren-8-one BDBM47565 MLS000551831
methyl 3-(4-chloro-5,6,7,8-tetrahydronaphthalen-1-ylimino)-2-oxa-4-azaspiro[5.5]undecane-4-carbodithioate CHEMBL480579 BDBM50256432
methyl 3-(benzo[c][1,2,5]oxadiazol-4-ylimino)-2-oxa-4-azaspiro[5.5]undecane-4-carbodithioate BDBM50256316 CHEMBL469896
(5S,7R,8S,9S,10R)-8,9,10-Trihydroxy-7-hydroxymethyl-6-oxa-1,3-diaza-spiro[4.5]decane-2,4-dione (5S,7R,8S,9S,10R)-8,9,10-trihydroxy-7-(hydroxymethyl)-6-oxa-1,3-diazaspiro[4.5]decane-2,4-dione CHEMBL510975 BETA-D-GLUCOPYRANOSE SPIROHYDANTOIN BDBM50263768
BDBM50045388 CHEMBL432949 (20RS)-4-Hydroxy-4-(2-hydroxy-ethyl)-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione 4-Hydroxy-4-(2-hydroxy-ethyl)-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione
BDBM50127165 10-hydroxy-17-methoxy-4,13-dimethyl-(13R,17S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7,9,11(18)-trien-14-one 10-hydroxy-17-methoxy-4,13-dimethyl-(13R,17S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-one
CHEMBL76023 BDBM50000790 methyl 2-[4-cyclopropylmethyl-10,17-dihydroxy-(13R)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7,9,11(18)-trien-14-yloxymethyl]acrylate methyl 2-[4-cyclopropylmethyl-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-yloxymethyl]acrylate
Lithium; (2R,5R)-3-[2-hydroxy-eth-(Z)-ylidene]-7-oxo-4-oxa-1-aza-bicyclo[3.2.0]heptane-2-carboxylate CHEMBL9306 BDBM50240349 lithium (2R,5R,Z)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-aza-bicyclo[3.2.0]heptane-2-carboxylate
4-[3-(3-bromophenyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-en-8-yl]-3-[[(4-bromophenyl)-oxomethyl]amino]-N-propylbenzamide SMR001196018 cid_24978962 MLS001074394 3-[(4-bromobenzoyl)amino]-4-[3-(3-bromophenyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-en-8-yl]-N-propylbenzamide 3-[(4-bromobenzoyl)amino]-4-[3-(3-bromophenyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-en-8-yl]-N-propyl-benzamide 3-[(4-bromophenyl)carbonylamino]-4-[3-(3-bromophenyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-en-8-yl]-N-propyl-benzamide BDBM64476
(naloxone) 4-allyl-10,17-dihydroxy-(1S,5R,13R,17S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-one 4-allyl-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-one NARCAN Analog of 14-(Arylhydroxyamino)codeinone NALOXONE SUBOXONE (naloxone)4-allyl-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-one BDBM50000788 (morphine)4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraene-10,14-diol [17-(2,3-3H-2-propenyl)]-4, 5a -epoxy-3,14-dihydroxymorphinan-6-one (naloxone)4-allyl-10,17-dihydroxy-(1S,5R,13R,17S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-one 4-allyl-10,17-dihydroxy-(1S,5R,13R,17S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-one( Naloxone) 4-allyl-10,17-dihydroxy-(1S,5R,13R,17S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-one 4-allyl-10,17-dihydroxy-(1S,5R,13R,17S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-one(Naxolone) 4-allyl-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-one(naloxone)C2H2O4 4-allyl-10,17-dihydroxy-(1S,5R,13R,17S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-one (naloxone)
(8R)-3-(3-methacrylamidophenyl)-7-propionyl-1-oxa-2,7-diazaspiro[4.4]non-2-ene-8-carboxamide cid_16745481 (8R)-3-[3-(2-methylprop-2-enoylamino)phenyl]-7-propanoyl-1-oxa-2,7-diazaspiro[4.4]non-2-ene-8-carboxamide SMR000390647 (8R)-3-[3-[(2-methyl-1-oxoprop-2-enyl)amino]phenyl]-7-(1-oxopropyl)-1-oxa-2,7-diazaspiro[4.4]non-2-ene-8-carboxamide BDBM45731 MLS000561974
(8S)-3-[3-(caproylamino)phenyl]-7-[(E)-pent-2-enoyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene-8-carboxamide MLS000561993 BDBM32978 cid_16681939 SMR000390657 (8S)-3-[3-(hexanoylamino)phenyl]-7-[(E)-pent-2-enoyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene-8-carboxamide (8S)-3-[3-(1-oxohexylamino)phenyl]-7-[(E)-1-oxopent-2-enyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene-8-carboxamide
(8S)-7-hexanoyl-3-[3-(2-methylprop-2-enoylamino)phenyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene-8-carboxamide cid_16745484 SMR000390642 BDBM61723 (8S)-3-[3-[(2-methyl-1-oxoprop-2-enyl)amino]phenyl]-7-(1-oxohexyl)-1-oxa-2,7-diazaspiro[4.4]non-2-ene-8-carboxamide MLS000561998 (8S)-7-caproyl-3-(3-methacrylamidophenyl)-1-oxa-2,7-diazaspiro[4.4]non-2-ene-8-carboxamide
BDBM113903 (8S)-7-(4-chlorobenzoyl)-3-[3-(3,3-diphenylpropanoylamino)phenyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene-8-carboxamide cid_16681904 MLS000562060 (8S)-7-(4-chlorophenyl)carbonyl-3-[3-(3,3-diphenylpropanoylamino)phenyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene-8-carboxamide (8S)-7-[(4-chlorophenyl)-oxomethyl]-3-[3-[(1-oxo-3,3-diphenylpropyl)amino]phenyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene-8-carboxamide SMR000390693
BDBM50013625 22-cyclopropylmethyl-11-methyl-(2S,13R)-14-oxa-11,22-diazaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5(10),6,8,15(25),16,18-heptaene-2,16-diol(HCl2H2O) 22-cyclopropylmethyl-11-methyl-(1S,2S,13R)-14-oxa-11,22-diazaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5(10),6,8,15,17,19(25)-heptaene-2,16-diol 22-cyclopropylmethyl-11-methyl-14-oxa-11,22-diazaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5(10),6,8,15,17,19(25)-heptaene-2,16-diol
N-[5-[oxo(propylamino)methyl]-2-(3-phenyl-1-oxa-2,8-diazaspiro[4.5]dec-2-en-8-yl)phenyl]-2-furancarboxamide N-[2-(3-phenyl-1-oxa-2,8-diazaspiro[4.5]dec-2-en-8-yl)-5-(propylcarbamoyl)phenyl]-2-furamide MLS001074376 cid_24816792 N-[2-(3-phenyl-1-oxa-2,8-diazaspiro[4.5]dec-2-en-8-yl)-5-(propylcarbamoyl)phenyl]furan-2-carboxamide BDBM58653 SMR000718491
(11-Fluoro-2,3,3a,12b-tetrahydro-1-oxa-8-thia-dibenzo[e,h]azulen-2-ylmethyl)-dimethyl-amine CHEMBL193639 BDBM50162957
(1S,4R)-3-(4-Ethoxycarbonyl-phenylcarbamoyl)-7-oxa-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid cid_2837866 BDBM50143520 CHEMBL367750
(3R,11R)-6-fluoro-3,11-dimethyl-10-oxa-2,14,18,19,22-pentaazapentacyclo[14.5.2.18,11.04,9.019,23]tetracosa-1(22),4,6,8,16 BDBM769505 US12410191, Example 20
(3R,4S,5R,10R,13S)-10,13-Dimethyl-hexadecahydro-20-oxa-cyclopropa[3,4]cyclopenta[a]phenanthren-17-one CHEMBL372334 BDBM50174541
(4-Methoxy-2,5-dioxo-7-oxa-bicyclo[4.1.0]hept-3-en-1-yl)-acetic acid methyl ester BDBM50114885 CHEMBL47315
(4R,5S)-2,2,4-Trimethyl-5-(3-trifluoromethyl-phenyl)-1,2,4,5-tetrahydro-6-oxa-1-aza-chrysen-3-one CHEMBL286158 BDBM50076296
(4R,5S)-5-(4-Chloro-phenyl)-2,2,4-trimethyl-1,2,4,5-tetrahydro-6-oxa-1-aza-chrysen-3-one BDBM50076305 CHEMBL34015
(4S,5S)-2,2,4-Trimethyl-5-(3-trifluoromethyl-phenyl)-1,2,4,5-tetrahydro-6-oxa-1-aza-chrysen-3-one CHEMBL36065 BDBM50076302
(4aR,12bR)-8-Hexyl-2,5,5-trimethyl-1,4a,5,8,9,10,11,12b-octahydro-4H-6-oxa-benzo[a]anthracen-12-ol BDBM50080032 CHEMBL303479
(4aS,7S,12cS)-4,4,7,12c-Tetramethyl-2,3,4,4a,5,6,7,12c-octahydro-1H-8-oxa-dibenzo[a,h]azulen-10-ol BDBM50332738 CHEMBL1630536
(5-(1-benzylpiperidin-4-yl)-4-oxa-7- azaspiro[2.5]octan-7- yl)(phenyl)methanone BDBM413872 US10421750, Example 4
(5-(1-phenethylpiperidin-4-yl)-4-oxa-7- azaspiro[2.5]octan-7- yl)(phenyl)methanone BDBM413870 US10421750, Example 2
(5-Allyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysen-9-yloxy)-acetonitrile BDBM50124602 CHEMBL8055
(7,8-dimethoxy-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-yl)-m-tolyl-amine CHEMBL386365 BDBM50192472
(9-(2-isopropoxyethyl)-2,2- dimethyl-1-oxa-4,9- diazaspiro[5.6]dodecan-4- yl)(phenyl)methanone US10689398, Example 50 BDBM448144
(E)-(7S,11S)-2,4,11-Trihydroxy-7-methyl-7,8,9,10,11,12,13,14-octahydro-6-oxa-benzocyclotetradecen-5-one BDBM50240982 CHEMBL372840 BETA-ZEARALENOL cid_107645
(R)-2-isobutyl-8- isopropyl-6-methyl-5-oxa- 2,8-diazaspiro[3.5]nonan- 7-one BDBM448136 US10689398, Example 42
(R)-8-ethyl-2-isopentyl-6- methyl-5-oxa-2,8- diazaspiro[3.5]nonan-7- one BDBM448130 US10689398, Example 36
(R)-8-ethyl-6-methyl-2- neopentyl-5-oxa-2,8- diazaspiro[3.5]nonan-7- one US10689398, Example 75 BDBM448173
(R)-9-Methyl-8,9,10,11-tetrahydro-3-oxa-6-thia-8,11-diaza-cyclohepta[b]-as-indacen-7-one CHEMBL557318 BDBM50297120
(RS)-4-(Cyclopropylmethoxy)-N-[4-(5-oxa-2-azabicyclo[2.2.2]octan-4-yl)phenyl]benzamide BDBM330167 US9663530, Example 11
(RS)-4-Chloro-N-[4-(5-oxa-2-azabicyclo[2.2.2]octan-4-yl)phenyl]benzamide BDBM330161 US9663530, Example 5
(S)-8-isopropyl-6- methyl-2-neopentyl-5-oxa- 2,8-diazaspiro[3.5]nonan- 7-one US10689398, Example 76 BDBM448174
1-(3-Bromo-phenylamino)-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cycloheptene-8-carboxylic acid BDBM50180440 CHEMBL205148
1-({5-[5- (trifluoro- methyl)- 1,2,4-oxa- diazol-3- yl]pyridin- 2-yl} methoxy) phthalazine BDBM504890 US11066396, Example 298
10,17-dihydroxy-4-(2-hydroxycyclohexyl)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-one CHEMBL282727 BDBM50018118
12-ethyl-8-propyl-4-oxa-8,12- diazadispiro[2.1.5.3]tridecan-13-one BDBM484109 US10927128, Example 30 US11649248, Example 30
2-(2-(cyclobutanecarbonyl)-9- oxo-7-oxa-2,10-diazaspiro- [5.6]dodecan-10-yl)acetic acid US20240425519, Compound AC904 BDBM708901
2-({5-[5- (trifluoro- methyl)- 1,2,4-oxa- diazol-3- yl]pyrimidin- 2-yl} methoxy) quinoline US11066396, Example 473 BDBM505076
3-(3,4- dihydro- isoquinolin- 2(1H)-yl)- 2-hydroxy- propyl 3- (3-oxa-8- azabicyclo- BDBM579967 US11485731, Example 4U
3-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)thieno[3,2-d]pyrimidin-2-yl)phenol CHEMBL593156 BDBM50304682
3-({3- fluoro-4-[5- (trifluoro- methyl)- 1,2,4-oxa- diazol-3- yl]phenyl} methoxy) benzamide US11066396, Example 264 BDBM504855
3-({3- fluoro-4-[5- (trifluoro- methyl)- 1,2,4-oxa- diazol-3- yl]phenyl} methoxy) pyridazine BDBM504848 US11066396, Example 257
3-[5-(2-Difluoromethoxyphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-aza-spiro[4.5]dec-2-ene CHEMBL1650517 BDBM50335153
3-[5-(2-Trifluoromethoxyphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-aza-spiro[4.5]dec-2-ene CHEMBL1650514 BDBM50335154
4-((1R,5R)-5-Hydroxymethyl-8-methyl-3-oxa-bicyclo[3.3.1]non-7-en-2-yl)-phenol CHEMBL294889 BDBM50128414
4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)thieno[3,2-d]pyrimidin-2-yl)phenol BDBM50304684 CHEMBL595288
4-Isopropyl-2-methyl-9- phenethyl-1-oxa-4,9- diazaspiro[5.5]undecane US10927128, Example 109 BDBM484188 US11649248, Example 109
4-cyclopropylmethyl-14-(2-oxiranylmethoxy)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-triene-10,17-diol BDBM50000793 CHEMBL311912
4-cyclopropylmethyl-14-(2-oxiranylmethoxy)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-triene-10,17-diol BDBM50000797 CHEMBL80434
4-isopropyl-2,2-dimethyl-9- phenethyl-1-oxa-4,9- diazaspiro[5.5]undecane BDBM484192 US10927128, Example 113 US11649248, Example 113
5-(1-benzylazetidin-3-yl)-7-phenyl- 4-oxa-7-azaspiro[2.5]octan-8-one BDBM413909 US10421750, Example 45
5-(1-benzylpiperidin-4-yl)-7-ethyl-4- oxa-7-azaspiro[2.5]octan-8-one BDBM413873 US10421750, Example 5
5-(2-(4-Fluorophenyl)-8-(2-oxa-6-azaspiro[3;3]heptan-6-yl)imidazo[1,2- US10513523, Example 108 BDBM426169
5-({3- fluoro-4-[5- (trifluoro- methyl)- 1,2,4-oxa- diazol-3- yl]phenyl} methoxy) pyrimidine BDBM504826 US11066396, Example 236
5-Allyl-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene-10-carboxylic acid methyl ester BDBM50124592 CHEMBL7844
5-[2-(4-Fluorophenyl)-8-(6-oxa-2-azaspiro[3;3]heptan-2-yl)imidazo[1,2- US10513523, Example 24 BDBM426085
5-[2-(4-Fluorophenyl)-8-(6-oxa-2-azaspiro[3;3]heptan-2-yl)imidazo[1,2- US10513523, Example 26 BDBM426087
5Z-(9S,11R,15R)-13-Oxa-17-(3-trifluoromethyl)phenyl-9,11,15-trihydroxy-18,19,20-trinor-5-prostadienoic acid BDBM50247863 CHEMBL521964
5Z-(9S,11R,15S)-13-Oxa-17-(3-trifluoromethyl)phenyl-9,11,15-trihydroxy-18,19,20-trinor-5-prostadienoic acid BDBM50247862 CHEMBL491667
7-[(11R)-11-Methyl-18-oxa-3,4,10-triazatetracyclo[17.3.1.13,6.113,17]pentacosa-1(23),4,6(25),13,15,17 BDBM434850 US10577383, Example 8
7-[10-(2-Methoxyethyl)-18-oxa-3,4,10-triazatetracyclo[17.3.1.13,6.113,17]pentacosa-1(23),4,6(25),13,15,17 US10577383, Example 37 BDBM434877
7-ethyl-5-(1-isopentylpiperidin-4- yl)-4-oxa-7-azaspiro[2.5]octan-8- one BDBM413904 US10421750, Example 40
7-ethyl-5-(1-phenethylazetidin-3- yl)-4-oxa-7-azaspiro[2.5]octan-8- one BDBM413907 US10421750, Example 43
7-{3-[(2-Nonanoylamino-acetylamino)-methyl]-7-oxa-bicyclo[2.2.1]hept-2-yl}-hept-5-enoic acid CHEMBL82146 BDBM50015852
8-(2-(3-fluoropyridin-2-yl)ethyl)-12- isopropyl-4-oxa-8,12-diazadispiro [2.1.5.3]tridecane BDBM603055 US11649248, Example 36
8-benzyl-12-ethyl-4-oxa-8,12- diazadispiro[2.1.5.3]tridecan-13-one US11649248, Example 17 BDBM484096 US10927128, Example 17
8-benzyl-12-isobutyl-4-oxa-8,12- diazadispiro[2.1.5.3]tridecan-13-one US11649248, Example 27 BDBM484106 US10927128, Example 27
8-benzyl-12-isopropyl-4-oxa-8,12- diazadispiro[2.1.5.3]tridecan-13-one US10927128, Example 20 BDBM484099 US11649248, Example 20
8-benzyl-12-methyl-4-oxa-8,12- diazadispiro[2.1.5.3]tridecan-13-one US11649248, Example 18 BDBM484097 US10927128, Example 18
8-butyl-12-ethyl-4-oxa-8,12- diazadispiro[2.1.5.3]tridecan-13-one BDBM484091 US10927128, Example 12 US11649248, Example 12
8-isopentyl-12-methyl-4-oxa-8,12- diazadispiro[2.1.5.3]tridecan-13-one BDBM484082 US10927128, Example 3 US11649248, Example 3
9-isopentyl-4-propyl-1-oxa- 4,9-diazaspiro[5.5]undecan- 3-one US11649248, Example 49 BDBM484128 US10927128, Example 49
Acetic acid N'-[2,8-dimethyl-1-oxa-8-aza-spiro[4.5]dec-(3E)-ylidene]-N-methyl-hydrazide BDBM50288151 CHEMBL84278
BDBM413878 5-(1-benzylpiperidin-4-yl)-7-phenyl-4- oxa-7-azaspiro[2.5]octan-8-one US10421750, Example 10
BDBM413901 US10421750, Example 37 5-(1-benzylpiperidin-4-yl)-7- isopropyl-4-oxa-7- azaspiro[2.5]octan-3-one
BDBM413906 US10421750, Example 42 5-(1-benzylazetidin-3-yl)-7-ethyl-4- oxa-7-azaspiro[2.5]octan-8-one
BDBM413908 US10421750, Example 44 5-(1-isopentylpiperidin-4-yl)-7- phenyl-4-oxa-7- azaspiro[2.5]octan-8-one
BDBM413915 (5-(1-Isopentylpiperidin-4-yl)-4- oxa-7-azaspiro[2.5]octan-7- yl)(phenyl)methanone US10421750, Example 51
BDBM426259 5-[2-tert-Butyl-7-(6-oxa-2-azaspiro[3;3]heptan-2-yl)pyrazolo[1,5- US10513523, Example 199
BDBM434852 US10577383, Example 10 7-[(17R)-17-Methyl-18-oxa-3,4,10-triazatetracyclo[17.3.1.13,6.112,16]pentacosa-1(23),4,6(25),12,14,16
BDBM448131 (S)-8-ethyl-2-isopentyl-6- methyl-5-oxa-2,8- diazaspiro[3.5]nonan-7- one US10689398, Example 37
BDBM448132 (R)-8-ethyl-2-isobutyl- 6-methyl-5-oxa-2,8- diazaspiro[3.5]nonan-7- one US10689398, Example 38
BDBM448137 US10689398, Example 43 (S)-2-isobutyl-8- isopropyl-6-methyl-5-oxa- 2,8-diazaspiro[3.5]nonan- 7-one
BDBM448169 US10689398, Example 73 4-((13-methyl-14-oxo-4- oxa-8,13- diazadispiro[2.1.6.3] tetradecan-8-yl)methyl) benzonitrile.
BDBM448170 US10689398, Example 74 (S)-8-ethyl-6-methyl-2- neopentyl-5-oxa-2,8- diazaspiro[3.5]nonan-7- one
BDBM448175 US10689398, Example 77 (R)-8-isopropyl-6- methyl-2-neopentyl-5-oxa- 2,8-diazaspiro[3.5]nonan- 7-one
BDBM484093 8-cyclopentyl-12-ethyl-4-oxa-8,12- diazadispiro[2.1.5.3]tridecan-13-one US10927128, Example 14 US11649248, Example 14
BDBM484105 8-benzyl-12-propyl-4-oxa-8,12- diazadispiro[2.1.5.3]tridecan-13-one US11649248, Example 26 US10927128, Example 26
BDBM484113 US10927128, Example 34 US11649248, Example 34 8-cyclobutyl-12-ethyl-4-oxa-8,12- diazadispiro[2.1.5.3]tridecan-13-one
BDBM484115 8-(2-(3-fluoropyridin-2-yl)ethyl)-12-isopropyl-4- oxa-8,12-diazadispiro[2.1.5.3]tridecane US10927128, Example 36
BDBM484135 4-cydopropyl-9-isopentyl-1- oxa-4,9- diazaspiro[5.5]undecan-3- one US10927128, Example 56 US11649248, Example 56
BDBM50001677 22-phenethyl-14-oxa-11,22-diazaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5(10),6,8,15(25),16,18-heptaen-16-ol
BDBM50001679 22-phenethyl-14-oxa-11,22-diazaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5(10),6,8,15(25),16,18-heptaene-2,16-diol
BDBM50015854 CHEMBL312360 7-{3-[(2-Heptanethioylamino-thioacetylamino)-methyl]-7-oxa-bicyclo[2.2.1]hept-2-yl}-hept-5-enoic acid
BDBM50018093 4-(2-hydroxycyclohexyl)-10-methoxy-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraen-14-ol CHEMBL20571
BDBM50044692 CHEMBL553865 3-tert-Butyl-8-methyl-2-thioxo-1-oxa-3,8-diaza-spiro[4.5]decan-4-one; hydrochloride
BDBM50044700 (8-Methyl-2,4-dioxo-1-oxa-3,8-diaza-spiro[4.5]dec-3-yl)-acetic acid methyl ester CHEMBL76063
BDBM50058658 18-cyclopropylmethyl-5-phenyl-10-oxa-7,18-diazahexacyclo[9.9.1.01,9.02,17.04,8.015,21]henicosa-4(8),5,11,13,15(21)-pentaene-2,12-diol CHEMBL305146
BDBM50058659 18-cyclopropylmethyl-5,6-dimethyl-10-oxa-7,18-diazahexacyclo[9.9.1.01,9.02,17.04,8.015,21]henicosa-4(8),5,11,13,15(21)-pentaene-2,12-diol CHEMBL60404
BDBM50076306 CHEMBL35525 (4R,5S)-5-(3-Fluoro-phenyl)-2,2,4-trimethyl-1,2,4,5-tetrahydro-6-oxa-1-aza-chrysen-3-one
BDBM50076308 CHEMBL36564 (4S,5S)-5-(3-Fluoro-phenyl)-2,2,4-trimethyl-1,2,4,5-tetrahydro-6-oxa-1-aza-chrysen-3-one
BDBM50080031 (4aR,12bR)-2,5,5-Trimethyl-9-pentyl-1,4a,5,8,9,10,11,12b-octahydro-4H-6-oxa-benzo[a]anthracen-12-ol CHEMBL63553
BDBM50124608 CHEMBL8637 (5-Allyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysen-9-yl)-methanol
BDBM50127594 2-(4,5-Dihydro-1H-imidazol-2-yl)-7-methyl-2,3,5,6-tetrahydro-4H-1-oxa-3a-aza-phenalene CHEMBL13793
BDBM50137349 CHEMBL157082 1-Cyano-4-ethoxy-2-oxo-2H-3-oxa-benzo[a]azulene-10-carboxylic acid ethyl ester
BDBM50159654 CHEMBL435542 (1R,4R)-2-(2-Oxa-5-aza-bicyclo[2.2.1]hept-5-yl)-benzo[h]chromen-4-one
BDBM50162959 CHEMBL366164 (11-Fluoro-2,3,3a,12b-tetrahydro-1-oxa-8-thia-dibenzo[e,h]azulen-2-ylmethyl)-dimethyl-amine
BDBM50180444 CHEMBL203132 N*1*-(3-Bromo-phenyl)-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cycloheptene-1,8-diamine
BDBM50262455 11-Amino-12-(4-fluoro-phenyl)-3,3-dimethyl-2,3,4,7,8,9,10,12-octahydro-5-oxa-6-aza-naphthacen-1-one CHEMBL514858
BDBM50262511 11-Amino-12-(4-methoxy-phenyl)-3,3-dimethyl-2,3,4,7,8,9,10,12-octahydro-5-oxa-6-aza-naphthacen-1-one CHEMBL516255
BDBM50288156 CHEMBL81954 Octanoic acid N'-[2,8-dimethyl-1-oxa-8-aza-spiro[4.5]dec-(3E)-ylidene]-N-methyl-hydrazide
BDBM50288161 Butyric acid N'-[2,8-dimethyl-1-oxa-8-aza-spiro[4.5]dec-(3E)-ylidene]-N-methyl-hydrazide CHEMBL278681
BDBM50297121 (R)-9-Methyl-1,2,8,9,10,11-hexahydro-3-oxa-6-thia-8,11-diaza-cyclohepta[b]-as-indacen-7-one CHEMBL562754
BDBM50332736 CHEMBL1630542 (4aS,7R,12cS)-4,4,7,12c-Tetramethyl-2,3,4,4a,5,6,7,12c-octahydro-1H-8-oxa-dibenzo[a,h]azulen-11-ol
BDBM50332737 (4aS,7R,12cS)-4,4,7,12c-Tetramethyl-2,3,4,4a,5,6,7,12c-octahydro-1H-8-oxa-dibenzo[a,h]azulen-10-ol CHEMBL1630543
BDBM50335155 CHEMBL1650512 3-[5-(2-Fluorophenyl)-1H-benzimidazol-2-yl]-1-oxa-2-aza-spiro-[4.5]dec-2-ene
BDBM504949 US11066396, Example 351 N-({4-[5- (trifluoro- methyl)- 1,2,4-oxa- diazol-3- yl]phenyl} methyl)- 5,6,7,8- tetrahydro- quinolin-
BDBM579899 4-(3-oxa-8- azabicyclo [3.2.1] octane- 8- carbonyl)- N-((S)-3- (3,4- dihydro- isoquin- US11485731, Example 1AZ
BDBM708900 2-(2-(cyclopentanecarbonyl)- 9-oxo-7-oxa-2,10-diazaspiro- [5.6]dodecan-10-yl)acetic acid US20240425519, Compound AC903
BDBM719501 US20250051309, Example 5.5 2'-(3-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-carbonyl)-2-fluorophenyl)-3-
BDBM769500 US12410191, Example 8 (3R,11R)-6-fluoro-3,11-dimethyl-10-oxa-2,13,17,18,21-pentaazapentacyclo[13.5.2.18,11.04,9.018,22]tricosa-1(21),4,6,8,15
CHEMBL1218 N-[2-(1,6,7,8-Tetrahydro-2H-3-oxa-as-indacen-8-yl)-ethyl]-propionamide(S)-(-)-22b BDBM50118470 RAMELTEON Rozerem
CHEMBL135391 Ethyl-carbamic acid 7-chloro-5-phenyl-6-oxa-10b-aza-benzo[e]azulen-4-yl ester BDBM50118537
CHEMBL135428 Diethyl-carbamic acid 5-(3,5-difluoro-phenyl)-6-oxa-10b-aza-benzo[e]azulen-4-yl ester BDBM50118547
CHEMBL163704 BDBM50013387 4-cyclopropylmethyl-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7,9,11(18)-trien-14-yl 2-methylacrylate
CHEMBL1650507 2-(5-(2-(Trifluoromethyl)phenyl)-1H-benzimidazol-2-yl)-1-oxa-3-azaspiro[4.5]dec-2-ene BDBM50335167
CHEMBL1650516 3-[5-(2-Chlorophenyl)-1H-benzimidazol-2-yl]-1-oxa-2-aza-spiro-[4.5]dec-2-ene BDBM50335151
CHEMBL236478 BDBM50216926 l-2-((S)-1-phenyl-ethylamino)-1-oxa-3,8-diaza-spiro[4.5]dec-2-en-4-one
CHEMBL286662 5-(4-Chloro-phenyl)-2,2-dimethyl-2,3-dihydro-1H,5H-6-oxa-1-aza-chrysen-4-one BDBM50076314
CHEMBL32603 2,2,4-Trimethyl-5-[1-phenyl-meth-(Z)-ylidene]-1,2,4,5-tetrahydro-6-oxa-1-aza-chrysen-3-one BDBM50076300
CHEMBL327606 BDBM50118671 3-(2-Methoxy-5-trifluoromethoxy-phenyl)-6-phenyl-1-oxa-7-aza-spiro[4.5]dec-3-ene
CHEMBL348336 BDBM50139199 23-oxo-8-oxa-1,15,17,21-tetraazapentacyclo[19.2.2.13,7.19,13.015,19]heptacosa-3(27),4,6,9(26),10,12,16,18-octaen-10-yl cyanide
CHEMBL35429 (4S,5S)-5-(4-Chloro-phenyl)-2,2,4-trimethyl-1,2,4,5-tetrahydro-6-oxa-1-aza-chrysen-3-one BDBM50076297
CHEMBL363581 (11-Fluoro-2,3,3a,12b-tetrahydro-1-oxa-8-thia-dibenzo[e,h]azulen-2-ylmethyl)-dimethyl-amine BDBM50162964
CHEMBL436273 BDBM50108791 18-cyclopropylmethyl-5-phenyl-10-oxa-7,18-diazahexacyclo[9.9.1.01,9.02,17.04,8.015,21]henicosa-4(8),5,11,13,15(21)-pentaene-2,12-diol
CHEMBL47956 (4-Methoxy-2,5-dioxo-7-oxa-bicyclo[4.1.0]hept-3-en-1-yl)-acetic acid methyl ester BDBM50114884
CHEMBL594350 BDBM50304686 4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)thieno[3,2-d]pyrimidin-2-yl)aniline
CHEMBL79287 7-{3-[(2-Heptanethioylamino-acetylamino)-methyl]-7-oxa-bicyclo[2.2.1]hept-2-yl}-hept-5-enoic acid BDBM50015848
CHEMBL81263 7-{3-[(2-Octanoylamino-acetylamino)-methyl]-7-oxa-bicyclo[2.2.1]hept-2-yl}-hept-5-enoic acid BDBM50015849
CHEMBL90136 (20RS)-6-Ethyl-6-hydroxy-9,11-dihydro-6H-8-oxa-4,10a-diaza-benzo[b]fluorene-7,10-dione BDBM50045361
CHEMBL92554 BDBM50045402 3,17-Dihydroxy-10,13-dimethyl-1,4,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-20-oxa-cyclopropa[4,5]cyclopenta[a]phenanthrene-2-carboxylic acid amide
Diethyl-carbamic acid 5-thiophen-2-yl-6-oxa-10,10b-diaza-benzo[e]azulen-4-yl ester CHEMBL136036 BDBM50118539
Diethyl-carbamic acid 5-thiophen-2-yl-6-oxa-10b-aza-benzo[e]azulen-4-yl ester CHEMBL135663 BDBM50118538
N-{4-[5- (trifluoro- methyl)- 1,2,4-oxa- diazol-3- yl]benzyl}- 2H-indazol- 6-amine US11066396, Example 411 BDBM505014
Naphthalen-2-yl-acetic acid [2,8-dimethyl-1-oxa-8-aza-spiro[4.5]dec-(3E)-ylidene]-hydrazide BDBM50288163 CHEMBL84109
SMR000146186 8-Trifluoromethyl-2,3,5,6-tetrahydro-1H,4H-11-oxa-3a-aza-benzo[de]anthracen-10-one MLS000552671 BDBM50875 cid_72652
US10421750, Example 22 7-ethyl-5-(1-isopentylazetidin-3-yl)- 4-oxa-7-azaspiro[2.5]octan-8-one BDBM413886
US10421750, Example 7 7-ethyl-5-(1-phenethylpiperidin-4-yl)- 4-oxa-7-azaspiro[2.5]octan-8-one BDBM413875
US10421750, Example 8 7-isopropyl-5-(1-phenethylpiperidin-4- yl)-4-oxa-7-azaspiro[2.5]octan-8-one BDBM413876
US10421750, Example 9 5-(1-phenethylpiperidin-4-yl)-7- phenyl-4-oxa-7-azaspiro[2.5]octan-8- one BDBM413877
US10513523, Example 7 4-[2-(4-Fluorophenyl)-8-(6-oxa-2-azaspiro[3;3]heptan-2-yl)imidazo[1,2- BDBM426068
US10577383, Example 7 BDBM434849 7-[(11S)-11-Methyl-18-oxa-3,4,10-triazatetracyclo[17.3.1.13,6.113,17]pentacosa-1(23),4,6(25),13,15,17
US10689398, Example 39 (S)-8-ethyl-2-isobutyl-6- methyl-5-oxa-2,8- diazaspiro[3.5]nonan-7- one BDBM448133
US10689398, Example 40 (R)-2-isopentyl-8- isopropyl-6-methyl-5-oxa- 2,8-diazaspiro[3.5]nonan- 7-one BDBM448134
US10689398, Example 41 BDBM448135 (S)-2-isopentyl-8- isopropyl-6-methyl-5-oxa- 2,8-diazaspiro[3.5]nonan- 7-one
US10927128, Example 10 US11649248, Example 10 12-isobutyl-8-isopentyl-4-oxa-8,12- diazadispiro[2.1.5.3]tridecan-13-one BDBM484089
US10927128, Example 33 8-cyclobutyl-12-ethyl-4-oxa-8,12- diazadispiro[2.1.5.3]tridecan-13-one BDBM484112 US11649248, Example 33
US10927128, Example 53 9-isopentyl-4-isopropyl-1- oxa-4,9- diazaspiro[5.5]undecan-3- one BDBM484132 US11649248, Example 53
US10927128, Example 9 8-isopentyl-12-propyl-4-oxa-8,12- diazadispiro[2.1.5.3]tridecan-13-one US11649248, Example 9 BDBM484088
US11066396, Example 194 BDBM504779 {5-[5- (trifluoro- methyl)- 1,2,4-oxa- diazol-3- yl]pyridin- 2-yl} methyl methyl- carbamate
US11066396, Example 228 BDBM504817 1-({3- fluoro-4-[5- (trifluoro- methyl)- 1,2,4-oxa- diazol-3- yl]phenyl} methoxy) phthalazine
US11066396, Example 251 2-[(2- fluoro- phenoxy) methyl]- 5-[5- (trifluoro- methyl)- 1,2,4-oxa- diazol-3- yl]pyridine BDBM504842
US11066396, Example 285 BDBM504877 7-({3- fluoro-4-[5- (trifluoro- methyl)- 1,2,4-oxa- diazol-3- yl]phenyl} methoxy) quinazoline
US11066396, Example 349 BDBM504947 1-(3- methyl- phenyl)- N-({4-[5- (trifluoro- methyl)- 1,2,4-oxa- diazol-3- yl]phenyl}
US11066396, Example 415 BDBM505018 N-{4-[5- (trifluoro- methyl)- 1,2,4-oxa- diazol-3- yl]benzyl}- 1H-indazol- 4-amine
US11066396, Example 461 BDBM505064 2-({5-[5- (trifluoro- methyl)- 1,2,4-oxa- diazol-3- yl]pyridin- 2-yl} methoxy) quinoline
US11649248, Example 1 BDBM484080 US10927128, Example 1 12-ethyl-8-isopentyl-4-oxa-8,12- diazadispiro[2.1.5.3]tridecan-13-one
US11649248, Example 2 BDBM484081 US10927128, Example 2 4-ethyl-9-isopentyl-1-oxa-4,9- diazaspiro[5.5]undecan-3-one
US11649248, Example 5 BDBM484084 US10927128, Example 5 8-isopentyl-12-isopropyl-4-oxa-8,12- diazadispiro[2.1.5.3]tridecan-13-one
US11649248, Example 6 12-ethyl-8-isobutyl-4-oxa-8,12- diazadispiro[2.1.5.3]tridecan-13-one BDBM484085 US10927128, Example 6
US12410191, Example 21 BDBM769506 (3R,11S)-6-fluoro-3,11-dimethyl-10-oxa-2,14,18,19,22-pentaazapentacyclo[14.5.2.18,11.04,9.019,23]tetracosa-1(22),4,6,8,16
ethyl 14-hydroxy-9-methoxy-11-oxa-4-azatetracyclo[8.6.1.01,12.06,17]heptadeca-6(17),7,9,15-tetraene-4-carboxylate CHEMBL75699 BDBM50130149
{2-[9-Fluoro-2,2,4-trimethyl-1,2-dihydro-6-oxa-1-aza-chrysen-(5Z)-ylidenemethyl]-phenyl}-dimethyl-amine CHEMBL336353 BDBM50133151