Target (32)
Compound (59)
Article Title (67)
Article Author (670)
Assay (23)
US9956192, Compound TSA US9751832, TSA US10227295, Compound TSA US11207431, TSA BDBM337661
US9187397, 1 US11608309, Compound Curcumin US10669227, Compound Curcumin BDBM191763 US9187406, Curcumin curcumin
TSA BDBM198120
BDBM197336 R-TSA
BDBM197337 S-TSA
US20250250263, Compound trichostatin BDBM747161 US20250179065, Compound TSA (trichostatin A)
US10011611, Trichostatin A GNF-Pf-1011 CHEBI:46024 Trichostatin A (TSA) US20230322747, Compound trichostatin A BDBM50005711 Trichostatin A US9265734, TSA US11535598, Compound Trichostatin A US10722597, Compound Trichostatin TRICHOSTATIN
US9956192, Compound TSA BDBM390441
ETHYL CURCUMIN BDBM50487886
(2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide TSA Trichostatin A (TSA) BDBM19130 CHEMBL99
US9187397, 1 (curcumin) BDBM191759
BDBM50487871 DI-O-CHLOROPROPIONYLETHYL CURCUMIN
DI-O-CHLOROACETYLETHYL CURCUMIN BDBM50487872
CHEMBL140 US20240131036, Example 8 CHEBI:3962 Curcumin US9409845, Table 1, Compound 21: curcumin BDBM50140172
4-(4-hydroxybenzylidene) curcumin CHEMBL260079 BDBM50619501
DI-O-(2-THIENOYL)CURCUMIN BDBM50487873
N-(3-Nitrophenylpyrazole)Curcumin BDBM50553256 CHEMBL258632
US9187397, 3a US9187397, 1 (curcumin) BDBM191758
BDBM50303150 CHEMBL259731 licarine A (+)-licarin A licarin A
A-349,821 A-349821 BDBM50370569
BDBM253909 US9464092, A US9527857, A
BDBM50485671 ADOCIAQUINONE A Adociaquinones A
BDBM86690 A-348441 A 348441
US8987239, A BDBM150275 US9034856, A
US10807966, Compound A US11555039, Compound ID A US10392402, Compound A US10738007, Compound A BDBM412136
A-12825760 Glecaprevir A-1282576 A-1282576.0 ABT-493 BDBM50573891
US10294226, Compound A US11059823, Example A BDBM387815 US10487083, Example A
Azure A (12) AZURE A BDBM50434371
BDBM50303149 (-)-licarin A CHEMBL463526 Licarin A
BDBM50325942 Licoflavanone A licoflavone A CHEMBL506929
BDBM50509087 Ma'edamine A Ma''edamine A
BDBM616986 US11753373, Compound A-3-a
BDBM617009 US11753373, Compound A-4-a
BDBM764833 US20250257060, Compound 84j-A-A
BDBM764848 US20250257060, Compound 99j-A-A
CHEMBL379110 BDBM50185449 panduratin A (-)-panduratin A
CHEMBL465161 ginkgolide-A BDBM50292287 GINKGOLIDE A
Rel-Hypocrellin A Hypocrellin A BDBM50568789
US20250257060, Compound 88j-A-A BDBM764837
US9732093, Compound A US9073876, A BDBM166913
US11091471, Example RE-A US12344614, Example RE-A US20240270744, Example RE-A US20240279218, Example RE-A US12365687, Example RE-A BDBM513333
BDBM256591 US10435361, Example 84(a) US9481648, 84(a) US9790174, Example 84(a)
US9481648, 85(a) US10435361, Example 85(a) US9790174, Example 85(a) BDBM256599
US9790174, Example 83(a) US10435361, Example 83(a) BDBM256584 US9481648, 83(a)
BDBM32617 Botryllamide A, 1 US8470888, Botryllamide A
BDBM50096785 Dynorphin A DYNORPHIN A (1-17)
BDBM50185447 CHEMBL210882 4-hydroxypanduratin A (-)-hydroxypanduratin A
CHEMBL503797 ourateaproanthocyanidin A BDBM50260060 ouratea-proanthocyanidin A
LYCOGALIC ACID A LYCOGARIC ACID A BDBM50378456
Micropeptin 478 A MICROPEPTIN 478-A BDBM50478449
BDBM319604 US20230270730, Compound A-8 US20240327355, Compound A-8 US11964950, Compound A-8
BDBM614280 US11964950, Compound A-33 US20240327355, Compound A-33 US20230270730, Compound A-33
CHEMBL384047 BDBM50140007 A-G-N-H-A-A-G-I-L-T-L
US11964950, Compound A-18 US20230270730, Compound A-18 US20240327355, Compound A-18 BDBM614265
US20230270730, Compound A-20 US20240327355, Compound A-20 US11964950, Compound A-20 BDBM614267
US20230270730, Compound A-25 BDBM614272 US20240327355, Compound A-25 US11964950, Compound A-25
US20230270730, Compound A-27 US20240327355, Compound A-27 BDBM614274 US11964950, Compound A-27
US20240327355, Compound A-2 US11964950, Compound A-2 US20230270730, Compound A-2 BDBM312293
US11207431, Example D Tubastatin A US9751832, Tubastatin A US10227295, Compound Tubastatin A US10456394, Tubastatin A BDBM50380399 US8748451, 6 US9249087, Tubacin US9956192, Compound Tubastatin-A CHEMBL2018302
Liu, Z; Xie, Z; Jones, W; Pavlovicz, RE; Liu, S; Yu, J; Li, PK; Lin, J; Fuchs, JR; Marcucci, G; Li, C; Chan, KK Curcumin is a potent DNA hypomethylation agent. Bioorg Med Chem Lett 19: 706 -9 (2009)
Takahashi, T; Hijikuro, I; Sugimoto, H; Kihara, T; Shimmyo, Y; Niidome, T Curcumin derivative US Patent US8962674 (2015)
Vander Jagt, DL; Deck, LM; Abcouwer, SF; Orlando, RA; Royer, RE; Weber, WM; Bobrovnikova-Marjon, EV; Hunsaker, LA Therapeutic curcumin derivatives US Patent US9187397 (2015)
Kaur, S; Modi, NH; Panda, D; Roy, N Probing the binding site of curcumin in Escherichia coli and Bacillus subtilis FtsZ--a structural insight to unveil antibacterial activity of curcumin. Eur J Med Chem 45: 4209 -14 (2010)
Nelson, KM; Dahlin, JL; Bisson, J; Graham, J; Pauli, GF; Walters, MA The Essential Medicinal Chemistry of Curcumin. J Med Chem 60: 1620 -1637 (2017)
Hosseini-Zare, MS; Sarhadi, M; Zarei, M; Thilagavathi, R; Selvam, C Synergistic effects of curcumin and its analogs with other bioactive compounds: A comprehensive review. Eur J Med Chem 210: (2021)
Johnson, F; Golub, L Curcumin analogues as zinc chelators and their uses US Patent US9187406 (2015)
Hu, GX; Liang, G; Chu, Y; Li, X; Lian, QQ; Lin, H; He, Y; Huang, Y; Hardy, DO; Ge, RS Curcumin derivatives inhibit testicular 17beta-hydroxysteroid dehydrogenase 3. Bioorg Med Chem Lett 20: 2549 -51 (2010)
Wang, JQ; Wang, X; Wang, Y; Tang, WJ; Shi, JB; Liu, XH Novel curcumin analogue hybrids: Synthesis and anticancer activity. Eur J Med Chem 156: 493 -509 (2018)
Shen, L; Ji, HF Insights into the inhibition of xanthine oxidase by curcumin. Bioorg Med Chem Lett 19: 5990 -3 (2009)
Van Ommeslaeghe, K; Elaut, G; Brecx, V; Papeleu, P; Iterbeke, K; Geerlings, P; Tourwé, D; Rogiers, V Amide analogues of TSA: synthesis, binding mode analysis and HDAC inhibition. Bioorg Med Chem Lett 13: 1861 -4 (2003)
Lin, H; Hu, GX; Guo, J; Ge, Y; Liang, G; Lian, QQ; Chu, Y; Yuan, X; Huang, P; Ge, RS Mono-carbonyl curcumin analogues as 11ß-hydroxysteroid dehydrogenase 1 inhibitors. Bioorg Med Chem Lett 23: 4362 -6 (2013)
Deck, LM; Hunsaker, LA; Vander Jagt, TA; Whalen, LJ; Royer, RE; Vander Jagt, DL Activation of anti-oxidant Nrf2 signaling by enone analogues of curcumin. Eur J Med Chem 143: 854 -865 (2018)
Mayadevi, M; Sherin, DR; Keerthi, VS; Rajasekharan, KN; Omkumar, RV Curcumin is an inhibitor of calcium/calmodulin dependent protein kinase II. Bioorg Med Chem 20: 6040 -7 (2012)
Kim, TH; Kim, JK; Ito, H; Jo, C Enhancement of pancreatic lipase inhibitory activity of curcumin by radiolytic transformation. Bioorg Med Chem Lett 21: 1512 -4 (2011)
Brown, A; Shi, Q; Moore, TW; Yoon, Y; Prussia, A; Maddox, C; Liotta, DC; Shim, H; Snyder, JP Monocarbonyl curcumin analogues: heterocyclic pleiotropic kinase inhibitors that mediate anticancer properties. J Med Chem 56: 3456 -66 (2013)
Zhang, Y; Liu, Z; Wu, J; Bai, B; Chen, H; Xiao, Z; Chen, L; Zhao, Y; Lum, H; Wang, Y; Zhang, H; Liang, G New MD2 inhibitors derived from curcumin with improved anti-inflammatory activity. Eur J Med Chem 148: 291 -305 (2018)
Garigipati, RS; Seibel, G; Mayer, RJ; Bolognese, B; McCord, M; Marshall, LA; Adams, JL Novel frameworks for trifluoromethyl ketone and phosphonate tsa inhibitors of type II PLA2 Bioorg Med Chem Lett 7: 1421 -1426 (1997)
Wang, J; Zhang, X; Yan, J; Li, W; Jiang, Q; Wang, X; Zhao, D; Cheng, M Design, synthesis and biological evaluation of curcumin analogues as novel LSD1 inhibitors. Bioorg Med Chem Lett 29: (2019)
Pauff, JM; Hille, R Inhibition studies of bovine xanthine oxidase by luteolin, silibinin, quercetin, and curcumin. J Nat Prod 72: 725 -31 (2009)
Khor, PY; Mohd Aluwi, MFF; Rullah, K; Lam, KW Insights on the synthesis of asymmetric curcumin derivatives and their biological activities. Eur J Med Chem 183: (2019)
Ryu, EK; Choe, YS; Lee, KH; Choi, Y; Kim, BT Curcumin and dehydrozingerone derivatives: synthesis, radiolabeling, and evaluation for beta-amyloid plaque imaging. J Med Chem 49: 6111 -9 (2006)
Zang, WB; Wei, HL; Zhang, WW; Ma, W; Li, J; Yao, Y Curcumin hybrid molecules for the treatment of Alzheimer's disease: Structure and pharmacological activities. Eur J Med Chem 265:
Okuda, M; Hijikuro, I; Fujita, Y; Teruya, T; Kawakami, H; Takahashi, T; Sugimoto, H Design and synthesis of curcumin derivatives as tau and amyloidß dual aggregation inhibitors. Bioorg Med Chem Lett 26: 5024 -5028 (2016)
Minassi, A; Sánchez-Duffhues, G; Collado, JA; Muñoz, E; Appendino, G Dissecting the pharmacophore of curcumin. Which structural element is critical for which action? J Nat Prod 76: 1105 -12 (2013)
Ettari, R; Previti, S; Di Chio, C; Maiorana, S; Allegra, A; Schirmeister, T; Zappalà, M Drug Synergism: Studies of Combination of RK-52 and Curcumin against Rhodesain of ACS Med Chem Lett 11: 806 -810 (2020)
Badavath, VN; Baysal, I; Ucar, G; Sinha, BN; Jayaprakash, V Monoamine Oxidase Inhibitory Activity of Novel Pyrazoline Analogues: Curcumin Based Design and Synthesis. ACS Med Chem Lett 7: 56 -61 (2016)
Yuan, M; Luo, M; Song, Y; Xu, Q; Wang, X; Cao, Y; Bu, X; Ren, Y; Hu, X Identification of curcumin derivatives as human glyoxalase I inhibitors: A combination of biological evaluation, molecular docking, 3D-QSAR and molecular dynamics simulation studies. Bioorg Med Chem 19: 1189 -96 (2011)
Enyeart, JA; Liu, H; Enyeart, JJ Curcumin inhibits ACTH- and angiotensin II-stimulated cortisol secretion and Ca(v)3.2 current. J Nat Prod 72: 1533 -7 (2009)
Sharma, M; Manoharlal, R; Shukla, S; Puri, N; Prasad, T; Ambudkar, SV; Prasad, R Curcumin modulates efflux mediated by yeast ABC multidrug transporters and is synergistic with antifungals. Antimicrob Agents Chemother 53: 3256 -65 (2009)
Rodrigues, FC; Anil Kumar, NV; Thakur, G Developments in the anticancer activity of structurally modified curcumin: An up-to-date review. Eur J Med Chem 177: 76 -104 (2019)
Appiah-Opong, R; de Esch, I; Commandeur, JN; Andarini, M; Vermeulen, NP Structure-activity relationships for the inhibition of recombinant human cytochromes P450 by curcumin analogues. Eur J Med Chem 43: 1621 -31 (2008)
Batie, S; Lee, JH; Jama, RA; Browder, DO; Montano, LA; Huynh, CC; Marcus, LM; Tsosie, DG; Mohammed, Z; Trang, V; Marshall, PA; Jurutka, PW; Wagner, CE Synthesis and biological evaluation of halogenated curcumin analogs as potential nuclear receptor selective agonists. Bioorg Med Chem 21: 693 -702 (2013)
Gradl, S; Steuber, H; Weiske, J; Szewczyk, MM; Schmees, N; Siegel, S; Stoeckigt, D; Christ, CD; Li, F; Organ, S; Abbey, M; Kennedy, S; Chau, I; Trush, V; Barsyte-Lovejoy, D; Brown, PJ; Vedadi, M; Arrowsmith, C; Husemann, M; Badock, V; Bauser, M; Haegebarth, A; Hartung, IV; Stresemann, C Discovery of the SMYD3 Inhibitor BAY-6035 Using Thermal Shift Assay (TSA)-Based High-Throughput Screening. SLAS Discov 26: 947 -960
Liu, W; Zhang, W; Xing, LZ; Zhao, YD; Xu, J; Li, RJ; Zhang, YX 4-Arylidene curcumin derivatives in vitro inhibit α-Synuclein aggregation and disaggregate the preformed fibril. Bioorg Med Chem 96: (2023)
Ao, GZ; Zhou, MZ; Li, YY; Li, SN; Wang, HN; Wan, QW; Li, HQ; Hu, QH Discovery of novel curcumin derivatives targeting xanthine oxidase and urate transporter 1 as anti-hyperuricemic agents. Bioorg Med Chem 25: 166 -174 (2017)
Zhang, W; Bai, H; Han, L; Zhang, H; Xu, B; Cui, J; Wang, X; Ge, Z; Li, R Synthesis and biological evaluation of curcumin derivatives modified with α-amino boronic acid as proteasome inhibitors. Bioorg Med Chem Lett 28: 2459 -2464 (2018)
Mazumder, A; Neamati, N; Sunder, S; Schulz, J; Pertz, H; Eich, E; Pommier, Y Curcumin analogs with altered potencies against HIV-1 integrase as probes for biochemical mechanisms of drug action. J Med Chem 40: 3057 -63 (1997)
Ai, Y; Zhu, B; Ren, C; Kang, F; Li, J; Huang, Z; Lai, Y; Peng, S; Ding, K; Tian, J; Zhang, Y Discovery of New Monocarbonyl Ligustrazine-Curcumin Hybrids for Intervention of Drug-Sensitive and Drug-Resistant Lung Cancer. J Med Chem 59: 1747 -60 (2016)
Lee, KH; Ab Aziz, FH; Syahida, A; Abas, F; Shaari, K; Israf, DA; Lajis, NH Synthesis and biological evaluation of curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities. Eur J Med Chem 44: 3195 -200 (2009)
Di Martino, RM; De Simone, A; Andrisano, V; Bisignano, P; Bisi, A; Gobbi, S; Rampa, A; Fato, R; Bergamini, C; Perez, DI; Martinez, A; Bottegoni, G; Cavalli, A; Belluti, F Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3ß Inhibitors. J Med Chem 59: 531 -44 (2016)
Majhi, A; Rahman, GM; Panchal, S; Das, J Binding of curcumin and its long chain derivatives to the activator binding domain of novel protein kinase C. Bioorg Med Chem 18: 1591 -8 (2010)
Das, J; Pany, S; Panchal, S; Majhi, A; Rahman, GM Binding of isoxazole and pyrazole derivatives of curcumin with the activator binding domain of novel protein kinase C. Bioorg Med Chem 19: 6196 -202 (2011)
Sanabria-Ríos, DJ; Rivera-Torres, Y; Rosario, J; Gutierrez, R; Torres-García, Y; Montano, N; Ortíz-Soto, G; Ríos-Olivares, E; Rodríguez, JW; Carballeira, NM Chemical conjugation of 2-hexadecynoic acid to C5-curcumin enhances its antibacterial activity against multi-drug resistant bacteria. Bioorg Med Chem Lett 25: 5067 -71 (2015)
Selvam, C; Jachak, SM; Thilagavathi, R; Chakraborti, AK Design, synthesis, biological evaluation and molecular docking of curcumin analogues as antioxidant, cyclooxygenase inhibitory and anti-inflammatory agents. Bioorg Med Chem Lett 15: 1793 -7 (2005)
Konno, H; Endo, H; Ise, S; Miyazaki, K; Aoki, H; Sanjoh, A; Kobayashi, K; Hattori, Y; Akaji, K Synthesis and evaluation of curcumin derivatives toward an inhibitor of beta-site amyloid precursor protein cleaving enzyme 1. Bioorg Med Chem Lett 24: 685 -90 (2014)
Li, Y; Peng, P; Tang, L; Hu, Y; Hu, Y; Sheng, R Design, synthesis and evaluation of rivastigmine and curcumin hybrids as site-activated multitarget-directed ligands for Alzheimer's disease therapy. Bioorg Med Chem 22: 4717 -25 (2014)
Xu, YY; Cao, Y; Ma, H; Li, HQ; Ao, GZ Design, synthesis and molecular docking ofa,ß-unsaturated cyclohexanone analogous of curcumin as potent EGFR inhibitors with antiproliferative activity. Bioorg Med Chem 21: 388 -94 (2012)
Yan, J; Hu, J; Liu, A; He, L; Li, X; Wei, H Design, synthesis, and evaluation of multitarget-directed ligands against Alzheimer's disease based on the fusion of donepezil and curcumin. Bioorg Med Chem 25: 2946 -2955 (2017)
Qiu, X; Du, Y; Lou, B; Zuo, Y; Shao, W; Huo, Y; Huang, J; Yu, Y; Zhou, B; Du, J; Fu, H; Bu, X Synthesis and identification of new 4-arylidene curcumin analogues as potential anticancer agents targeting nuclear factor-κB signaling pathway. J Med Chem 53: 8260 -73 (2010)
Ahmad, W; Kumolosasi, E; Jantan, I; Bukhari, SN; Jasamai, M Effects of novel diarylpentanoid analogues of curcumin on secretory phospholipase A2 , cyclooxygenases, lipo-oxygenase, and microsomal prostaglandin E synthase-1. Chem Biol Drug Des 83: 670 -81 (2014)
Liu, Z; Fang, L; Zhang, H; Gou, S; Chen, L Design, synthesis and biological evaluation of multifunctional tacrine-curcumin hybrids as new cholinesterase inhibitors with metal ions-chelating and neuroprotective property. Bioorg Med Chem 25: 2387 -2398 (2017)
Mohd Aluwi, MF; Rullah, K; Yamin, BM; Leong, SW; Abdul Bahari, MN; Lim, SJ; Mohd Faudzi, SM; Jalil, J; Abas, F; Mohd Fauzi, N; Ismail, NH; Jantan, I; Lam, KW Synthesis of unsymmetrical monocarbonyl curcumin analogues with potent inhibition on prostaglandin E2 production in LPS-induced murine and human macrophages cell lines. Bioorg Med Chem Lett 26: 2531 -8 (2016)
Zuo, Y; Huang, J; Zhou, B; Wang, S; Shao, W; Zhu, C; Lin, L; Wen, G; Wang, H; Du, J; Bu, X Synthesis, cytotoxicity of new 4-arylidene curcumin analogues and their multi-functions in inhibition of both NF-¿B and Akt signalling. Eur J Med Chem 55: 346 -57 (2012)
Iranshahi, M; Chini, MG; Masullo, M; Sahebkar, A; Javidnia, A; Chitsazian Yazdi, M; Pergola, C; Koeberle, A; Werz, O; Pizza, C; Terracciano, S; Piacente, S; Bifulco, G Can Small Chemical Modifications of Natural Pan-inhibitors Modulate the Biological Selectivity? The Case of Curcumin Prenylated Derivatives Acting as HDAC or mPGES-1 Inhibitors. J Nat Prod 78: 2867 -79 (2015)
Tanaka, R; Tsujii, H; Yamada, T; Kajimoto, T; Amano, F; Hasegawa, J; Hamashima, Y; Node, M; Katoh, K; Takebe, Y Novel 3alpha-methoxyserrat-14-en-21beta-ol (PJ-1) and 3beta-methoxyserrat-14-en-21beta-ol (PJ-2)-curcumin, kojic acid, quercetin, and baicalein conjugates as HIV agents. Bioorg Med Chem 17: 5238 -46 (2009)
Tosh, DK; Salmaso, V; Campbell, RG; Rao, H; Bitant, A; Pottie, E; Stove, CP; Liu, N; Gavrilova, O; Gao, ZG; Auchampach, JA; Jacobson, KA A Eur J Med Chem 228: (2022)
Suchankova, A; Stampelou, M; Koutsouki, K; Pousias, A; Dhingra, L; Barkan, K; Pouli, N; Marakos, P; Tenta, R; Kolocouris, A; Lougiakis, N; Ladds, G Discovery of a High Affinity Adenosine A ACS Med Chem Lett 13: 923 -934 (2022)
Kanki, D; Nakamukai, S; Ogura, Y; Takikawa, H; Ise, Y; Morii, Y; Yamawaki, N; Takatani, T; Arakawa, O; Okada, S; Matsunaga, S Homophymamide A, Heterodetic Cyclic Tetrapeptide from a J Nat Prod 84: 1848 -1853 (2021)
Bae, J; Cho, E; Park, JS; Won, TH; Seo, SY; Oh, DC; Oh, KB; Shin, J Isocadiolides A-H: Polybrominated Aromatics from a J Nat Prod 83: 429 -437 (2020)
Jayasuriya, H; Ball, RG; Zink, DL; Smith, JL; Goetz, MA; Jenkins, RG; Nallin-Omstead, M; Silverman, KC; Bills, GF; Lingham, RB Barceloneic acid A, a new farnesyl-protein transferase inhibitor from a Phoma species. J Nat Prod 58: 986 -91 (1995)
Baek, SC; Kang, MG; Park, JE; Lee, JP; Lee, H; Ryu, HW; Park, CM; Park, D; Cho, ML; Oh, SR; Kim, H Osthenol, a prenylated coumarin, as a monoamine oxidase A inhibitor with high selectivity. Bioorg Med Chem Lett 29: 839 -843 (2019)
Wu-Wong, JR; Dixon, DB; Chiou, WJ; Dayton, BD; Novosad, EI; Adler, AL; Wessale, JL; Calzadilla, SV; Hernandez, L; Marsh, KC; Liu, G; Szczepankiewicz, B; von Geldern, TW; Opgenorth, TJ Pharmacology of A-216546: a highly selective antagonist for endothelin ET(A) receptor. Eur J Pharmacol 366: 189 -201
Inoue, T; Higuchi, Y; Yoneyama, T; Lin, B; Nunomura, K; Honma, Y; Kato, N Semisynthesis and biological evaluation of a cotylenin A mimic derived from fusicoccin A. Bioorg Med Chem Lett 28: 646 -650 (2018)
Yu, F; Zhu, C; Xie, Q; Wang, Y Adenosine A J Med Chem 63: 12196 -12212 (2020)
Federico, S; Margiotta, E; Moro, S; Kozma, E; Gao, ZG; Jacobson, KA; Spalluto, G Conjugable A Eur J Med Chem 186: (2020)
Suresh, RR; Gao, ZG; Salmaso, V; Chen, E; Campbell, RG; Poe, RB; Liston, TE; Jacobson, KA Selective A ACS Med Chem Lett 13: 623 -631 (2022)
Trabanco, AA; Tresadern, G; Macdonald, GJ; Vega, JA; de Lucas, AI; Matesanz, E; García, A; Linares, ML; Alonso de Diego, SA; Alonso, JM; Oehlrich, D; Ahnaou, A; Drinkenburg, W; Mackie, C; Andrés, JI; Lavreysen, H; Cid, JM J Med Chem 55: 2688 -701 (2012)
Sánchez-Martín, R; Campos, JM; Conejo-García, A; Cruz-López, O; Báñez-Coronel, M; Rodríguez-González, A; Gallo, MA; Lacal, JC; Espinosa, A J Med Chem 48: 3354 -63 (2005)
Bekhit, AA; Fahmy, HT; Rostom, SA; El-Din A Bekhit, A Eur J Med Chem 45: 6027 -38 (2010)
Recio, E; Musso-Buendía, A; Vidal, AE; Ruda, GF; Kasinathan, G; Nguyen, C; Ruiz-Pérez, LM; Gilbert, IH; González-Pacanowska, D Eur J Med Chem 46: 3309 -14 (2011)
PASTOR FERNÁNDEZ, J; MARTÍNEZ GONZÁLEZ, S; BLANCO APARICIO, C; GARCÍA GARCÍA, AB; RODRÍGUEZ ARÍSTEGUI, S; GÓMEZ DE LA OLIVA, CA; ALBARRÁN SANTIÑO, MI; CEBRIÁ GÓMEZ, A; MALUMBRES MARTÍNEZ, M US Patent US20240199630 (2024)
Furet, P; Gay, B; Caravatti, G; García-Echeverría, C; Rahuel, J; Schoepfer, J; Fretz, H J Med Chem 41: 3442 -9 (1998)
Olmo, F; Marín, C; Clares, MP; Blasco, S; Albelda, MT; Soriano, C; Gutiérrez-Sánchez, R; Arrebola-Vargas, F; García-España, E; Sánchez-Moreno, M Eur J Med Chem 70: 189 -98 (2013)
A., AK; Irina, CM; M., HD; C., KJ; Jian, L; J., MP; L., RV; T., RM; A., SC; Zhe, W; Dong, X WIPO WO2022094012 (2022)
A., AK; Irina, CM; M., HD; C., KJ; Jian, L; J., MP; L., RV; T., RM; A., SC; Zhe, W; Dong, X WIPO WO2022094012 (2022)
Thaler, F; Varasi, M; Abate, A; Carenzi, G; Colombo, A; Bigogno, C; Boggio, R; Zuffo, RD; Rapetti, D; Resconi, A; Regalia, N; Vultaggio, S; Dondio, G; Gagliardi, S; Minucci, S; Mercurio, C Eur J Med Chem 64: 273 -84 (2013)
Suman, P; Murthy, TR; Rajkumar, K; Srikanth, D; Dayakar, Ch; Kishor, C; Addlagatta, A; Kalivendi, SV; Raju, BC Eur J Med Chem 90: 603 -19 (2015)
Lutsenko, K; Hagenow, S; Affini, A; Reiner, D; Stark, H Bioorg Med Chem Lett 29: (2019)
Wiles, JA; Phadke, AS; Deshpande, M; Agarwal, A; Chen, D; Gadhachanda, VR; Hashimoto, A; Pais, G; Wang, Q; Wang, X; Greenlee, W US Patent US11407738 (2022)
Wang, S; Aguilar, A; Zheng, K; Xu, S; Xu, T; Bernard, D; Huang, L US Patent US10899738 (2021)
Akdemir, A; Güzel-Akdemir, Ö; Karali, N; Supuran, CT Bioorg Med Chem 24: 1648 -52 (2016)
Alagha, A; Moman, E; Adamo, MF; Nolan, KB; Chubb, AJ Bioorg Med Chem Lett 19: 4213 -6 (2009)
Yueh, C; Rettenmaier, J; Xia, B; Hall, DR; Alekseenko, A; Porter, KA; Barkovich, K; Keseru, G; Whitty, A; Wells, JA; Vajda, S; Kozakov, D J Med Chem 62: 6512 -6524 (2019)
Lockbaum, GJ; Rusere, LN; Henes, M; Kosovrasti, K; Rao, DN; Spielvogel, E; Lee, SK; Nalivaika, EA; Swanstrom, R; Yilmaz, NK; Schiffer, CA; Ali, A Eur J Med Chem 257:
Gibon, J; Kang, MS; Aliaga, A; Sharif, B; Rosa-Neto, P; Séguéla, P; Barker, PA; Kostikov, A Bioorg Med Chem 24: 4759 -4765 (2016)
Barsyte-Lovejoy, D; Li, F; Oudhoff, MJ; Tatlock, JH; Dong, A; Zeng, H; Wu, H; Freeman, SA; Schapira, M; Senisterra, GA; Kuznetsova, E; Marcellus, R; Allali-Hassani, A; Kennedy, S; Lambert, JP; Couzens, AL; Aman, A; Gingras, AC; Al-Awar, R; Fish, PV; Gerstenberger, BS; Roberts, L; Benn, CL; Grimley, RL; Braam, MJ; Rossi, FM; Sudol, M; Brown, PJ; Bunnage, ME; Owen, DR; Zaph, C; Vedadi, M; Arrowsmith, CH Proc Natl Acad Sci U S A 111: 12853 -8
Maccallini, C; Arias, F; Gallorini, M; Amoia, P; Ammazzalorso, A; De Filippis, B; Fantacuzzi, M; Giampietro, L; Cataldi, A; Camacho, ME; Amoroso, R ACS Med Chem Lett 11: 1470 -1475 (2020)
Down, K; Amour, A; Anderson, NA; Barton, N; Campos, S; Cannons, EP; Clissold, C; Convery, MA; Coward, JJ; Doyle, K; Duempelfeld, B; Edwards, CD; Goldsmith, MD; Krause, J; Mallett, DN; McGonagle, GA; Patel, VK; Rowedder, J; Rowland, P; Sharpe, A; Sriskantharajah, S; Thomas, DA; Thomson, DW; Uddin, S; Hamblin, JN; Hessel, EM J Med Chem 64: 13780 -13792 (2021)
Gowthaman, R; Miller, SA; Rogers, S; Khowsathit, J; Lan, L; Bai, N; Johnson, DK; Liu, C; Xu, L; Anbanandam, A; Aubé, J; Roy, A; Karanicolas, J J Med Chem 59: 4152 -70 (2016)
Angeli, A; Pinteala, M; Maier, SS; Toti, A; Di Cesare Mannelli, L; Ghelardini, C; Selleri, S; Carta, F; Supuran, CT Bioorg Med Chem Lett 45: (2021)
Tintori, C; Fallacara, AL; Radi, M; Zamperini, C; Dreassi, E; Crespan, E; Maga, G; Schenone, S; Musumeci, F; Brullo, C; Richters, A; Gasparrini, F; Angelucci, A; Festuccia, C; Delle Monache, S; Rauh, D; Botta, M J Med Chem 58: 347 -61 (2015)
Shi, J; Gu, Z; Jurica, EA; Wu, X; Haque, LE; Williams, KN; Hernandez, AS; Hong, Z; Gao, Q; Dabros, M; Davulcu, AH; Mathur, A; Rampulla, RA; Gupta, AK; Jayaram, R; Apedo, A; Moore, DB; Liu, H; Kunselman, LK; Brady, EJ; Wilkes, JJ; Zinker, BA; Cai, H; Shu, YZ; Sun, Q; Dierks, EA; Foster, KA; Xu, C; Wang, T; Panemangalore, R; Cvijic, ME; Xie, C; Cao, GG; Zhou, M; Krupinski, J; Whaley, JM; Robl, JA; Ewing, WR; Ellsworth, BA J Med Chem 61: 681 -694 (2018)
Ceccarelli, SM; Chomienne, O; Gubler, M; Arduini, A J Med Chem 54: 3109 -52 (2011)
Argade, A; Bhamidipati, S; Li, H; Carroll, D; Clough, J; Keim, H; Sylvain, C; Rossi, AB; Coquilla, C; Issakani, SD; Masuda, ES; Payan, DG; Singh, R Bioorg Med Chem Lett 25: 2117 -21 (2015)
Sarkar, D; Olejniczak, ET; Phan, J; Coker, JA; Sai, J; Arnold, A; Beesetty, Y; Waterson, AG; Fesik, SW J Med Chem 63: 8325 -8337 (2020)
Fukuda, M; Sasaki, T; Hashimoto, T; Miyachi, H; Waki, M; Asai, A; Takikawa, O; Ohno, O; Matsuno, K Bioorg Med Chem Lett 28: 2846 -2849 (2018)
Asghar, A; Yousuf, M; Mubeen, H; Nazir, R; Haruna, K; Onawole, AT; Rasheed, L Bioorg Med Chem 27: 2397 -2404 (2019)
Pismataro, MC; Astolfi, A; Barreca, ML; Pacetti, M; Schenone, S; Bandiera, T; Carbone, A; Massari, S J Med Chem 66: 6498 -6522 (2023)
Casañola-Martín, GM; Marrero-Ponce, Y; Khan, MT; Ather, A; Khan, KM; Torrens, F; Rotondo, R Eur J Med Chem 42: 1370 -81 (2007)
Leban, JJ; Heyer, D; Landavazo, A; Matthews, J; Aulabaugh, A; Daniels, AJ J Med Chem 38: 1150 -7 (1995)
Qiu, W; Zhou, M; Mazumdar, M; Azzi, A; Ghanmi, D; Luu-The, V; Labrie, F; Lin, SX J Biol Chem 282: 8368 -79 (2007)
NILSSON-LILL, S; GIBLIN, K; GOLDBERG, FW; KETTLE, JG; BALAZS, A; ESCOBAR, R; GREBE, T; GRIMSTER, NP; METRANO, A; MFUH, A; MORRILL, L; SHA, L; SHEPPECK, J; SHIELDS, J; SONG, K; WU, D; WU, Y; ZIEGLER, RE US Patent US20240374606 (2024)
Camps, P; Gómez, E; Muñoz-Torrero, D; Badia, A; Clos, MV; Curutchet, C; Muñoz-Muriedas, J; Luque, FJ J Med Chem 49: 6833 -40 (2006)
Perkins, DR; Finlay, MR; Nissink, JW; Raubo, PA; Smith, PD; Bailey, A US Patent US10040789 (2018)
Cee, VJ; Schenkel, LB; Hodous, BL; Deak, HL; Nguyen, HN; Olivieri, PR; Romero, K; Bak, A; Be, X; Bellon, S; Bush, TL; Cheng, AC; Chung, G; Coats, S; Eden, PM; Hanestad, K; Gallant, PL; Gu, Y; Huang, X; Kendall, RL; Lin, MH; Morrison, MJ; Patel, VF; Radinsky, R; Rose, PE; Ross, S; Sun, JR; Tang, J; Zhao, H; Payton, M; Geuns-Meyer, SD J Med Chem 53: 6368 -77 (2010)
Grimster, NP; Gingipalli, L; Balazs, A; Barlaam, B; Boiko, S; Boyd, S; Dry, H; Goldberg, FW; Ikeda, T; Johnson, T; Kawatkar, S; Kemmitt, P; Lamont, S; Lorthioir, O; Mfuh, A; Patel, J; Pike, A; Read, J; Romero, R; Sarkar, U; Sha, L; Simpson, I; Song, K; Su, Q; Wang, H; Watson, D; Wu, A; Zehnder, TE; Zheng, X; Li, S; Dong, Z; Yang, D; Song, Y; Wang, P; Liu, X; Dowling, JE; Edmondson, SD Bioorg Med Chem Lett 91: (2023)
Balog, A; Salvati, ME; Shan, W; Mathur, A; Leith, LW; Wei, DD; Attar, RM; Geng, J; Rizzo, CA; Wang, C; Krystek, SR; Tokarski, JS; Hunt, JT; Gottardis, M; Weinmann, R Bioorg Med Chem Lett 14: 6107 -11 (2004)
Colabufo, NA; Berardi, F; Perrone, R; Rapposelli, S; Digiacomo, M; Vanni, M; Balsamo, A J Med Chem 51: 1415 -22 (2008)
Banerjee, A; Narayana, L; Raje, FA; Pisal, DV; Kadam, PA; Gullapalli, S; Kumar, H; More, SV; Bajpai, M; Sangana, RR; Jadhav, S; Gudi, GS; Khairatkar-Joshi, N; Merugu, RR; Voleti, SR; Gharat, LA Bioorg Med Chem Lett 23: 6747 -54 (2013)
Ravez, S; Arsenlis, S; Barczyk, A; Dupont, A; Frédérick, R; Hesse, S; Kirsch, G; Depreux, P; Goossens, L Bioorg Med Chem 23: 7340 -7 (2015)
Pham, SM; Chakravarty, S; Kankanala, J; Chen, J; Miller, CP; Pettigrew, JD; Nayak, AK; Barde, A US Patent US11584756 (2023)
Smolinski, MP; Bu, Y; Clements, J; Gelman, IH; Hegab, T; Cutler, DL; Fang, JWS; Fetterly, G; Kwan, R; Barnett, A; Lau, JYN; Hangauer, DG J Med Chem 61: 4704 -4719 (2018)
Zhang, X; Raghavan, S; Ihnat, M; Hamel, E; Zammiello, C; Bastian, A; Mooberry, SL; Gangjee, A Bioorg Med Chem 23: 2408 -23 (2015)
Fernández-Bachiller, MI; Hwang, S; Schembri, ME; Lindemann, P; Guberman, M; Herziger, S; Specker, E; Matter, H; Will, DW; Czech, J; Wagner, M; Bauer, A; Schreuder, H; Ritter, K; Urmann, M; Wehner, V; Sun, H; Nazaré, M J Med Chem 65: 13013 -13028 (2022)
Maga, G; Falchi, F; Garbelli, A; Belfiore, A; Witvrouw, M; Manetti, F; Botta, M J Med Chem 51: 6635 -8 (2008)
Elhalem, E; Bellomo, A; Cooke, M; Scravaglieri, A; Pearce, LV; Peach, ML; Gandolfi Donadío, L; Kazanietz, MG; Comin, MJ J Med Chem 64: 11418 -11431 (2021)
Svensson, F; Bender, A; Bailey, D J Med Chem 61: 1415 -1424 (2018)
Toledo, MA; Pedregal, C; Lafuente, C; Diaz, N; Martinez-Grau, MA; Jiménez, A; Benito, A; Torrado, A; Mateos, C; Joshi, EM; Kahl, SD; Rash, KS; Mudra, DR; Barth, VN; Shaw, DB; McKinzie, D; Witkin, JM; Statnick, MA J Med Chem 57: 3418 -29 (2014)
Concha, N; Huang, J; Bai, X; Benowitz, A; Brady, P; Grady, LC; Kryn, LH; Holmes, D; Ingraham, K; Jin, Q; Pothier Kaushansky, L; McCloskey, L; Messer, JA; O'Keefe, H; Patel, A; Satz, AL; Sinnamon, RH; Schneck, J; Skinner, SR; Summerfield, J; Taylor, A; Taylor, JD; Evindar, G; Stavenger, RA J Med Chem 59: 7299 -304 (2016)
Cabedo, N; Andreu, I; Ramírez De Arellano, MC; Chagraoui, A; Serrano, A; Bermejo, A; Protais, P; Cortes, D J Med Chem 44: 1794 -801 (2001)
Nguyen, TX; Morrell, A; Conda-Sheridan, M; Marchand, C; Agama, K; Bermingham, A; Bermingam, A; Stephen, AG; Chergui, A; Naumova, A; Fisher, R; O'Keefe, BR; Pommier, Y; Cushman, M J Med Chem 55: 4457 -78 (2012)
Reck, F; Bermingham, A; Blais, J; Capka, V; Cariaga, T; Casarez, A; Colvin, R; Dean, CR; Fekete, A; Gong, W; Growcott, E; Guo, H; Jones, AK; Li, C; Li, F; Lin, X; Lindvall, M; Lopez, S; McKenney, D; Metzger, L; Moser, HE; Prathapam, R; Rasper, D; Rudewicz, P; Sethuraman, V; Shen, X; Shaul, J; Simmons, RL; Tashiro, K; Tang, D; Tjandra, M; Turner, N; Uehara, T; Vitt, C; Whitebread, S; Yifru, A; Zang, X; Zhu, Q Bioorg Med Chem Lett 28: 748 -755 (2018)
Galley, G; Beurier, A; Décoret, G; Goergler, A; Hutter, R; Mohr, S; Pähler, A; Schmid, P; Türck, D; Unger, R; Zbinden, KG; Hoener, MC; Norcross, RD ACS Med Chem Lett 7: 192 -7 (2016)
Valluri, H; Bhanot, A; Shah, S; Bhandaru, N; Sundriyal, S J Med Chem 66: 8382 -8406 (2023)
Singh, P; Bhardwaj, A J Med Chem 53: 3707 -17 (2010)
Roberts, LR; Brady, K; Brown, A; Davey, D; Feng, L; Huang, H; Liu, D; Malet, L; McMurray, G; Phelan, A; Saunders, K; Bhat, A Bioorg Med Chem Lett 22: 4173 -8 (2012)
Browne, LJ; Gude, C; Rodriguez, H; Steele, RE; Bhatnager, A J Med Chem 34: 725 -36 (1991)
Campestre, C; Tortorella, P; Agamennone, M; Preziuso, S; Biasone, A; Nuti, E; Rossello, A; Gallina, C Eur J Med Chem 43: 1008 -14 (2008)
Ettmayer, P; Billich, A; Hecht, P; Rosenwirth, B; Gstach, H J Med Chem 39: 3291 -9 (1996)
Murage, EN; Gao, G; Bisello, A; Ahn, JM J Med Chem 53: 6412 -20 (2010)
Buzard, DJ; Lopez, L; Moody, J; Kawasaki, A; Schrader, TO; Kasem, M; Johnson, B; Zhu, X; Thoresen, L; Kim, SH; Gharbaoui, T; Sengupta, D; Calvano, L; Krishnan, A; Gao, Y; Semple, G; Edwards, J; Barden, J; Morgan, M; Usmani, K; Chen, C; Sadeque, A; Chen, W; Christopher, RJ; Thatte, J; Fu, L; Solomon, M; Whelan, K; Al-Shamma, H; Gatlin, J; Gaidarov, I; Anthony, T; Le, M; Unett, DJ; Stirn, S; Blackburn, A; Behan, DP; Jones, RM ACS Med Chem Lett 5: 1334 -9 (2014)
Zheng, N; Christensen, SB; Blakely, A; Dowell, C; Purushottam, L; McIntosh, JM; Chou, DH J Med Chem 63: 8380 -8387 (2020)
Bochen, A; Marelli, UK; Otto, E; Pallarola, D; Mas-Moruno, C; Di Leva, FS; Boehm, H; Spatz, JP; Novellino, E; Kessler, H; Marinelli, L J Med Chem 56: 1509 -19 (2013)
Bogdan, A; Cowart, MD; DeGoey, DA; Jinkerson, TK; Koenig, JR; Kort, ME; Liu, B; Matulenko, MA; Nelson, DW; Patel, MV; Peltier, H; Scanio, MJ; Wakefield, BD US Patent US9452986 (2016)
Distinto, S; Yáñez, M; Alcaro, S; Cardia, MC; Gaspari, M; Sanna, ML; Meleddu, R; Ortuso, F; Kirchmair, J; Markt, P; Bolasco, A; Wolber, G; Secci, D; Maccioni, E Eur J Med Chem 48: 284 -95 (2012)
Montagne, C; Bombrun, A; Desforges-Bouscary, G; Quattropani, A; Gaillard, P US Patent US8609666 (2013)
Bua, S; Nocentini, A; Bonardi, A; Palma, G; Ciampi, G; Giliberti, A; Iannelli, F; Bruzzese, F; Supuran, CT; de Nigris, F J Med Chem 67: 15892 -15907
Pevarello, P; Traquandi, G; Bonsignori, A; McArthur, RA; Maj, R; Caccia, C; Salvati, P; Varasi, M Bioorg Med Chem Lett 9: 1783 -8 (1999)
Bornot, A; Bauer, U; Brown, A; Firth, M; Hellawell, C; Engkvist, O J Med Chem 56: 1197 -210 (2013)
Manzoni, L; Gornati, D; Manzotti, M; Cairati, S; Bossi, A; Arosio, D; Lecis, D; Seneci, P Bioorg Med Chem Lett 26: 4613 -4619 (2016)
Gualtieri, MJ; Malafronte, N; Vassallo, A; Braca, A; Cotugno, R; Vasaturo, M; De Tommasi, N; Dal Piaz, F J Nat Prod 77: 596 -602 (2014)
La Regina, G; Coluccia, A; Brancale, A; Piscitelli, F; Gatti, V; Maga, G; Samuele, A; Pannecouque, C; Schols, D; Balzarini, J; Novellino, E; Silvestri, R J Med Chem 54: 1587 -98 (2011)
Papillon, JPN; Nakajima, K; Adair, CD; Hempel, J; Jouk, AO; Karki, RG; Mathieu, S; Möbitz, H; Ntaganda, R; Smith, T; Visser, M; Hill, SE; Hurtado, FK; Chenail, G; Bhang, HC; Bric, A; Xiang, K; Bushold, G; Gilbert, T; Vattay, A; Dooley, J; Costa, EA; Park, I; Li, A; Farley, D; Lounkine, E; Yue, QK; Xie, X; Zhu, X; Kulathila, R; King, D; Hu, T; Vulic, K; Cantwell, J; Luu, C; Jagani, Z J Med Chem 61: 10155 -10172 (2018)
Guan, J; Zhu, XK; Tachibana, Y; Bastow, KF; Brossi, A; Hamel, E; Lee, KH J Med Chem 41: 1956 -61 (1998)
Bornot, A; Bauer, U; Brown, A; Firth, M; Hellawell, C; Engkvist, O J Med Chem 56: 1197 -210 (2013)
Bertini, S; Parkkari, T; Savinainen, JR; Arena, C; Saccomanni, G; Saguto, S; Ligresti, A; Allarà, M; Bruno, A; Marinelli, L; Di Marzo, V; Novellino, E; Manera, C; Macchia, M Eur J Med Chem 90: 526 -36 (2015)
Griebenow, N; Buchmueller, A; Kolkhof, P; Schamberger, J; Bischoff, H Bioorg Med Chem Lett 21: 3648 -53 (2011)
Shah, U; Jayne, C; Chackalamannil, S; Velázquez, F; Guo, Z; Buevich, A; Howe, JA; Chase, R; Soriano, A; Agrawal, S; Rudd, MT; McCauley, JA; Liverton, NJ; Romano, J; Bush, K; Coleman, PJ; Grisé-Bard, C; Brochu, MC; Charron, S; Aulakh, V; Bachand, B; Beaulieu, P; Zaghdane, H; Bhat, S; Han, Y; Vacca, JP; Davies, IW; Weber, AE; Venkatraman, S ACS Med Chem Lett 5: 264 -9 (2014)
Burgess, A; Wigan, M; Giles, N; Depinto, W; Gillespie, P; Stevens, F; Gabrielli, B J Biol Chem 281: 9987 -95 (2006)
Marchand, JR; Lolli, G; Caflisch, A J Med Chem 59: 9919 -9927 (2016)
Camps, P; Formosa, X; Galdeano, C; Gómez, T; Muñoz-Torrero, D; Scarpellini, M; Viayna, E; Badia, A; Clos, MV; Camins, A; Pallàs, M; Bartolini, M; Mancini, F; Andrisano, V; Estelrich, J; Lizondo, M; Bidon-Chanal, A; Luque, FJ J Med Chem 51: 3588 -98 (2008)
Ioannidis, S; Talbot, AC; Follows, B; Buckmelter, AJ; Wang, M; Campbell, A; Lancia, Jr., DR US Patent US10836741 (2020)
Prezzavento, O; Campisi, A; Parenti, C; Ronsisvalle, S; Aricò, G; Arena, E; Pistolozzi, M; Scoto, GM; Bertucci, C; Vanella, A; Ronsisvalle, G J Med Chem 53: 5881 -5 (2010)
Cappelli, A; Manini, M; Paolino, M; Gallelli, A; Anzini, M; Mennuni, L; Del Cadia, M; De Rienzo, F; Menziani, MC; Vomero, S ACS Med Chem Lett 2: 571 -576 (2011)
Tanini, D; Ricci, L; Capperucci, A; Di Cesare Mannelli, L; Ghelardini, C; Peat, TS; Carta, F; Angeli, A; Supuran, CT Eur J Med Chem 181: (2019)
Schillaci, D; Spanò, V; Parrino, B; Carbone, A; Montalbano, A; Barraja, P; Diana, P; Cirrincione, G; Cascioferro, S J Med Chem 60: 8268 -8297 (2017)
Harper, S; Avolio, S; Pacini, B; Di Filippo, M; Altamura, S; Tomei, L; Paonessa, G; Di Marco, S; Carfi, A; Giuliano, C; Padron, J; Bonelli, F; Migliaccio, G; De Francesco, R; Laufer, R; Rowley, M; Narjes, F J Med Chem 48: 4547 -57 (2005)
Conejo-García, A; Pisani, L; Núñez, Mdel C; Catto, M; Nicolotti, O; Leonetti, F; Campos, JM; Gallo, MA; Espinosa, A; Carotti, A J Med Chem 54: 2627 -45 (2011)
Piemontese, L; Fracchiolla, G; Carrieri, A; Parente, M; Laghezza, A; Carbonara, G; Sblano, S; Tauro, M; Gilardi, F; Tortorella, P; Lavecchia, A; Crestani, M; Desvergne, B; Loiodice, F Eur J Med Chem 90: 583 -94 (2015)
Leblond, B; Taverne, T; Chauvignac, C; Beausoleil, E; Casagrande, A; Desire, L; Pando, MP; Donello, JE; Yang, R US Patent US9200016 (2015)
Reck, F; Bermingham, A; Blais, J; Capka, V; Cariaga, T; Casarez, A; Colvin, R; Dean, CR; Fekete, A; Gong, W; Growcott, E; Guo, H; Jones, AK; Li, C; Li, F; Lin, X; Lindvall, M; Lopez, S; McKenney, D; Metzger, L; Moser, HE; Prathapam, R; Rasper, D; Rudewicz, P; Sethuraman, V; Shen, X; Shaul, J; Simmons, RL; Tashiro, K; Tang, D; Tjandra, M; Turner, N; Uehara, T; Vitt, C; Whitebread, S; Yifru, A; Zang, X; Zhu, Q Bioorg Med Chem Lett 28: 748 -755 (2018)
Mincione, F; Starnotti, M; Menabuoni, L; Scozzafava, A; Casini, A; Supuran, CT Bioorg Med Chem Lett 11: 1787 -91 (2001)
Cioffi, G; D'Auria, M; Braca, A; Mendez, J; Castillo, A; Morelli, I; De Simone, F; De Tommasi, N J Nat Prod 65: 1526 -9 (2002)
Maccallini, C; Arias, F; Gallorini, M; Amoia, P; Ammazzalorso, A; De Filippis, B; Fantacuzzi, M; Giampietro, L; Cataldi, A; Camacho, ME; Amoroso, R ACS Med Chem Lett 11: 1470 -1475 (2020)
Prati, F; Bottegoni, G; Bolognesi, ML; Cavalli, A J Med Chem 61: 619 -637 (2018)
Martínez-González, S; Rodríguez-Arístegui, S; Gómez de la Oliva, CA; Hernández, AI; González Cantalapiedra, E; Varela, C; García, AB; Rabal, O; Oyarzabal, J; Bischoff, JR; Klett, J; Albarrán, MI; Cebriá, A; Ajenjo, N; García-Serelde, B; Gómez-Casero, E; Cuadrado-Urbano, M; Cebrián, D; Blanco-Aparicio, C; Pastor, J Eur J Med Chem 168: 87 -109 (2019)
Zhang, MM; Green, BR; Catlin, P; Fiedler, B; Azam, L; Chadwick, A; Terlau, H; McArthur, JR; French, RJ; Gulyas, J; Rivier, JE; Smith, BJ; Norton, RS; Olivera, BM; Yoshikami, D; Bulaj, G J Biol Chem 282: 30699 -706 (2007)
Cabedo, N; Andreu, I; Ramírez De Arellano, MC; Chagraoui, A; Serrano, A; Bermejo, A; Protais, P; Cortes, D J Med Chem 44: 1794 -801 (2001)
Chaikuad, A; Diharce, J; Schröder, M; Foucourt, A; Leblond, B; Casagrande, AS; Désiré, L; Bonnet, P; Knapp, S; Besson, T J Med Chem 59: 10315 -10321 (2016)
Zahid, H; Buchholz, CR; Singh, M; Ciccone, MF; Chan, A; Nithianantham, S; Shi, K; Aihara, H; Fischer, M; Schönbrunn, E; Dos Santos, CO; Landry, JW; Pomerantz, WCK J Med Chem 64: 13902 -13917 (2021)
Gallant, M; Belley, M; Carrière, MC; Chateauneuf, A; Denis, D; Lachance, N; Lamontagne, S; Metters, KM; Sawyer, N; Slipetz, D; Truchon, JF; Labelle, M Bioorg Med Chem Lett 13: 3813 -6 (2003)
Lacivita, E; Leopoldo, M; Masotti, AC; Inglese, C; Berardi, F; Perrone, R; Ganguly, S; Jafurulla, M; Chattopadhyay, A J Med Chem 52: 7892 -6 (2009)
Micheli, F; Cavanni, P; Andreotti, D; Arban, R; Benedetti, R; Bertani, B; Bettati, M; Bettelini, L; Bonanomi, G; Braggio, S; Carletti, R; Checchia, A; Corsi, M; Fazzolari, E; Fontana, S; Marchioro, C; Merlo-Pich, E; Negri, M; Oliosi, B; Ratti, E; Read, KD; Roscic, M; Sartori, I; Spada, S; Tedesco, G; Tarsi, L; Terreni, S; Visentini, F; Zocchi, A; Zonzini, L; Di Fabio, R J Med Chem 53: 4989 -5001 (2010)
Xu, J; Chen, A; Go, ML; Nacro, K; Liu, B; Chai, CL ACS Med Chem Lett 2: 662 -666 (2011)
DiMauro, EF; Newcomb, J; Nunes, JJ; Bemis, JE; Boucher, C; Buchanan, JL; Buckner, WH; Cheng, A; Faust, T; Hsieh, F; Huang, X; Lee, JH; Marshall, TL; Martin, MW; McGowan, DC; Schneider, S; Turci, SM; White, RD; Zhu, X Bioorg Med Chem Lett 17: 2305 -9 (2007)
Nguyen, TX; Morrell, A; Conda-Sheridan, M; Marchand, C; Agama, K; Bermingham, A; Bermingam, A; Stephen, AG; Chergui, A; Naumova, A; Fisher, R; O'Keefe, BR; Pommier, Y; Cushman, M J Med Chem 55: 4457 -78 (2012)
Carabet, LA; Lallous, N; Leblanc, E; Ban, F; Morin, H; Lawn, S; Ghaidi, F; Lee, J; Mills, IG; Gleave, ME; Rennie, PS; Cherkasov, A Eur J Med Chem 160: 108 -119 (2018)
Lesuisse, D; Tiraboschi, G; Krick, A; Abecassis, PY; Dutruc-Rosset, G; Babin, D; Halley, F; Châtreau, F; Lachaud, S; Chevalier, A; Quarteronet, D; Burgevin, MC; Amara, C; Bertrand, P; Rooney, T Bioorg Med Chem Lett 20: 2344 -9 (2010)
Melchiorre, C; Bolognesi, ML; Chiarini, A; Minarini, A; Spampinato, S J Med Chem 36: 3734 -7 (1993)
Pellicciari, R; Natalini, B; Costantino, G; Mahmoud, MR; Mattoli, L; Sadeghpour, BM; Moroni, F; Chiarugi, A; Carpenedo, R J Med Chem 37: 647 -55 (1994)
Yamamoto, T; Fujita, K; Asari, S; Chiba, A; Kataba, Y; Ohsumi, K; Ohmuta, N; Iida, Y; Ijichi, C; Iwayama, S; Fukuchi, N; Shoji, M Bioorg Med Chem Lett 17: 3736 -40 (2007)
Marzaro, G; Guiotto, A; Borgatti, M; Finotti, A; Gambari, R; Breveglieri, G; Chilin, A J Med Chem 56: 1830 -42 (2013)
Nair, S; Kumar, SR; Paidi, VR; Sistla, R; Kantheti, D; Polimera, SR; Thangavel, S; Mukherjee, AJ; Das, M; Bhide, RS; Pitts, WJ; Murugesan, N; Dudhgoankar, S; Nagar, J; Subramani, S; Mazumder, D; Carman, JA; Holloway, DA; Li, X; Fereshteh, MP; Ruepp, S; Palanisamy, K; Mariappan, TT; Maddi, S; Saxena, A; Elzinga, P; Chimalakonda, A; Ruan, Q; Ghosh, K; Bose, S; Sack, J; Yan, C; Kiefer, SE; Xie, D; Newitt, JA; Saravanakumar, SP; Rampulla, RA; Barrish, JC; Carter, PH; Hynes, J ACS Med Chem Lett 11: 1402 -1409 (2020)
De Luca, L; Ferro, S; Damiano, FM; Supuran, CT; Vullo, D; Chimirri, A; Gitto, R Eur J Med Chem 71: 105 -11 (2014)
Aktoudianakis, E; Cho, A; Du, Z; Graupe, M; Lad, LT; Machicao Tello, PA; Medley, JW; Metobo, SE; Mukherjee, PK; Naduthambi, D; Parkhill, EQ; Phillips, BW; Simonovich, SP; Squires, NH; Wang, P; Watkins, WJ; Xu, J; Yang, KS; Ziebenhaus, CA US Patent US10899735 (2021)
Tummalapalli, SR; Bhat, R; Chojnowski, A; Prorok, M; Kreiss, T; Goldberg, R; Canan, S; Hawryluk, N; Mortensen, D; Khetani, V; Zeldis, J; Siekierka, JJ; Rotella, DP ACS Med Chem Lett 9: 210 -214 (2018)
Kumar, N; Kaur, K; Aeron, S; Dharmarajan, S; Silamkoti, AD; Mehta, A; Gupta, S; Chugh, A; Gupta, JB; Salman, M; Palle, VP; Cliffe, IA Bioorg Med Chem Lett 17: 5256 -60 (2007)
Toti, KS; Osborne, D; Ciancetta, A; Boison, D; Jacobson, KA J Med Chem 59: 6860 -77 (2016)
Franchini, S; Battisti, UM; Prandi, A; Tait, A; Borsari, C; Cichero, E; Fossa, P; Cilia, A; Prezzavento, O; Ronsisvalle, S; Aricò, G; Parenti, C; Brasili, L Eur J Med Chem 112: 1 -19 (2016)
Rusali, LE; Lopez-Hernandez, AM; Kremiller, KM; Kulkarni, GC; Gour, A; Straub, CJ; Argade, MD; Peters, CJ; Sharma, A; Toll, L; Cippitelli, A; Riley, AP J Med Chem 67: 529 -542
Vanotti, E; Caldarelli, M; Cirla, A; Forte, B; Ermoli, A; Menichincheri, M; Pillan, A; Scolaro, A US Patent US9670191 (2017)
Thaler, F; Varasi, M; Abate, A; Carenzi, G; Colombo, A; Bigogno, C; Boggio, R; Zuffo, RD; Rapetti, D; Resconi, A; Regalia, N; Vultaggio, S; Dondio, G; Gagliardi, S; Minucci, S; Mercurio, C Eur J Med Chem 64: 273 -84 (2013)
La Regina, G; Coluccia, A; Brancale, A; Piscitelli, F; Gatti, V; Maga, G; Samuele, A; Pannecouque, C; Schols, D; Balzarini, J; Novellino, E; Silvestri, R J Med Chem 54: 1587 -98 (2011)
Saquib, M; Ansari, MI; Johnson, CR; Khatoon, S; Kamil Hussain, M; Coop, A Eur J Med Chem 182: (2019)
Dichiara, M; Ambrosio, FA; Lee, SM; Ruiz-Cantero, MC; Lombino, J; Coricello, A; Costa, G; Shah, D; Costanzo, G; Pasquinucci, L; Son, KN; Cosentino, G; González-Cano, R; Marrazzo, A; Aakalu, VK; Cobos, EJ; Alcaro, S; Amata, E J Med Chem 66: 11447 -11463 (2023)
La Pietra, V; La Regina, G; Coluccia, A; Famiglini, V; Pelliccia, S; Plotkin, B; Eldar-Finkelman, H; Brancale, A; Ballatore, C; Crowe, A; Brunden, KR; Marinelli, L; Novellino, E; Silvestri, R J Med Chem 56: 10066 -78 (2013)
Yamazaki, K; Kusunose, N; Fujita, K; Sato, H; Asano, S; Dan, A; Kanaoka, M Bioorg Med Chem Lett 16: 1371 -9 (2006)
Meena, CL; Singh, D; Weinmüller, M; Reichart, F; Dangi, A; Marelli, UK; Zahler, S; Sanjayan, GJ Bioorg Med Chem Lett 30: (2020)
Roy, J; Watson, JE; Hong, IS; Fan, TM; Das, A J Med Chem 61: 5569 -5579 (2018)
Harris, PA; Faucher, N; George, N; Eidam, PM; King, BW; White, GV; Anderson, NA; Bandyopadhyay, D; Beal, AM; Beneton, V; Berger, SB; Campobasso, N; Campos, S; Capriotti, CA; Cox, JA; Daugan, A; Donche, F; Fouchet, MH; Finger, JN; Geddes, B; Gough, PJ; Grondin, P; Hoffman, BL; Hoffman, SJ; Hutchinson, SE; Jeong, JU; Jigorel, E; Lamoureux, P; Leister, LK; Lich, JD; Mahajan, MK; Meslamani, J; Mosley, JE; Nagilla, R; Nassau, PM; Ng, SL; Ouellette, MT; Pasikanti, KK; Potvain, F; Reilly, MA; Rivera, EJ; Sautet, S; Schaeffer, MC; Sehon, CA; Sun, H; Thorpe, JH; Totoritis, RD; Ward, P; Wellaway, N; Wisnoski, DD; Woolven, JM; Bertin, J; Marquis, RW J Med Chem 62: 5096 -5110 (2019)
Bonhaus, DW; Loury, DN; Jakeman, LB; To, Z; DeSouza, A; Eglen, RM; Wong, EH J Pharmacol Exp Ther 267: 961 -70 (1993)
Kuo, GH; Deangelis, A; Emanuel, S; Wang, A; Zhang, Y; Connolly, PJ; Chen, X; Gruninger, RH; Rugg, C; Fuentes-Pesquera, A; Middleton, SA; Jolliffe, L; Murray, WV J Med Chem 48: 4535 -46 (2005)
Handzlik, J; Szymańska, E; Wójcik, R; Dela, A; Jastrzębska-Więsek, M; Karolak-Wojciechowska, J; Fruziński, A; Siwek, A; Filipek, B; Kieć-Kononowicz, K Bioorg Med Chem 20: 4245 -57 (2012)
Durek, T; Cromm, PM; White, AM; Schroeder, CI; Kaas, Q; Weidmann, J; Ahmad Fuaad, A; Cheneval, O; Harvey, PJ; Daly, NL; Zhou, Y; Dellsén, A; Österlund, T; Larsson, N; Knerr, L; Bauer, U; Kessler, H; Cai, M; Hruby, VJ; Plowright, AT; Craik, DJ J Med Chem 61: 3674 -3684 (2018)
Doukas, J; Wrasidlo, W; Noronha, G; Dneprovskaia, E; Fine, R; Weis, S; Hood, J; Demaria, A; Soll, R; Cheresh, D Proc Natl Acad Sci U S A 103: 19866 -71 (2006)
Schormann, N; Velu, SE; Murugesan, S; Senkovich, O; Walker, K; Chenna, BC; Shinkre, B; Desai, A; Chattopadhyay, D Bioorg Med Chem 18: 4056 -66 (2010)
Desphande, A; Xia, G; Boerma, LJ; Vines, KK; Atigadda, VR; Lobo-Ruppert, S; Grubbs, CJ; Moeinpour, FL; Smith, CD; Christov, K; Brouillette, WJ; Muccio, DD Bioorg Med Chem 22: 178 -85 (2013)
Ovais, S; Pushpalatha, H; Reddy, GB; Rathore, P; Bashir, R; Yaseen, S; Dheyaa, A; Yaseen, R; Tanwar, O; Akthar, M; Samim, M; Javed, K Eur J Med Chem 80: 209 -17 (2014)
Sun, L; Dick, A; Meuser, ME; Huang, T; Zalloum, WA; Chen, CH; Cherukupalli, S; Xu, S; Ding, X; Gao, P; Kang, D; De Clercq, E; Pannecouque, C; Cocklin, S; Lee, KH; Liu, X; Zhan, P J Med Chem 63: 4790 -4810 (2020)
McCoull, W; Boyd, S; Brown, MR; Coen, M; Collingwood, O; Davies, NL; Doherty, A; Fairley, G; Goldberg, K; Hardaker, E; He, G; Hennessy, EJ; Hopcroft, P; Hodgson, G; Jackson, A; Jiang, X; Karmokar, A; Lainé, AL; Lindsay, N; Mao, Y; Markandu, R; McMurray, L; McLean, N; Mooney, L; Musgrove, H; Nissink, JWM; Pflug, A; Reddy, VP; Rawlins, PB; Rivers, E; Schimpl, M; Smith, GF; Tentarelli, S; Travers, J; Troup, RI; Walton, J; Wang, C; Wilkinson, S; Williamson, B; Winter-Holt, J; Yang, D; Zheng, Y; Zhu, Q; Smith, PD J Med Chem 64: 13524 -13539 (2021)
Schaschke, N; Dominik, A; Matschiner, G; Sommerhoff, CP Bioorg Med Chem Lett 12: 985 -8 (2002)
Shen, Y; Li, F; Szewczyk, MM; Halabelian, L; Chau, I; Eram, MS; Dela Seña, C; Park, KS; Meng, F; Chen, H; Zeng, H; Dong, A; Wu, H; Trush, VV; McLeod, D; Zepeda-Velázquez, CA; Campbell, RM; Mader, MM; Watson, BM; Schapira, M; Arrowsmith, CH; Al-Awar, R; Barsyte-Lovejoy, D; Kaniskan, HÜ; Brown, PJ; Vedadi, M; Jin, J J Med Chem 64: 3697 -3706 (2021)
Drakopoulos, A; Tzitzoglaki, C; McGuire, K; Hoffmann, A; Konstantinidi, A; Kolokouris, D; Ma, C; Freudenberger, K; Hutterer, J; Gauglitz, G; Wang, J; Schmidtke, M; Busath, DD; Kolocouris, A ACS Med Chem Lett 9: 198 -203 (2018)
Li, L; Chenna, BC; Yang, KS; Cole, TR; Goodall, ZT; Giardini, M; Moghadamchargari, Z; Hernandez, EA; Gomez, J; Calvet, CM; Bernatchez, JA; Mellott, DM; Zhu, J; Rademacher, A; Thomas, D; Blankenship, LR; Drelich, A; Laganowsky, A; Tseng, CK; Liu, WR; Wand, AJ; Cruz-Reyes, J; Siqueira-Neto, JL; Meek, TD J Med Chem 64: 11267 -11287 (2021)
Shi, J; Van de Water, R; Hong, K; Lamer, RB; Weichert, KW; Sandoval, CM; Kasibhatla, SR; Boehm, MF; Chao, J; Lundgren, K; Timple, N; Lough, R; Ibanez, G; Boykin, C; Burrows, FJ; Kehry, MR; Yun, TJ; Harning, EK; Ambrose, C; Thompson, J; Bixler, SA; Dunah, A; Snodgrass-Belt, P; Arndt, J; Enyedy, IJ; Li, P; Hong, VS; McKenzie, A; Biamonte, MA J Med Chem 55: 7786 -95 (2012)
Ravez, S; Arsenlis, S; Barczyk, A; Dupont, A; Frédérick, R; Hesse, S; Kirsch, G; Depreux, P; Goossens, L Bioorg Med Chem 23: 7340 -7 (2015)
Skácel, J; Djukic, S; Baszczyňski, O; Kalčic, F; Bílek, T; Chalupský, K; Kozák, J; Dvořáková, A; Tloušt'ová, E; Král'ová, Z; Šmídková, M; Voldřich, J; Rumlová, M; Pachl, P; Brynda, J; Vučková, T; Fábry, M; Snášel, J; Pichová, I; Řezáčová, P; Mertlíková-Kaiserová, H; Janeba, Z J Med Chem 66: 6652 -6681 (2023)
Neochoritis, CG; Wang, K; Estrada-Ortiz, N; Herdtweck, E; Kubica, K; Twarda, A; Zak, KM; Holak, TA; Dömling, A Bioorg Med Chem Lett 25: 5661 -6 (2015)
Sanfilippo, PJ; Urbanski, MJ; Beers, KN; Eckardt, A; Falotico, R; Ginsberg, MH; Offord, S; Press, JB; Tighe, J; Tomko, K J Med Chem 38: 34 -41 (1995)
Vazquez, J; De, SK; Chen, LH; Riel-Mehan, M; Emdadi, A; Cellitti, J; Stebbins, JL; Rega, MF; Pellecchia, M J Med Chem 51: 3460 -5 (2008)
Sund, C; Belda, O; Wiktelius, D; Sahlberg, C; Vrang, L; Sedig, S; Hamelink, E; Henderson, I; Agback, T; Jansson, K; Borkakoti, N; Derbyshire, D; Eneroth, A; Samuelsson, B Bioorg Med Chem Lett 21: 358 -62 (2010)
Juknaite, L; Sugamata, Y; Tokiwa, K; Ishikawa, Y; Takamizawa, S; Eng, A; Sakai, R; Pickering, DS; Frydenvang, K; Swanson, GT; Kastrup, JS; Oikawa, M J Med Chem 56: 2283 -93 (2013)
Menichincheri, M; Albanese, C; Alli, C; Ballinari, D; Bargiotti, A; Caldarelli, M; Ciavolella, A; Cirla, A; Colombo, M; Colotta, F; Croci, V; D'Alessio, R; D'Anello, M; Ermoli, A; Fiorentini, F; Forte, B; Galvani, A; Giordano, P; Isacchi, A; Martina, K; Molinari, A; Moll, JK; Montagnoli, A; Orsini, P; Orzi, F; Pesenti, E; Pillan, A; Roletto, F; Scolaro, A; Tatò, M; Tibolla, M; Valsasina, B; Varasi, M; Vianello, P; Volpi, D; Santocanale, C; Vanotti, E J Med Chem 53: 7296 -315 (2010)
Rossi, C; Porcelloni, M; D'Andrea, P; Fincham, CI; Ettorre, A; Mauro, S; Squarcia, A; Bigioni, M; Parlani, M; Nardelli, F; Binaschi, M; Maggi, CA; Fattori, D Bioorg Med Chem Lett 21: 2305 -8 (2011)
Letavic, MA; Aluisio, L; Atack, JR; Bonaventure, P; Carruthers, NI; Dugovic, C; Everson, A; Feinstein, MA; Fraser, IC; Hoey, K; Jiang, X; Keith, JM; Koudriakova, T; Leung, P; Lord, B; Lovenberg, TW; Ly, KS; Morton, KL; Motley, ST; Nepomuceno, D; Rizzolio, M; Rynberg, R; Sepassi, K; Shelton, J Bioorg Med Chem Lett 20: 4210 -4 (2010)
Gilbert, AM; Kirisits, M; Toy, P; Nunn, DS; Failli, A; Dushin, EG; Novikova, E; Petersen, PJ; Joseph-McCarthy, D; McFadyen, I; Fritz, CC Bioorg Med Chem Lett 14: 37 -41 (2003)
Fang, A; Luo, H; Liu, L; Fan, H; Zhou, Y; Yao, Y; Zhang, Y Bioorg Med Chem Lett 27: 5450 -5453 (2017)
Belei, D; Dumea, C; Samson, A; Farce, A; Dubois, J; Bîcu, E; Ghinet, A Bioorg Med Chem Lett 22: 4517 -22 (2012)
Teng, M; Nammalwar, B; Li, X; Perez, C; Yule, I; Faulkner, A; Atton, H; Parkes, A; Convers-Reignier, S; Southey, M; Puerta, DT US Patent US11407740 (2022)
Reck, F; Bermingham, A; Blais, J; Capka, V; Cariaga, T; Casarez, A; Colvin, R; Dean, CR; Fekete, A; Gong, W; Growcott, E; Guo, H; Jones, AK; Li, C; Li, F; Lin, X; Lindvall, M; Lopez, S; McKenney, D; Metzger, L; Moser, HE; Prathapam, R; Rasper, D; Rudewicz, P; Sethuraman, V; Shen, X; Shaul, J; Simmons, RL; Tashiro, K; Tang, D; Tjandra, M; Turner, N; Uehara, T; Vitt, C; Whitebread, S; Yifru, A; Zang, X; Zhu, Q Bioorg Med Chem Lett 28: 748 -755 (2018)
Balestrieri, E; Pizzimenti, F; Ferlazzo, A; Giofrè, SV; Iannazzo, D; Piperno, A; Romeo, R; Chiacchio, MA; Mastino, A; Macchi, B Bioorg Med Chem 19: 2084 -9 (2011)
Nuzzi, A; Fiasella, A; Ortega, JA; Pagliuca, C; Ponzano, S; Pizzirani, D; Bertozzi, SM; Ottonello, G; Tarozzo, G; Reggiani, A; Bandiera, T; Bertozzi, F; Piomelli, D Eur J Med Chem 111: 138 -59 (2016)
Pessoa-Mahana, H; González-Lira, C; Fierro, A; Zapata-Torres, G; Pessoa-Mahana, CD; Ortiz-Severin, J; Iturriaga-Vásquez, P; Reyes-Parada, M; Silva-Matus, P; Saitz-Barría, C; Araya-Maturana, R Bioorg Med Chem 21: 7604 -11 (2013)
Marzaro, G; Guiotto, A; Borgatti, M; Finotti, A; Gambari, R; Breveglieri, G; Chilin, A J Med Chem 56: 1830 -42 (2013)
Fensome, A; Ambler, CM; Arnold, E; Banker, ME; Brown, MF; Chrencik, J; Clark, JD; Dowty, ME; Efremov, IV; Flick, A; Gerstenberger, BS; Gopalsamy, A; Hayward, MM; Hegen, M; Hollingshead, BD; Jussif, J; Knafels, JD; Limburg, DC; Lin, D; Lin, TH; Pierce, BS; Saiah, E; Sharma, R; Symanowicz, PT; Telliez, JB; Trujillo, JI; Vajdos, FF; Vincent, F; Wan, ZK; Xing, L; Yang, X; Yang, X; Zhang, L J Med Chem 61: 8597 -8612 (2018)
Tosstorff, A; Rudolph, MG; Cole, JC; Reutlinger, M; Kramer, C; Schaffhauser, H; Nilly, A; Flohr, A; Kuhn, B J Comput Aided Mol Des 36: 753 -765 (2022)
Flores, A; Sicinski, RR; Grzywacz, P; Thoden, JB; Plum, LA; Clagett-Dame, M; DeLuca, HF J Med Chem 55: 4352 -66 (2012)
Razavi, SF; Khoobi, M; Nadri, H; Sakhteman, A; Moradi, A; Emami, S; Foroumadi, A; Shafiee, A Eur J Med Chem 64: 252 -9 (2013)
Chaikuad, A; Diharce, J; Schröder, M; Foucourt, A; Leblond, B; Casagrande, AS; Désiré, L; Bonnet, P; Knapp, S; Besson, T J Med Chem 59: 10315 -10321 (2016)
Dang, X; Williams, SB; Devanathan, S; Franco, A; Fu, L; Bernstein, PR; Walters, D; Dorn, GW J Med Chem 64: 12506 -12524 (2021)
Cecchetti, V; Fravolini, A; Schiaffella, F; Tabarrini, O; Bruni, G; Segre, G J Med Chem 36: 157 -61 (1993)
Handzlik, J; Szymańska, E; Wójcik, R; Dela, A; Jastrzębska-Więsek, M; Karolak-Wojciechowska, J; Fruziński, A; Siwek, A; Filipek, B; Kieć-Kononowicz, K Bioorg Med Chem 20: 4245 -57 (2012)
Lizarzaburu, M; Turcotte, S; Du, X; Duquette, J; Fu, A; Houze, J; Li, L; Liu, J; Murakoshi, M; Oda, K; Okuyama, R; Nara, F; Reagan, J; Yu, M; Medina, JC Bioorg Med Chem Lett 22: 5942 -7 (2012)
Dallavalle, S; Musso, L; Cincinelli, R; Darwiche, N; Gervasoni, S; Vistoli, G; Guglielmi, MB; La Porta, I; Pizzulo, M; Modica, E; Prosperi, F; Signorino, G; Colelli, F; Cardile, F; Fucci, A; D'Andrea, EL; Riccio, A; Pisano, C Eur J Med Chem 228: (2022)
Menear, KA; Adcock, C; Alonso, FC; Blackburn, K; Copsey, L; Drzewiecki, J; Fundo, A; Le Gall, A; Gomez, S; Javaid, H; Lence, CF; Martin, NM; Mydlowski, C; Smith, GC Bioorg Med Chem Lett 18: 3942 -5 (2008)
Wang, G; Dyatkina, N; Prhavc, M; Williams, C; Serebryany, V; Hu, Y; Huang, Y; Wan, J; Wu, X; Deval, J; Fung, A; Jin, Z; Tan, H; Shaw, K; Kang, H; Zhang, Q; Tam, Y; Stoycheva, A; Jekle, A; Smith, DB; Beigelman, L J Med Chem 62: 4555 -4570 (2019)
Meng, W; Brigance, RP; Chao, HJ; Fura, A; Harrity, T; Marcinkeviciene, J; O'Connor, SP; Tamura, JK; Xie, D; Zhang, Y; Klei, HE; Kish, K; Weigelt, CA; Turdi, H; Wang, A; Zahler, R; Kirby, MS; Hamann, LG J Med Chem 53: 5620 -8 (2010)
BROEKER, J; ABBOTT, J; CUI, J; FESIK, SW; GOLLNER, A; HERDEIS, L; HODGES, T; LITTLE, A; MANTOULIDIS, A; RAMHARTER, J; SARKAR, D; SOKOL, K; WATERSON, A; WUNBERG, T US Patent US20250019385 (2025)
Nasveschuk, CG; Gagnon, A; Garapaty-Rao, S; Balasubramanian, S; Campbell, R; Lee, C; Zhao, F; Bergeron, L; Cummings, R; Trojer, P; Audia, JE; Albrecht, BK; Harmange, JC ACS Med Chem Lett 5: 378 -83 (2014)
Takle, AK; Brown, MJ; Davies, S; Dean, DK; Francis, G; Gaiba, A; Hird, AW; King, FD; Lovell, PJ; Naylor, A; Reith, AD; Steadman, JG; Wilson, DM Bioorg Med Chem Lett 16: 378 -81 (2005)
Cappelli, A; Manini, M; Paolino, M; Gallelli, A; Anzini, M; Mennuni, L; Del Cadia, M; De Rienzo, F; Menziani, MC; Vomero, S ACS Med Chem Lett 2: 571 -576 (2011)
Menichincheri, M; Albanese, C; Alli, C; Ballinari, D; Bargiotti, A; Caldarelli, M; Ciavolella, A; Cirla, A; Colombo, M; Colotta, F; Croci, V; D'Alessio, R; D'Anello, M; Ermoli, A; Fiorentini, F; Forte, B; Galvani, A; Giordano, P; Isacchi, A; Martina, K; Molinari, A; Moll, JK; Montagnoli, A; Orsini, P; Orzi, F; Pesenti, E; Pillan, A; Roletto, F; Scolaro, A; Tatò, M; Tibolla, M; Valsasina, B; Varasi, M; Vianello, P; Volpi, D; Santocanale, C; Vanotti, E J Med Chem 53: 7296 -315 (2010)
Zhang, X; Raghavan, S; Ihnat, M; Hamel, E; Zammiello, C; Bastian, A; Mooberry, SL; Gangjee, A Bioorg Med Chem 23: 2408 -23 (2015)
Qiu, W; Campbell, RL; Gangloff, A; Dupuis, P; Boivin, RP; Tremblay, MR; Poirier, D; Lin, SX FASEB J 16: 1829 -31 (2002)
Casara, P; Ganzhorn, A; Philippo, C; Chanal, MC; Danzin, C Bioorg Med Chem Lett 6: 393 -396 (1996)
Elliott, JD; Lago, MA; Cousins, RD; Gao, A; Leber, JD; Erhard, KF; Nambi, P; Elshourbagy, NA; Kumar, C; Lee, JA J Med Chem 37: 1553 -7 (1994)
Maga, G; Falchi, F; Garbelli, A; Belfiore, A; Witvrouw, M; Manetti, F; Botta, M J Med Chem 51: 6635 -8 (2008)
Rojas, S; Parravicini, O; Vettorazzi, M; Tosso, R; Garro, A; Gutiérrez, L; Andújar, S; Enriz, R Eur J Med Chem 208: (2020)
Letribot, B; Akué-Gédu, R; Santio, NM; El-Ghozzi, M; Avignant, D; Cisnetti, F; Koskinen, PJ; Gautier, A; Anizon, F; Moreau, P Eur J Med Chem 50: 304 -10 (2012)
Borza, I; Kolok, S; Gere, A; Agai-Csongor, E; Agai, B; Tárkányi, G; Horváth, C; Barta-Szalai, G; Bozó, E; Kiss, C; Bielik, A; Nagy, J; Farkas, S; Domány, G Bioorg Med Chem Lett 13: 3859 -61 (2003)
Belei, D; Dumea, C; Samson, A; Farce, A; Dubois, J; Bîcu, E; Ghinet, A Bioorg Med Chem Lett 22: 4517 -22 (2012)
van den Berg, RJ; Wennekes, T; Ghisaidoobe, A; Donker-Koopman, WE; Strijland, A; Boot, RG; van der Marel, GA; Aerts, JM; Overkleeft, HS ACS Med Chem Lett 2: 519 -522 (2011)
Ahuja, V; Basavarajappa, H; P, SH; Boriack-Sjodin, PA; McKinney, D; Ganguly, S; Kranthi, U; Gaonkar, S; Jena, Lk; Ghorpade, SR; Ghosh, A; Barde, S; Kale, MG; Koushik, K; Kumar, CN; Manjunatha, MR; Ogg, D; Panduga, V; Ramya, VK; Reddy, J; Kumar, KN; Giridhar, J; Rudrapatna, S; Sharma, S; Tucker, JA; Vachaspati, P; Waterson, D; de Sousa, SM Cell Chem Biol 56: 8834 -48 (2013)
Castelli, R; Taranto, S; Furiassi, L; Bozza, N; Marseglia, G; Ferlenghi, F; Rivara, S; Retini, M; Bedini, A; Spadoni, G; Matarazzo, S; Ronca, R; Presta, M; Mor, M; Giacomini, A Eur J Med Chem 221: (2021)
Bua, S; Nocentini, A; Bonardi, A; Palma, G; Ciampi, G; Giliberti, A; Iannelli, F; Bruzzese, F; Supuran, CT; de Nigris, F J Med Chem 67: 15892 -15907
Giordanetto, F; Revell, JD; Knerr, L; Hostettler, M; Paunovic, A; Priest, C; Janefeldt, A; Gill, A ACS Med Chem Lett 4: 1163 -8 (2013)
Cappelli, A; Manini, M; Valenti, S; Castriconi, F; Giuliani, G; Anzini, M; Brogi, S; Butini, S; Gemma, S; Campiani, G; Giorgi, G; Mennuni, L; Lanza, M; Giordani, A; Caselli, G; Letari, O; Makovec, F Eur J Med Chem 63: 85 -94 (2013)
Krüger, DM; Glas, A; Bier, D; Pospiech, N; Wallraven, K; Dietrich, L; Ottmann, C; Koch, O; Hennig, S; Grossmann, TN J Med Chem 60: 8982 -8988 (2017)
Galley, G; Beurier, A; Décoret, G; Goergler, A; Hutter, R; Mohr, S; Pähler, A; Schmid, P; Türck, D; Unger, R; Zbinden, KG; Hoener, MC; Norcross, RD ACS Med Chem Lett 7: 192 -7 (2016)
Schmidt, B; Lindman, S; Tong, W; Lindeberg, G; Gogoll, A; Lai, Z; Thörnwall, M; Synnergren, B; Nilsson, A; Welch, CJ; Sohtell, M; Westerlund, C; Nyberg, F; Karlén, A; Hallberg, A J Med Chem 40: 903 -19 (1997)
Carroll, C; Goldby, A; Teall, M US Patent US9475795 (2016)
Gomtsyan, A; Didomenico, S; Lee, CH; Matulenko, MA; Kim, K; Kowaluk, EA; Wismer, CT; Mikusa, J; Yu, H; Kohlhaas, K; Jarvis, MF; Bhagwat, SS J Med Chem 45: 3639 -48 (2002)
Malhotra, S; Siu, M; Wang, W; Wei, B; Zhou, A; Chan, BK; Gazzard, LJ; Heffron, T; Lainchbury, M; Madin, A; Seward, EM; Cartwright, MW; Gancia, E; Favor, D; Fong, KC; Good, A; Hu, Y US Patent US20240368170 (2024)
Gopalsamy, A; Chopra, R; Lim, K; Ciszewski, G; Shi, M; Curran, KJ; Sukits, SF; Svenson, K; Bard, J; Ellingboe, JW; Agarwal, A; Krishnamurthy, G; Howe, AY; Orlowski, M; Feld, B; O'Connell, J; Mansour, TS J Med Chem 49: 3052 -5 (2006)
Xiao, Y; Karra, S; Goutopoulos, A; Morse, NT; Zhang, S; Dhanabal, M; Tian, H; Seenisamy, J; Jayadevan, J; Caldwell, R; Potnick, J; Bleich, M; Chekler, E; Sherer, B; Sriraman, V Bioorg Med Chem Lett 29: 1660 -1664 (2019)
Blaquiere, N; Castanedo, GM; Burch, JD; Berezhkovskiy, LM; Brightbill, H; Brown, S; Chan, C; Chiang, PC; Crawford, JJ; Dong, T; Fan, P; Feng, J; Ghilardi, N; Godemann, R; Gogol, E; Grabbe, A; Hole, AJ; Hu, B; Hymowitz, SG; Alaoui Ismaili, MH; Le, H; Lee, P; Lee, W; Lin, X; Liu, N; McEwan, PA; McKenzie, B; Silvestre, HL; Suto, E; Sujatha-Bhaskar, S; Wu, G; Wu, LC; Zhang, Y; Zhong, Z; Staben, ST J Med Chem 61: 6801 -6813 (2018)
Devine, SM; Gregg, A; Figler, H; McIntosh, K; Urmaliya, V; Linden, J; Pouton, CW; White, PJ; Bottle, SE; Scammells, PJ Bioorg Med Chem 18: 3078 -87 (2010)
Eddie, SL; Gregson, A; Graham, E; Burton, S; Harrison, T; Burden, R; Scott, CJ; Mullan, PB; Williams, R Bioorg Med Chem Lett 29: 1546 -1548 (2019)
D'Agostino, LA; Sjin, RT; Niu, D; McDonald, JJ; Zhu, Z; Liu, H; Mazdiyasni, H; Petter, RC; Singh, J; Barrague, M; Gross, A; Munson, M US Patent US9695132 (2017)
Vandurm, P; Guiguen, A; Cauvin, C; Georges, B; Le Van, K; Michaux, C; Cardona, C; Mbemba, G; Mouscadet, JF; Hevesi, L; Van Lint, C; Wouters, J Eur J Med Chem 46: 1749 -56 (2011)
Marzaro, G; Guiotto, A; Borgatti, M; Finotti, A; Gambari, R; Breveglieri, G; Chilin, A J Med Chem 56: 1830 -42 (2013)
Heimann, AS; Gomes, I; Dale, CS; Pagano, RL; Gupta, A; de Souza, LL; Luchessi, AD; Castro, LM; Giorgi, R; Rioli, V; Ferro, ES; Devi, LA Proc Natl Acad Sci U S A 104: 20588 -93 (2007)
Jarvis, MF; Honore, P; Shieh, CC; Chapman, M; Joshi, S; Zhang, XF; Kort, M; Carroll, W; Marron, B; Atkinson, R; Thomas, J; Liu, D; Krambis, M; Liu, Y; McGaraughty, S; Chu, K; Roeloffs, R; Zhong, C; Mikusa, JP; Hernandez, G; Gauvin, D; Wade, C; Zhu, C; Pai, M; Scanio, M; Shi, L; Drizin, I; Gregg, R; Matulenko, M; Hakeem, A; Gross, M; Johnson, M; Marsh, K; Wagoner, PK; Sullivan, JP; Faltynek, CR; Krafte, DS Proc Natl Acad Sci U S A 104: 8520 -5 (2007)
Nikas, SP; Alapafuja, SO; Papanastasiou, I; Paronis, CA; Shukla, VG; Papahatjis, DP; Bowman, AL; Halikhedkar, A; Han, X; Makriyannis, A J Med Chem 53: 6996 -7010 (2010)
Rosenström, U; Sköld, C; Lindeberg, G; Botros, M; Nyberg, F; Karlén, A; Hallberg, A J Med Chem 49: 6133 -7 (2006)
Lawson, M; Rodrigo, J; Baratte, B; Robert, T; Delehouzé, C; Lozach, O; Ruchaud, S; Bach, S; Brion, JD; Alami, M; Hamze, A Eur J Med Chem 123: 105 -114 (2016)
Meng, G; Pu, J; Li, Y; Han, A; Tian, Y; Xu, W; Zhang, T; Li, X; Lu, L; Wang, C; Jiang, S; Liu, K J Med Chem 62: 8773 -8783 (2019)
Fotouhi, N; Joshi, P; Fry, D; Cook, C; Tilley, JW; Kaplan, G; Hanglow, A; Rowan, K; Schwinge, V; Wolitzky, B Bioorg Med Chem Lett 10: 1171 -3 (2000)
El-Kabbani, O; Dhagat, U; Soda, M; Endo, S; Matsunaga, T; Hara, A Bioorg Med Chem Lett 21: 2564 -7 (2011)
Chu, M; Mierzwa, R; He, L; King, A; Patel, M; Pichardo, J; Hart, A; Butkiewicz, N; Puar, MS Bioorg Med Chem Lett 9: 1949 -52 (1999)
Wiles, JA; Phadke, AS; Deshpande, M; Agarwal, A; Chen, D; Gadhachanda, VR; Hashimoto, A; Pais, G; Wang, Q; Wang, X; Greenlee, W US Patent US11407738 (2022)
Gornati, D; Ciccone, R; Vinciguerra, A; Ippati, S; Pannaccione, A; Petrozziello, T; Pizzi, E; Hassan, A; Colombo, E; Barbini, S; Milani, M; Caccavone, C; Randazzo, P; Muzio, L; Annunziato, L; Menegon, A; Secondo, A; Mastrangelo, E; Pignataro, G; Seneci, P J Med Chem 64: 8333 -8353 (2021)
Kumata, K; Yui, J; Hatori, A; Fujinaga, M; Yanamoto, K; Yamasaki, T; Kawamura, K; Wakizaka, H; Nengaki, N; Yoshida, Y; Ogawa, M; Fukumura, T; Zhang, MR J Med Chem 54: 6040 -9 (2011)
Demont, EH; Arpino, S; Bit, RA; Campbell, CA; Deeks, N; Desai, S; Dowell, SJ; Gaskin, P; Gray, JR; Harrison, LA; Haynes, A; Heightman, TD; Holmes, DS; Humphreys, PG; Kumar, U; Morse, MA; Osborne, GJ; Panchal, T; Philpott, KL; Taylor, S; Watson, R; Willis, R; Witherington, J J Med Chem 54: 6724 -33 (2011)
Rovnyak, GC; Kimball, SD; Beyer, B; Cucinotta, G; DiMarco, JD; Gougoutas, J; Hedberg, A; Malley, M; McCarthy, JP; Zhang, R J Med Chem 38: 119 -29 (1995)
Fleck, M; Heine, N; Nosse, B; Roth, GJ; Heimann, A US Patent US9169205 (2015)
Braun, F; Bertoletti, N; Möller, G; Adamski, J; Steinmetzer, T; Salah, M; Abdelsamie, AS; van Koppen, CJ; Heine, A; Klebe, G; Marchais-Oberwinkler, S J Med Chem 59: 10719 -10737 (2016)
Helmboldt, A; Petitou, M; Mallet, J; Herault, J; Lormeau, J; Driguez, PA; Herbert, J; Sinay, P Bioorg Med Chem Lett 7: 1507 -1510 (1997)
Yu, G; Mason, HJ; Wu, X; Wang, J; Chong, S; Dorough, G; Henwood, A; Pongrac, R; Seliger, L; He, B; Normandin, D; Adam, L; Krupinski, J; Macor, JE J Med Chem 44: 1025 -7 (2001)
Dhanya, RP; Sidique, S; Sheffler, DJ; Nickols, HH; Herath, A; Yang, L; Dahl, R; Ardecky, R; Semenova, S; Markou, A; Conn, PJ; Cosford, ND J Med Chem 54: 342 -53 (2011)
Leroux, F; Bosc, D; Beghyn, T; Hermant, P; Warenghem, S; Landry, V; Pottiez, V; Guillaume, V; Charton, J; Herledan, A; Urata, S; Liang, W; Sheng, L; Tang, WJ; Deprez, B; Deprez-Poulain, R Eur J Med Chem 179: 557 -566 (2019)
Vandeusen, CL; Weiberth, FJ; Gill, HS; Lee, G; Hillegass, A US Patent US9469627 (2016)
Chonan, T; Tanaka, H; Yamamoto, D; Yashiro, M; Oi, T; Wakasugi, D; Ohoka-Sugita, A; Io, F; Koretsune, H; Hiratate, A Bioorg Med Chem Lett 20: 3965 -8 (2010)
Hoffman, A; Qadri, B; Frant, J; Katz, Y; Bhusare, SR; Breuer, E; Hadar, R; Reich, R J Med Chem 51: 1406 -14 (2008)
Drakopoulos, A; Tzitzoglaki, C; McGuire, K; Hoffmann, A; Konstantinidi, A; Kolokouris, D; Ma, C; Freudenberger, K; Hutterer, J; Gauglitz, G; Wang, J; Schmidtke, M; Busath, DD; Kolocouris, A ACS Med Chem Lett 9: 198 -203 (2018)
Deddouche-Grass, S; Andouche, C; Bärenz, F; Halter, C; Hohwald, A; Lebrun, L; Membré, N; Morales, R; Muzet, N; Poirot, M; Reynaud, M; Roujean, V; Weber, F; Zimmermann, A; Heng, R; Basse, N ACS Med Chem Lett 12: 1137 -1142 (2021)
Han, SH; Goins, CM; Arya, T; Shin, WJ; Maw, J; Hooper, A; Sonawane, DP; Porter, MR; Bannister, BE; Crouch, RD; Lindsey, AA; Lakatos, G; Martinez, SR; Alvarado, J; Akers, WS; Wang, NS; Jung, JU; Macdonald, JD; Stauffer, SR J Med Chem 65: 2880 -2904 (2021)
Chatterjee, J; Laufer, B; Beck, JG; Helyes, Z; Pintér, E; Szolcsányi, J; Horvath, A; Mandl, J; Reubi, JC; Kéri, G; Kessler, H ACS Med Chem Lett 2: 509 -514 (2011)
Walker, AL; Denis, A; Bingham, RP; Bouillot, A; Edgar, EV; Ferrie, A; Holmes, DS; Laroze, A; Liddle, J; Fouchet, MH; Moquette, A; Nassau, P; Pearce, AC; Polyakova, O; Smith, KJ; Thomas, P; Thorpe, JH; Trottet, L; Wang, Y; Hovnanian, A Bioorg Med Chem Lett 29: (2019)
Wang, Y; Huang, A; Chen, L; Sun, F; Zhao, M; Zhang, M; Xie, Y; Xu, S; Li, M; Hong, L; Li, G; Wang, R Eur J Med Chem 264:
Albaugh, PA; Marshall, L; Gregory, J; White, G; Hutchison, A; Ross, PC; Gallagher, DW; Tallman, JF; Crago, M; Cassella, JV J Med Chem 45: 5043 -51 (2002)
Wada, S; Iida, A; Tanaka, R J Nat Prod 65: 1657 -9 (2002)
Shirai, J; Sugiyama, H; Morimoto, S; Maezaki, H; Yamamoto, Y; Okanishi, S; Kamo, I; Matsumoto, S; Ishigami, K; Inatomi, N; Imanishi, A; Kawamoto, M; Tarui, N; Hashimoto, T; Ikeura, Y Bioorg Med Chem 20: 962 -77 (2012)
Singer, M; Lopez, M; Bornaghi, LF; Innocenti, A; Vullo, D; Supuran, CT; Poulsen, SA Bioorg Med Chem Lett 19: 2273 -6 (2009)
Inoue, A; Kawai, T; Wakita, M; Iimura, Y; Sugimoto, H; Kawakami, Y J Med Chem 39: 4460 -70 (1996)
Iraji, A; Nouri, A; Edraki, N; Pirhadi, S; Khoshneviszadeh, M; Khoshneviszadeh, M Bioorg Med Chem 28: (2020)
Menichincheri, M; Albanese, C; Alli, C; Ballinari, D; Bargiotti, A; Caldarelli, M; Ciavolella, A; Cirla, A; Colombo, M; Colotta, F; Croci, V; D'Alessio, R; D'Anello, M; Ermoli, A; Fiorentini, F; Forte, B; Galvani, A; Giordano, P; Isacchi, A; Martina, K; Molinari, A; Moll, JK; Montagnoli, A; Orsini, P; Orzi, F; Pesenti, E; Pillan, A; Roletto, F; Scolaro, A; Tatò, M; Tibolla, M; Valsasina, B; Varasi, M; Vianello, P; Volpi, D; Santocanale, C; Vanotti, E J Med Chem 53: 7296 -315 (2010)
Yuan, J; Simpson, RD; Zhao, W; Tice, CM; Xu, Z; Cacatian, S; Jia, L; Flaherty, PT; Guo, J; Ishchenko, A; Wu, Z; McKeever, BM; Scott, BB; Bukhtiyarov, Y; Berbaum, J; Panemangalore, R; Bentley, R; Doe, CP; Harrison, RK; McGeehan, GM; Singh, SB; Dillard, LW; Baldwin, JJ; Claremon, DA Bioorg Med Chem Lett 21: 4836 -43 (2011)
Ito, M; Sakamoto, T; Suzuki, T; Egashira, S; Moriya, M; Ishihara, A; Iwaasa, H; Matsushita, H; Nakase, K; Wallace, MA; Dean, D; Sato, N; Tokita, S; Kanatani, A Bioorg Med Chem Lett 19: 2835 -9 (2009)
Kato, T; Fukao, K; Ohara, T; Naya, N; Tokuyama, R; Muto, S; Fukasawa, H; Itai, A; Matsumura, KI J Med Chem 66: 11428 -11446 (2023)
Irie, O; Kosaka, T; Ehara, T; Yokokawa, F; Kanazawa, T; Hirao, H; Iwasaki, A; Sakaki, J; Teno, N; Hitomi, Y; Iwasaki, G; Fukaya, H; Nonomura, K; Tanabe, K; Koizumi, S; Uchiyama, N; Bevan, SJ; Malcangio, M; Gentry, C; Fox, AJ; Yaqoob, M; Culshaw, AJ J Med Chem 51: 5502 -5 (2008)
Ishida, J; Hattori, K; Yamamoto, H; Iwashita, A; Mihara, K; Matsuoka, N Bioorg Med Chem Lett 15: 4221 -5 (2005)
Xiang, Y; Hirth, B; Asmussen, G; Biemann, HP; Bishop, KA; Good, A; Fitzgerald, M; Gladysheva, T; Jain, A; Jancsics, K; Liu, J; Metz, M; Papoulis, A; Skerlj, R; Stepp, JD; Wei, RR Bioorg Med Chem Lett 21: 3050 -6 (2011)
Gagnon, A; Landry, S; Coulombe, R; Jakalian, A; Guse, I; Thavonekham, B; Bonneau, PR; Yoakim, C; Simoneau, B Bioorg Med Chem Lett 19: 1199 -205 (2009)
Janas, A; Przybylski, P Eur J Med Chem 182: (2019)
Giordanetto, F; Revell, JD; Knerr, L; Hostettler, M; Paunovic, A; Priest, C; Janefeldt, A; Gill, A ACS Med Chem Lett 4: 1163 -8 (2013)
Wang, G; Dyatkina, N; Prhavc, M; Williams, C; Serebryany, V; Hu, Y; Huang, Y; Wan, J; Wu, X; Deval, J; Fung, A; Jin, Z; Tan, H; Shaw, K; Kang, H; Zhang, Q; Tam, Y; Stoycheva, A; Jekle, A; Smith, DB; Beigelman, L J Med Chem 62: 4555 -4570 (2019)
Onyameh, EK; Bricker, BA; Eyunni, SVK; Voshavar, C; Gonela, UM; Ofori, E; Jenkins, A; Ablordeppey, SY Bioorg Med Chem 30: (2021)
Dossetter, AG; Beeley, H; Bowyer, J; Cook, CR; Crawford, JJ; Finlayson, JE; Heron, NM; Heyes, C; Highton, AJ; Hudson, JA; Jestel, A; Kenny, PW; Krapp, S; Martin, S; MacFaul, PA; McGuire, TM; Gutierrez, PM; Morley, AD; Morris, JJ; Page, KM; Ribeiro, LR; Sawney, H; Steinbacher, S; Smith, C; Vickers, M J Med Chem 55: 6363 -74 (2012)
Toledo, MA; Pedregal, C; Lafuente, C; Diaz, N; Martinez-Grau, MA; Jiménez, A; Benito, A; Torrado, A; Mateos, C; Joshi, EM; Kahl, SD; Rash, KS; Mudra, DR; Barth, VN; Shaw, DB; McKinzie, D; Witkin, JM; Statnick, MA J Med Chem 57: 3418 -29 (2014)
Jadav, P; Bahekar, R; Shah, SR; Patel, D; Joharapurkar, A; Jain, M; Sairam, KV; Singh, PK Bioorg Med Chem Lett 24: 1918 -22 (2014)
Austin, NE; Avenell, KY; Boyfield, I; Branch, CL; Coldwell, MC; Hadley, MS; Jeffrey, P; Johns, A; Johnson, CN; Nash, DJ; Riley, GJ; Smith, SA; Stacey, RC; Stemp, G; Thewlis, KM; Vong, AK Bioorg Med Chem Lett 9: 179 -84 (1999)
Castanedo, GM; Blaquiere, N; Beresini, M; Bravo, B; Brightbill, H; Chen, J; Cui, HF; Eigenbrot, C; Everett, C; Feng, J; Godemann, R; Gogol, E; Hymowitz, S; Johnson, A; Kayagaki, N; Kohli, PB; Knüppel, K; Kraemer, J; Krüger, S; Loke, P; McEwan, P; Montalbetti, C; Roberts, DA; Smith, M; Steinbacher, S; Sujatha-Bhaskar, S; Takahashi, R; Wang, X; Wu, LC; Zhang, Y; Staben, ST J Med Chem 60: 627 -640 (2017)
Jones, A; Kemp, M; Stockley, M; Gibson, K; Whitlock, G US Patent US11053198 (2021)
Bansal, S; Bala, M; Suthar, SK; Choudhary, S; Bhattacharya, S; Bhardwaj, V; Singla, S; Joseph, A Eur J Med Chem 80: 167 -74 (2014)
Vallée, F; Carrez, C; Pilorge, F; Dupuy, A; Parent, A; Bertin, L; Thompson, F; Ferrari, P; Fassy, F; Lamberton, A; Thomas, A; Arrebola, R; Guerif, S; Rohaut, A; Certal, V; Ruxer, JM; Gouyon, T; Delorme, C; Jouanen, A; Dumas, J; Grépin, C; Combeau, C; Goulaouic, H; Dereu, N; Mikol, V; Mailliet, P; Minoux, H J Med Chem 54: 7206 -19 (2011)
Roecker, AJ; Layton, ME; Pero, JE; Kelly, MJ; Greshock, TJ; Kraus, RL; Li, Y; Klein, R; Clements, M; Daley, C; Jovanovska, A; Ballard, JE; Wang, D; Zhao, F; Brunskill, APJ; Peng, X; Wang, X; Sun, H; Houghton, AK; Burgey, CS ACS Med Chem Lett 12: 1038 -1049 (2021)
Vogensen, SB; Jørgensen, L; Madsen, KK; Jurik, A; Borkar, N; Rosatelli, E; Nielsen, B; Ecker, GF; Schousboe, A; Clausen, RP Bioorg Med Chem 23: 2480 -8 (2015)
Swahn, BM; Sandell, J; Pyring, D; Bergh, M; Jeppsson, F; Juréus, A; Neelissen, J; Johnström, P; Schou, M; Svensson, S Bioorg Med Chem Lett 22: 4332 -7 (2012)
Marineau, JJ; Hamman, KB; Hu, S; Alnemy, S; Mihalich, J; Kabro, A; Whitmore, KM; Winter, DK; Roy, S; Ciblat, S; Ke, N; Savinainen, A; Wilsily, A; Malojcic, G; Zahler, R; Schmidt, D; Bradley, MJ; Waters, NJ; Chuaqui, C J Med Chem 65: 1458 -1480 (2022)
Kakizuka, A; Hori, S; Ikeda, H; Yoshimura, N; Nakano, N; Shudo, T; Fuchigami, T US Patent US9206129 (2015)
Barf, T; Kaptein, A J Med Chem 55: 6243 -62 (2012)
Karki, A; Juarez, R; Namballa, HK; Alberts, I; Harding, WW Bioorg Med Chem Lett 30: (2020)
Wang, Y; Liu, JJ; Dransfield, PJ; Zhu, L; Wang, Z; Du, X; Jiao, X; Su, Y; Li, AR; Brown, SP; Kasparian, A; Vimolratana, M; Yu, M; Pattaropong, V; Houze, JB; Swaminath, G; Tran, T; Nguyen, K; Guo, Q; Zhang, J; Zhuang, R; Li, F; Miao, L; Bartberger, MD; Correll, TL; Chow, D; Wong, S; Luo, J; Lin, DC; Medina, JC ACS Med Chem Lett 4: 551 -5 (2013)
Yoshimoto, N; Sakamaki, Y; Haeta, M; Kato, A; Inaba, Y; Itoh, T; Nakabayashi, M; Ito, N; Yamamoto, K J Med Chem 55: 4373 -81 (2012)
Rachid, Z; Katsoulas, A; Brahimi, F; Jean-Claude, BJ Bioorg Med Chem Lett 13: 3297 -300 (2003)
Iyer, MR; Cinar, R; Wood, CM; Zawatsky, CN; Coffey, NJ; Kim, KA; Liu, Z; Katz, A; Abdalla, J; Hassan, SA; Lee, YS J Med Chem 65: 2374 -2387 (2022)
Goi, T; Nakajima, T; Komatsu, Y; Kawata, A; Yamakoshi, S; Okada, O; Sugahara, M; Umeda, A; Takada, Y; Murakami, J; Ohashi, R; Watanabe, T; Fukase, K ACS Med Chem Lett 11: 1416 -1420 (2020)
Bianco, G; Meleddu, R; Distinto, S; Cottiglia, F; Gaspari, M; Melis, C; Corona, A; Angius, R; Angeli, A; Taverna, D; Alcaro, S; Leitans, J; Kazaks, A; Tars, K; Supuran, CT; Maccioni, E ACS Med Chem Lett 8: 792 -796 (2017)
Olson, KM; Keresztes, A; Tashiro, JK; Daconta, LV; Hruby, VJ; Streicher, JM J Med Chem 61: 6075 -6086 (2018)
Kobayashi, T; Sasaki, S; Tomita, N; Fukui, S; Kuroda, N; Nakayama, M; Kiba, A; Takatsu, Y; Ohtaki, T; Itoh, F; Baba, A Bioorg Med Chem 18: 3841 -59 (2010)
Chu, M; Mierzwa, R; He, L; King, A; Patel, M; Pichardo, J; Hart, A; Butkiewicz, N; Puar, MS Bioorg Med Chem Lett 9: 1949 -52 (1999)
Asada, M; Obitsu, T; Kinoshita, A; Nagase, T; Yoshida, T; Yamaura, Y; Takizawa, H; Yoshikawa, K; Sato, K; Narita, M; Nakai, H; Toda, M; Tobe, Y Bioorg Med Chem 18: 3212 -23 (2010)
Nie, Z; Feher, V; Natala, S; McBride, C; Kiryanov, A; Jones, B; Lam, B; Liu, Y; Kaldor, S; Stafford, J; Hikami, K; Uchiyama, N; Kawamoto, T; Hikichi, Y; Matsumoto, S; Amano, N; Zhang, L; Hosfield, D; Skene, R; Zou, H; Cao, X; Ichikawa, T Bioorg Med Chem Lett 23: 3662 -6 (2013)
Perlikowska, R; Piekielna, J; Gentilucci, L; De Marco, R; Cerlesi, MC; Calo, G; Artali, R; Tömböly, C; Kluczyk, A; Janecka, A Eur J Med Chem 109: 276 -86 (2016)
Kluge, A; Lagu, B; Maiti, P; Panigrahi, SK US Patent US10968172 (2021)
Scanio, MJ; Shi, L; Drizin, I; Gregg, RJ; Atkinson, RN; Thomas, JB; Johnson, MS; Chapman, ML; Liu, D; Krambis, MJ; Liu, Y; Shieh, CC; Zhang, X; Simler, GH; Joshi, S; Honore, P; Marsh, KC; Knox, A; Werness, S; Antonio, B; Krafte, DS; Jarvis, MF; Faltynek, CR; Marron, BE; Kort, ME Bioorg Med Chem 18: 7816 -25 (2010)
Kobe, A; Caaveiro, JM; Tashiro, S; Kajihara, D; Kikkawa, M; Mitani, T; Tsumoto, K J Med Chem 56: 2155 -9 (2013)
Verner, E; Katz, BA; Spencer, JR; Allen, D; Hataye, J; Hruzewicz, W; Hui, HC; Kolesnikov, A; Li, Y; Luong, C; Martelli, A; Radika, K; Rai, R; She, M; Shrader, W; Sprengeler, PA; Trapp, S; Wang, J; Young, WB; Mackman, RL J Med Chem 44: 2753 -71 (2001)
Buchler, I; Akuma, D; Au, V; Carr, G; de León, P; DePasquale, M; Ernst, G; Huang, Y; Kimos, M; Kolobova, A; Poslusney, M; Wei, H; Swinnen, D; Montel, F; Moureau, F; Jigorel, E; Schulze, MED; Wood, M; Barrow, JC J Med Chem 61: 9647 -9665 (2018)
Konishi, A; Tokumasu, M; Suzuki, T; Koshiba, T; Ohsumi, K; Ikehara, O; Kodama, Y US Patent US8609715 (2013)
Smith, RA; Fathi, Z; Achebe, F; Akuche, C; Brown, SE; Choi, S; Fan, J; Jenkins, S; Kluender, HC; Konkar, A; Lavoie, R; Mays, R; Natoli, J; O'Connor, SJ; Ortiz, AA; Su, N; Taing, C; Tomlinson, S; Tritto, T; Wang, G; Wirtz, SN; Wong, W; Yang, XF; Ying, S; Zhang, Z Bioorg Med Chem Lett 17: 2706 -11 (2007)
Drakopoulos, A; Tzitzoglaki, C; McGuire, K; Hoffmann, A; Konstantinidi, A; Kolokouris, D; Ma, C; Freudenberger, K; Hutterer, J; Gauglitz, G; Wang, J; Schmidtke, M; Busath, DD; Kolocouris, A ACS Med Chem Lett 9: 198 -203 (2018)
Gibon, J; Kang, MS; Aliaga, A; Sharif, B; Rosa-Neto, P; Séguéla, P; Barker, PA; Kostikov, A Bioorg Med Chem 24: 4759 -4765 (2016)
Guillemont, JE; Lançois, DF; Motte, MM; Koul, A; Balemans, WM US Patent US9598407 (2017)
Kozlova, A; Thabault, L; Dauguet, N; Deskeuvre, M; Stroobant, V; Pilotte, L; Liberelle, M; Van den Eynde, B; Frédérick, R Eur J Med Chem 227: (2022)
Fan, J; Krasinski, A; Lange, CW; Lui, RM; McMahon, JP; Powers, JP; Zeng, Y; Zhang, P US Patent US11059825 (2021)
Buzard, DJ; Lopez, L; Moody, J; Kawasaki, A; Schrader, TO; Kasem, M; Johnson, B; Zhu, X; Thoresen, L; Kim, SH; Gharbaoui, T; Sengupta, D; Calvano, L; Krishnan, A; Gao, Y; Semple, G; Edwards, J; Barden, J; Morgan, M; Usmani, K; Chen, C; Sadeque, A; Chen, W; Christopher, RJ; Thatte, J; Fu, L; Solomon, M; Whelan, K; Al-Shamma, H; Gatlin, J; Gaidarov, I; Anthony, T; Le, M; Unett, DJ; Stirn, S; Blackburn, A; Behan, DP; Jones, RM ACS Med Chem Lett 5: 1334 -9 (2014)
Raudszus, R; Nowotny, R; Gertzen, CGW; Schöler, A; Krizsan, A; Gockel, I; Kalwa, H; Gohlke, H; Thieme, R; Hansen, FK Bioorg Med Chem 27: (2019)
Rak, M; Tesch, R; Berger, LM; Shevchenko, E; Raab, M; Tjaden, A; Zhubi, R; Balourdas, DI; Joerger, AC; Poso, A; Krämer, A; Elson, L; Lučić, A; Kronenberger, T; Hanke, T; Strebhardt, K; Sanhaji, M; Knapp, S Eur J Med Chem 254: (2023)
Bartels, B; Dolente, C; Guba, W; Haap, W; Kuglstatter, A; Obst Sander, U; Peters, J; Rogers-Evans, M; Woltering, T; Schnider, C; Wermuth, R US Patent US10829500 (2020)
Tormählen, NM; Martorelli, M; Kuhn, A; Maier, F; Guezguez, J; Burnet, M; Albrecht, W; Laufer, SA; Koch, P J Med Chem 65: 1225 -1242 (2022)
Muthukaman, N; Tambe, M; Deshmukh, S; Pisal, D; Tondlekar, S; Shaikh, M; Sarode, N; Kattige, VG; Pisat, M; Sawant, P; Honnegowda, S; Karande, V; Kulkarni, A; Behera, D; Jadhav, SB; Sangana, RR; Gudi, GS; Khairatkar-Joshi, N; Gharat, LA Bioorg Med Chem Lett 27: 5131 -5138 (2017)
Liu, X; Kung, A; Malinoski, B; Prakash, GK; Zhang, C J Med Chem 58: 9228 -37 (2015)
Ruel, R; L'Heureux, A; Thibeault, C; Daris, JP; Martel, A; Price, LA; Wu, Q; Hua, J; Wexler, RR; Rehfuss, R; Lam, PY Bioorg Med Chem Lett 23: 3519 -22 (2013)
BROEKER, J; ABBOTT, J; CUI, J; FESIK, SW; GOLLNER, A; HERDEIS, L; HODGES, T; LITTLE, A; MANTOULIDIS, A; RAMHARTER, J; SARKAR, D; SOKOL, K; WATERSON, A; WUNBERG, T US Patent US20250019385 (2025)
Li, L; Chenna, BC; Yang, KS; Cole, TR; Goodall, ZT; Giardini, M; Moghadamchargari, Z; Hernandez, EA; Gomez, J; Calvet, CM; Bernatchez, JA; Mellott, DM; Zhu, J; Rademacher, A; Thomas, D; Blankenship, LR; Drelich, A; Laganowsky, A; Tseng, CK; Liu, WR; Wand, AJ; Cruz-Reyes, J; Siqueira-Neto, JL; Meek, TD J Med Chem 64: 11267 -11287 (2021)
Pinelli, A; Godio, C; Laghezza, A; Mitro, N; Fracchiolla, G; Tortorella, V; Lavecchia, A; Novellino, E; Fruchart, JC; Staels, B; Crestani, M; Loiodice, F J Med Chem 48: 5509 -19 (2005)
Yang, W; Wang, Y; Lai, A; Clark, CG; Corte, JR; Fang, T; Gilligan, PJ; Jeon, Y; Pabbisetty, KB; Rampulla, RA; Mathur, A; Kaspady, M; Neithnadka, PR; Arumugam, A; Raju, S; Rossi, KA; Myers, JE; Sheriff, S; Lou, Z; Zheng, JJ; Chacko, SA; Bozarth, JM; Wu, Y; Crain, EJ; Wong, PC; Seiffert, DA; Luettgen, JM; Lam, PYS; Wexler, RR; Ewing, WR J Med Chem 63: 7226 -7242 (2020)
Vallée, F; Carrez, C; Pilorge, F; Dupuy, A; Parent, A; Bertin, L; Thompson, F; Ferrari, P; Fassy, F; Lamberton, A; Thomas, A; Arrebola, R; Guerif, S; Rohaut, A; Certal, V; Ruxer, JM; Gouyon, T; Delorme, C; Jouanen, A; Dumas, J; Grépin, C; Combeau, C; Goulaouic, H; Dereu, N; Mikol, V; Mailliet, P; Minoux, H J Med Chem 54: 7206 -19 (2011)
Christov, PP; Kim, K; Jana, S; Romaine, IM; Rai, G; Mott, BT; Allweil, AA; Lamers, A; Brimacombe, KR; Urban, DJ; Lee, TD; Hu, X; Lukacs, CM; Davies, DR; Jadhav, A; Hall, MD; Green, N; Moore, WJ; Stott, GM; Flint, AJ; Maloney, DJ; Sulikowski, GA; Waterson, AG Bioorg Med Chem Lett 41: (2021)
Leban, JJ; Heyer, D; Landavazo, A; Matthews, J; Aulabaugh, A; Daniels, AJ J Med Chem 38: 1150 -7 (1995)
Marsault, E; Hoveyda, HR; Peterson, ML; Saint-Louis, C; Landry, A; Vézina, M; Ouellet, L; Wang, Z; Ramaseshan, M; Beaubien, S; Benakli, K; Beauchemin, S; Déziel, R; Peeters, T; Fraser, GL J Med Chem 49: 7190 -7 (2006)
Laurent, A; Rose, Y; Jaquith, JB US Patent US9796716 (2017)
Chiellini, G; Nesi, G; Sestito, S; Chiarugi, S; Runfola, M; Espinoza, S; Sabatini, M; Bellusci, L; Laurino, A; Cichero, E; Gainetdinov, RR; Fossa, P; Raimondi, L; Zucchi, R; Rapposelli, S J Med Chem 59: 9825 -9836 (2016)
Pinelli, A; Godio, C; Laghezza, A; Mitro, N; Fracchiolla, G; Tortorella, V; Lavecchia, A; Novellino, E; Fruchart, JC; Staels, B; Crestani, M; Loiodice, F J Med Chem 48: 5509 -19 (2005)
Saczewski, J; Hudson, A; Scheinin, M; Wasilewska, A; Saczewski, F; Rybczynska, A; Ferdousi, M; Laurila, JM; Boblewski, K; Lehmann, A; Watts, H; Ma, D Eur J Med Chem 115: 406 -15 (2016)
Beveridge, RE; Wallweber, HA; Ashkenazi, A; Beresini, M; Clark, KR; Gibbons, P; Ghiro, E; Kaufman, S; Larivée, A; Leblanc, M; Leclerc, JP; Lemire, A; Ly, C; Rudolph, J; Schwarz, JB; Srivastava, S; Wang, W; Zhao, L; Braun, MG ACS Med Chem Lett 11: 2389 -2396 (2020)
Paillet-Loilier, M; Fabis, F; Lepailleur, A; Bureau, R; Butt-Gueulle, S; Dauphin, F; Delarue, C; Vaudry, H; Rault, S Bioorg Med Chem Lett 15: 3753 -7 (2005)
Ballet, S; Betti, C; Novoa, A; Tömböly, C; Nielsen, CU; Helms, HC; Lesniak, A; Kleczkowska, P; Chung, NN; Lipkowski, AW; Brodin, B; Tourwé, D; Schiller, PW ACS Med Chem Lett 5: 352 -357 (2014)
Liu, Q; Qian, W; Li, A; Biswas, K; Chen, JJ; Fotsch, C; Han, N; Yuan, C; Arik, L; Biddlecome, G; Johnson, E; Kumar, G; Lester-Zeiner, D; Ng, GY; Hungate, RW; Askew, BC Bioorg Med Chem Lett 20: 4593 -7 (2010)
Shaw, KJ; Guilford, WJ; Dallas, JL; Koovakkaat, SK; McCarrick, MA; Liang, A; Light, DR; Morrissey, MM J Med Chem 41: 3551 -6 (1998)
Mavunkel, BJ; Perumattam, JJ; Tan, X; Luedtke, GR; Lu, Q; Lim, D; Kizer, D; Dugar, S; Chakravarty, S; Xu, YJ; Jung, J; Liclican, A; Levy, DE; Tabora, J Bioorg Med Chem Lett 20: 1059 -62 (2010)
Bertini, S; Parkkari, T; Savinainen, JR; Arena, C; Saccomanni, G; Saguto, S; Ligresti, A; Allarà, M; Bruno, A; Marinelli, L; Di Marzo, V; Novellino, E; Manera, C; Macchia, M Eur J Med Chem 90: 526 -36 (2015)
Ahn, JH; Kim, H; Suh, J; Lee, I; Kim, K; Park, K; Bae, EJ; Shong, KE; Pagire, SH; Lim, A; Jeon, J; Pagire, HS; Zhang, H; Kim, M; Pyo, J US Patent US11407763 (2022)
Rodríguez Sarmiento, RM; Bissantz, C; Bylund, J; Limberg, A; Neidhart, W; Jakob-Roetne, R; Wang, L; Baumann, K J Med Chem 63: 8534 -8553 (2020)
Focken, T; Burford, K; Grimwood, ME; Zenova, A; Andrez, JC; Gong, W; Wilson, M; Taron, M; Decker, S; Lofstrand, V; Chowdhury, S; Shuart, N; Lin, S; Goodchild, SJ; Young, C; Soriano, M; Tari, PK; Waldbrook, M; Nelkenbrecher, K; Kwan, R; Lindgren, A; de Boer, G; Lee, S; Sojo, L; DeVita, RJ; Cohen, CJ; Wesolowski, SS; Johnson, JP; Dehnhardt, CM; Empfield, JR J Med Chem 62: 9618 -9641 (2019)
Gharbaoui, T; Skinner, PJ; Shin, YJ; Averbuj, C; Jung, JK; Johnson, BR; Duong, T; Decaire, M; Uy, J; Cherrier, MC; Webb, PJ; Tamura, SY; Zou, N; Rodriguez, N; Boatman, PD; Sage, CR; Lindstrom, A; Xu, J; Schrader, TO; Smith, BM; Chen, R; Richman, JG; Connolly, DT; Colletti, SL; Tata, JR; Semple, G Bioorg Med Chem Lett 17: 4914 -9 (2007)
Lorthiois, E; Gerspacher, M; Beyer, KS; Vaupel, A; Leblanc, C; Stringer, R; Weiss, A; Wilcken, R; Guthy, DA; Lingel, A; Bomio-Confaglia, C; Machauer, R; Rigollier, P; Ottl, J; Arz, D; Bernet, P; Desjonqueres, G; Dussauge, S; Kazic-Legueux, M; Lozac'h, MA; Mura, C; Sorge, M; Todorov, M; Warin, N; Zink, F; Voshol, H; Zecri, FJ; Sedrani, RC; Ostermann, N; Brachmann, SM; Cotesta, S J Med Chem 65: 16173 -16203 (2022)
Salimbeni, A; Paleari, F; Canevotti, R; Criscuoli, M; Criscuoli, M; Lippi, A; Angiolini, M; Belvisi, L; Scolastico, C; Colombo, L Bioorg Med Chem Lett 7: 2205 -2210 (1997)
Trapero, A; Llebaria, A ACS Med Chem Lett 2: 614 -619 (2011)
Caprioglio, D; Mattoteia, D; Pollastro, F; Negri, R; Lopatriello, A; Chianese, G; Minassi, A; Collado, JA; Munoz, E; Taglialatela-Scafati, O; Appendino, G J Nat Prod 83: 1711 -1715 (2020)
Ju, H; Murugan, NA; Hou, L; Li, P; Guizzo, L; Zhang, Y; Bertagnin, C; Kong, X; Kang, D; Jia, R; Ma, X; Du, R; Poongavanam, V; Loregian, A; Huang, B; Liu, X; Zhan, P J Med Chem 64: 17992 -18009 (2021)
Volpini, R; Costanzi, S; Lambertucci, C; Vittori, S; Klotz, K; Lorenzen, A; Cristalli, G Bioorg Med Chem Lett 11: 1931 -4 (2001)
Dubuffet, T; Newman-Tancredi, A; Cussac, D; Audinot, V; Loutz, A; Millan, MJ; Lavielle, G Bioorg Med Chem Lett 9: 2059 -64 (1999)
Felicetti, T; Cannalire, R; Pietrella, D; Latacz, G; Lubelska, A; Manfroni, G; Barreca, ML; Massari, S; Tabarrini, O; Kieć-Kononowicz, K; Schindler, BD; Kaatz, GW; Cecchetti, V; Sabatini, S J Med Chem 61: 7827 -7848 (2018)
Ferrarini, PL; Mori, C; Manera, C; Martinelli, A; Mori, F; Saccomanni, G; Barili, PL; Betti, L; Giannaccini, G; Trincavelli, L; Lucacchini, A J Med Chem 43: 2814 -23 (2000)
Craig, RA; Fox, BM; Hu, C; Lexa, KW; Osipov, M; Thottumkara, AP; Larhammar, M; Miyamoto, T; Rana, A; Kane, LA; Yulyaningsih, E; Solanoy, H; Nguyen, H; Chau, R; Earr, T; Kajiwara, Y; Fleck, D; Lucas, A; Haddick, PCG; Takahashi, RH; Tong, V; Wang, J; Canet, MJ; Poda, SB; Scearce-Levie, K; Srivastava, A; Sweeney, ZK; Xu, M; Zhang, R; He, J; Lei, Y; Zhuo, Z; de Vicente, J J Med Chem 65: 16290 -16312 (2022)
Bongartz, JA; Meerpoel, L; Boeckx, GM; Van Lommen, GR; Buyck, CF; Obrecht, D; Ermert, P; Luther, A US Patent US9688696 (2017)
Miguet, L; Zervosen, A; Gerards, T; Pasha, FA; Luxen, A; Distèche-Nguyen, M; Thomas, A J Med Chem 52: 5926 -36 (2009)
Rak, M; Tesch, R; Berger, LM; Shevchenko, E; Raab, M; Tjaden, A; Zhubi, R; Balourdas, DI; Joerger, AC; Poso, A; Krämer, A; Elson, L; Lučić, A; Kronenberger, T; Hanke, T; Strebhardt, K; Sanhaji, M; Knapp, S Eur J Med Chem 254: (2023)
BROEKER, J; ABBOTT, J; CUI, J; FESIK, SW; GOLLNER, A; HERDEIS, L; HODGES, T; LITTLE, A; MANTOULIDIS, A; RAMHARTER, J; SARKAR, D; SOKOL, K; WATERSON, A; WUNBERG, T US Patent US20250019385 (2025)
NILSSON-LILL, S; GIBLIN, K; GOLDBERG, FW; KETTLE, JG; BALAZS, A; ESCOBAR, R; GREBE, T; GRIMSTER, NP; METRANO, A; MFUH, A; MORRILL, L; SHA, L; SHEPPECK, J; SHIELDS, J; SONG, K; WU, D; WU, Y; ZIEGLER, RE US Patent US20240374606 (2024)
Konze, KD; Ma, A; Li, F; Barsyte-Lovejoy, D; Parton, T; Macnevin, CJ; Liu, F; Gao, C; Huang, XP; Kuznetsova, E; Rougie, M; Jiang, A; Pattenden, SG; Norris, JL; James, LI; Roth, BL; Brown, PJ; Frye, SV; Arrowsmith, CH; Hahn, KM; Wang, GG; Vedadi, M; Jin, J ACS Chem Biol 8: 1324 -34
Costantino, G; Macchiarulo, A; Entrena-Guadix, A; Camaioni, E; Pellicciari, R Bioorg Med Chem Lett 13: 1865 -8 (2003)
Caligiuri, M; Becker, F; Murthi, K; Kaplan, F; Dedier, S; Kaufmann, C; Machl, A; Zybarth, G; Richard, J; Bockovich, N; Kluge, A; Kley, N Chem Biol 12: 1103 -15 (2005)
Hancock, CN; Macias, A; Lee, EK; Yu, SY; Mackerell, AD; Shapiro, P J Med Chem 48: 4586 -95 (2005)
Dechantsreiter, M; Grob, JE; Macsweeney, A; Miltz, W; Randl, SA; Sedrani, R; Sellner, H; Sirockin, F; Valeur, E US Patent US9452990 (2016)
Chen, C; Chen, Y; Pontillo, J; Guo, Z; Huang, CQ; Wu, D; Madan, A; Chen, T; Wen, J; Xie, Q; Tucci, FC; Rowbottom, M; Zhu, YF; Wade, W; Saunders, J; Bozigian, H; Struthers, RS Bioorg Med Chem Lett 18: 3301 -5 (2008)
Malhotra, S; Siu, M; Wang, W; Wei, B; Zhou, A; Chan, BK; Gazzard, LJ; Heffron, T; Lainchbury, M; Madin, A; Seward, EM; Cartwright, MW; Gancia, E; Favor, D; Fong, KC; Good, A; Hu, Y US Patent US20240368170 (2024)
Swahn, BM; Xue, Y; Arzel, E; Kallin, E; Magnus, A; Plobeck, N; Viklund, J Bioorg Med Chem Lett 16: 1397 -401 (2006)
Pannek, M; Alhalabi, Z; Tomaselli, D; Menna, M; Fiorentino, F; Robaa, D; Weyand, M; Puhlmann, M; Tomassi, S; Barreca, F; Tafani, M; Zaganjor, E; Haigis, MC; Sippl, W; Rotili, D; Mai, A; Steegborn, C J Med Chem 67: 1843 -1860
Barnett-Norris, J; Hurst, DP; Lynch, DL; Guarnieri, F; Makriyannis, A; Reggio, PH J Med Chem 45: 3649 -59 (2002)
Guerlet, G; Spangenberg, T; Mann, A; Faure, H; Ruat, M Bioorg Med Chem Lett 21: 3608 -12 (2011)
Roca, C; Martinez-González, L; Daniel-Mozo, M; Sastre, J; Infantes, L; Mansilla, A; Chaves-Sanjuan, A; González-Rubio, JM; Gil, C; Cañada, FJ; Martinez, A; Sanchez-Barrena, MJ; Campillo, NE J Med Chem 61: 5910 -5921 (2018)
Michaelis, S; Marais, A; Schrey, AK; Graebner, OY; Schaudt, C; Sefkow, M; Kroll, F; Dreger, M; Glinski, M; Koester, H; Metternich, R; Fischer, JJ J Med Chem 55: 3934 -44 (2012)
Bueno, AB; Agejas, J; Broughton, H; Dally, R; Durham, TB; Espinosa, JF; González, R; Hahn, PJ; Marcos, A; Rodríguez, R; Sanz, G; Soriano, JF; Timm, D; Vidal, P; Yang, HC; McCarthy, JR J Med Chem 60: 9807 -9820 (2017)
Hen, N; Bialer, M; Yagen, B; Maresca, A; Aggarwal, M; Robbins, AH; McKenna, R; Scozzafava, A; Supuran, CT J Med Chem 54: 3977 -81 (2011)
Liu, Q; Chang, JW; Wang, J; Kang, SA; Thoreen, CC; Markhard, A; Hur, W; Zhang, J; Sim, T; Sabatini, DM; Gray, NS J Med Chem 53: 7146 -55 (2010)
Altmeyer, MA; Marschner, A; Schiffmann, R; Klein, CD Bioorg Med Chem Lett 20: 4038 -44 (2010)
Ruel, R; L'Heureux, A; Thibeault, C; Daris, JP; Martel, A; Price, LA; Wu, Q; Hua, J; Wexler, RR; Rehfuss, R; Lam, PY Bioorg Med Chem Lett 23: 3519 -22 (2013)
Katz, BA; Sprengeler, PA; Luong, C; Verner, E; Elrod, K; Kirtley, M; Janc, J; Spencer, JR; Breitenbucher, JG; Hui, H; McGee, D; Allen, D; Martelli, A; Mackman, RL Chem Biol 8: 1107 -21 (2001)
Manera, C; Betti, L; Cavallini, T; Giannaccini, G; Martinelli, A; Ortore, G; Saccomanni, G; Trincavelli, L; Tuccinardi, T; Ferrarini, PL Bioorg Med Chem Lett 15: 4604 -10 (2005)
Palomo, V; Perez, DI; Perez, C; Morales-Garcia, JA; Soteras, I; Alonso-Gil, S; Encinas, A; Castro, A; Campillo, NE; Perez-Castillo, A; Gil, C; Martinez, A J Med Chem 55: 1645 -61 (2012)
Yamaguchi, M; Kamei, K; Koga, T; Akima, M; Maruyama, A; Kuroki, T; Ohi, N J Med Chem 36: 4061 -8 (1994)
Segretti, ND; Takarada, JE; Ferreira, MA; da Silva Santiago, A; Teodoro, BVM; Damião, MCFCB; Godoi, PH; Cunha, MR; Fala, AM; Ramos, PZ; Ishikawa, EE; Mascarello, A; Serafim, RAM; Azevedo, H; Guimarães, CRW; Couñago, RM Bioorg Med Chem Lett 68: (2022)
Balestrieri, E; Pizzimenti, F; Ferlazzo, A; Giofrè, SV; Iannazzo, D; Piperno, A; Romeo, R; Chiacchio, MA; Mastino, A; Macchi, B Bioorg Med Chem 19: 2084 -9 (2011)
Manca, I; Mastinu, A; Olimpieri, F; Falzoi, M; Sani, M; Ruiu, S; Loriga, G; Volonterio, A; Tambaro, S; Bottazzi, ME; Zanda, M; Pinna, GA; Lazzari, P Eur J Med Chem 62: 256 -69 (2013)
Macdonald, D; Mastracchio, A; Perrier, H; Dubé, D; Gallant, M; Lacombe, P; Deschênes, D; Roy, B; Scheigetz, J; Bateman, K; Li, C; Trimble, LA; Day, S; Chauret, N; Nicoll-Griffith, DA; Silva, JM; Huang, Z; Laliberté, F; Liu, S; Ethier, D; Pon, D; Muise, E; Boulet, L; Chan, CC; Styhler, A; Charleson, S; Mancini, J; Masson, P; Claveau, D; Nicholson, D; Turner, M; Young, RN; Girard, Y Bioorg Med Chem Lett 15: 5241 -6 (2005)
Teno, N; Yamashita, Y; Masuda, A; Iguchi, Y; Oda, K; Fujimori, K; Hiramoto, T; Nishimaki-Mogami, T; Une, M; Gohda, K Bioorg Med Chem 27: 2220 -2227 (2019)
Leivers, M; Miller, JF; Chan, SA; Lauchli, R; Liehr, S; Mo, W; Ton, T; Turner, EM; Youngman, M; Falls, JG; Long, S; Mathis, A; Walker, J J Med Chem 57: 1964 -75 (2014)
Shi, J; Gu, Z; Jurica, EA; Wu, X; Haque, LE; Williams, KN; Hernandez, AS; Hong, Z; Gao, Q; Dabros, M; Davulcu, AH; Mathur, A; Rampulla, RA; Gupta, AK; Jayaram, R; Apedo, A; Moore, DB; Liu, H; Kunselman, LK; Brady, EJ; Wilkes, JJ; Zinker, BA; Cai, H; Shu, YZ; Sun, Q; Dierks, EA; Foster, KA; Xu, C; Wang, T; Panemangalore, R; Cvijic, ME; Xie, C; Cao, GG; Zhou, M; Krupinski, J; Whaley, JM; Robl, JA; Ewing, WR; Ellsworth, BA J Med Chem 61: 681 -694 (2018)
Saeed, A; Mahesar, PA; Zaib, S; Khan, MS; Matin, A; Shahid, M; Iqbal, J Eur J Med Chem 78: 43 -53 (2014)
Shuto, S; Ono, S; Imoto, H; Yoshii, K; Matsuda, A J Med Chem 41: 3507 -14 (1998)
Dhorma, LP; Teli, MK; Nangunuri, BG; Venkanna, A; Ragam, R; Maturi, A; Mirzaei, A; Vo, DK; Maeng, HJ; Kim, MH Eur J Med Chem 227: (2022)
Hashimi, SM; Huang, G; Maxwell, A; Birch, RG Antimicrob Agents Chemother 52: 1382 -90 (2008)
Lee, YS; Fernandes, S; Kulkarani, V; Mayorov, A; Davis, P; Ma, SW; Brown, K; Gillies, RJ; Lai, J; Porreca, F; Hruby, VJ Bioorg Med Chem Lett 20: 4080 -4 (2010)
Aebi, J; Amrein, KE; Chen, J; Hornsperger, B; Kuhn, B; Liu, Y; Li, D; Maerki, HP; Martin, RE; Mayweg, A; Tan, X; Wu, J; Yu, J US Patent US10035804 (2018)
Strachan, JP; Kombo, DC; Mazurov, A; Heemstra, R; Bhatti, BS; Akireddy, R; Murthy, S; Miao, L; Jett, JE; Speake, J; Bencherif, M Eur J Med Chem 86: 60 -74 (2014)
Hill, T; Odell, LR; Edwards, JK; Graham, ME; McGeachie, AB; Rusak, J; Quan, A; Abagyan, R; Scott, JL; Robinson, PJ; McCluskey, A J Med Chem 48: 7781 -8 (2005)
Shi, J; Van de Water, R; Hong, K; Lamer, RB; Weichert, KW; Sandoval, CM; Kasibhatla, SR; Boehm, MF; Chao, J; Lundgren, K; Timple, N; Lough, R; Ibanez, G; Boykin, C; Burrows, FJ; Kehry, MR; Yun, TJ; Harning, EK; Ambrose, C; Thompson, J; Bixler, SA; Dunah, A; Snodgrass-Belt, P; Arndt, J; Enyedy, IJ; Li, P; Hong, VS; McKenzie, A; Biamonte, MA J Med Chem 55: 7786 -95 (2012)
Rewcastle, GW; Palmer, BD; Bridges, AJ; Showalter, HD; Sun, L; Nelson, J; McMichael, A; Kraker, AJ; Fry, DW; Denny, WA J Med Chem 39: 918 -28 (1996)
Andrés, JI; Alonso, JM; Díaz, A; Fernández, J; Iturrino, L; Martínez, P; Matesanz, E; Freyne, EJ; Deroose, F; Boeckx, G; Petit, D; Diels, G; Megens, A; Somers, M; Van Wauwe, J; Stoppie, P; Cools, M; De Clerck, F; Peeters, D; de Chaffoy, D Bioorg Med Chem Lett 12: 653 -8 (2002)
Kumar, N; Kaur, K; Aeron, S; Dharmarajan, S; Silamkoti, AD; Mehta, A; Gupta, S; Chugh, A; Gupta, JB; Salman, M; Palle, VP; Cliffe, IA Bioorg Med Chem Lett 17: 5256 -60 (2007)
Barawkar, DA; Bandyopadhyay, A; Deshpande, A; Koul, S; Kandalkar, S; Patil, P; Khose, G; Vyas, S; Mone, M; Bhosale, S; Singh, U; De, S; Meru, A; Gundu, J; Chugh, A; Palle, VP; Mookhtiar, KA; Vacca, JP; Chakravarty, PK; Nargund, RP; Wright, SD; Roy, S; Graziano, MP; Cully, D; Cai, TQ; Singh, SB Bioorg Med Chem Lett 22: 4341 -7 (2012)
Abad, JL; Casas, J; Abián, J; Messeguer, A Bioorg Med Chem Lett 3: 2581 -2586 (1993)
Di Maro, S; Di Leva, FS; Trotta, AM; Brancaccio, D; Portella, L; Aurilio, M; Tomassi, S; Messere, A; Sementa, D; Lastoria, S; Carotenuto, A; Novellino, E; Scala, S; Marinelli, L J Med Chem 60: 9641 -9652 (2017)
Hall, A; Brown, SH; Chessell, IP; Chowdhury, A; Clayton, NM; Coleman, T; Giblin, GM; Hammond, B; Healy, MP; Johnson, MR; Metcalf, A; Michel, AD; Naylor, A; Novelli, R; Spalding, DJ; Sweeting, J Bioorg Med Chem Lett 17: 732 -5 (2007)
Winter-Holt, JJ; Bardelle, C; Chiarparin, E; Dale, IL; Davey, PRJ; Davies, NL; Denz, C; Fillery, SM; Guérot, CM; Han, F; Hughes, SJ; Kulkarni, M; Liu, Z; Milbradt, A; Moss, TA; Niu, H; Patel, J; Rabow, AA; Schimpl, M; Shi, J; Sun, D; Yang, D; Guichard, S J Med Chem 65: 3306 -3331 (2022)
De Simone, A; Bartolini, M; Baschieri, A; Apperley, KYP; Chen, HH; Guardigni, M; Montanari, S; Kobrlova, T; Soukup, O; Valgimigli, L; Andrisano, V; Keillor, JW; Basso, M; Milelli, A Eur J Med Chem 139: 378 -389 (2017)
Whittaker, M; Thompson, TM; Spavold, ZM; Price, M; Miller, A; Galloway, W; Fraser, F; Floyd, CD; Drummond, AH; Davidson, AH; Bowles, SA; Bebbington, DS Bioorg Med Chem Lett 3: 1493 -1498 (1993)
Melchiorre, C; Bolognesi, ML; Chiarini, A; Minarini, A; Spampinato, S J Med Chem 36: 3734 -7 (1993)
Caprioglio, D; Mattoteia, D; Pollastro, F; Negri, R; Lopatriello, A; Chianese, G; Minassi, A; Collado, JA; Munoz, E; Taglialatela-Scafati, O; Appendino, G J Nat Prod 83: 1711 -1715 (2020)
Zhang, L; Cheng, C; Li, J; Wang, L; Chumanevich, AA; Porter, DC; Mindich, A; Gorbunova, S; Roninson, IB; Chen, M; McInnes, C J Med Chem 65: 3420 -3433 (2022)
Dhorma, LP; Teli, MK; Nangunuri, BG; Venkanna, A; Ragam, R; Maturi, A; Mirzaei, A; Vo, DK; Maeng, HJ; Kim, MH Eur J Med Chem 227: (2022)
Kramer, GJ; Mohd, A; Schwager, SL; Masuyer, G; Acharya, KR; Sturrock, ED; Bachmann, BO ACS Med Chem Lett 5: 346 -51 (2014)
Menichincheri, M; Albanese, C; Alli, C; Ballinari, D; Bargiotti, A; Caldarelli, M; Ciavolella, A; Cirla, A; Colombo, M; Colotta, F; Croci, V; D'Alessio, R; D'Anello, M; Ermoli, A; Fiorentini, F; Forte, B; Galvani, A; Giordano, P; Isacchi, A; Martina, K; Molinari, A; Moll, JK; Montagnoli, A; Orsini, P; Orzi, F; Pesenti, E; Pillan, A; Roletto, F; Scolaro, A; Tatò, M; Tibolla, M; Valsasina, B; Varasi, M; Vianello, P; Volpi, D; Santocanale, C; Vanotti, E J Med Chem 53: 7296 -315 (2010)
Zhang, N; Zhang, X; Zhu, J; Turpoff, A; Chen, G; Morrill, C; Huang, S; Lennox, W; Kakarla, R; Liu, R; Li, C; Ren, H; Almstead, N; Venkatraman, S; Njoroge, FG; Gu, Z; Clausen, V; Graci, J; Jung, SP; Zheng, Y; Colacino, JM; Lahser, F; Sheedy, J; Mollin, A; Weetall, M; Nomeir, A; Karp, GM J Med Chem 57: 2121 -35 (2014)
Mahy, W; Willis, NJ; Zhao, Y; Woodward, HL; Svensson, F; Sipthorp, J; Vecchia, L; Ruza, RR; Hillier, J; Kjær, S; Frew, S; Monaghan, A; Bictash, M; Salinas, PC; Whiting, P; Vincent, JP; Jones, EY; Fish, PV J Med Chem 63: 12942 -12956 (2020)
Monge, A; Peña, MC; Palop, JA; Calderó, JM; Roca, J; García, E; Romero, G; del Río, J; Lasheras, B J Med Chem 37: 1320 -5 (1994)
Vittori, S; Camaioni, E; Di Francesco, E; Volpini, R; Monopoli, A; Dionisotti, S; Ongini, E; Cristalli, G J Med Chem 39: 4211 -7 (1996)
Menichincheri, M; Albanese, C; Alli, C; Ballinari, D; Bargiotti, A; Caldarelli, M; Ciavolella, A; Cirla, A; Colombo, M; Colotta, F; Croci, V; D'Alessio, R; D'Anello, M; Ermoli, A; Fiorentini, F; Forte, B; Galvani, A; Giordano, P; Isacchi, A; Martina, K; Molinari, A; Moll, JK; Montagnoli, A; Orsini, P; Orzi, F; Pesenti, E; Pillan, A; Roletto, F; Scolaro, A; Tatò, M; Tibolla, M; Valsasina, B; Varasi, M; Vianello, P; Volpi, D; Santocanale, C; Vanotti, E J Med Chem 53: 7296 -315 (2010)
Schillaci, D; Spanò, V; Parrino, B; Carbone, A; Montalbano, A; Barraja, P; Diana, P; Cirrincione, G; Cascioferro, S J Med Chem 60: 8268 -8297 (2017)
Velma, GR; Laham, MS; Lewandowski, C; Valencia-Olvera, AC; Balu, D; Moore, A; Ackerman-Berrier, M; Rychetsky, P; Penton, C; Musku, SR; Annadurai, A; Sulaiman, MI; Ma, N; J Thatcher, GR J Med Chem 67: 15061 -15079
Walker, AL; Denis, A; Bingham, RP; Bouillot, A; Edgar, EV; Ferrie, A; Holmes, DS; Laroze, A; Liddle, J; Fouchet, MH; Moquette, A; Nassau, P; Pearce, AC; Polyakova, O; Smith, KJ; Thomas, P; Thorpe, JH; Trottet, L; Wang, Y; Hovnanian, A Bioorg Med Chem Lett 29: (2019)
Razavi, SF; Khoobi, M; Nadri, H; Sakhteman, A; Moradi, A; Emami, S; Foroumadi, A; Shafiee, A Eur J Med Chem 64: 252 -9 (2013)
Huang, A; Moretto, A; Janz, K; Lowe, M; Bedard, PW; Tam, S; Di, L; Clerin, V; Sushkova, N; Tchernychev, B; Tsao, DH; Keith, JC; Shaw, GD; Schaub, RG; Wang, Q; Kaila, N J Med Chem 53: 6003 -17 (2010)
Fukunaga, K; Uehara, F; Aritomo, K; Shoda, A; Hiki, S; Okuyama, M; Usui, Y; Watanabe, K; Yamakoshi, K; Kohara, T; Hanano, T; Tanaka, H; Tsuchiya, S; Sunada, S; Saito, K; Eguchi, J; Yuki, S; Asano, S; Tanaka, S; Mori, A; Yamagami, K; Baba, H; Horikawa, T; Fujimura, M Bioorg Med Chem Lett 23: 6933 -7 (2013)
Inoue, T; Morita, M; Tojo, T; Nagashima, A; Moritomo, A; Miyake, H Bioorg Med Chem 21: 3873 -81 (2013)
Morreale, A; Gálvez-Ruano, E; Iriepa-Canalda, I; Boyd, DB J Med Chem 41: 2029 -39 (1998)
Nguyen, TX; Morrell, A; Conda-Sheridan, M; Marchand, C; Agama, K; Bermingham, A; Bermingam, A; Stephen, AG; Chergui, A; Naumova, A; Fisher, R; O'Keefe, BR; Pommier, Y; Cushman, M J Med Chem 55: 4457 -78 (2012)
Toda, N; Hao, X; Ogawa, Y; Oda, K; Yu, M; Fu, Z; Chen, Y; Kim, Y; Lizarzaburu, M; Lively, S; Lawlis, S; Murakoshi, M; Nara, F; Watanabe, N; Reagan, JD; Tian, H; Fu, A; Motani, A; Liu, Q; Lin, YJ; Zhuang, R; Xiong, Y; Fan, P; Medina, J; Li, L; Izumi, M; Okuyama, R; Shibuya, S ACS Med Chem Lett 4: 790 -4 (2013)
Bazin, HG; Murray, TJ; Bowen, WS; Mozaffarian, A; Fling, SP; Bess, LS; Livesay, MT; Arnold, JS; Johnson, CL; Ryter, KT; Cluff, CW; Evans, JT; Johnson, DA Bioorg Med Chem Lett 18: 5350 -4 (2008)
Macegoniuk, K; Tabor, W; Mazzei, L; Cianci, M; Giurg, M; Olech, K; Burda-Grabowska, M; Kaleta, R; Grabowiecka, A; Mucha, A; Ciurli, S; Berlicki, Ł J Med Chem 66: 2054 -2063 (2023)
Muhlman, A; Classon, B; Hallberg, A; Samuelsson, B J Med Chem 44: 3402 -6 (2001)
Marhefka, CA; Moore, BM; Bishop, TC; Kirkovsky, L; Mukherjee, A; Dalton, JT; Miller, DD J Med Chem 44: 1729 -40 (2001)
Nguyen, P; Doan, P; Rimpilainen, T; Konda Mani, S; Murugesan, A; Yli-Harja, O; Candeias, NR; Kandhavelu, M J Med Chem 64: 10908 -10918 (2021)
Ahn, JS; Radhakrishnan, ML; Mapelli, M; Choi, S; Tidor, B; Cuny, GD; Musacchio, A; Yeh, LA; Kosik, KS Chem Biol 12: 811 -23 (2005)
Jain, N; Kanojia, RM; Xu, J; Jian-Zhong, G; Pacia, E; Lai, MT; Du, F; Musto, A; Allan, G; Hahn, D; Lundeen, S; Sui, Z J Med Chem 49: 3056 -9 (2006)
Boyer, SH; Ugarkar, BG; Solbach, J; Kopcho, J; Matelich, MC; Ollis, K; Gomez-Galeno, JE; Mendonca, R; Tsuchiya, M; Nagahisa, A; Nakane, M; Wiesner, JB; Erion, MD J Med Chem 48: 6430 -41 (2005)
Kusumi, K; Shinozaki, K; Yamaura, Y; Hashimoto, A; Kurata, H; Naganawa, A; Otsuki, K; Matsushita, T; Sekiguchi, T; Kakuuchi, A; Yamamoto, H; Seko, T Bioorg Med Chem Lett 26: 1209 -13 (2016)
Inoue, T; Morita, M; Tojo, T; Nagashima, A; Moritomo, A; Miyake, H Bioorg Med Chem 21: 3873 -81 (2013)
Nagle, A; Wu, T; Kuhen, K; Gagaring, K; Borboa, R; Francek, C; Chen, Z; Plouffe, D; Lin, X; Caldwell, C; Ek, J; Skolnik, S; Liu, F; Wang, J; Chang, J; Li, C; Liu, B; Hollenbeck, T; Tuntland, T; Isbell, J; Chuan, T; Alper, PB; Fischli, C; Brun, R; Lakshminarayana, SB; Rottmann, M; Diagana, TT; Winzeler, EA; Glynne, R; Tully, DC; Chatterjee, AK J Med Chem 55: 4244 -73 (2012)
Mizutani, T; Ishikawa, S; Nagase, T; Takahashi, H; Fujimura, T; Sasaki, T; Nagumo, A; Shimamura, K; Miyamoto, Y; Kitazawa, H; Kanesaka, M; Yoshimoto, R; Aragane, K; Tokita, S; Sato, N J Med Chem 52: 7289 -300 (2009)
Fushimi, M; Fujimori, I; Wakabayashi, T; Hasui, T; Kawakita, Y; Imamura, K; Kato, T; Murakami, M; Ishii, T; Kikko, Y; Kasahara, M; Nakatani, A; Hiura, Y; Miyamoto, M; Saikatendu, K; Zou, H; Lane, SW; Lawson, JD; Imoto, H J Med Chem 62: 4915 -4935 (2019)
Manetti, F; Brullo, C; Magnani, M; Mosci, F; Chelli, B; Crespan, E; Schenone, S; Naldini, A; Bruno, O; Trincavelli, ML; Maga, G; Carraro, F; Martini, C; Bondavalli, F; Botta, M J Med Chem 51: 1252 -9 (2008)
Naqvi, A; Malasoni, R; Srivastava, A; Pandey, RR; Dwivedi, AK Bioorg Med Chem Lett 24: 5181 -4 (2014)
Napolitano, C; Natoni, A; Santocanale, C; Evensen, L; Lorens, JB; Murphy, PV Bioorg Med Chem Lett 21: 1167 -70 (2011)
Wu, SC; Yoon, D; Chin, J; van Kirk, K; Seethala, R; Golla, R; He, B; Harrity, T; Kunselman, LK; Morgan, NN; Ponticiello, RP; Taylor, JR; Zebo, R; Harper, TW; Li, W; Wang, M; Zhang, L; Sleczka, BG; Nayeem, A; Sheriff, S; Camac, DM; Morin, PE; Everlof, JG; Li, YX; Ferraro, CA; Kieltyka, K; Shou, W; Vath, MB; Zvyaga, TA; Gordon, DA; Robl, JA Bioorg Med Chem Lett 21: 6693 -8 (2011)
McCarthy, TD; Naylor, A US Patent US9714224 (2017)
Chaudhaery, SS; Roy, KK; Shakya, N; Saxena, G; Sammi, SR; Nazir, A; Nath, C; Saxena, AK J Med Chem 53: 6490 -505 (2010)
Schaller, D; Hagenow, S; Alpert, G; Naß, A; Schulz, R; Bermudez, M; Stark, H; Wolber, G ACS Med Chem Lett 8: 648 -653 (2017)
de Lera Ruiz, M; Favuzza, P; Guo, Z; Zhao, L; Hu, B; Lei, Z; Zhan, D; Murgolo, N; Boyce, CW; Vavrek, M; Thompson, J; Ngo, A; Jarman, KE; Robbins, J; Boddey, J; Sleebs, BE; Lowes, KN; Cowman, AF; Olsen, DB; McCauley, JA ACS Med Chem Lett 13: 1745 -1754 (2022)
Therrien, E; Larouche, G; Nguyen, N; Rahil, J; Lemieux, AM; Li, Z; Fournel, M; Yan, TP; Landry, AJ; Lefebvre, S; Wang, JJ; MacBeth, K; Heise, C; Nguyen, A; Besterman, JM; Déziel, R; Wahhab, A Bioorg Med Chem Lett 25: 2514 -8 (2015)
Cheng, H; Davis, L; Holl, W; Nichols, A; Hwang, S; Johanson, K; Wong, A Bioorg Med Chem Lett 3: 1179 -1184 (1993)
Nishizawa, N; Niida, A; Masuda, Y; Kumano, S; Yokoyama, K; Hirabayashi, H; Amano, N; Ohtaki, T; Asami, T ACS Med Chem Lett 8: 628 -631 (2017)
Tosstorff, A; Rudolph, MG; Cole, JC; Reutlinger, M; Kramer, C; Schaffhauser, H; Nilly, A; Flohr, A; Kuhn, B J Comput Aided Mol Des 36: 753 -765 (2022)
Schmidt, B; Lindman, S; Tong, W; Lindeberg, G; Gogoll, A; Lai, Z; Thörnwall, M; Synnergren, B; Nilsson, A; Welch, CJ; Sohtell, M; Westerlund, C; Nyberg, F; Karlén, A; Hallberg, A J Med Chem 40: 903 -19 (1997)
El-Azab, AS; Abdel-Aziz, AA; Bua, S; Nocentini, A; AlSaif, NA; Almehizia, AA; Alanazi, MM; Hefnawy, MM; Supuran, CT Eur J Med Chem 181: (2019)
Zhang, N; Zhang, X; Zhu, J; Turpoff, A; Chen, G; Morrill, C; Huang, S; Lennox, W; Kakarla, R; Liu, R; Li, C; Ren, H; Almstead, N; Venkatraman, S; Njoroge, FG; Gu, Z; Clausen, V; Graci, J; Jung, SP; Zheng, Y; Colacino, JM; Lahser, F; Sheedy, J; Mollin, A; Weetall, M; Nomeir, A; Karp, GM J Med Chem 57: 2121 -35 (2014)
Kotoku, M; Maeba, T; Fujioka, S; Yokota, M; Seki, N; Ito, K; Suwa, Y; Ikenogami, T; Hirata, K; Hase, Y; Katsuda, Y; Miyagawa, N; Arita, K; Asahina, K; Noguchi, M; Nomura, A; Doi, S; Adachi, T; Crowe, P; Tao, H; Thacher, S; Hashimoto, H; Suzuki, T; Shiozaki, M J Med Chem 62: 2837 -2842 (2019)
Iraji, A; Nouri, A; Edraki, N; Pirhadi, S; Khoshneviszadeh, M; Khoshneviszadeh, M Bioorg Med Chem 28: (2020)
Ballet, S; Betti, C; Novoa, A; Tömböly, C; Nielsen, CU; Helms, HC; Lesniak, A; Kleczkowska, P; Chung, NN; Lipkowski, AW; Brodin, B; Tourwé, D; Schiller, PW ACS Med Chem Lett 5: 352 -357 (2014)
Goracci, L; Nurisso, A; Roussel, E; Pérès, B; Chaptal, V; Falson, P; Marminon, C; Jose, J; Le Borgne, M; Boumendjel, A Eur J Med Chem 248: (2023)
Nuzzi, A; Fiasella, A; Ortega, JA; Pagliuca, C; Ponzano, S; Pizzirani, D; Bertozzi, SM; Ottonello, G; Tarozzo, G; Reggiani, A; Bandiera, T; Bertozzi, F; Piomelli, D Eur J Med Chem 111: 138 -59 (2016)
Olivier, A; Sevrin, M; Durant, F; George, P Bioorg Med Chem Lett 7: 2277 -2282 (1997)
Zapf, CW; Bloom, JD; Li, Z; Dushin, RG; Nittoli, T; Otteng, M; Nikitenko, A; Golas, JM; Liu, H; Lucas, J; Boschelli, F; Vogan, E; Olland, A; Johnson, M; Levin, JI Bioorg Med Chem Lett 21: 4602 -7 (2011)
Manning, M; Cheng, LL; Klis, WA; Balaspiri, L; Olma, A; Sawyer, WH; Wo, NC; Chan, WY J Med Chem 38: 1762 -9 (1995)
Tamamura, H; Omagari, A; Hiramatsu, K; Gotoh, K; Kanamoto, T; Xu, Y; Kodama, E; Matsuoka, M; Hattori, T; Yamamoto, N; Nakashima, H; Otaka, A; Fujii, N Bioorg Med Chem Lett 11: 1897 -902 (2001)
Kawai, M; Nakamura, H; Sakurada, I; Shimokawa, H; Tanaka, H; Matsumizu, M; Ando, K; Hattori, K; Ohta, A; Nukui, S; Omura, A; Kawamura, M Bioorg Med Chem Lett 17: 5533 -6 (2007)
Castillo, M; Forns, P; Erra, M; Mir, M; López, M; Maldonado, M; Orellana, A; Carreño, C; Ramis, I; Miralpeix, M; Vidal, B Bioorg Med Chem Lett 22: 5419 -23 (2012)
Tamamura, H; Araki, T; Ueda, S; Wang, Z; Oishi, S; Esaka, A; Trent, JO; Nakashima, H; Yamamoto, N; Peiper, SC; Otaka, A; Fujii, N J Med Chem 48: 3280 -9 (2005)
Ovat, A; Li, ZZ; Hampton, CY; Asress, SA; Fernández, FM; Glass, JD; Powers, JC J Med Chem 53: 6326 -36 (2010)
Weber, C; Sipos, M; Paczal, A; Balint, B; Kun, V; Foloppe, N; Dokurno, P; Massey, AJ; Walmsley, DL; Hubbard, RE; Murray, J; Benwell, K; Edmonds, T; Demarles, D; Bruno, A; Burbridge, M; Cruzalegui, F; Kotschy, A J Med Chem 64: 6745 -6764 (2021)
Zarantonello, P; Bettini, E; Paio, A; Simoncelli, C; Terreni, S; Cardullo, F Bioorg Med Chem Lett 21: 2059 -63 (2011)
Campos-Sandoval, JA; Redondo, C; Kinsella, GK; Pal, A; Jones, G; Eyre, GS; Hirst, SC; Findlay, JB J Med Chem 54: 4378 -87 (2011)
Palani, A; Nawrocki, AR; Orvieto, F; Bianchi, E; Mandić, E; Pessi, A; Huang, C; Deng, Q; Toussaint, N; Walsh, E; Reddy, V; Ashley, E; He, H; Mumick, S; Hawes, B; Marsh, D; Erion, M; Nargund, R; Carrington, PE ACS Med Chem Lett 13: 1248 -1254 (2022)
Pandey, A; Rose, JW US Patent US9200268 (2015)
Gornati, D; Ciccone, R; Vinciguerra, A; Ippati, S; Pannaccione, A; Petrozziello, T; Pizzi, E; Hassan, A; Colombo, E; Barbini, S; Milani, M; Caccavone, C; Randazzo, P; Muzio, L; Annunziato, L; Menegon, A; Secondo, A; Mastrangelo, E; Pignataro, G; Seneci, P J Med Chem 64: 8333 -8353 (2021)
Moss, N; Choi, Y; Cogan, D; Flegg, A; Kahrs, A; Loke, P; Meyn, O; Nagaraja, R; Napier, S; Parker, A; Thomas Peterson, J; Ramsden, P; Sarko, C; Skow, D; Tomlinson, J; Tye, H; Whitaker, M Bioorg Med Chem Lett 19: 2206 -10 (2009)
Teng, M; Nammalwar, B; Li, X; Perez, C; Yule, I; Faulkner, A; Atton, H; Parkes, A; Convers-Reignier, S; Southey, M; Puerta, DT US Patent US11407740 (2022)
Buffham, W; Canning, H; Davenport, R; Farnaby, W; Mack, S; Parmar, A; Wright, S US Patent US9464060 (2016)
Parodi, A; Righetti, G; Pesce, E; Salis, A; Tasso, B; Urbinati, C; Tomati, V; Damonte, G; Rusnati, M; Pedemonte, N; Cichero, E; Millo, E Eur J Med Chem 208: (2020)
Smith, AB; Cantin, LD; Pasternak, A; Guise-Zawacki, L; Yao, W; Charnley, AK; Barbosa, J; Sprengeler, PA; Hirschmann, R; Munshi, S; Olsen, DB; Schleif, WA; Kuo, LC J Med Chem 46: 1831 -44 (2003)
Luker, T; Bonnert, R; Schmidt, J; Sargent, C; Paine, SW; Thom, S; Pairaudeau, G; Patel, A; Mohammed, R; Akam, E; Dougall, I; Davis, AM; Abbott, P; Brough, S; Millichip, I; McInally, T Bioorg Med Chem Lett 21: 3616 -21 (2011)
Giordanetto, F; Revell, JD; Knerr, L; Hostettler, M; Paunovic, A; Priest, C; Janefeldt, A; Gill, A ACS Med Chem Lett 4: 1163 -8 (2013)
Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V US Patent US9713606 (2017)
Conway, JG; McDonald, B; Parham, J; Keith, B; Rusnak, DW; Shaw, E; Jansen, M; Lin, P; Payne, A; Crosby, RM; Johnson, JH; Frick, L; Lin, MH; Depee, S; Tadepalli, S; Votta, B; James, I; Fuller, K; Chambers, TJ; Kull, FC; Chamberlain, SD; Hutchins, JT Proc Natl Acad Sci U S A 102: 16078 -83 (2005)
Clark, JM; Salgado-Polo, F; Macdonald, SJF; Barrett, TN; Perrakis, A; Jamieson, C J Med Chem 65: 6338 -6351 (2022)
Lavecchia, A; Di Giovanni, C; Pesapane, A; Montuori, N; Ragno, P; Martucci, NM; Masullo, M; De Vendittis, E; Novellino, E J Med Chem 55: 4142 -58 (2012)
Peschiulli, A; Oehlrich, D; Rombouts, F; Vos, A; Gijsen, HJ Bioorg Med Chem Lett 30: (2020)
Palani, A; Nawrocki, AR; Orvieto, F; Bianchi, E; Mandić, E; Pessi, A; Huang, C; Deng, Q; Toussaint, N; Walsh, E; Reddy, V; Ashley, E; He, H; Mumick, S; Hawes, B; Marsh, D; Erion, M; Nargund, R; Carrington, PE ACS Med Chem Lett 13: 1248 -1254 (2022)
Pace, P; Di Francesco, ME; Gardelli, C; Harper, S; Muraglia, E; Nizi, E; Orvieto, F; Petrocchi, A; Poma, M; Rowley, M; Scarpelli, R; Laufer, R; Gonzalez Paz, O; Monteagudo, E; Bonelli, F; Hazuda, D; Stillmock, KA; Summa, V J Med Chem 50: 2225 -39 (2007)
Xu, J; Wei, L; Mathvink, RJ; Edmondson, SD; Eiermann, GJ; He, H; Leone, JF; Leiting, B; Lyons, KA; Marsilio, F; Patel, RA; Patel, SB; Petrov, A; Scapin, G; Wu, JK; Thornberry, NA; Weber, AE Bioorg Med Chem Lett 16: 5373 -7 (2006)
Roberts, LR; Brady, K; Brown, A; Davey, D; Feng, L; Huang, H; Liu, D; Malet, L; McMurray, G; Phelan, A; Saunders, K; Bhat, A Bioorg Med Chem Lett 22: 4173 -8 (2012)
Bagal, SK; Gregson, C; O' Donovan, DH; Pike, KG; Bloecher, A; Barton, P; Borodovsky, A; Code, E; Fillery, SM; Hsu, JH; Kawatkar, SP; Li, C; Longmire, D; Nai, Y; Nash, SC; Pike, A; Robinson, J; Read, JA; Rawlins, PB; Shen, M; Tang, J; Wang, P; Woods, H; Williamson, B J Med Chem 64: 17146 -17183 (2021)
Menichincheri, M; Albanese, C; Alli, C; Ballinari, D; Bargiotti, A; Caldarelli, M; Ciavolella, A; Cirla, A; Colombo, M; Colotta, F; Croci, V; D'Alessio, R; D'Anello, M; Ermoli, A; Fiorentini, F; Forte, B; Galvani, A; Giordano, P; Isacchi, A; Martina, K; Molinari, A; Moll, JK; Montagnoli, A; Orsini, P; Orzi, F; Pesenti, E; Pillan, A; Roletto, F; Scolaro, A; Tatò, M; Tibolla, M; Valsasina, B; Varasi, M; Vianello, P; Volpi, D; Santocanale, C; Vanotti, E J Med Chem 53: 7296 -315 (2010)
Pinelli, A; Godio, C; Laghezza, A; Mitro, N; Fracchiolla, G; Tortorella, V; Lavecchia, A; Novellino, E; Fruchart, JC; Staels, B; Crestani, M; Loiodice, F J Med Chem 48: 5509 -19 (2005)
Balestrieri, E; Pizzimenti, F; Ferlazzo, A; Giofrè, SV; Iannazzo, D; Piperno, A; Romeo, R; Chiacchio, MA; Mastino, A; Macchi, B Bioorg Med Chem 19: 2084 -9 (2011)
McBride, C; Cheruvallath, Z; Komandla, M; Tang, M; Farrell, P; Lawson, JD; Vanderpool, D; Wu, Y; Dougan, DR; Plonowski, A; Holub, C; Larson, C Bioorg Med Chem Lett 26: 2779 -2783 (2016)
Camodeca, C; Nuti, E; Tepshi, L; Boero, S; Tuccinardi, T; Stura, EA; Poggi, A; Zocchi, MR; Rossello, A Eur J Med Chem 111: 193 -201 (2016)
Cee, VJ; Albrecht, BK; Geuns-Meyer, S; Hughes, P; Bellon, S; Bready, J; Caenepeel, S; Chaffee, SC; Coxon, A; Emery, M; Fretland, J; Gallant, P; Gu, Y; Hodous, BL; Hoffman, D; Johnson, RE; Kendall, R; Kim, JL; Long, AM; McGowan, D; Morrison, M; Olivieri, PR; Patel, VF; Polverino, A; Powers, D; Rose, P; Wang, L; Zhao, H J Med Chem 50: 627 -40 (2007)
Rak, M; Tesch, R; Berger, LM; Shevchenko, E; Raab, M; Tjaden, A; Zhubi, R; Balourdas, DI; Joerger, AC; Poso, A; Krämer, A; Elson, L; Lučić, A; Kronenberger, T; Hanke, T; Strebhardt, K; Sanhaji, M; Knapp, S Eur J Med Chem 254: (2023)
Wen, Z; Pramanik, A; Lewicki, SA; Jung, YH; Gao, ZG; Randle, JCR; Cronin, C; Chen, Z; Giancotti, LA; Whitehead, GS; Liang, BT; Breton, S; Salvemini, D; Cook, DN; Jacobson, KA J Med Chem 66: 9076 -9094 (2023)
Franchini, S; Battisti, UM; Prandi, A; Tait, A; Borsari, C; Cichero, E; Fossa, P; Cilia, A; Prezzavento, O; Ronsisvalle, S; Aricò, G; Parenti, C; Brasili, L Eur J Med Chem 112: 1 -19 (2016)
Cesati, RR; Radeke, HS; Pandey, SK; Purohit, A; Robinson, SP US Patent US9713651 (2017)
Galley, G; Beurier, A; Décoret, G; Goergler, A; Hutter, R; Mohr, S; Pähler, A; Schmid, P; Türck, D; Unger, R; Zbinden, KG; Hoener, MC; Norcross, RD ACS Med Chem Lett 7: 192 -7 (2016)
Blake, JF; Burkard, M; Chan, J; Chen, H; Chou, KJ; Diaz, D; Dudley, DA; Gaudino, JJ; Gould, SE; Grina, J; Hunsaker, T; Liu, L; Martinson, M; Moreno, D; Mueller, L; Orr, C; Pacheco, P; Qin, A; Rasor, K; Ren, L; Robarge, K; Shahidi-Latham, S; Stults, J; Sullivan, F; Wang, W; Yin, J; Zhou, A; Belvin, M; Merchant, M; Moffat, J; Schwarz, JB J Med Chem 59: 5650 -60 (2016)
Montagne, C; Bombrun, A; Desforges-Bouscary, G; Quattropani, A; Gaillard, P US Patent US8609666 (2013)
Li, L; Chenna, BC; Yang, KS; Cole, TR; Goodall, ZT; Giardini, M; Moghadamchargari, Z; Hernandez, EA; Gomez, J; Calvet, CM; Bernatchez, JA; Mellott, DM; Zhu, J; Rademacher, A; Thomas, D; Blankenship, LR; Drelich, A; Laganowsky, A; Tseng, CK; Liu, WR; Wand, AJ; Cruz-Reyes, J; Siqueira-Neto, JL; Meek, TD J Med Chem 64: 11267 -11287 (2021)
Taha, M; Ismail, NH; Imran, S; Selvaraj, M; Rahim, A; Ali, M; Siddiqui, S; Rahim, F; Khan, KM Bioorg Med Chem 23: 7394 -404 (2015)
McDermott, LA; Higgins, B; Simcox, M; Luk, KC; Nevins, T; Kolinsky, K; Smith, M; Yang, H; Li, JK; Chen, Y; Ke, J; Mallalieu, N; Egan, T; Kolis, S; Railkar, A; Gerber, L; Liu, JJ; Konzelmann, F; Zhang, Z; Flynn, T; Morales, O; Chen, Y Bioorg Med Chem Lett 16: 1950 -3 (2006)
Belluti, F; De Simone, A; Tarozzi, A; Bartolini, M; Djemil, A; Bisi, A; Gobbi, S; Montanari, S; Cavalli, A; Andrisano, V; Bottegoni, G; Rampa, A Eur J Med Chem 78: 157 -66 (2014)
Butini, S; Brindisi, M; Cosconati, S; Marinelli, L; Borrelli, G; Coccone, SS; Ramunno, A; Campiani, G; Novellino, E; Zanoli, S; Samuele, A; Giorgi, G; Bergamini, A; Mattia, MD; Lalli, S; Galletti, B; Gemma, S; Maga, G J Med Chem 52: 1224 -8 (2009)
Ranise, A; Spallarossa, A; Cesarini, S; Bondavalli, F; Schenone, S; Bruno, O; Menozzi, G; Fossa, P; Mosti, L; La Colla, M; Sanna, G; Murreddu, M; Collu, G; Busonera, B; Marongiu, ME; Pani, A; La Colla, P; Loddo, R J Med Chem 48: 3858 -73 (2005)
Kankanala, J; Ribeiro, CJA; Kiselev, E; Ravji, A; Williams, J; Xie, J; Aihara, H; Pommier, Y; Wang, Z J Med Chem 62: 4669 -4682 (2019)
Bach, P; Boström, J; Brickmann, K; van Giezen, JJ; Hovland, R; Petersson, AU; Ray, A; Zetterberg, F Bioorg Med Chem Lett 21: 2877 -81 (2011)
Sorrenti, V; Pittalà, V; Romeo, G; Amata, E; Dichiara, M; Marrazzo, A; Turnaturi, R; Prezzavento, O; Barbagallo, I; Vanella, L; Rescifina, A; Floresta, G; Tibullo, D; Di Raimondo, F; Intagliata, S; Salerno, L Eur J Med Chem 158: 937 -950 (2018)
Betzi, S; Restouin, A; Opi, S; Arold, ST; Parrot, I; Guerlesquin, F; Morelli, X; Collette, Y Proc Natl Acad Sci U S A 104: 19256 -61 (2007)
Dallavalle, S; Musso, L; Cincinelli, R; Darwiche, N; Gervasoni, S; Vistoli, G; Guglielmi, MB; La Porta, I; Pizzulo, M; Modica, E; Prosperi, F; Signorino, G; Colelli, F; Cardile, F; Fucci, A; D'Andrea, EL; Riccio, A; Pisano, C Eur J Med Chem 228: (2022)
Tintori, C; Fallacara, AL; Radi, M; Zamperini, C; Dreassi, E; Crespan, E; Maga, G; Schenone, S; Musumeci, F; Brullo, C; Richters, A; Gasparrini, F; Angelucci, A; Festuccia, C; Delle Monache, S; Rauh, D; Botta, M J Med Chem 58: 347 -61 (2015)
Reinart, R; Gyulai, Z; Berényi, S; Antus, S; Vonk, A; Rinken, A; Sipos, A Eur J Med Chem 46: 2992 -9 (2011)
Vallée, F; Carrez, C; Pilorge, F; Dupuy, A; Parent, A; Bertin, L; Thompson, F; Ferrari, P; Fassy, F; Lamberton, A; Thomas, A; Arrebola, R; Guerif, S; Rohaut, A; Certal, V; Ruxer, JM; Gouyon, T; Delorme, C; Jouanen, A; Dumas, J; Grépin, C; Combeau, C; Goulaouic, H; Dereu, N; Mikol, V; Mailliet, P; Minoux, H J Med Chem 54: 7206 -19 (2011)
Kalaba, P; Aher, NY; Ilić, M; Dragačević, V; Wieder, M; Miklosi, AG; Zehl, M; Wackerlig, J; Roller, A; Beryozkina, T; Radoman, B; Saroja, SR; Lindner, W; Gonzalez, EP; Bakulev, V; Leban, JJ; Sitte, HH; Urban, E; Langer, T; Lubec, G J Med Chem 60: 9330 -9348 (2017)
Camodeca, C; Nuti, E; Tepshi, L; Boero, S; Tuccinardi, T; Stura, EA; Poggi, A; Zocchi, MR; Rossello, A Eur J Med Chem 111: 193 -201 (2016)
Di Capua, A; Sticozzi, C; Brogi, S; Brindisi, M; Cappelli, A; Sautebin, L; Rossi, A; Pace, S; Ghelardini, C; Di Cesare Mannelli, L; Valacchi, G; Giorgi, G; Giordani, A; Poce, G; Biava, M; Anzini, M Eur J Med Chem 109: 99 -106 (2016)
Gowthaman, R; Miller, SA; Rogers, S; Khowsathit, J; Lan, L; Bai, N; Johnson, DK; Liu, C; Xu, L; Anbanandam, A; Aubé, J; Roy, A; Karanicolas, J J Med Chem 59: 4152 -70 (2016)
De Nanteuil, G; Gloanec, P; Béguin, S; Giesen, PL; Hemker, HC; Mennecier, P; Rupin, A; Verbeuren, TJ J Med Chem 49: 5047 -50 (2006)
Stucchi, M; Gmeiner, P; Huebner, H; Rainoldi, G; Sacchetti, A; Silvani, A; Lesma, G ACS Med Chem Lett 6: 882 -7 (2015)
Buzard, DJ; Lopez, L; Moody, J; Kawasaki, A; Schrader, TO; Kasem, M; Johnson, B; Zhu, X; Thoresen, L; Kim, SH; Gharbaoui, T; Sengupta, D; Calvano, L; Krishnan, A; Gao, Y; Semple, G; Edwards, J; Barden, J; Morgan, M; Usmani, K; Chen, C; Sadeque, A; Chen, W; Christopher, RJ; Thatte, J; Fu, L; Solomon, M; Whelan, K; Al-Shamma, H; Gatlin, J; Gaidarov, I; Anthony, T; Le, M; Unett, DJ; Stirn, S; Blackburn, A; Behan, DP; Jones, RM ACS Med Chem Lett 5: 1334 -9 (2014)
Saeed, A; Mahesar, PA; Zaib, S; Khan, MS; Matin, A; Shahid, M; Iqbal, J Eur J Med Chem 78: 43 -53 (2014)
Nagar, S; Saha, A Eur J Med Chem 45: 4307 -15 (2010)
Fujii, H; Hayashida, K; Saitoh, A; Yokoyama, A; Hirayama, S; Iwai, T; Nakata, E; Nemoto, T; Sudo, Y; Uezono, Y; Yamada, M; Nagase, H ACS Med Chem Lett 5: 368 -72 (2014)
Shiraishi, T; Kadono, S; Haramura, M; Kodama, H; Ono, Y; Iikura, H; Esaki, T; Koga, T; Hattori, K; Watanabe, Y; Sakamoto, A; Yoshihashi, K; Kitazawa, T; Esaki, K; Ohta, M; Sato, H; Kozono, T Bioorg Med Chem Lett 18: 4533 -7 (2008)
Razavi, SF; Khoobi, M; Nadri, H; Sakhteman, A; Moradi, A; Emami, S; Foroumadi, A; Shafiee, A Eur J Med Chem 64: 252 -9 (2013)
Kempf, DJ; Codacovi, L; Wang, XC; Kohlbrenner, WE; Wideburg, NE; Saldivar, A; Vasavanonda, S; Marsh, KC; Bryant, P; Sham, HL J Med Chem 36: 320 -30 (1993)
Salimbeni, A; Paleari, F; Canevotti, R; Criscuoli, M; Criscuoli, M; Lippi, A; Angiolini, M; Belvisi, L; Scolastico, C; Colombo, L Bioorg Med Chem Lett 7: 2205 -2210 (1997)
Parodi, A; Righetti, G; Pesce, E; Salis, A; Tasso, B; Urbinati, C; Tomati, V; Damonte, G; Rusnati, M; Pedemonte, N; Cichero, E; Millo, E Eur J Med Chem 208: (2020)
Belei, D; Dumea, C; Samson, A; Farce, A; Dubois, J; Bîcu, E; Ghinet, A Bioorg Med Chem Lett 22: 4517 -22 (2012)
La Regina, G; Coluccia, A; Brancale, A; Piscitelli, F; Gatti, V; Maga, G; Samuele, A; Pannecouque, C; Schols, D; Balzarini, J; Novellino, E; Silvestri, R J Med Chem 54: 1587 -98 (2011)
Guardigni, M; Greco, G; Poeta, E; Santini, A; Tassinari, E; Bergamini, C; Zalambani, C; De Simone, A; Andrisano, V; Uliassi, E; Monti, B; Bolognesi, ML; Fimognari, C; Milelli, A RSC Med Chem 15: 2045 -2062
Manetti, F; Santucci, A; Locatelli, GA; Maga, G; Spreafico, A; Serchi, T; Orlandini, M; Bernardini, G; Caradonna, NP; Spallarossa, A; Brullo, C; Schenone, S; Bruno, O; Ranise, A; Bondavalli, F; Hoffmann, O; Bologna, M; Angelucci, A; Botta, M J Med Chem 50: 5579 -88 (2007)
Sasse, A; Stark, H; Reidemeister, S; Hüls, A; Elz, S; Ligneau, X; Ganellin, CR; Schwartz, JC; Schunack, W J Med Chem 42: 4269 -74 (1999)
Zhang, Y; Ali, A; Cumming, J; DeMong, D; Deng, Q; Graham, TH; Hennessy, E; Larsen, MA; Liu, K; Liu, P; Mansoor, UF; Pan, J; Plummer, CW; Sather, A; Swaminathan, U; Wang, H US Patent US12263171 (2025)
Nakanishi, I; Kinoshita, T; Tada, T; Fujita, T; Hatanaka, H; Sato, A Bioorg Med Chem Lett 9: 2397 -402 (1999)
Nair, S; Kumar, SR; Paidi, VR; Sistla, R; Kantheti, D; Polimera, SR; Thangavel, S; Mukherjee, AJ; Das, M; Bhide, RS; Pitts, WJ; Murugesan, N; Dudhgoankar, S; Nagar, J; Subramani, S; Mazumder, D; Carman, JA; Holloway, DA; Li, X; Fereshteh, MP; Ruepp, S; Palanisamy, K; Mariappan, TT; Maddi, S; Saxena, A; Elzinga, P; Chimalakonda, A; Ruan, Q; Ghosh, K; Bose, S; Sack, J; Yan, C; Kiefer, SE; Xie, D; Newitt, JA; Saravanakumar, SP; Rampulla, RA; Barrish, JC; Carter, PH; Hynes, J ACS Med Chem Lett 11: 1402 -1409 (2020)
Hall, C; Wolfe, H; Wells, A; Chien, HC; Colas, C; Schlessinger, A; Giacomini, KM; Thomas, AA Bioorg Med Chem Lett 29: 2254 -2258 (2019)
Nar, H; Bauer, M; Schmid, A; Stassen, JM; Wienen, W; Priepke, HW; Kauffmann, IK; Ries, UJ; Hauel, NH Structure 9: 29 -37 (2001)
Hoenke, C; Bouyssou, T; Tautermann, CS; Rudolf, K; Schnapp, A; Konetzki, I Bioorg Med Chem Lett 19: 6640 -4 (2009)
Lücking, U; Böhnke, N; Scholz, A; Lienau, P; Siemeister, G; Bömer, U; Kosemund, D; Bohlmann, R; Zorn, L US Patent US9670161 (2017)
Vogensen, SB; Jørgensen, L; Madsen, KK; Jurik, A; Borkar, N; Rosatelli, E; Nielsen, B; Ecker, GF; Schousboe, A; Clausen, RP Bioorg Med Chem 23: 2480 -8 (2015)
Parmentier, JM; Voss, J; Graff, C; Schwartz, A; Argiriadi, M; Friedman, M; Camp, HS; Padley, RJ; George, JS; Hyland, D; Rosebraugh, M; Wishart, N; Olson, L; Long, AJ BMC Rheumatol 2:
Sundén, H; Schäfer, A; Scheepstra, M; Leysen, S; Malo, M; Ma, JN; Burstein, ES; Ottmann, C; Brunsveld, L; Olsson, R J Med Chem 59: 1232 -8 (2016)
Rueda, DC; Schöffmann, A; De Mieri, M; Raith, M; Jähne, EA; Hering, S; Hamburger, M Bioorg Med Chem 22: 1276 -84 (2014)
Raudszus, R; Nowotny, R; Gertzen, CGW; Schöler, A; Krizsan, A; Gockel, I; Kalwa, H; Gohlke, H; Thieme, R; Hansen, FK Bioorg Med Chem 27: (2019)
Vanotti, E; Caldarelli, M; Cirla, A; Forte, B; Ermoli, A; Menichincheri, M; Pillan, A; Scolaro, A US Patent US9670191 (2017)
Di Fiore, A; Pedone, C; D'Ambrosio, K; Scozzafava, A; De Simone, G; Supuran, CT Bioorg Med Chem Lett 16: 437 -42 (2005)
Elhalem, E; Bellomo, A; Cooke, M; Scravaglieri, A; Pearce, LV; Peach, ML; Gandolfi Donadío, L; Kazanietz, MG; Comin, MJ J Med Chem 64: 11418 -11431 (2021)
Mahboobi, S; Uecker, A; Sellmer, A; Cénac, C; Höcher, H; Pongratz, H; Eichhorn, E; Hufsky, H; Trümpler, A; Sicker, M; Heidel, F; Fischer, T; Stocking, C; Elz, S; Böhmer, FD; Dove, S J Med Chem 49: 3101 -15 (2006)
Cabedo, N; Andreu, I; Ramírez De Arellano, MC; Chagraoui, A; Serrano, A; Bermejo, A; Protais, P; Cortes, D J Med Chem 44: 1794 -801 (2001)
Razavi, SF; Khoobi, M; Nadri, H; Sakhteman, A; Moradi, A; Emami, S; Foroumadi, A; Shafiee, A Eur J Med Chem 64: 252 -9 (2013)
Chaudhry, S; Castro, JR; Totiger, TM; Afaghani, J; Khurshid, R; Nicholls, M; Zhang, Z; Schürer, SC; Shah, A; Taylor, J; Feng, Y ACS Med Chem Lett 15: 945 -949
Shahripour, A; Plummer, MS; Lunney, EA; Para, KS; Stankovic, CJ; Rubin, JR; Humblet, C; Fergus, JH; Marks, JS; Herrera, R; Hubbell, SE; Saltiel, AR; Sawyer, TK Bioorg Med Chem Lett 6: 1209 -1214 (1996)
Johnson, CN; Berdini, V; Beke, L; Bonnet, P; Brehmer, D; Coyle, JE; Day, PJ; Frederickson, M; Freyne, EJ; Gilissen, RA; Hamlett, CC; Howard, S; Meerpoel, L; McMenamin, R; Patel, S; Rees, DC; Sharff, A; Sommen, F; Wu, T; Linders, JT ACS Med Chem Lett 6: 25 -30 (2015)
Sharma, A; Agrahari, AK; Rajkhowa, S; Tiwari, VK Eur J Med Chem 238: (2022)
Shiriaeva, A; Park, D; Kim, G; Lee, Y; Hou, X; Jarhad, DB; Kim, G; Yu, J; Hyun, YE; Kim, W; Gao, ZG; Jacobson, KA; Han, GW; Stevens, RC; Jeong, LS; Choi, S; Cherezov, V J Med Chem 65: 11648 -11657 (2022)
Stucchi, M; Gmeiner, P; Huebner, H; Rainoldi, G; Sacchetti, A; Silvani, A; Lesma, G ACS Med Chem Lett 6: 882 -7 (2015)
Thakur, A; Tawa, GJ; Henderson, MJ; Danchik, C; Liu, S; Shah, P; Wang, AQ; Dunn, G; Kabir, M; Padilha, EC; Xu, X; Simeonov, A; Kharbanda, S; Stone, R; Grewal, G J Med Chem 63: 4256 -4292 (2020)
Singh, A; Dirain, M; Witek, R; Rocca, JR; Edison, AS; Haskell-Luevano, C J Med Chem 56: 2747 -63 (2013)
Wang, E; Kolb, HC; Szardenings, AK; Liu, C; Walsh, JC; Chen, G; Sinha, A; Kasi, D; Yu, C; Gangadharmath, UB; Zhang, W; Zhao, T; Mocharla, VP US Patent US10894807 (2021)
Reinart, R; Gyulai, Z; Berényi, S; Antus, S; Vonk, A; Rinken, A; Sipos, A Eur J Med Chem 46: 2992 -9 (2011)
Zehnder, L; Bennett, M; Meng, J; Huang, B; Ninkovic, S; Wang, F; Braganza, J; Tatlock, J; Jewell, T; Zhou, JZ; Burke, B; Wang, J; Maegley, K; Mehta, PP; Yin, MJ; Gajiwala, KS; Hickey, MJ; Yamazaki, S; Smith, E; Kang, P; Sistla, A; Dovalsantos, E; Gehring, MR; Kania, R; Wythes, M; Kung, PP J Med Chem 54: 3368 -85 (2011)
Smith, CJ; Ali, A; Balkovec, JM; Graham, DW; Hammond, ML; Patel, GF; Rouen, GP; Smith, SK; Tata, JR; Einstein, M; Ge, L; Harris, GS; Kelly, TM; Mazur, P; Thompson, CM; Wang, CF; Williamson, JM; Miller, DK; Pandit, S; Santoro, JC; Sitlani, A; Yamin, TT; O'Neill, EA; Zaller, DM; Carballo-Jane, E; Forrest, MJ; Luell, S Bioorg Med Chem Lett 15: 2926 -31 (2005)
Handzlik, J; Szymańska, E; Wójcik, R; Dela, A; Jastrzębska-Więsek, M; Karolak-Wojciechowska, J; Fruziński, A; Siwek, A; Filipek, B; Kieć-Kononowicz, K Bioorg Med Chem 20: 4245 -57 (2012)
Quan, ML; Pinto, DJ; Rossi, KA; Sheriff, S; Alexander, RS; Amparo, E; Kish, K; Knabb, RM; Luettgen, JM; Morin, P; Smallwood, A; Woerner, FJ; Wexler, RR Bioorg Med Chem Lett 20: 1373 -7 (2010)
Imbriglio, JE; Chang, S; Liang, R; Raghavan, S; Schmidt, D; Smenton, A; Tria, S; Schrader, TO; Jung, JK; Esser, C; Taggart, AK; Cheng, K; Carballo-Jane, E; Gerard Waters, M; Tata, JR; Colletti, SL Bioorg Med Chem Lett 19: 2121 -4 (2009)
Hummel, J; Vechorkin, O; Sokolsky, A; Ye, Q; Liu, K; Yao, W US Patent US10899755 (2021)
Song, A; Zhang, J; Ge, Y; Wang, C; Meng, Q; Tang, Z; Peng, J; Liu, K; Li, Y; Ma, X Bioorg Med Chem 25: 2724 -2729 (2017)
Shah, U; Jayne, C; Chackalamannil, S; Velázquez, F; Guo, Z; Buevich, A; Howe, JA; Chase, R; Soriano, A; Agrawal, S; Rudd, MT; McCauley, JA; Liverton, NJ; Romano, J; Bush, K; Coleman, PJ; Grisé-Bard, C; Brochu, MC; Charron, S; Aulakh, V; Bachand, B; Beaulieu, P; Zaghdane, H; Bhat, S; Han, Y; Vacca, JP; Davies, IW; Weber, AE; Venkatraman, S ACS Med Chem Lett 5: 264 -9 (2014)
Ranise, A; Spallarossa, A; Cesarini, S; Bondavalli, F; Schenone, S; Bruno, O; Menozzi, G; Fossa, P; Mosti, L; La Colla, M; Sanna, G; Murreddu, M; Collu, G; Busonera, B; Marongiu, ME; Pani, A; La Colla, P; Loddo, R J Med Chem 48: 3858 -73 (2005)
Miller, JF; Andrews, CW; Brieger, M; Furfine, ES; Hale, MR; Hanlon, MH; Hazen, RJ; Kaldor, I; McLean, EW; Reynolds, D; Sammond, DM; Spaltenstein, A; Tung, R; Turner, EM; Xu, RX; Sherrill, RG Bioorg Med Chem Lett 16: 1788 -94 (2006)
Manetti, F; Santucci, A; Locatelli, GA; Maga, G; Spreafico, A; Serchi, T; Orlandini, M; Bernardini, G; Caradonna, NP; Spallarossa, A; Brullo, C; Schenone, S; Bruno, O; Ranise, A; Bondavalli, F; Hoffmann, O; Bologna, M; Angelucci, A; Botta, M J Med Chem 50: 5579 -88 (2007)
Rossi, C; Porcelloni, M; D'Andrea, P; Fincham, CI; Ettorre, A; Mauro, S; Squarcia, A; Bigioni, M; Parlani, M; Nardelli, F; Binaschi, M; Maggi, CA; Fattori, D Bioorg Med Chem Lett 21: 2305 -8 (2011)
Naqvi, A; Malasoni, R; Srivastava, A; Pandey, RR; Dwivedi, AK Bioorg Med Chem Lett 24: 5181 -4 (2014)
Majellaro, M; Jespers, W; Crespo, A; Núñez, MJ; Novio, S; Azuaje, J; Prieto-Díaz, R; Gioé, C; Alispahic, B; Brea, J; Loza, MI; Freire-Garabal, M; Garcia-Santiago, C; Rodríguez-García, C; García-Mera, X; Caamaño, O; Fernandez-Masaguer, C; Sardina, JF; Stefanachi, A; El Maatougui, A; Mallo-Abreu, A; Åqvist, J; Gutiérrez-de-Terán, H; Sotelo, E J Med Chem 64: 458 -480 (2021)
Scott, JS; deSchoolmeester, J; Kilgour, E; Mayers, RM; Packer, MJ; Hargreaves, D; Gerhardt, S; Ogg, DJ; Rees, A; Selmi, N; Stocker, A; Swales, JG; Whittamore, PR J Med Chem 55: 10136 -47 (2012)
Wang, G; Dyatkina, N; Prhavc, M; Williams, C; Serebryany, V; Hu, Y; Huang, Y; Wan, J; Wu, X; Deval, J; Fung, A; Jin, Z; Tan, H; Shaw, K; Kang, H; Zhang, Q; Tam, Y; Stoycheva, A; Jekle, A; Smith, DB; Beigelman, L J Med Chem 62: 4555 -4570 (2019)
Bosquez-Berger, T; Gudorf, JA; Kuntz, CP; Desmond, JA; Schlebach, JP; VanNieuwenhze, MS; Straiker, A J Med Chem 66: 9466 -9494 (2023)
van den Berg, RJ; Wennekes, T; Ghisaidoobe, A; Donker-Koopman, WE; Strijland, A; Boot, RG; van der Marel, GA; Aerts, JM; Overkleeft, HS ACS Med Chem Lett 2: 519 -522 (2011)
Powell, DA; Black, WC; Bleasby, K; Chan, CC; Deschenes, D; Gagnon, M; Gordon, R; Guay, J; Guiral, S; Hafey, MJ; Huang, Z; Isabel, E; Leblanc, Y; Styhler, A; Xu, LJ; Zhang, L; Oballa, RM Bioorg Med Chem Lett 21: 7281 -6 (2011)
Zhang, C; Wang, L; Xu, Y; Huang, Y; Huang, J; Zhu, J; Wang, W; Li, W; Sun, A; Li, X; Zhang, H; Li, J Eur J Med Chem 236: (2022)
Sheppard, D; Sundaram, A; Degrado, WF; Jo, H; McIntosh, J US Patent US10836720 (2020)
Nelson, FC; Delos Santos, E; Levin, JI; Chen, JM; Skotnicki, JS; DiJoseph, JF; Sharr, MA; Sung, A; Killar, LM; Cowling, R; Jin, G; Roth, CE; Albright, JD Bioorg Med Chem Lett 12: 2867 -70 (2002)
Banerjee, M; Middya, S; Shrivastava, R; Raina, S; Surya, A; Yadav, DB; Yadav, VK; Kapoor, KK; Venkatesan, A; Smith, RA; Thompson, SK US Patent US10294212 (2019)
Cirillo, PF; Hickey, ER; Moss, N; Breitfelder, S; Betageri, R; Fadra, T; Gaenzler, F; Gilmore, T; Goldberg, DR; Kamhi, V; Kirrane, T; Kroe, RR; Madwed, J; Moriak, M; Netherton, M; Pargellis, CA; Patel, UR; Qian, KC; Sharma, R; Sun, S; Swinamer, A; Torcellini, C; Takahashi, H; Tsang, M; Xiong, Z Bioorg Med Chem Lett 19: 2386 -91 (2009)
Vandyck, K; Rombouts, G; Stoops, B; Tahri, A; Vos, A; Verschueren, W; Wu, Y; Yang, J; Hou, F; Huang, B; Vergauwen, K; Dehertogh, P; Berke, JM; Raboisson, P J Med Chem 61: 6247 -6260 (2018)
Franchini, S; Battisti, UM; Prandi, A; Tait, A; Borsari, C; Cichero, E; Fossa, P; Cilia, A; Prezzavento, O; Ronsisvalle, S; Aricò, G; Parenti, C; Brasili, L Eur J Med Chem 112: 1 -19 (2016)
Ogawa, S; Uetsuki, S; Tezuka, Y; Morikawa, T; Takahashi, A; Sato, K Bioorg Med Chem Lett 9: 1493 -8 (1999)
Taniguchi, T; Miura, S; Hasui, T; Halldin, C; Stepanov, V; Takano, A US Patent US9579407 (2017)
Rahm, F; Viklund, J; Trésaugues, L; Ellermann, M; Giese, A; Ericsson, U; Forsblom, R; Ginman, T; Günther, J; Hallberg, K; Lindström, J; Persson, LB; Silvander, C; Talagas, A; Díaz-Sáez, L; Fedorov, O; Huber, KVM; Panagakou, I; Siejka, P; Gorjánácz, M; Bauser, M; Andersson, M J Med Chem 61: 2533 -2551 (2018)
Das, N; Bandopadhyay, P; Roy, S; Sinha, BP; Dastidar, UG; Rahaman, O; Pal, S; Ganguly, D; Talukdar, A J Med Chem 65: 11607 -11632 (2022)
Hu, E; Tasker, A; White, RD; Kunz, RK; Human, J; Chen, N; Bürli, R; Hungate, R; Novak, P; Itano, A; Zhang, X; Yu, V; Nguyen, Y; Tudor, Y; Plant, M; Flynn, S; Xu, Y; Meagher, KL; Whittington, DA; Ng, GY J Med Chem 51: 3065 -8 (2008)
Arora, J; Bordeleau, M; Dube, L; Jarvie, K; Mazzocco, L; Peragine, J; Tehim, A; Egle, I Bioorg Med Chem Lett 15: 5253 -6 (2005)
Dal Piaz, F; Vassallo, A; Temraz, A; Cotugno, R; Belisario, MA; Bifulco, G; Chini, MG; Pisano, C; De Tommasi, N; Braca, A J Med Chem 56: 1583 -95 (2013)
Meena, CL; Thakur, A; Nandekar, PP; Sharma, SS; Sangamwar, AT; Jain, R Eur J Med Chem 111: 72 -83 (2016)
Juli, C; Sippel, M; Jäger, J; Thiele, A; Weiwad, M; Schweimer, K; Rösch, P; Steinert, M; Sotriffer, CA; Holzgrabe, U J Med Chem 54: 277 -83 (2011)
Miguet, L; Zervosen, A; Gerards, T; Pasha, FA; Luxen, A; Distèche-Nguyen, M; Thomas, A J Med Chem 52: 5926 -36 (2009)
Thorarensen, A; Presley-Bodnar, AL; Marotti, KR; Boyle, TP; Heckaman, CL; Bohanon, MJ; Tomich, PK; Zurenko, GE; Sweeney, MT; Yagi, BH Bioorg Med Chem Lett 11: 1903 -6 (2001)
Ito, M; Tanaka, T; Toita, A; Uchiyama, N; Kokubo, H; Morishita, N; Klein, MG; Zou, H; Murakami, M; Kondo, M; Sameshima, T; Araki, S; Endo, S; Kawamoto, T; Morin, GB; Aparicio, SA; Nakanishi, A; Maezaki, H; Imaeda, Y J Med Chem 61: 7710 -7728 (2018)
Toledo, MA; Pedregal, C; Lafuente, C; Diaz, N; Martinez-Grau, MA; Jiménez, A; Benito, A; Torrado, A; Mateos, C; Joshi, EM; Kahl, SD; Rash, KS; Mudra, DR; Barth, VN; Shaw, DB; McKinzie, D; Witkin, JM; Statnick, MA J Med Chem 57: 3418 -29 (2014)
Tosstorff, A; Rudolph, MG; Cole, JC; Reutlinger, M; Kramer, C; Schaffhauser, H; Nilly, A; Flohr, A; Kuhn, B J Comput Aided Mol Des 36: 753 -765 (2022)
Angeli, A; Pinteala, M; Maier, SS; Toti, A; Di Cesare Mannelli, L; Ghelardini, C; Selleri, S; Carta, F; Supuran, CT Bioorg Med Chem Lett 45: (2021)
Trapero, A; Llebaria, A ACS Med Chem Lett 2: 614 -619 (2011)
Corminboeuf, O; Bezençon, O; Remen, L; Grisostomi, C; Richard-Bildstein, S; Bur, D; Prade, L; Strickner, P; Hess, P; Fischli, W; Steiner, B; Treiber, A Bioorg Med Chem Lett 20: 6291 -6 (2010)
Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G US Patent US9796706 (2017)
Lane, T; Makarov, V; Nelson, JAE; Meeker, RB; Sanna, G; Riabova, O; Kazakova, E; Monakhova, N; Tsedilin, A; Urbina, F; Jones, T; Suchy, A; Ekins, S J Med Chem 66: 6193 -6217 (2023)
Shishodia, S; Demetriades, M; Zhang, D; Tam, NY; Maheswaran, P; Clunie-O'Connor, C; Tumber, A; Leung, IKH; Ng, YM; Leissing, TM; El-Sagheer, AH; Salah, E; Brown, T; Aik, WS; McDonough, MA; Schofield, CJ J Med Chem 64: 16609 -16625 (2021)
Ernst, JT; Neubert, T; Liu, M; Sperry, S; Zuccola, H; Turnbull, A; Fleck, B; Kargo, W; Woody, L; Chiang, P; Tran, D; Chen, W; Snyder, P; Alcacio, T; Nezami, A; Reynolds, J; Alvi, K; Goulet, L; Stamos, D J Med Chem 57: 3382 -400 (2014)
Neochoritis, CG; Wang, K; Estrada-Ortiz, N; Herdtweck, E; Kubica, K; Twarda, A; Zak, KM; Holak, TA; Dömling, A Bioorg Med Chem Lett 25: 5661 -6 (2015)
Mahboobi, S; Uecker, A; Sellmer, A; Cénac, C; Höcher, H; Pongratz, H; Eichhorn, E; Hufsky, H; Trümpler, A; Sicker, M; Heidel, F; Fischer, T; Stocking, C; Elz, S; Böhmer, FD; Dove, S J Med Chem 49: 3101 -15 (2006)
Vaz, RJ; Gao, Z; Pribish, J; Chen, X; Levell, J; Davis, L; Albert, E; Brollo, M; Ugolini, A; Cramer, DM; Cairns, J; Sides, K; Liu, F; Kwong, J; Kang, J; Rebello, S; Elliot, M; Lim, H; Chellaraj, V; Singleton, RW; Li, Y Bioorg Med Chem Lett 14: 6053 -6 (2004)
Szokol, B; Gyulavári, P; Kurkó, I; Baska, F; Szántai-Kis, C; Greff, Z; Orfi, Z; Peták, I; Pénzes, K; Torka, R; Ullrich, A; Orfi, L; Vántus, T; Kéri, G ACS Med Chem Lett 5: 298 -303 (2014)
Goi, T; Nakajima, T; Komatsu, Y; Kawata, A; Yamakoshi, S; Okada, O; Sugahara, M; Umeda, A; Takada, Y; Murakami, J; Ohashi, R; Watanabe, T; Fukase, K ACS Med Chem Lett 11: 1416 -1420 (2020)
Bjørnstad, F; Havik, S; Aarhus, TI; Mahdi, I; Unger, A; Habenberger, P; Degenhart, C; Eickhoff, J; Klebl, BM; Sundby, E; Hoff, BH Eur J Med Chem 265:
Feledziak, M; Michaux, C; Urbach, A; Labar, G; Muccioli, GG; Lambert, DM; Marchand-Brynaert, J J Med Chem 52: 7054 -68 (2009)
Lavogina, D; Enkvist, E; Viht, K; Uri, A Chembiochem 15: 443 -50 (2014)
Sipos, A; Csutorás, C; Berényi, S; Uustare, A; Rinken, A Bioorg Med Chem 16: 4563 -8 (2008)
Jain, AK; Vaidya, A; Ravichandran, V; Kashaw, SK; Agrawal, RK Bioorg Med Chem 20: 3378 -95 (2012)
Michels, M; Briem, H; Vakalopoulos, A; Zimmermann, K; Teusch, N US Patent US8604028 (2013)
Manera, C; Benetti, V; Castelli, MP; Cavallini, T; Lazzarotti, S; Pibiri, F; Saccomanni, G; Tuccinardi, T; Vannacci, A; Martinelli, A; Ferrarini, PL J Med Chem 49: 5947 -57 (2006)
Dal Piaz, F; Vassallo, A; Temraz, A; Cotugno, R; Belisario, MA; Bifulco, G; Chini, MG; Pisano, C; De Tommasi, N; Braca, A J Med Chem 56: 1583 -95 (2013)
Hurth, K; Enz, A; Floersheim, P; Gentsch, C; Hoyer, D; Langenegger, D; Neumann, P; Pfäffli, P; Sorg, D; Swoboda, R; Vassout, A; Troxler, T Bioorg Med Chem Lett 17: 3988 -91 (2007)
Papillon, JPN; Nakajima, K; Adair, CD; Hempel, J; Jouk, AO; Karki, RG; Mathieu, S; Möbitz, H; Ntaganda, R; Smith, T; Visser, M; Hill, SE; Hurtado, FK; Chenail, G; Bhang, HC; Bric, A; Xiang, K; Bushold, G; Gilbert, T; Vattay, A; Dooley, J; Costa, EA; Park, I; Li, A; Farley, D; Lounkine, E; Yue, QK; Xie, X; Zhu, X; Kulathila, R; King, D; Hu, T; Vulic, K; Cantwell, J; Luu, C; Jagani, Z J Med Chem 61: 10155 -10172 (2018)
Robinson, RP; Bartlett, JA; Bertinato, P; Bessire, AJ; Cosgrove, J; Foley, PM; Manion, TB; Minich, ML; Ramos, B; Reese, MR; Schmahai, TJ; Swick, AG; Tess, DA; Vaz, A; Wolford, A Bioorg Med Chem Lett 21: 4150 -4 (2011)
Wu, WL; Burnett, DA; Domalski, M; Greenlee, WJ; Li, C; Bertorelli, R; Fredduzzi, S; Lozza, G; Veltri, A; Reggiani, A J Med Chem 50: 5550 -3 (2007)
Dhorma, LP; Teli, MK; Nangunuri, BG; Venkanna, A; Ragam, R; Maturi, A; Mirzaei, A; Vo, DK; Maeng, HJ; Kim, MH Eur J Med Chem 227: (2022)
Banerjee, M; Middya, S; Shrivastava, R; Raina, S; Surya, A; Yadav, DB; Yadav, VK; Kapoor, KK; Venkatesan, A; Smith, RA; Thompson, SK US Patent US10294212 (2019)
Bryk, R; Arango, N; Venugopal, A; Warren, JD; Park, YH; Patel, MS; Lima, CD; Nathan, C Biochemistry 49: 1616 -27 (2010)
Pierre, F; Chua, PC; O'Brien, SE; Siddiqui-Jain, A; Bourbon, P; Haddach, M; Michaux, J; Nagasawa, J; Schwaebe, MK; Stefan, E; Vialettes, A; Whitten, JP; Chen, TK; Darjania, L; Stansfield, R; Anderes, K; Bliesath, J; Drygin, D; Ho, C; Omori, M; Proffitt, C; Streiner, N; Trent, K; Rice, WG; Ryckman, DM J Med Chem 54: 635 -54 (2011)
Gornati, D; Ciccone, R; Vinciguerra, A; Ippati, S; Pannaccione, A; Petrozziello, T; Pizzi, E; Hassan, A; Colombo, E; Barbini, S; Milani, M; Caccavone, C; Randazzo, P; Muzio, L; Annunziato, L; Menegon, A; Secondo, A; Mastrangelo, E; Pignataro, G; Seneci, P J Med Chem 64: 8333 -8353 (2021)
Manca, I; Mastinu, A; Olimpieri, F; Falzoi, M; Sani, M; Ruiu, S; Loriga, G; Volonterio, A; Tambaro, S; Bottazzi, ME; Zanda, M; Pinna, GA; Lazzari, P Eur J Med Chem 62: 256 -69 (2013)
Palucki, BL; Park, MK; Nargund, RP; Ye, Z; Sebhat, IK; Pollard, PG; Kalyani, RN; Tang, R; Macneil, T; Weinberg, DH; Vongs, A; Rosenblum, CI; Doss, GA; Miller, RR; Stearns, RA; Peng, Q; Tamvakopoulos, C; McGowan, E; Martin, WJ; Metzger, JM; Shepherd, CA; Strack, AM; Macintyre, DE; Van der Ploeg, LH; Patchett, AA Bioorg Med Chem Lett 15: 171 -5 (2004)
Reinart, R; Gyulai, Z; Berényi, S; Antus, S; Vonk, A; Rinken, A; Sipos, A Eur J Med Chem 46: 2992 -9 (2011)
Peschiulli, A; Oehlrich, D; Rombouts, F; Vos, A; Gijsen, HJ Bioorg Med Chem Lett 30: (2020)
O'Neill, DJ; Adedoyin, A; Bray, JA; Deecher, DC; Fensome, A; Goldberg, JA; Harrison, J; Leventhal, L; Mann, C; Mark, L; Nogle, L; Sullivan, NR; Spangler, TB; Terefenko, EA; Trybulski, EJ; Uveges, AJ; Vu, A; Whiteside, GT; Zhang, P J Med Chem 54: 6824 -31 (2011)
Váradi, A; Hosztafi, S; Le Rouzic, V; Tóth, G; Urai, Á; Noszál, B; Pasternak, GW; Grinnell, SG; Majumdar, S Eur J Med Chem 69: 786 -9 (2013)
Taha, M; Ismail, NH; Imran, S; Wadood, A; Rahim, F; Riaz, M Bioorg Med Chem 23: 7211 -8 (2015)
Lebon, F; Pégurier, C; Ledecq, M; Mathieu, B; Bosman, N; Frycia, A; Lengelé, S; Dhurke, K; Kanduluru, AK; Meunier, S; Wagner, A; Wolff, C; Provins, L Bioorg Med Chem Lett 22: 3978 -82 (2012)
Therrien, E; Larouche, G; Nguyen, N; Rahil, J; Lemieux, AM; Li, Z; Fournel, M; Yan, TP; Landry, AJ; Lefebvre, S; Wang, JJ; MacBeth, K; Heise, C; Nguyen, A; Besterman, JM; Déziel, R; Wahhab, A Bioorg Med Chem Lett 25: 2514 -8 (2015)
Wang, A; Lv, K; Tao, Z; Gu, J; Fu, L; Liu, M; Wan, B; Franzblau, SG; Ma, C; Ma, X; Han, B; Wang, A; Xu, S; Lu, Y Eur J Med Chem 181: (2019)
Kolaczkowski, M; Marcinkowska, M; Bucki, A; Sniecikowska, J; Pawlowski, M; Kazek, G; Siwek, A; Jastrzebska-Wiesek, M; Partyka, A; Wasik, A; Wesolowska, A; Mierzejewski, P; Bienkowski, P Eur J Med Chem 92: 221 -35 (2015)
Landry, DW; Deng, S; Arancio, O; Fiorito, J; Wasmuth, A US Patent US10899756 (2021)
Asaba, KN; Adachi, Y; Tokumaru, K; Watanabe, A; Goto, Y; Aoki, T Bioorg Med Chem Lett 41: (2021)
Buchstaller, HP; Anlauf, U; Dorsch, D; Kögler, S; Kuhn, D; Lehmann, M; Leuthner, B; Lodholz, S; Musil, D; Radtki, D; Rettig, C; Ritzert, C; Rohdich, F; Schneider, R; Wegener, A; Weigt, S; Wilkinson, K; Esdar, C J Med Chem 64: 10371 -10392 (2021)
Glunz, PW; Cheng, X; Cheney, DL; Weigelt, CA; Wei, A; Luettgen, JM; Wong, PC; Wexler, RR; Priestley, ES Bioorg Med Chem Lett 25: 2169 -73 (2015)
Hall, C; Wolfe, H; Wells, A; Chien, HC; Colas, C; Schlessinger, A; Giacomini, KM; Thomas, AA Bioorg Med Chem Lett 29: 2254 -2258 (2019)
Kolaczkowski, M; Marcinkowska, M; Bucki, A; Sniecikowska, J; Pawlowski, M; Kazek, G; Siwek, A; Jastrzebska-Wiesek, M; Partyka, A; Wasik, A; Wesolowska, A; Mierzejewski, P; Bienkowski, P Eur J Med Chem 92: 221 -35 (2015)
Yueh, C; Rettenmaier, J; Xia, B; Hall, DR; Alekseenko, A; Porter, KA; Barkovich, K; Keseru, G; Whitty, A; Wells, JA; Vajda, S; Kozakov, D J Med Chem 62: 6512 -6524 (2019)
Jin, H; Cianchetta, G; Devasagayaraj, A; Gu, K; Marinelli, B; Samala, L; Scott, S; Stouch, T; Tunoori, A; Wang, Y; Zang, Y; Zhang, C; David Kimball, S; Main, AJ; Ding, ZM; Sun, W; Yang, Q; Yu, XQ; Powell, DR; Wilson, A; Liu, Q; Shi, ZC Bioorg Med Chem Lett 19: 5229 -32 (2009)
Rabindran, SK; Discafani, CM; Rosfjord, EC; Baxter, M; Floyd, MB; Golas, J; Hallett, WA; Johnson, BD; Nilakantan, R; Overbeek, E; Reich, MF; Shen, R; Shi, X; Tsou, HR; Wang, YF; Wissner, A Cancer Res 64: 3958 -65
Wichur, T; Pasieka, A; Godyń, J; Panek, D; Góral, I; Latacz, G; Honkisz-Orzechowska, E; Bucki, A; Siwek, A; Głuch-Lutwin, M; Knez, D; Brazzolotto, X; Gobec, S; Kołaczkowski, M; Sabate, R; Malawska, B; Więckowska, A Eur J Med Chem 225: (2021)
Choi, Y; Syeda, F; Walker, JR; Finerty, PJ; Cuerrier, D; Wojciechowski, A; Liu, Q; Dhe-Paganon, S; Gray, NS Bioorg Med Chem Lett 19: 4467 -70 (2009)
Robinson, RP; Bartlett, JA; Bertinato, P; Bessire, AJ; Cosgrove, J; Foley, PM; Manion, TB; Minich, ML; Ramos, B; Reese, MR; Schmahai, TJ; Swick, AG; Tess, DA; Vaz, A; Wolford, A Bioorg Med Chem Lett 21: 4150 -4 (2011)
Cheng, H; Davis, L; Holl, W; Nichols, A; Hwang, S; Johanson, K; Wong, A Bioorg Med Chem Lett 3: 1179 -1184 (1993)
Armour, DR; de Groot, MJ; Price, DA; Stammen, BL; Wood, A; Perros, M; Burt, C Chem Biol Drug Des 67: 305 -8 (2006)
Kobayashi, JI; Hirasawa, H; Fujimori, Y; Nakanishi, O; Kamada, N; Ikeda, T; Yamamoto, A; Kanbe, H Bioorg Med Chem 30: (2021)
Yamashita, A; Takahashi, N; Mochizuki, D; Tsujita, R; Yamada, S; Kawakubo, H; Suzuki, Y; Watanabe, H Bioorg Med Chem Lett 7: 2303 -2306 (1997)
Kitbunnadaj, R; Hashimoto, T; Poli, E; Zuiderveld, OP; Menozzi, A; Hidaka, R; de Esch, IJ; Bakker, RA; Menge, WM; Yamatodani, A; Coruzzi, G; Timmerman, H; Leurs, R J Med Chem 48: 2100 -7 (2005)
Duggan, PJ; Lewis, RJ; Phei Lok, Y; Lumsden, NG; Tuck, KL; Yang, A Bioorg Med Chem Lett 19: 2763 -5 (2009)
Fujii, H; Hayashida, K; Saitoh, A; Yokoyama, A; Hirayama, S; Iwai, T; Nakata, E; Nemoto, T; Sudo, Y; Uezono, Y; Yamada, M; Nagase, H ACS Med Chem Lett 5: 368 -72 (2014)
Fox, BM; Sugimoto, K; Iio, K; Yoshida, A; Zhang, JK; Li, K; Hao, X; Labelle, M; Smith, ML; Rubenstein, SM; Ye, G; McMinn, D; Jackson, S; Choi, R; Shan, B; Ma, J; Miao, S; Matsui, T; Ogawa, N; Suzuki, M; Kobayashi, A; Ozeki, H; Okuma, C; Ishii, Y; Tomimoto, D; Furakawa, N; Tanaka, M; Matsushita, M; Takahashi, M; Inaba, T; Sagawa, S; Kayser, F J Med Chem 57: 3464 -83 (2014)
Oyama, T; Takahashi, S; Yoshimori, A; Yamamoto, T; Sato, A; Kamiya, T; Abe, H; Abe, T; Tanuma, SI Bioorg Med Chem 24: 4509 -4515 (2016)
Wu, JS; Lin, SY; Liao, FY; Hsiao, WC; Lee, LC; Peng, YH; Hsieh, CL; Wu, MH; Song, JS; Yueh, A; Chen, CH; Yeh, SH; Liu, CY; Lin, SY; Yeh, TK; Hsu, JT; Shih, C; Ueng, SH; Hung, MS; Wu, SY J Med Chem 58: 7807 -19 (2015)
XU, W; SHAN, Z; ZHANG, Y; ZHANG, G; GE, Y; ZHANG, A; ZHANG, X US Patent US20240101551 (2024)
Kattar, SD; Surdi, LM; Zabierek, A; Methot, JL; Middleton, RE; Hughes, B; Szewczak, AA; Dahlberg, WK; Kral, AM; Ozerova, N; Fleming, JC; Wang, H; Secrist, P; Harsch, A; Hamill, JE; Cruz, JC; Kenific, CM; Chenard, M; Miller, TA; Berk, SC; Tempest, P Bioorg Med Chem Lett 19: 1168 -72 (2009)
Nugiel, DA; Krumrine, JR; Hill, DC; Damewood, JR; Bernstein, PR; Sobotka-Briner, CD; Liu, J; Zacco, A; Pierson, ME J Med Chem 53: 1876 -80 (2010)
Čapkauskaitė, E; Zakšauskas, A; Ruibys, V; Linkuvienė, V; Paketurytė, V; Gedgaudas, M; Kairys, V; Matulis, D Bioorg Med Chem 26: 675 -687 (2018)
Arfaie, S; Zarghi, A Eur J Med Chem 45: 4013 -7 (2010)
Levin, JI; Chen, J; Du, M; Hogan, M; Kincaid, S; Nelson, FC; Venkatesan, AM; Wehr, T; Zask, A; DiJoseph, J; Killar, LM; Skala, S; Sung, A; Sharr, M; Roth, C; Jin, G; Cowling, R; Mohler, KM; Black, RA; March, CJ; Skotnicki, JS Bioorg Med Chem Lett 11: 2189 -92 (2001)
Miguet, L; Zervosen, A; Gerards, T; Pasha, FA; Luxen, A; Distèche-Nguyen, M; Thomas, A J Med Chem 52: 5926 -36 (2009)
Tan, J; Wu, B; Chen, T; Fan, C; Zhao, J; Xiong, C; Feng, C; Xiao, R; Ding, C; Tang, W; Zhang, A J Med Chem 64: 7667 -7690 (2021)
Rich, JO; Budde, CL; McConeghey, LD; Cotterill, IC; Mozhaev, VV; Singh, SB; Goetz, MA; Zhao, A; Michels, PC; Khmelnitsky, YL Bioorg Med Chem Lett 19: 3059 -62 (2009)
Xu, J; Qi, H; Wang, Z; Wang, L; Steurer, B; Cai, X; Liu, J; Aliper, A; Zhang, M; Ren, F; Zhavoronkov, A; Ding, X J Med Chem 67: 8161 -8171
Labadie, S; Dragovich, PS; Chen, J; Fauber, BP; Boggs, J; Corson, LB; Ding, CZ; Eigenbrot, C; Ge, H; Ho, Q; Lai, KW; Ma, S; Malek, S; Peterson, D; Purkey, HE; Robarge, K; Salphati, L; Sideris, S; Ultsch, M; VanderPorten, E; Wei, B; Xu, Q; Yen, I; Yue, Q; Zhang, H; Zhang, X; Zhou, A Bioorg Med Chem Lett 25: 75 -82 (2015)
Zhu, A; Zhan, W; Liang, Z; Yoon, Y; Yang, H; Grossniklaus, HE; Xu, J; Rojas, M; Lockwood, M; Snyder, JP; Liotta, DC; Shim, H J Med Chem 53: 8556 -68 (2010)
Micheli, F; Cavanni, P; Andreotti, D; Arban, R; Benedetti, R; Bertani, B; Bettati, M; Bettelini, L; Bonanomi, G; Braggio, S; Carletti, R; Checchia, A; Corsi, M; Fazzolari, E; Fontana, S; Marchioro, C; Merlo-Pich, E; Negri, M; Oliosi, B; Ratti, E; Read, KD; Roscic, M; Sartori, I; Spada, S; Tedesco, G; Tarsi, L; Terreni, S; Visentini, F; Zocchi, A; Zonzini, L; Di Fabio, R J Med Chem 53: 4989 -5001 (2010)
ChEMBL_1989579 (CHEMBL4623314) Inhibition of human Cav3.1 expressed in tsA-201 cells by patch clamp electrophysiology
ChEMBL_1989580 (CHEMBL4623315) Inhibition of human Cav3.2 expressed in tsA-201 cells by patch clamp electrophysiology
ChEMBL_1989581 (CHEMBL4623316) Inhibition of human Cav3.3 expressed in tsA-201 cells by patch clamp electrophysiology
Inhibition Assay Table 10: The efficacy of MMP-2 inhibition was as follows: compound 6>compound 7>compound 8. Although compound 6 showed similar efficacy as curcumin when comparing MMP-2 inhibitory potency, the amide-containing compounds are much more soluble than the famously insoluble curcumin. The amide-containing curcumin derivatives are much more potent inhibitors of MMP-13 (Collagenase-3) than curcumin and even more potent than compound 1 (Table 9 and 10).:
ChEMBL_1456651 (CHEMBL3370251) Agonist activity at human GABAAalpha1beta2gamma2S receptor expressed in tsA-201cells by FLIPR membrane potential blue assay
ChEMBL_1456653 (CHEMBL3370253) Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assay
ChEMBL_1456657 (CHEMBL3370257) Agonist activity at human GABAAalpha2beta2gamma2S receptor expressed in tsA-201cells by FLIPR membrane potential blue assay
ChEMBL_1456659 (CHEMBL3370259) Agonist activity at human GABAAalpha3beta2gamma2S receptor expressed in tsA-201cells by FLIPR membrane potential blue assay
ChEMBL_494699 (CHEMBL938658) Displacement of [3H]MLA from rat alpha-7 nAChR/mouse 5HT3A chimera expressed in human tsA-201 cells
ChEMBL_143234 (CHEMBL752377) Binding affinity against nicotinic acetylcholine receptor alpha2-beta4 using [3H]epibatidine as radioligand expressed in HEK293 cells or tsA cells
ChEMBL_143411 (CHEMBL750054) Binding affinity against nicotinic acetylcholine receptor alpha3-beta4 using [3H]epibatidine as radioligand expressed in HEK293 cells or tsA cells
ChEMBL_143881 (CHEMBL751864) Binding affinity against nicotinic acetylcholine receptor alpha4-beta2 using [3H]epibatidine as radioligand expressed in HEK293 cells or tsA cells
ChEMBL_144019 (CHEMBL750434) Binding affinity against nicotinic acetylcholine receptor alpha4-beta4 using [3H]epibatidine as radioligand expressed in HEK293 cells or tsA cells
Cellular Firefly Luciferase Assay (AP-1) Curcumin is a known inhibitor of the AP-1 activation cascade. Therefore, modification of the structure of curcumin could lead to analogs with enhanced activity. The library consisting of three series of curcumin analogs were used to examine the role of the enone functionality in aryl systems where the spacer is 7-carbons (as in curcumin), 5-carbons or 3-carbons in length. In addition, the importance of aryl ring substituents was assessed. The AP-1 activities of curcumin and analogs were determined by a cellular firefly luciferase assay. This assay utilized a commercially available cell line (Panomics 293-luc cellular assay) developed for screening inhibitors of AP-1. This cell line is stably transfected with a luciferase reporter controlled by an AP-1 dependent promoter. The cell is stimulated with phorbol ester which activates AP-1. AP-1 then binds to one of three promoter regions on the cells DNA leading to the production of a luciferase enzyme. Luciferin is added to the cell lysates and the luciferase enzyme catalyzes a cleavage of luciferin leading to the emission of light.
ChEBML_1693686 Inhibition of human Cav3.2 alpha1H expressed in HEK tsA-201 cells at holding potential of -110 mV by whole cell patch clamp method
ChEMBL_1673553 (CHEMBL4023582) Displacement of [3H]-Diprenorphine from human mu opioid receptor expressed in HEK293-TSA cell membranes after 4 hrs by scintillation counting method
ChEMBL_1982621 (CHEMBL4615883) Inhibition of Trypanosoma brucei rhodesain in presence of curcumin using Cbz-Phe-Arg-AMC as substrate incubated for 30 mins by fluorometric assay
ChEMBL_1645342 (CHEMBL3994271) Inhibition of GFP-fused Cav3.2-alpha1 (unknown origin) expressed in human tsA-201 cells at holding potential of -110 mV by whole cell patch clamp method
ChEMBL_936603 (CHEMBL2318766) Displacement of [3H]MLA from rat nAChR alpha7 linked to ion channel portion of 5-HT3A receptor expressed in human tsA-201 cells after 2.5 hrs by scintillation counting analysis
Inhibition of MMPs It has been observed that 50 and 100 μM concentrations of curcumin decreased TNFα production by endotoxin-stimulated human monocytes (HMs) in culture by 80-90% (lower concentrations of curcumin, 10 and 20 μM, had no effect). However, this inhibitory effect was associated with some precipitation of the curcumin in cell culture and with significant cytotoxicity. It was hypothesized that increasing the solubility of curcumin will: (i) enhance its efficacy as an inhibitor of cytokine expression, (ii) reduce its cytotoxicity, and (iii) preserve (perhaps even enhance; see below) its potency, as an MMP inhibitor (MMPI) compound, which was found to be similar to that of the Zn++ chelating compound, 1,10-O-phenanthroline (FIG. 1). However, it should be noted that excessive inhibition of MMP activity may not be desirable therapeutically because a minimal, or basal, level of MMPs may be necessary for optimal defense of the host.
Thermal Shift Assay (TSA) The thermal shift assay (TSA) measurements were performed in a Corbett Rotor-Gene 6000 (QIAGEN Rotor-Gene Q, Sydney, Australia) instrument using the blue channel (excitation 365±20, detection 460±15 nm). Samples contained 10 μM protein, 0-200 μM compound, 50 mM solvatochromic dye ANS (8-anilino-1-naphthalene sulfonate) and 50mM phosphate buffer containing 100 mM NaCl at pH 7.0, with the final DMSO concentration at 2%. The applied heating rate was 1 °C/min. Data analysis was performed as previously described [Kazlauska et al., PLoS ONE, 7:e36899].
Thermal Shift Assay (TSA) In a typical TSA, 0.4 μg of BRD4 BD1 protein were mixed with 5× Sypro Orange (Molecular Probe) and adjusted to a final volume of 5 μl with 100 mM HEPES buffer, pH 7.5 (Applichem), and 150 mM NaCl (Sigma). For binding experiments, 1% DMSO (Sigma) or JQ1 in serial dilution (0.14 μM to 100 μM, 3-fold) was added to the mixture. To protect samples from evaporation, they were overlaid with 1 μl of silicone oil DC200 (Sigma). Melting curves were recorded using a ThermoFluor system (Johnson and Johnson Pharmaceutical Research and Development) after heating the samples from 25 up to 95 °C while measuring the fluorescence intensity of the dye with the excitation and emission filters set to 465 and 590 nm, respectively.
Cellular Firefly Luciferase Assay (NFkB) The NF-kB activities of curcumin and analogs were determined by a cellular firefly luciferase assay. This assay utilized a commercially available cell line (Panomics 293T-luc cellular assay) developed for screening inhibitors of NF-kB. This cell line is stably transfected with a luciferase reporter controlled by an NF-kB dependent promoter. The cell is stimulated with tumor necrosis factor alpha (TNFalpha) which activates NF-kB. NF-kB then binds to one of six promoter regions on the cell's DNA leading to the production of a luciferase enzyme. Luciferin is added to the cell lysates and the luciferase enzyme catalyzes a cleavage of luciferin leading to the emission of light.