447 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
Data
Article Title
Organization
Discovery of N-Substituted (2-Phenylcyclopropyl)methylamines as Functionally Selective Serotonin 2C Receptor Agonists for Potential Use as Antipsychotic Medications.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Illinois At Chicago
Utilization of an Active Site Mutant Receptor for the Identification of Potent and Selective Atypical 5-HT![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bristol-Myers Squibb
Scaffold Repurposing of Nucleosides (Adenosine Receptor Agonists): Enhanced Activity at the Human Dopamine and Norepinephrine Sodium Symporters.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
National Institute of Diabetes and Digestive and Kidney Diseases
(+/-) 3-Amino-6-carboxamido-1,2,3,4-tetrahydrocarbazole: a conformationally restricted analogue of 5-carboxamidotryptamine with selectivity for the serotonin 5-HT1D receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Smithkline Beecham Pharmaceuticals
Synthesis and alpha 2-adrenoceptor effects of substituted catecholimidazoline and catecholimidazole analogues in human platelets.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Ohio State University
Structure-activity relationships in potentially hallucinogenic N,N-dialkyltryptamines substituted in the benzene moiety.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Chemoenzymatic synthesis and binding affinity of novel (R)- and (S)-3-aminomethyl-1-tetralones, potential atypical antipsychotics.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universidad De Santiago De Compostela
New tetrahydrobenzindoles as potent and selective 5-HT(7) antagonists with increased In vitro metabolic stability.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Meiji Seika Kaisha
SB-656104-A: a novel 5-HT(7) receptor antagonist with improved in vivo properties.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Glaxosmithkline
Bicyclic piperazinylbenzenesulphonamides are potent and selective 5-HT6 receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Glaxosmithkline
Design and synthesis of novel 2,3-dihydro-1H-isoindoles with high affinity and selectivity for the dopamine D3 receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Smithkline Beecham Pharmaceuticals
Novel (4-piperazin-1-ylquinolin-6-yl) arylsulfonamides with high affinity and selectivity for the 5-HT(6) receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Glaxosmithkline
1,3-Biarylureas as selective non-peptide antagonists of the orexin-1 receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Glaxosmithkline
Pharmacological evaluation of a diarylmethylene-piperidine derivative: a new potent atypical antipsychotic?![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Ucb Pharma
1-[2-[(Heteroarylmethoxy)aryl]carbamoyl]indolines are selective and orally active 5-HT2C receptor inverse agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Smithkline Beecham Pharmaceuticals
1-[2-[(Heteroaryloxy)heteroaryl]carbamoyl]indolines: novel and selective 5-HT2C receptor inverse agonists with potential as antidepressant/anxiolytic agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Smithkline Beecham Pharmaceuticals
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Jagiellonian University Medical College
Discovery of dual positive allosteric modulators (PAMs) of the metabotropic glutamate 2 receptor and CysLT1 antagonists for treating migraine headache.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eli Lilly
Tetrahydroquinoline-based tricyclic amines as potent and selective agonists of the 5-HT![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Arena Pharmaceuticals
Decahydrobenzoquinolin-5-one sigma receptor ligands: Divergent development of both sigma 1 and sigma 2 receptor selective examples.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Kansas
Structure-Based Scaffold Repurposing for G Protein-Coupled Receptors: Transformation of Adenosine Derivatives into 5HT![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
National Institute of Diabetes and Digestive and Kidney Diseases
Synthesis and evaluation of the structural elements in alkylated tetrahydroisoquinolines for binding to CNS receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Florida A&M University
Development of CNS multi-receptor ligands: Modification of known D2 pharmacophores.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Florida A&M University
New halogenated tris-(phenylalkyl)amines as h5-HT2B receptor ligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
City University of New York
Synthesis, structure-activity relationships, and biological evaluation of a series of benzamides as potential multireceptor antipsychotics.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Shanghai Institute of Materia Medica
Optimization of N'-(arylsulfonyl)pyrazoline-1-carboxamidines by exploiting a novel interaction site in the 5-HT6 antagonistic binding pocket.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Abbott Healthcare Products
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Jagiellonian University Medical College
Further Advances in Optimizing (2-Phenylcyclopropyl)methylamines as Novel Serotonin 2C Agonists: Effects on Hyperlocomotion, Prepulse Inhibition, and Cognition Models.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Illinois At Chicago
Structure-Based Discovery of Novel and Selective 5-Hydroxytryptamine 2B Receptor Antagonists for the Treatment of Irritable Bowel Syndrome.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
National Institute of Biological Sciences, Beijing
Melatonergic ligands: Design, synthesis and pharmacological evaluation of novel series of naphthofuranic derivatives.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universit£
The influence of 5-HT(2A) activity on a 5-HT(2C) specific in vivo assay used for early identification of multiple acting SERT and 5-HT(2C) receptor ligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Gedeon Richter
Receptor binding profiles and quantitative structure-affinity relationships of some 5-substituted-N,N-diallyltryptamines.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
The Alexander Shulgin Research Institute
Selective Allosteric Antagonists for the G Protein-Coupled Receptor GPRC6A Based on the 2-Phenylindole Privileged Structure Scaffold.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Copenhagen
Synthesis and evaluation of aporphine analogs containing C1 allyl isosteres at the h5-HT(2A) receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
City University of New York
High Affinity Dopamine D3 Receptor (D3R)-Selective Antagonists Attenuate Heroin Self-Administration in Wild-Type but not D3R Knockout Mice.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
National Institute On Drug Abuse-Intramural Research Program
Synthesis and pharmacological evaluation of N-benzyl substituted 4-bromo-2,5-dimethoxyphenethylamines as 5-HT2A/2C partial agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Copenhagen
Semisynthetic Studies on and Biological Evaluation of N-Methyllaurotetanine Analogues as Ligands for 5-HT Receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
City University of New York
Design, Synthesis, and Evaluation of Tetrasubstituted Pyridines as Potent 5-HT2C Receptor Agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Cambridge
Optimization of 2-phenylcyclopropylmethylamines as selective serotonin 2C receptor agonists and their evaluation as potential antipsychotic agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Illinois At Chicago
Novel 5-HT6 receptor antagonists/D2 receptor partial agonists targeting behavioral and psychological symptoms of dementia.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Jagiellonian University Collegium Medicum
In vivo phenotypic screening for treating chronic neuropathic pain: modification of C2-arylethynyl group of conformationally constrained A3 adenosine receptor agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
National Institute of Diabetes and Digestive and Kidney Diseases
Novel 4-substituted-N,N-dimethyltetrahydronaphthalen-2-amines: synthesis, affinity, and in silico docking studies at serotonin 5-HT2-type and histamine H1 G protein-coupled receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Florida
Synthesis and biological evaluation of 4-nitroindole derivatives as 5-HT2A receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Ewha Womans University
Novel N-biphenyl-2-ylmethyl 2-methoxyphenylpiperazinylalkanamides as 5-HT7R antagonists for the treatment of depression.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Yonsei University
Synthesis and structure-activity relationships of new carbonyl guanidine derivatives as novel dual 5-HT2B and 5-HT7 receptor antagonists. Part 2.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Astellas Pharma
Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Glaxosmithkline
Targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors for developing effective antipsychotics: synthesis, biological characterization, and behavioral studies.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universit£
Novel aza-analogous ergoline derived scaffolds as potent serotonin 5-HT6 and dopamine D2 receptor ligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Copenhagen
Multiparameter optimization in CNS drug discovery: design of pyrimido[4,5-d]azepines as potent 5-hydroxytryptamine 2C (5-HT2C) receptor agonists with exquisite functional selectivity over 5-HT2A and 5-HT2B receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Pfizer
Novel arylsulfonamide derivatives with 5-HT6/5-HT7 receptor antagonism targeting behavioral and psychological symptoms of dementia.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Adamed
Lactam and oxazolidinone derived potent 5-hydroxytryptamine 6 receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Cephalon
Selective 5-HT Receptor Modulators May Deliver Focused Targeting with Fewer Adverse Effects.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Therachem Research Medilab (India)
Discovery of a tetracyclic quinoxaline derivative as a potent and orally active multifunctional drug candidate for the treatment of neuropsychiatric and neurological disorders.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Intra-Cellular Therapies
Diaryl substituted pyrrolidinones and pyrrolones as 5-HT2C inhibitors: synthesis and biological evaluation.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Glaxosmithkline
Discovery of disubstituted piperidines and homopiperidines as potent dual NK1 receptor antagonists-serotonin reuptake transporter inhibitors for the treatment of depression.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bristol-Myers Squibb
[11C]olanzapine, radiosynthesis and lipophilicity of a new potential PET 5-HT2 and D2 receptor radioligand.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Indiana University School of Medicine
Biotransformation of LASSBio-579 and pharmacological evaluation of p-hydroxylated metabolite a N-phenylpiperazine antipsychotic lead compound.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universidade Federal De Goi£S
Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT(2A)/5-HT(2C) receptor agonists with pro-cognitive properties.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Copenhagen
Synthesis and SAR of 2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-ones as 5-HT2C receptor agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bristol-Myers Squibb Research and Development
2-(Dimethylaminomethyl)-tetrahydroisoxazolopyridobenzazepine derivatives. Synthesis of a new 5-HT(2C) antagonist with potential anxiolytic properties.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Janssen-Cilag
Synthesis and serotonergic activity of benzofuran and dihydrogenzofuran analogues of 5-carboxamidotryptamine.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Novel imidazobenzazepine derivatives as dual H1/5-HT2A antagonists for the treatment of sleep disorders.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Glaxosmithkline
Synthesis and binding affinity of potential atypical antipsychotics with the tetrahydroquinazolinone motif.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universidad De Santiago De Compostela
The discovery of a selective, small molecule agonist for the MAS-related gene X1 receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Glaxosmithkline
Synthesis, binding affinity, and molecular docking analysis of new benzofuranone derivatives as potential antipsychotics.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universidad De Santiago De Compostela
Novel 5-HT(1A/1B/1D) receptors antagonists with potent 5-HT reuptake inhibitory activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Glaxosmithkline
Discovery of potent, orally bioavailable, selective 5-HT1A/B/D receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Glaxosmithkline
A series of bisaryl imidazolidin-2-ones has shown to be selective and orally active 5-HT2C receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Glaxosmithkline
Influence of the 5-HT6 receptor on acetylcholine release in the cortex: pharmacological characterization of 4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a potent and selective 5-HT6 receptor antagonist.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
F. Hoffmann-La Roche
The selective 5-HT1B receptor inverse agonist 1'-methyl-5-[[2'-methyl-4'-(5-methyl-1,2, 4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydro- spiro[furo[2,3-f]indole-3,4'-piperidine] (SB-224289) potently blocks terminal 5-HT autoreceptor function both in vitro and in vivo.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Smithkline Beecham Pharmaceuticals
Novel and selective partial agonists of 5-HT3 receptors. 2. Synthesis and biological evaluation of piperazinopyridopyrrolopyrazines, piperazinopyrroloquinoxalines, and piperazinopyridopyrroloquinoxalines.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universit£
Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universit£
Synthesis and serotonergic activity of N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine and analogues: potent agonists for 5-HT1D receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Sharp & Dohme Research Laboratories
Synthesis and serotonergic activity of 5-(oxadiazolyl)tryptamines: potent agonists for 5-HT1D receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Sharp and Dohme Research Laboratories
Synthesis and structure-activity relationship of 2-(aminoalkyl)-2,3,3a,8-tetrahydrodibenzo[c,f]isoxazolo[2,3-a]azepine derivatives: a novel series of 5-HT(2A/2C) receptor antagonists. Part 2.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Janssen-Cilag
Synthesis and structure-activity relationship of 2-(aminoalkyl)-2,3,3a,8-tetrahydrodibenzo[c,f]isoxazolo[2,3-a]azepine derivatives: a novel series of 5-HT(2A/2C) receptor antagonists. Part 1.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Janssen-Cilag
Phenyl benzenesulfonamides are novel and selective 5-HT6 antagonists: identification of N-(2,5-dibromo-3-fluorophenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide (SB-357134).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Smithkline Beecham Pharmaceuticals
As(1) receptor pharmacophore derived from a series of N-substituted 4-azahexacyclo[5.4.1.0(2,6).0(3,10).0(5,9).0(8,11)]dodecan-3-ols (AHDs).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
The University of Sydney
Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
H. Lundbeck
From a4ß2 Nicotinic Ligands to the Discovery of s1 Receptor Ligands: Pharmacophore Analysis and Rational Design.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Synthesis and structure-affinity relationships of selective high-affinity 5-HT(4) receptor antagonists: application to the design of new potential single photon emission computed tomography tracers.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universit£
Design, synthesis, and pharmacological evaluation of piperidin-4-yl amino aryl sulfonamides: novel, potent, selective, orally active, and brain penetrant 5-HT6 receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Suven Life Sciences
A Divergent SAR Study Allows Optimization of a Potent 5-HT2c Inhibitor to a Promising Antimalarial Scaffold.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Structure-functional selectivity relationship studies ofß-arrestin-biased dopamine D2 receptor agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of North Carolina At Chapel Hill
Life beyond kinases: structure-based discovery of sorafenib as nanomolar antagonist of 5-HT receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
National Institute of Biological Sciences
Benzothiazoles as probes for the 5HT1A receptor and the serotonin transporter (SERT): a search for new dual-acting agents as potential antidepressants.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Florida A&M University
Discovery of a novel melanin concentrating hormone receptor 1 (MCHR1) antagonist with reduced hERG inhibition.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Amgen
Radiosynthesis and evaluation of an (18)F-labeled positron emission tomography (PET) radioligand for brain histamine subtype-3 receptors based on a nonimidazole 2-aminoethylbenzofuran chemotype.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
National Institute of Mental Health
Melanin-concentrating hormone receptor 1 antagonists. Synthesis and structure-activity relationships of novel 3-(aminomethyl)quinolines.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Takeda Pharmaceutical
Rational Drug Design Leading to the Identification of a Potent 5-HT(2C) Agonist Lacking 5-HT(2B) Activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Synthesis and SAR study of 4-arylpiperidines and 4-aryl-1,2,3,6-tetrahydropyridines as 5-HT2C agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Monash University (Parkville Campus)
Syntheses of 2-amino and 2-halothiazole derivatives as high-affinity metabotropic glutamate receptor subtype 5 ligands and potential radioligands for in vivo imaging.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
National Institute of Mental Health
Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
H. Lundbeck
Synthesis and structure-affinity relationships of novel small molecule natural product derivatives capable of discriminating between serotonin 5-HT1A, 5-HT2A, 5-HT2C receptor subtypes.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of North Texas Health Science Center
Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Hunter College and The Graduate Center of The City University of New York
Indene-based scaffolds. 2. An indole-indene switch: discovery of novel indenylsulfonamides as 5-HT6 serotonin receptor agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universitat De Barcelona
Potential modes of interaction of 9-aminomethyl-9,10-dihydroanthracene (AMDA) derivatives with the 5-HT2A receptor: a ligand structure-affinity relationship, receptor mutagenesis and receptor modeling investigation.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Virginia Commonwealth University
High specific activity tritium-labeled N-(2-methoxybenzyl)-2,5-dimethoxy-4-iodophenethylamine (INBMeO): a high-affinity 5-HT2A receptor-selective agonist radioligand.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Purdue University
(Phenylpiperazinyl-butyl)oxindoles as selective 5-HT7 receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Egis Pharmaceuticals
Novel quinazolinone derivatives as 5-HT7 receptor ligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Institute of Science and Technology
Synthesis and structure-activity relationships of a series of benzazepine derivatives as 5-HT2C receptor agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Astellas Pharma
Synthesis and structure-activity relationships of a series of substituted 2-(1H-furo[2,3-g]indazol-1-yl)ethylamine derivatives as 5-HT2C receptor agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Astellas Pharma
A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Abbott Laboratories
Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: optimising brain penetration.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
F. Hoffmann-La Roche
2-Alkyl-4-aryl-pyrimidine fused heterocycles as selective 5-HT2A antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Johnson & Johnson Pharmaceutical Research and Development
Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
F. Hoffmann-La Roche
2,5-Disubstituted pyridines: the discovery of a novel series of 5-HT2A ligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Sharp and Dohme Research Laboratories
Quinazolinone derivatives as orally available ghrelin receptor antagonists for the treatment of diabetes and obesity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bayer Pharmaceuticals
1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Organix
Novel CCR1 antagonists with oral activity in the mouse collagen induced arthritis.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Novartis Institutes For Biomedical Research
2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universit£
Discovery of 5-arylsulfonamido-3-(pyrrolidin-2-ylmethyl)-1H-indole derivatives as potent, selective 5-HT6 receptor agonists and antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Wyeth Research
Selective optimization of side activities: another way for drug discovery.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Prestwick Chemical
Synthesis and structure-affinity relationship investigations of 5-heteroaryl-substituted analogues of the antipsychotic sertindole. A new class of highly selective alpha(1) adrenoceptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
H. Lundbeck
A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Alcon Research
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Virginia Commonwealth University
4-(Phenylsulfonyl)piperidines: novel, selective, and bioavailable 5-HT(2A) receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Sharp and Dohme Research Laboratories
Current and novel approaches to the drug treatment of schizophrenia.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Sharp and Dohme Research Laboratories
N-[3-(2-Dimethylaminoethyl)-2-methyl-1H- indol-5-yl]-4-fluorobenzamide: a potent, selective, and orally active 5-HT(1F) receptor agonist potentially useful for migraine therapy.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eli Lilly
New benzocycloalkylpiperazines, potent and selective 5-HT1A receptor ligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Cooperation Pharmaceutique Fran�Aise
Synthesis and pharmacological evaluation of 1-(aminomethyl)-3,4-dihydro-5-hydroxy-1H-2-benzopyrans as dopamine D1 selective ligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Abbott Laboratories
(+/-)8-Amino-5,6,7,8-tetrahydroisoquinolines as novel antinociceptive agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Virginia Commonwealth University
Identification of fused bicyclic heterocycles as potent and selective 5-HT(2A) receptor antagonists for the treatment of insomnia.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Arena Pharmaceuticals
Discovery of 7-arylsulfonyl-1,2,3,4, 4a,9a-hexahydro-benzo[4,5]furo[2,3-c]pyridines: identification of a potent and selective 5-HT6 receptor antagonist showing activity in rat social recognition test.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Cephalon
Structure-activity relationship studies of SYA 013, a homopiperazine analog of haloperidol.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Florida A&M University
Design, synthesis and pharmacological evaluation of new series of naphthalenic analogues as melatoninergic (MT1/MT2) and serotoninergic 5-HT2C dual ligands (I).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Lille
5-HT2c receptor selectivity and structure-activity relationship of N-methyl-N-(1-methylpiperidin-4-yl)benzenesulfonamide analogs.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Korea Institute of Science and Technology
N'-(arylsulfonyl)pyrazoline-1-carboxamidines as novel, neutral 5-hydroxytryptamine 6 receptor (5-HT6R) antagonists with unique structural features.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Abbott Healthcare Products
CNS and antimalarial activity of synthetic meridianin and psammopemmin analogs.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of South Florida
Design and synthesis of novel arylpiperazine derivatives containing the imidazole core targeting 5-HT(2A) receptor and 5-HT transporter.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Green Cross
Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles as dual serotonin 5-HT2C and 5-HT6 receptor ligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Copenhagen
Pyrimido[4,5-d]azepines as potent and selective 5-HT2C receptor agonists: design, synthesis, and evaluation of PF-3246799 as a treatment for urinary incontinence.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Pfizer
Identification of 3-sulfonylindazole derivatives as potent and selective 5-HT(6) antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Wyeth Research
Novel 6,7,8,9-tetrahydro-5H-1,4,7,10a-tetraaza-cyclohepta[f]indene analogues as potent and selective 5-HT(2C) agonists for the treatment of metabolic disorders.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Evotec
1-(Arylsulfonyl)-2,3-dihydro-1H-quinolin-4-one derivatives as 5-HT(6) serotonin receptor ligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Korea Research Institute of Chemical Technology
Conformationally restricted homotryptamines. Part 7: 3-cis-(3-aminocyclopentyl)indoles as potent selective serotonin reuptake inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bristol-Myers Squibb
5-Piperazinyl-3-sulfonylindazoles as potent and selective 5-hydroxytryptamine-6 antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Wyeth Research
Arylpiperazine-containing pyrimidine 4-carboxamide derivatives targeting serotonin 5-HT(2A), 5-HT(2C), and the serotonin transporter as a potential antidepressant.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Green Cross
Exploring the neuroleptic substituent in octoclothepin: potential ligands for positron emission tomography with subnanomolar affinity fora(1)-adrenoceptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Copenhagen
Synthesis, structure-affinity relationships, and radiolabeling of selective high-affinity 5-HT4 receptor ligands as prospective imaging probes for positron emission tomography.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
National Institute of Mental Health
Spiroindolones, a potent compound class for the treatment of malaria.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Swiss Tropical and Public Health Institute
N-tetrahydrothiochromenoisoxazole-1-carboxamides as selective antagonists of cloned human 5-HT2B.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Csiro Molecular and Health Technologies
Synthesis and SAR of (piperazin-1-yl-phenyl)-arylsulfonamides: a novel series of atypical antipsychotic agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Korea Research Institute of Chemical Technology
Synthesis and in vivo evaluation of phenethylpiperazine amides: selective 5-hydroxytryptamine(2A) receptor antagonists for the treatment of insomnia.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Arena Pharmaceuticals
Further optimization of novel pyrrole 3-carboxamides for targeting serotonin 5-HT(2A), 5-HT(2C), and the serotonin transporter as a potential antidepressant.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Green Cross
Non-basic ligands for aminergic GPCRs: the discovery and development diaryl sulfones as selective, orally bioavailable 5-HT2A receptor antagonists for the treatment of sleep disorders.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Sharp & Dohme
Discovery and structure-activity relationship of 3-methoxy-N-(3-(1-methyl-1H-pyrazol-5-yl)-4-(2-morpholinoethoxy)phenyl)benzamide (APD791): a highly selective 5-hydroxytryptamine2A receptor inverse agonist for the treatment of arterial thrombosis.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Arena Pharmaceuticals
8-Sulfonyl-substituted tetrahydro-1H-pyrido[4,3-b]indoles as 5-HT6 receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Chemical Diversity Research Institute
Synthesis and biological evaluation of 3-aminopyrrolidine derivatives as CC chemokine receptor 2 antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Yangji Chemicals
Orally active and brain permeable proline amides as highly selective 5HT2c agonists for the treatment of obesity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Pfizer
Arylpiperazine-containing pyrrole 3-carboxamide derivatives targeting serotonin 5-HT(2A), 5-HT(2C), and the serotonin transporter as a potential antidepressant.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Green Cross
Identification of piperazine-bisamide GHSR antagonists for the treatment of obesity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Amgen
Tricyclic dihydroquinazolinones as novel 5-HT2C selective and orally efficacious anti-obesity agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bristol-Myers Squibb
Synthesis and biological evaluation of (phenylpiperazinyl-propyl)arylsulfonamides as selective 5-HT(2A) receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Ewha Womans University
Design and synthesis of orally-active and selective azaindane 5HT2c agonist for the treatment of obesity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Pfizer
Novel delta opioid receptor agonists exhibit differential stimulation of signaling pathways.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School and The Informatics Institute of Umdnj
Design and synthesis of piperazinylpyrimidinones as novel selective 5-HT(2C) agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Pfizer
Solubilized phenyl-pyrazole ureas as potent, selective 5-HT(2A) inverse-agonists and their application as antiplatelet agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Arena Pharmaceuticals
Discovery of a novel azepine series of potent and selective 5-HT2C agonists as potential treatments for urinary incontinence.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Pfizer
Novel 1-aminoethyl-3-arylsulfonyl-1H-pyrrolo[2,3-b]pyridines are potent 5-HT(6) agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Wyeth Research
Identification of novel indanylsulfonamide guanylhydrazones as potent 5-HT6 serotonin receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universitat De Barcelona
Special ergolines are highly selective, potent antagonists of the chemokine receptor CXCR3: discovery, characterization and preliminary SAR of a promising lead.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Novartis Institutes For Biomedical Research
Identification of novel serotonin 2C receptor ligands by sequential virtual screening.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Institute of Science and Technology
(Dipropylamino)-tetrahydronaphthofurans: centrally acting serotonin agonists and dopamine agonists-antagonists![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
The synthesis and biological activity of some known and putative metabolites of the atypical antipsychotic agent olanzapine (LY170053)![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
5-O-Carboxymethyl piperazide derivatives of serotonin: a new class of potent and selective 5-HT1D receptor agonists![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
The discovery of CP-96,021 and CP-96,486, balanced, combined, potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
Synthesis and in vitro affinities of various MDL 100907 derivatives as potential 18F-radioligands for 5-HT2A receptor imaging with PET.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Institute of Nuclear Chemistry Johannes Gutenberg-University Mainz
Selective 5-hydroxytryptamine 2C receptor agonists derived from the lead compound tranylcypromine: identification of drugs with antidepressant-like action.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Illinois At Chicago
7-Sulfonamido-3-benzazepines as potent and selective 5-HT2C receptor agonists: hit-to-lead optimization.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Pfizer
Synthesis and evaluation of ligands for D2-like receptors: the role of common pharmacophoric groups.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Florida A&M University
Structure-activity relationships for a novel series of dopamine D2-like receptor ligands based on N-substituted 3-aryl-8-azabicyclo[3.2.1]octan-3-ol.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
National Institute On Drug Abuses
Derivatives of (3S)-N-(biphenyl-2-ylmethyl)pyrrolidin-3-amine as selective noradrenaline reuptake inhibitors: Reducing P-gp mediated efflux by modulation of H-bond acceptor capacity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Pfizer
Synthesis and structure-activity relationship of 1H-indole-3-carboxylic acid pyridine-3-ylamides: a novel series of 5-HT2C receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Korea Research Institute of Chemical Technology
Identification of a butyrophenone analog as a potential atypical antipsychotic agent: 4-[4-(4-chlorophenyl)-1,4-diazepan-1-yl]-1-(4-fluorophenyl)butan-1-one.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Florida A&M University
A regiospecific synthesis of a series of 1-sulfonyl azepinoindoles as potent 5-HT6 ligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Wyeth Research
Urotensin-II receptor antagonists: synthesis and SAR of N-cyclic azaalkyl benzamides.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Glaxosmithkline
Preparation of piperazine derivatives as 5-HT7 receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Ewha Womans University
Brominated cyclodipeptides from the marine sponge Geodia barretti as selective 5-HT ligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Uppsala University
New antiinfective and human 5-HT2 receptor binding natural and semisynthetic compounds from the Jamaican sponge Smenospongia aurea.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
The University of Mississippi
Discovery of 3-aryl-3-methyl-1H-quinoline-2,4-diones as a new class of selective 5-HT6 receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Korea Research Institute of Chemical Technology
Heterocyclic analogues of N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)arylcarboxamides with functionalized linking chains as novel dopamine D3 receptor ligands: potential substance abuse therapeutic agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
National Institute On Drug Abuse-Intramural Research Program
Synthesis and simple 18F-labeling of 3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethynyl)benzonitrile as a high affinity radioligand for imaging monkey brain metabotropic glutamate subtype-5 receptors with positron emission tomography.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
National Institute of Mental Health
3-Arylamino-2H-1,2,4-benzothiadiazin-5-ol 1,1-dioxides as novel and selective CXCR2 antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Glaxosmithkline
Design and synthesis of novel hydantoin-containing melanin-concentrating hormone receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Cerep
Discovery of (R)-9-ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol- 6(2H)-one, a selective, orally active agonist of the 5-HT(2C) receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Pharmaceutical Research Institute
Novel pyrazolopiperazinone- and pyrrolopiperazinone-based MCH-R1 antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Procter and Gamble Pharmaceuticals
Aminomethyl tetrahydronaphthalene biphenyl carboxamide MCH-R1 antagonists--Increasing selectivity over hERG.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Procter & Gamble Pharmaceuticals
Identification and optimisation of 5-amino-7-aryldihydro-1,4-diazepines as 5-HT2A ligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Sharp and Dohme Research Laboratories
Design and synthesis of substituted quinolines as novel and selective melanin concentrating hormone antagonists as anti-obesity agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Procter and Gamble Pharmaceuticals
The design and synthesis of a tricyclic single-nitrogen scaffold that serves as a 5-HT2C receptor agonist.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Athersys
Discovery of a novel, orally active, small molecule gonadotropin-releasing hormone (GnRH) receptor antagonist.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Pfizer
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Predix Pharmaceuticals
Evaluation of the eutomer of 4-{3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl}-1-(4-fluorophenyl)butan-1-one, {(+)-SYA 09}, a pyrrolidine analog of haloperidol.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Florida A&M University
The identification of pyrimidine-diazabicyclo[3.3.0]octane derivatives as 5-HT2C receptor agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Athersys
1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Alcon Research
Synthesis and in vivo validation of [O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)piperazin- 1-yl]butyl}-4-methyl-2H-[1,2,4]triazine-3,5-dione: a novel 5-HT1A receptor agonist positron emission tomography ligand.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Columbia University College of Physicians and Surgeons
Synthesis and biological evaluation of novel hexahydro-pyrido[3',2':4,5]pyrrolo[1,2-a]pyrazines as potent and selective 5-HT(2C) receptor agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
F. Hoffmann-La Roche
Synthesis and SAR of highly potent dual 5-HT1A and 5-HT1B antagonists as potential antidepressant drugs.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Abbott
Synthesis of potent and selective serotonin 5-HT1B receptor ligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Columbia University College of Physicians and Surgeons
Improving the treatment of Parkinson's disease: Structure-based development of novel 5-HT![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Yantai University
6-Acylamino-2-aminoquinolines as potent melanin-concentrating hormone 1 receptor antagonists. Identification, structure-activity relationship, and investigation of binding mode.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
7Tm Pharma
2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT6 receptor agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Carlsson Research
4-Fluorosulfonylpiperidines: selective 5-HT2A ligands for the treatment of insomnia.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Sharp and Dohme Research Laboratories
Identification of 4-methyl-1,2,3,4,10,10a-hexahydropyrazino[1,2-a]indoles as 5-HT2C receptor agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Vernalis Research
Novel 2-N,N-dimethylaminomethyl-2,3,3a,12b-tetrahydrodibenzo[b,f]furo[2,3-d]oxepin derivatives displaying combined norepinephrine reuptake inhibition and 5-HT2A/2C receptor antagonism.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Janssen-Cilag
Distal kinetic deuterium isotope effect: Phenyl ring deuteration attenuates N-demethylation of Lu AF35700.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
H. Lundbeck
Functionalized quinoxalinones as privileged structures with broad-ranging pharmacological activities.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Central South University
Discovery of a new series of centrally active tricyclic isoxazoles combining serotonin (5-HT) reuptake inhibition with alpha2-adrenoceptor blocking activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Janssen-Cilag
Discovery of new tetracyclic tetrahydrofuran derivatives as potential broad-spectrum psychotropic agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Johnson & Johnson Pharmaceutical Research & Development
Positron Emission Tomography (PET) Imaging Tracers for Serotonin Receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Beijing Normal University
Alzheimer's disease: Updated multi-targets therapeutics are in clinical and in progress.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Guizhou Medical University
Discovery and SAR of new benzazepines as potent and selective 5-HT(2C) receptor agonists for the treatment of obesity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Arena Pharmaceuticals
Structure-Activity Relationship and Neuroprotective Activity of 1,5-Dihydro-2![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
National Institute of Diabetes and Digestive and Kidney Diseases
N1-arylsulfonyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives are potent and selective 5-HT6 receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Wyeth Research
Improved 5-HT2 Selective Receptor Modulators for the Treatment of Psychological Disorders.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Usona Institute
Bridged Piperidine Analogues of a High Affinity Naphthalene-Based P2Y![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
National Institute of Diabetes and Digestive and Kidney Diseases
Discovery of G Protein-Biased Ligands against 5-HT![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Korea Institute of Science and Technology
Diaminopyrimidine and diaminopyridine 5-HT7 ligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bristol-Myers Squibb Pharmaceutical Research Institute
Structure-activity relationships of a novel series of melanin-concentrating hormone (MCH) receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Argenta Discovery
Structure-Based Design and Optimization of FPPQ, a Dual-Acting 5-HT![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Jagiellonian University Medical College
Synthesis and structure-activity relationship of 2-(aminoalkyl)-3,3a,8,12b-tetrahydro-2H-dibenzocyclohepta[1,2-b]furan derivatives: a novel series of 5-HT(2A/2C) receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Janssen-Cilag
Cycloalkyl[b][1,4]benzodiazepinoindoles are agonists at the human 5-HT2C receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Wyeth Research
Synthesis and biological evaluation of 1-(4-(piperazin-1-yl)phenyl)pyridin-2(1H)-one derivatives as potential SSRIs.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Sunshine Lake Pharma
Structural determinants for high 5-HT(2A) receptor affinity of spiro[9,10-dihydroanthracene]-9,3(')-pyrrolidine (SpAMDA).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Virginia Commonwealth University
Design, synthesis and biological evaluation of pyridinylmethylenepiperidine derivatives as potent 5-HT![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Sunshine Lake Pharma
Discovery of G Protein-Biased Antagonists against 5-HT![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Korea Institute of Science and Technology
Binding of beta-carbolines at 5-HT(2) serotonin receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Virginia Commonwealth University
Radioligand and computational insight in structure - Activity relationship of saccharin derivatives being ipsapirone and revospirone analogues.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Cracow University of Technology
1H-Pyrazolo-[3,4-c]cyclophepta[1,2-c]thiophenes: a unique structural class of dopamine D4 selective ligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Neurogen
Discovery of a new class of multi-target heterocycle piperidine derivatives as potential antipsychotics with pro-cognitive effect.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Huazhong University of Science and Technology
New dual 5-HT1A and 5-HT7 receptor ligands derived from SYA16263.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Florida A&M University
Novel potent 5-HT(1F) receptor agonists: structure-activity studies of a series of substituted N-[3-(1-methyl-4-piperidinyl)-1H-pyrrolo[3,2-b]pyridin-5-yl]amides.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eli Lilly
2,3,4,5-tetrahydro- and 2,3,4,5,11,11a-hexahydro-1H-[1,4]diazepino[1,7-a]indoles: new templates for 5-HT(2C) agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Pharmacia
Semisynthetic preparation of amentoflavone: A negative modulator at GABA(A) receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Sydney
Identification of a novel series of selective 5-HT7 receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Glaxosmithkline
Novel, highly potent, selective 5-HT2A/D2 receptor antagonists as potential atypical antipsychotics.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bristol-Myers Squibb
Synthesis and pharmacological evaluation of piperidine (piperazine)-amide substituted derivatives as multi-target antipsychotics.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Jiangsu Ocean University
New benzo[h][1,6]naphthyridine and azepino[3,2-c]quinoline derivatives as selective antagonists of 5-HT4 receptors: binding profile and pharmacological characterization.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Université
Development of a presynaptic 5-HT1A antagonist.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bristol-Myers Squibb Pharmaceutical Research Institute
Yohimbine as a Starting Point to Access Diverse Natural Product-Like Agents with Re-programmed Activities against Cancer-Relevant GPCR Targets.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Florida
Design, synthesis, and pharmacological evaluation of multitarget-directed ligands with both serotonergic subtype 4 receptor (5-HT4R) partial agonist and 5-HT6R antagonist activities, as potential treatment of Alzheimer's disease.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Normandie Universit£
Synthesis and evaluation of 5-HT(2A) and 5-HT(2C) receptor binding affinities of novel pyrimidine derivatives.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Egis Pharmaceuticals
Homoazanicotine: a structure-affinity study for nicotinic acetylcholine (nACh) receptor binding.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universita Di Camerino
Novel (R)-6,6a,7,8,9,10-hexahydro-5H-pyrazino[1,2-a][1,n]naphthyridines as potent and selective agonists of the 5-HT![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Arena Pharmaceuticals
Ifenprodil Stereoisomers: Synthesis, Absolute Configuration, and Correlation with Biological Activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Westf£Lische Wilhelms-Universit£T M£Nster
Discovery of Potent and Brain-Penetrant GPR52 Agonist that Suppresses Psychostimulant Behavior.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Texas Medical Branch
Structure activity relationship of novel antiviral nucleosides against Enterovirus A71.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
National Institute of Diabetes and Digestive and Kidney Disease
Synthesis, receptor potency, and selectivity of halogenated diphenylpiperidines as serotonin 5-HT2A ligands for PET or SPECT brain imaging.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Yale University
A study of the structure-affinity relationship in SYA16263; is a D![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Florida A&M University
Design and Discovery of Functionally Selective Serotonin 2C (5-HT![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Illinois At Chicago
Discovery and SAR studies of 2-alkyl-3-phenyl-2,4,5,6,7,8-hexahydropyrazolo[3,4-d]azepines as 5-HT![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Janssen Research & Development
Evaluation of isotryptamine derivatives at 5-HT(2) serotonin receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Virginia Commonwealth University
Structure activity relationship exploration of 5-hydroxy-2-(3-phenylpropyl)chromones as a unique 5-HT![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Kalamazoo College
Conformationally restricted indolopiperidine derivatives as potent CCR2B receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Glaxosmithkline
Synthesis and biological evaluation of thioadatanserin and its dialkylated products as partial 5-HTR![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Dominican College
Synthesis of potent and selective dopamine D(4) antagonists as candidate radioligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Columbia University College of Physicians and Surgeons
3-(4-Fluoropiperidin-3-yl)-2-phenylindoles as high affinity, selective, and orally bioavailable h5-HT(2A) receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Sharp and Dohme Research Laboratories
Synthesis and biological investigation of triazolopyridinone derivatives as potential multireceptor atypical antipsychotics.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Chinese Academy of Sciences
Isolation and Synthesis of Veranamine, an Antidepressant Lead from the Marine Sponge ![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Mississippi
Evaluation of anti-depressant effects of phthalazinone-based triple-acting small molecules against 5-HT![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Korea Institute of Science and Technology
2-Aryl tryptamines: selective high-affinity antagonists for the h5-HT2A receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Sharp & Dohme Research Laboratories
Synthesis and 5-hydroxytryptamine (5-HT) activity of 2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5-(6H)ones and 2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoxalines.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Wyeth-Ayerst Research
Highly Selective Dopamine D3 Receptor (D3R) Antagonists and Partial Agonists Based on Eticlopride and the D3R Crystal Structure: New Leads for Opioid Dependence Treatment.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
National Institute On Drug Abuse-Intramural Research Program
Pyrrolo[3,2,1-ij]quinoline derivatives, a 5-HT2c receptor agonist with selectivity over the 5-HT2a receptor: potential therapeutic applications for epilepsy and obesity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Nps Allelix
Novel phenylpiperazine derivatives as dual cytokine regulators with TNF-alpha suppressing and IL-10 augmenting activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Yoshitomi Pharmaceutical Industries
Selective 5-HT2C receptor agonists: Design and synthesis of pyridazine-fused azepines.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Pfizer
Identification of dual role of piperazine-linked phenyl cyclopropyl methanone as positive allosteric modulator of 5-HT![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Csir-Central Drug Research Institute (Csir-Cdri)
Biarylcarbamoylindolines are novel and selective 5-HT(2C) receptor inverse agonists: identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Smithkline Beecham Pharmaceuticals
Investigation of Novel Primary and Secondary Pharmacophores and 3-Substitution in the Linking Chain of a Series of Highly Selective and Bitopic Dopamine D![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
National Institute On Drug Abuse-Intramural Research Program
Identification of a novel DGK? inhibitor for XLP-1 therapy by virtual screening.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Piemonte Orientale
Design and Synthesis of Bitopic 2-Phenylcyclopropylmethylamine (PCPMA) Derivatives as Selective Dopamine D3 Receptor Ligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Shanghaitech University
N-Substituted (2,3-dihydro-1,4-benzodioxin-2-yl)methylamine derivatives as D(2) antagonists/5-HT(1A) partial agonists with potential as atypical antipsychotic agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Knoll Pharmaceuticals
Leveraging a Low-Affinity Diazaspiro Orthosteric Fragment to Reduce Dopamine D![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Pennsylvania
Multi-targeting protein-protein interaction inhibitors: Evolution of macrocyclic ligands with embedded carbohydrates (MECs) to improve selectivity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
National University of Ireland Galway
Thieno[3,2-b]- and thieno[2,3-b]pyrrole bioisosteric analogues of the hallucinogen and serotonin agonist N,N-dimethyltryptamine.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Purdue University
Identification of fluorinated (R)-(-)-aporphine derivatives as potent and selective ligands at serotonin 5-HT![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Harvard Medical School
Design of fluorinated cyclopropane derivatives of 2-phenylcyclopropylmethylamine leading to identification of a selective serotonin 2C (5-HT![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Illinois At Chicago
A novel (benzodifuranyl)aminoalkane with extremely potent activity at the 5-HT2A receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Purdue University
Synthesis and serotonin receptor affinities of a series of trans-2-(indol-3-yl)cyclopropylamine derivatives.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Purdue University
Research progress in the biological activities of 3,4,5-trimethoxycinnamic acid (TMCA) derivatives.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Northwest University
Substituted naphthofurans as hallucinogenic phenethylamine-ergoline hybrid molecules with unexpected muscarinic antagonist activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Purdue University
Novel benzothiazolin-2-one and benzoxazin-3-one arylpiperazine derivatives with mixed 5HT1A/D2 affinity as potential atypical antipsychotics.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Institut De Chimie Pharmaceutique Albert Lespagnol
Selective, orally active 5-HT1D receptor agonists as potential antimigraine agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Merck Sharp and Dohme Research Laboratories
Dihydrobenzofuran analogues of hallucinogens. 4. Mescaline derivatives.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Purdue University
[[(Arylpiperazinyl)alkyl]thio]thieno[2,3-d]pyrimidinone derivatives as high-affinity, selective 5-HT1A receptor ligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Università
Synthesis and biological evaluation of new multi-target 3-(1H-indol-3-yl)pyrrolidine-2,5-dione derivatives with potential antidepressant effect.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Medical University of Warsaw
Design, Synthesis, and Characterization of 4-Undecylpiperidine-2-carboxamides as Positive Allosteric Modulators of the Serotonin (5-HT) 5-HT![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
TBA
3-Amino-chromanes and Tetrahydroquinolines as Selective 5-HT![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Minnesota Twin Cities
Dihydrobenzofuran analogues of hallucinogens. 3. Models of 4-substituted (2,5-dimethoxyphenyl)alkylamine derivatives with rigidified methoxy groups.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Purdue University
Benzazaborinines as Novel Bioisosteric Replacements of Naphthalene: Propranolol as an Example.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Janssen Pharmaceutica
Synthesis and pharmacological evaluation of optically pure, novel carbonyl guanidine derivatives as dual 5-HT2B and 5-HT7 receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Astellas Pharma
Imaging evaluation of 5HT2C agonists, [(11)C]WAY-163909 and [(11)C]vabicaserin, formed by Pictet-Spengler cyclization.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Harvard Medical School
Synthesis and pharmacological evaluation of new N-phenylpiperazine derivatives designed as homologues of the antipsychotic lead compound LASSBio-579.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universidade Federal Do Rio De Janeiro
Synthesis and SAR of potent and selective tetrahydropyrazinoisoquinolinone 5-HT(2C) receptor agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bristol-Myers Squibb Research and Development
Synthesis and pharmacological properties of novel hydrophilic 5-HT4 receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Drug Discovery Laboratory
Discovery and structure-activity relationship of (1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a selective serotonin 5-HT2C receptor agonist for the treatment of obesity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Arena Pharmaceuticals
Synthesis and binding affinity of new pyrazole and isoxazole derivatives as potential atypical antipsychotics.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universidad De Santiago De Compostela
3,4-Dihydro-2H-benzoxazinones as dual-acting 5-HT1A receptor antagonists and serotonin reuptake inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Glaxosmithkline
Principal component analysis differentiates the receptor binding profiles of three antipsychotic drug candidates from current antipsychotic drugs.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Solvay Pharma
5-HT2C antagonists based on fused heterotricyclic templates: design, synthesis and biological evaluation.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Glaxosmithkline
Isoindolone derivatives, a new class of 5-HT2C antagonists: synthesis and biological evaluation.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Glaxosmithkline Medicine Research Centre
SAR of biphenyl carboxamide ligands of the human melanin-concentrating hormone receptor 1 (MCH R1): discovery of antagonist SB-568849.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Glaxosmithkline
Discovery of the first potent, selective 5-hydroxytryptamine1D receptor antagonist.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Glaxosmithkline
Discovery of a potent and selective 5-ht5A receptor antagonist by high-throughput chemistry.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Glaxosmithkline
A novel ergot alkaloid as a 5-HT(1A) inhibitor produced by Dicyma sp.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Glaxosmithkline R&D
2a-[4-(Tetrahydropyridoindol-2-yl)butyl]tetrahydrobenzindole derivatives: new selective antagonists of the 5-hydroxytryptamine7 receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Meiji Seika Kaisha
Discovery of 4-[3-(trans-3-dimethylaminocyclobutyl)-1H-indol-5-ylmethyl]-(4S)-oxazolidin-2-one (4991W93), a 5HT(1B/1D) receptor partial agonist and a potent inhibitor of electrically induced plasma extravasation.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Glaxowellcome
Conformationally constrained butyrophenones with mixed dopaminergic (D(2)) and serotoninergic (5-HT(2A), 5-HT(2C)) affinities: synthesis, pharmacology, 3D-QSAR, and molecular modeling of (aminoalkyl)benzo- and -thienocycloalkanones as putative atypical antipsychotics.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Universidad De Santiago
Novel and selective 5-HT2C/2B receptor antagonists as potential anxiolytic agents: synthesis, quantitative structure-activity relationships, and molecular modeling of substituted 1-(3-pyridylcarbamoyl)indolines.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Smithkline Beecham Pharmaceuticals
Novel agonists of 5HT2C receptors. Synthesis and biological evaluation of substituted 2-(indol-1-yl)-1-methylethylamines and 2-(indeno[1,2-b]pyrrol-1-yl)-1-methylethylamines. Improved therapeutics for obsessive compulsive disorder.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
F. Hoffmann-La Roche
(+)-cis-4,5,7a,8,9,10,11,11a-octahydro-7H-10-methylindolo[1,7- bc][2,6]-naphthyridine: a 5-HT2C/2B receptor antagonist with low 5-HT2A receptor affinity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Sandoz Pharma
Analogs of penfluridol as chemotherapeutic agents with reduced central nervous system activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Texas Tech University Health Sciences Center
Synthesis and biological evaluation of a series of multi-target N-substituted cyclic imide derivatives with potential antipsychotic effect.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Shanghai Institute of Materia Medica
Synthesis and biological evaluation of new naphtho- and quinolinocyclopentane derivatives as potent melatoninergic (MT![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Univ. Lille
Discovery of ?-Arrestin Biased Ligands of 5-HT![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Korea Institute of Science and Technology
Modulating the Serotonin Receptor Spectrum of Pulicatin Natural Products.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of The Philippines
Synthesis and biological evaluation of a series of novel pyridinecarboxamides as potential multi-receptor antipsychotic drugs.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Chinese Academy of Sciences
Investigating isoindoline, tetrahydroisoquinoline, and tetrahydrobenzazepine scaffolds for their sigma receptor binding properties.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
University of Texas At Austin
3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Pfizer
Identification of selective 8-(piperidin-4-yloxy)quinoline sulfone and sulfonamide histamine H![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Glaxosmithkline
Identification of highly selective and potent orexin receptor 1 antagonists derived from a dual orexin receptor 1/2 antagonist based on the structural framework of pyrazoylethylbenzamide.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Taisho Pharmaceutical
Synthesis and biological investigation of tetrahydropyridopyrimidinone derivatives as potential multireceptor atypical antipsychotics.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Xinjiang Technical Institute of Physics and Chemistry
Hydrophilic, Potent, and Selective 7-Substituted 2-Aminoquinolines as Improved Human Neuronal Nitric Oxide Synthase Inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Northwestern University
Natural-Products-Inspired Use of the gem-Dimethyl Group in Medicinal Chemistry.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
St. John'S University
Conformational properties of semirigid antipsychotic drugs: the pharmacophore for dopamine D-2 antagonist activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Harvard Medical School
1-(2-Aminoethyl)-3-methyl-8,9-dihydropyrano[3,2-e]indole: a rotationally restricted phenolic analog of the neurotransmitter serotonin and agonist selective for serotonin (5-HT2-type) receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Pfizer
Novel indolodioxanes with antihypertensive effects: potent ligands for the 5-HT1A receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Upjohn
Synthesis, antielastase, antioxidant and radical scavenging activities of 4-(aza substituted) methylene substituted dihydroxy coumarines.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Giresun University
Synthesis, Biological Evaluation, and Molecular Docking of 8-imino-2-oxo-2H,8H-pyrano[2,3-f]chromene Analogs: New Dual AChE Inhibitors as Potential Drugs for the Treatment of Alzheimer's Disease.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Yogi Vemana University
The Synthesis of 1,3,5-triazine Derivatives and JNJ7777120 Analogues with Histamine H4 Receptor Affinity and Their Interaction with PTEN Promoter.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Jagiellonian University Medical College
Inhibition of Zinc-Dependent Histone Deacetylases with a Chemically Triggered Electrophile.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Broad Institute
Inhibition of isoleucyl-tRNA synthetase as a potential treatment for human African Trypanosomiasis.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
University of Washington
Synthesis and anti-acetylcholinesterase activity of scopoletin derivatives.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Chulabhorn Research Institute
Synthesis, Antifolate and Anticancer Activities of N(5) -Substituted 8,10-Dideazatetrahydrofolate Analogues.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Peking University
One-pot synthesis of tetrazole-1,2,5,6-tetrahydronicotinonitriles and cholinesterase inhibition: Probing the plausible reaction mechanism via computational studies.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
University of Karachi
Pyridine sulfonamide as a small key organic molecule for the potential treatment of type-II diabetes mellitus and Alzheimer's disease: In vitro studies against yeast a-glucosidase, acetylcholinesterase and butyrylcholinesterase.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Gc University
Design, Synthesis, Biological Evaluation, and Docking Study of Acetylcholinesterase Inhibitors: New Acridone-1,2,4-oxadiazole-1,2,3-triazole Hybrids.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Tehran University of Medical Sciences
Phosphorylation of Capsaicinoid Derivatives Provides Highly Potent and Selective Inhibitors of the Transcription Factor STAT5b.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
University of Leipzig
Structure and Inhibition of Microbiome ß-Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
University of North Carolina At Chapel Hill
Monoamine oxidase inhibitory activity of 2-aryl-4H-chromen-4-ones.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Birla Institute of Technology
Organocatalyzed solvent free an efficient novel synthesis of 2,4,5-trisubstituted imidazoles for a-glucosidase inhibition to treat diabetes.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Comsats Institute of Information Technology
Resolution, configurational assignment, and enantiopharmacology at glutamate receptors of 2-amino-3-(3-carboxy-5-methyl-4-isoxazolyl)propionic acid (ACPA) and demethyl-ACPA.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
The Royal Danish School of Pharmacy
Characterization of I2 imidazoline and sigma binding sites in the rat and human stomach.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
University of Bonn
A-85380 [3-(2(S)-azetidinylmethoxy) pyridine]: in vitro pharmacological properties of a novel, high affinity alpha 4 beta 2 nicotinic acetylcholine receptor ligand.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Abbott Laboratories
In vitro and in vivo pharmacological characterization of N6-cyclopentyl-9-methyladenine (N-0840): a selective, orally active A1 adenosine receptor antagonist.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Whitby Research
(S)-3-methyl-5-(1-methyl-2-pyrrolidinyl) isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: I. In vitro characterization.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Abbott Laboratories
Molecular cloning and characterization of a rat brain cDNA encoding a 5-hydroxytryptamine1B receptor.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
University of Heidelberg