Target (3)
Compound (537)
Article Title (16)
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Assay (2)
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5-fluorourasil CHEMBL185 5-Fluorouracil Fluracil Ro-2-9757 5-Fluoro-1H-pyrimidine-2,4-dione (5-Fluorouracil) 5-fluorouacil 5 fluorouracil 5-Fluoro-1H-pyrimidine-2,4-dione(5-FU) 5-fluoropyrimidine-2,4(1H,3H)-dione Carac 5-Fluoro-1H-pyrimidine-2,4-dione (5-FU) 5-Fluoro-1H-pyrimidine-2,4-dione(5FU) Efudex (5-fluorouracil)5-Fluoro-1H-pyrimidine-2,4-dione Adrucil 5-fluoro-uracil Fluoroplex 5-Fluoro-1H-pyrimidine-2,4-dione(5-fluorouracil)(5-FU) 5-Fluoro-1H-pyrimidine-2,4-dione(5-FUra) 5-Fluoro-1H-pyrimidine-2,4-dione 5F-uracil 5-Florouracil FLUOROURACIL, 5- 5-Fluoro-1H-pyrimidine-2,4-dione(5-fluoro uracil) BDBM50340677 5-FU
BDBM292850 US10106501, Example FU
BDBM173609 1-[3'-[4-[(Adenine-9-yl)methyl]-1,2,3-triazol-1-yl]-b-D-ribofuranosyl]5-fluorouracil (5c)
BDBM420221 US10485800, Cmpd ID FU US10485800, Example 175
BDBM242349 US10875864, EX. 8-5 US10047093, 8-5 US10392392, Example 8-5 US9416132, 8-5
US10072026, Example 8-5 US10947254, Example 8-5 US12358931, Example 8-5 US11780852, Example 8-5 BDBM277656
8-nitro-5-(8-quinolylthio)quinoline 8-nitro-5-(8-quinolinylthio)quinoline MLS000665904 BDBM51159 8-nitro-5-quinolin-8-ylsulfanylquinoline 8-nitro-5-quinolin-8-ylsulfanyl-quinoline cid_972178 SMR000294589
US10072026, Example 5-8 US10947254, Example 5-8 US12358931, Example 5-8 BDBM277546
CHEMBL25361 5',5',8',8'-Tetramethyl-5',6',7',8'-tetrahydro-[2,2']binaphthalenyl-6-carboxylic acid BDBM50048281 6-(5',6',7',8'-tetrahydro-5',5',8',8'-tetramethyl-2'-naphthalenyl)-2-naphthalenecarboxylic acid
US10093663, Example 5-8 BDBM159216 US9682968, Example-5-8
BDBM34925 5-fluoranylquinolin-8-ol cid_217907 5-fluoro-8-quinolinol 5-fluoroquinolin-8-ol SMR000338593 MLS000736043
5-(anilinomethyl)-8-quinolinol 5-(phenylazanylmethyl)quinolin-8-ol 5-Phenylaminomethyl-quinolin-8-ol MLS000075475 SMR000014638 BDBM34564 5-(anilinomethyl)quinolin-8-ol cid_644901
BDBM64662 SMR000298925 5-(isobutoxymethyl)-8-quinolinol 5-(isobutoxymethyl)quinolin-8-ol cid_761896 MLS000690668 5-(2-methylpropoxymethyl)-8-quinolinol 5-(2-methylpropoxymethyl)quinolin-8-ol
cid_16192748 5-bromoquinolin-8-amine;hydrochloride SMR000283735 (5-bromo-8-quinolyl)amine;hydrochloride 5-bromo-8-quinolinamine;hydrochloride MLS000688277 BDBM76536 5-bromanylquinolin-8-amine;hydrochloride
5-chloro-8-quinolinol US12377086, Compound 46 SMR000274338 cid_2817 5-chloroquinolin-8-ol BDBM76305 5-chloranylquinolin-8-ol MLS002695956
8-(5-azanylpentylamino)quinolin-6-ol cid_245091 BDBM32219 8-(5-aminopentylamino)quinolin-6-ol 8-(5-aminopentylamino)-6-quinolinol
BDBM173431 US9096601, 8-5
BDBM237729 US9394282, 5-8
US8742110, 5-8 BDBM123272
US8778970, 5-8 BDBM126700
US8993756, 5-8 BDBM153196
US9035059, 8-5 BDBM159666
US9247759, 5-8 BDBM211087
US9725445, 5-8 BDBM331010
cid_19103 5-nitrosoquinolin-8-ol 5-nitroso-8-quinolinol SMR000369353 MLS000775787 BDBM68169
5-amino-8-quinolinol 5-aminoquinolin-8-ol BDBM32142 5-azanylquinolin-8-ol US12377086, Compound 42 AS-0308-225 cid_416002
MLS000069750 cid_19910 nitroxoline SMR000059036 5-nitro-8-quinolinol 5-nitroquinolin-8-ol BDBM64987 US12377086, Compound 41 8-HYDROXY-5-NITROQUINOLINE
(5-bromanylquinolin-8-yl) methanesulfonate methanesulfonic acid (5-bromo-8-quinolinyl) ester methanesulfonic acid (5-bromo-8-quinolyl) ester SMR000528846 (5-bromoquinolin-8-yl) methanesulfonate cid_269431 BDBM90785 MLS000766232
8-nitro-5-pyrrolidin-1-ylisoquinoline 8-nitro-5-pyrrolidino-isoquinoline MLS001007577 BDBM63690 8-nitro-5-(1-pyrrolidinyl)isoquinoline cid_4780308 SMR000384710 8-nitro-5-pyrrolidin-1-yl-isoquinoline
BDBM39771 5-nitro-8-piperazin-1-yl-quinoline 5-nitro-8-piperazin-1-ylquinoline SMR000174166 cid_2829613 MLS000563385 5-nitro-8-piperazino-quinoline 5-nitro-8-(1-piperazinyl)quinoline
MLS000706654 5-nitro-8-pyrrolidin-1-yl-quinoline BDBM79706 5-nitro-8-(1-pyrrolidinyl)quinoline 5-nitro-8-pyrrolidino-quinoline 5-nitro-8-pyrrolidin-1-ylquinoline cid_2829609 SMR000288106
SMR000124298 BDBM49364 5-(piperidinomethyl)quinolin-8-ol 5-Piperidin-1-ylmethyl-quinolin-8-ol 5-(1-piperidinylmethyl)-8-quinolinol cid_279619 5-(piperidin-1-ylmethyl)quinolin-8-ol MLS000123698
BMS-205603-01 Lamivudine impurity e SQ-7726 NSC-3970 BDBM50549809 CHEBI:17568 Fluorouracil specified compound c Hybar x SQ-8493 Lamivudine impurity e rs SQ-6201 Uracil Pyrod
US9657001, 8 BDBM223233 2-(5-((Cyclopropylmethyl)(8-methylquinolin-5-yl)amino)-3-methoxypicolinoyl)cyclopropanecarboxylic acid US20160326143, 8
BDBM34659 MLS000123699 5-[(2-methylanilino)methyl]-8-quinolinol cid_1090312 5-(o-toluidinomethyl)quinolin-8-ol 5-[[(2-methylphenyl)amino]methyl]quinolin-8-ol SMR000124308 5-[(2-methylanilino)methyl]quinolin-8-ol 5-(o-Tolylamino-methyl)-quinolin-8-ol
US10744104, Example 8-5 BDBM458413 US11547687, Example 8-6
(5-bromo-6-methoxy-8-quinolyl)amine 5-bromo-6-methoxy-8-quinolinamine MLS002667702 cid_244159 5-bromo-6-methoxyquinolin-8-amine BDBM114196 5-bromanyl-6-methoxy-quinolin-8-amine SMR001557462
5-fluoro-7-nitro-quinolin-8-ol cid_260644 BDBM66065 5-fluoro-7-nitroquinolin-8-ol 5-fluoro-7-nitro-8-quinolinol 5-fluoranyl-7-nitro-quinolin-8-ol MLS000736929 SMR000528432
7-chloranyl-5-nitro-quinolin-8-ol 7-chloro-5-nitroquinolin-8-ol cid_1511784 7-chloro-5-nitro-quinolin-8-ol 7-chloro-5-nitro-8-quinolinol BDBM60253 SMR000313735 MLS000674533
MLS000626658 5-chloro-7-nitro-8-quinolinol cid_260645 5-chloro-7-nitro-quinolin-8-ol BDBM64648 5-chloro-7-nitroquinolin-8-ol 5-chloranyl-7-nitro-quinolin-8-ol SMR000298953
cid_3241933 BDBM32094 N-(1,3-benzodioxol-5-yl)-8-ethoxyquinoline-5-sulfonamide SMR000021581 N-(1,3-benzodioxol-5-yl)-8-ethoxy-5-quinolinesulfonamide N-1,3-benzodioxol-5-yl-8-ethoxyquinoline-5-sulfonamide MLS000086053 N-(1,3-benzodioxol-5-yl)-8-ethoxy-quinoline-5-sulfonamide
(R)-5-(8-Aza-spiro[4.5]dec-8-yl)-4-[5-(8-aza-spiro[4.5]dec-8-yl)-4-(3,5-dichloro-benzoylamino)-5-oxo-pentanoylamino]-5-oxo-pentanoic acid CHEMBL282476 BDBM50048795
BDBM50048776 (S)-5-(8-Aza-spiro[4.5]dec-8-yl)-4-[5-(8-aza-spiro[4.5]dec-8-yl)-4-(3,5-dichloro-benzoylamino)-5-oxo-pentanoylamino]-5-oxo-pentanoic acid CHEMBL31101
SMR000277274 5-(p-toluidinomethyl)quinolin-8-ol 5-[[(4-methylphenyl)amino]methyl]quinolin-8-ol BDBM34885 MLS000715757 cid_965016 5-[(4-methylanilino)methyl]-8-quinolinol 5-[(4-methylanilino)methyl]quinolin-8-ol
cid_1090313 5-[[(3-methylphenyl)amino]methyl]quinolin-8-ol BDBM34859 SMR000277166 5-(m-toluidinomethyl)quinolin-8-ol MLS000715649 5-[(3-methylanilino)methyl]-8-quinolinol 5-[(3-methylanilino)methyl]quinolin-8-ol
SMR000174168 8-(4-methylpiperazino)-5-nitro-quinoline BDBM63083 MLS000568313 8-(4-methyl-1-piperazinyl)-5-nitroquinoline 8-(4-methylpiperazin-1-yl)-5-nitroquinoline cid_2829619 8-(4-Methyl-piperazin-1-yl)-5-nitro-quinoline 8-(4-methylpiperazin-1-yl)-5-nitro-quinoline
nicotinic acid (5-chloro-8-quinolyl) ester SMR000515718 3-pyridinecarboxylic acid (5-chloro-8-quinolinyl) ester cid_746299 (5-chloranylquinolin-8-yl) pyridine-3-carboxylate (5-chloroquinolin-8-yl) pyridine-3-carboxylate MLS001210687 Nicotinic acid 5-chloro-quinolin-8-yl ester BDBM80036
BDBM143351 US9682953, 8.A-5
BDBM195596 US9216974, WC-5-8
BDBM298310 US10123984, Example 8-5
BDBM300765 US10130642, Example 8-5
BDBM392100 US10301272, Example 8/5
BDBM514131 US11052091, Example 5-8
BDBM525056 US11168102, Example 8-5.
BDBM570081 US11427581, Compound 8-5
BDBM573141 US11453668, Example 8-5
BDBM582673 US11547687, Example 8-5
BDBM624952 US11780852, Example 5-8
BDBM656607 US11919896, Compound 5-8
BDBM724061 US20250066290, Example 5/8
BDBM93415 PHD Inhibitor, 8{5}
US10550102, Example 5-8 BDBM430879
US10550118, Example 8-5 BDBM431898
US10954237, Example 8-5 BDBM488302
US11040970, Compound 5-8 BDBM504353
US11040970, Compound 8-5 BDBM504373
US11365192, Example 8-5 BDBM558194
US20230285340, Example 8-5 BDBM617445
US9533989, 8 US9533989, 5 BDBM260695
US9682953, 5.A-8 BDBM143306
(5E)-5-[(2-methoxy-5-methylphenyl)hydrazinylidene]-8-quinolinone BDBM48092 SMR000312330 (5E)-5-[(2-methoxy-5-methyl-phenyl)hydrazinylidene]quinolin-8-one MLS000681646 5-[(E)-(2-methoxy-5-methylphenyl)diazenyl]quinolin-8-ol cid_5718132 (5E)-5-[(2-methoxy-5-methyl-phenyl)hydrazono]quinolin-8-one (5E)-5-[(2-methoxy-5-methylphenyl)hydrazinylidene]quinolin-8-one
MLS000033120 5-Methyl-pyrazine-2-carboxylic acid quinolin-8-ylamide SMR000006036 5-methyl-N-(8-quinolyl)pyrazinamide 5-methyl-N-quinolin-8-yl-pyrazine-2-carboxamide 5-methyl-N-quinolin-8-ylpyrazine-2-carboxamide cid_647549 5-methyl-N-(8-quinolinyl)-2-pyrazinecarboxamide BDBM38852
5-[(4-Fluoro-phenylamino)-methyl]-quinolin-8-ol 5-[(4-fluoroanilino)methyl]-8-quinolinol 5-[[(4-fluorophenyl)amino]methyl]quinolin-8-ol 5-[(4-fluoroanilino)methyl]quinolin-8-ol BDBM34566 MLS000075517 SMR000014632 cid_648581
SMR000030696 [5-(benzenesulfonylmethyl)-2-furanyl]-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methanone cid_3242171 [5-(besylmethyl)-2-furyl]-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methanone 1,4-dioxa-8-azaspiro[4.5]decan-8-yl-[5-(phenylsulfonylmethyl)furan-2-yl]methanone [5-(benzenesulfonylmethyl)furan-2-yl]-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methanone 8-{5-[(phenylsulfonyl)methyl]-2-furoyl}-1,4-dioxa-8-azaspiro[4.5]decane BDBM49134 MLS000095142
US8822534, Example 5-39 US8993631, 5-8 BDBM130359
8-[5-(diethylamino)pentylamino]-6-quinolinol cid_245086 BDBM32200 8-[5-(diethylamino)pentylamino]quinolin-6-ol
5-[(E)-(3-methylphenyl)diazenyl]quinolin-8-ol (5E)-5-[(3-methylphenyl)hydrazinylidene]-8-quinolinone cid_12005480 BDBM66053 (5E)-5-[(3-methylphenyl)hydrazinylidene]quinolin-8-one (5E)-5-(m-tolylhydrazono)quinolin-8-one SMR000207508 MLS000585527
N-(6-methoxy-5-nitro-quinolin-8-yl)ethanamide cid_540557 MLS000698166 N-{5-nitro-6-methoxy-8-quinolinyl}acetamide N-(6-methoxy-5-nitroquinolin-8-yl)acetamide SMR000229302 BDBM34828 N-(6-methoxy-5-nitro-8-quinolinyl)acetamide N-(6-methoxy-5-nitro-8-quinolyl)acetamide
furan-2-carboxylic acid (5-chloro-8-quinolyl) ester (5-chloroquinolin-8-yl) furan-2-carboxylate MLS000528333 Furan-2-carboxylic acid 5-chloro-quinolin-8-yl ester (5-chloranylquinolin-8-yl) furan-2-carboxylate BDBM33451 cid_699693 2-furancarboxylic acid (5-chloro-8-quinolinyl) ester SMR000120908
quinolin-8-yl 5-bromanylfuran-2-carboxylate 5-Bromo-furan-2-carboxylic acid quinolin-8-yl ester quinolin-8-yl 5-bromofuran-2-carboxylate 5-bromo-2-furancarboxylic acid 8-quinolinyl ester MLS000072257 BDBM71632 cid_648162 5-bromofuran-2-carboxylic acid 8-quinolyl ester SMR000009514
US9260450, 5 US9938289, 5 BDBM172453 US9090625, 5 US20240307363, Compound 8
5-chloranylquinazolino[2,3-a]phthalazin-8-one MLS000687154 5-chloro-8-quinazolino[2,3-a]phthalazinone SMR000284122 BDBM47634 5-chloroquinazolino[2,3-a]phthalazin-8-one cid_722599
BDBM34858 MLS000715650 5-[(2,3-dimethylanilino)methyl]quinolin-8-ol 5-[[(2,3-dimethylphenyl)amino]methyl]quinolin-8-ol SMR000277167 5-[(2,3-dimethylanilino)methyl]-8-quinolinol cid_1090315
cid_1090314 SMR000277275 5-[(3,4-dimethylanilino)methyl]-8-quinolinol 5-[[(3,4-dimethylphenyl)amino]methyl]quinolin-8-ol BDBM34884 MLS000715758 5-[(3,4-dimethylanilino)methyl]quinolin-8-ol
(R)-8-(7-methyl-8- phenylimidazo[1,2- c]pyrimidin-5-yl)-8- azaspiro[4.5] decan-1-amine US11179397, Example 5 BDBM527788
BDBM605736 US11673901, Compound 5 (1R)-8-[8-(2,3-dichlorophenyl)imidazo[1,5-a]pyridin-5-yl]-8-azaspiro[4.5]decan-1-amine 
(5E)-5-[(2,5-dimethylphenyl)hydrazinylidene]quinolin-8-one (5E)-5-[(2,5-dimethylphenyl)hydrazono]quinolin-8-one SMR000312806 BDBM54335 (5E)-5-[(2,5-dimethylphenyl)hydrazinylidene]-8-quinolinone 5-[(E)-(2,5-dimethylphenyl)diazenyl]quinolin-8-ol MLS000681763 cid_16194507
(5E)-5-[(2-methoxyphenyl)hydrazinylidene]-8-quinolinone cid_15871826 (5E)-5-[(2-methoxyphenyl)hydrazinylidene]quinolin-8-one MLS001197129 5-[(E)-(2-methoxyphenyl)diazenyl]quinolin-8-ol SMR000555503 (5E)-5-[(2-methoxyphenyl)hydrazono]quinolin-8-one BDBM64125
(5E)-5-[(3,4-dimethylphenyl)hydrazinylidene]quinolin-8-one (5E)-5-[(3,4-dimethylphenyl)hydrazono]quinolin-8-one SMR000312805 BDBM67275 (5E)-5-[(3,4-dimethylphenyl)hydrazinylidene]-8-quinolinone 5-[(E)-(3,4-dimethylphenyl)diazenyl]quinolin-8-ol cid_16194446 MLS000681762
MLS000716156 5-(morpholinomethyl)-7-nitro-quinolin-8-ol cid_721887 5-(morpholin-4-ylmethyl)-7-nitro-quinolin-8-ol BDBM48811 SMR000277673 5-(morpholin-4-ylmethyl)-7-nitroquinolin-8-ol 5-(4-morpholinylmethyl)-7-nitro-8-quinolinol
US10675284, Example 5 US11304949, Compound 8 4-[(4-{3-cyano-2-[3- (7H-pyrrolo[2,3- d]pyrimidin-4-yl)-1H- pyrrol-1- yl]propyl}piperazin-1- yl)carbonyl]-3- fluorobenzonitrile US11130767, # 5 US20240307353, Compound 8 US10519163, Example 5 US11957661, Compound 8 US10077277, Example 6 US11406640, Comp. No. 8 US20250049817, Compound 8 US11918581, Compound 8 US11136326, Example 5 US11324749, Comp. No. 8 US10336759, # 5 US10479803, Example 5 US9732097, Example 5 BDBM285696 US11992490, Compound 8 US20240058343, Compound 8
US11312705, Example 5 8-(8-Methylquinolin-6-yl)-7-phenyl-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine 5 BDBM550795
BDBM221867 US9314468, Table 8, Compound 5
BDBM333127 BDBM431898 US10196393, Example 8-5
US20240016777, Table1a.5 8- Lavandulylkaempferol BDBM645354
US9212144, 5 (Ex. 8) CHEMBL3126213 BDBM50449048
5-chloro-8-(2-nitrophenoxy)quinoline MLS000721853 BDBM69282 cid_1487022 SMR000336998 5-chloranyl-8-(2-nitrophenoxy)quinoline
8-[5-(isopropylamino)pentylamino]quinolin-6-ol cid_408620 8-[5-(propan-2-ylamino)pentylamino]quinolin-6-ol 8-[5-(propan-2-ylamino)pentylamino]-6-quinolinol BDBM32220
5-bromo-7-(piperidin-1-ylmethyl)quinolin-8-ol 5-bromanyl-7-(piperidin-1-ylmethyl)quinolin-8-ol BDBM34601 5-bromo-7-(1-piperidinylmethyl)-8-quinolinol 5-bromo-7-(piperidinomethyl)quinolin-8-ol MLS000090125 cid_678099 SMR000024743
8-ethoxy-N-(2-oxolanylmethyl)-5-quinolinesulfonamide 8-ethoxy-N-(tetrahydrofurfuryl)quinoline-5-sulfonamide 8-ethoxy-N-(tetrahydrofuran-2-ylmethyl)quinoline-5-sulfonamide SMR000021580 BDBM42370 cid_3244767 MLS000086052 8-ethoxy-N-(oxolan-2-ylmethyl)quinoline-5-sulfonamide
N-[(4-chlorophenyl)methyl]-8-nitro-5-isoquinolinamine MLS001179978 SMR000588276 (4-chlorobenzyl)-(8-nitro-5-isoquinolyl)amine cid_4880770 N-[(4-chlorophenyl)methyl]-8-nitro-isoquinolin-5-amine N-[(4-chlorophenyl)methyl]-8-nitroisoquinolin-5-amine BDBM58488
2-[(5-bromo-8-quinolyl)carbamoyl]benzoic acid 2-[(5-bromoquinolin-8-yl)carbamoyl]benzoic acid 2-[(5-bromanylquinolin-8-yl)carbamoyl]benzoic acid 2-[[(5-bromo-8-quinolinyl)amino]-oxomethyl]benzoic acid BDBM74953 cid_1218429 MLS000676485 SMR000299035 2-{[(5-bromo-8-quinolinyl)amino]carbonyl}benzoic acid
5-(4-Benzyl-piperazin-1-ylmethyl)-quinolin-8-ol cid_651866 5-[(4-benzylpiperazino)methyl]quinolin-8-ol 5-[[4-(phenylmethyl)piperazin-1-yl]methyl]quinolin-8-ol BDBM49181 MLS000075465 5-[[4-(phenylmethyl)-1-piperazinyl]methyl]-8-quinolinol 5-[(4-benzylpiperazin-1-yl)methyl]quinolin-8-ol SMR000014637
BDBM50172802 Sodium 8-hydroxy-8-(2-pentyloxy-quinolin-3-yl)-oct-5-ynoate (9a) CHEMBL383607 Sodium; 8-hydroxy-8-(2-pentyloxy-quinolin-3-yl)-oct-5-ynoate
2-(5-bromanylquinolin-8-yl)-5-(2-methoxyphenoxy)isoindole-1,3-dione cid_1214014 2-(5-bromo-8-quinolyl)-5-(2-methoxyphenoxy)isoindoline-1,3-quinone MLS000576738 SMR000197206 2-(5-bromo-8-quinolinyl)-5-(2-methoxyphenoxy)isoindole-1,3-dione BDBM63135 2-(5-bromo-8-quinolinyl)-5-(2-methoxyphenoxy)-1H-isoindole-1,3(2H)-dione 2-(5-bromoquinolin-8-yl)-5-(2-methoxyphenoxy)isoindole-1,3-dione
5-[(2E)-2-(8-oxidanylidenequinolin-5-ylidene)hydrazinyl]naphthalene-1-sulfonic acid 5-[(2E)-2-(8-oxo-5-quinolinylidene)hydrazinyl]-1-naphthalenesulfonic acid 5-[(N'E)-N'-(8-keto-5-quinolylidene)hydrazino]naphthalene-1-sulfonic acid SMR000555383 5-[(E)-(8-hydroxyquinolin-5-yl)diazenyl]naphthalene-1-sulfonic acid BDBM51788 MLS001197249 cid_5876309 5-[(2E)-2-(8-oxoquinolin-5-ylidene)hydrazinyl]naphthalene-1-sulfonic acid
BDBM426116 US10513523, Example 55 5-[8-(1,4-Dioxa-8-azaspiro[4;5]decan-8-yl)-2-(4-
BDBM624653 {[8-hydroxy-5-(8-methoxyquinazolin-4-yl)-5- azaspiro[2.5]octan-8- yl]methyl}(imino)methyl-lambda6-sulfanone US11780849, Compound 194
5-BZT CHEMBL1288652 CAS_20776-45-8 5-BENZYLOXYTRYPTAMINE BDBM82302
N-(5-methoxy-8-quinolinyl)-2-naphthalenesulfonamide MLS001221398 N-(5-methoxyquinolin-8-yl)naphthalene-2-sulfonamide Naphthalene-2-sulfonic acid (5-methoxy-quinolin-8-yl)-amide cid_1096078 SMR000612899 N-(5-methoxy-8-quinolyl)naphthalene-2-sulfonamide BDBM58588
BDBM227639 8-Oxo-dGTP 8-Oxo-2'-deoxyguanosine-5'-triphosphate
CHEMBL370374 Sodium; 8-hydroxy-8-(2-pentyloxy-phenyl)-oct-5-ynoate BDBM50172815
5-(methoxymethyl)-7-(pyrrolidinomethyl)quinolin-8-ol SMR000111795 cid_689261 5-(methoxymethyl)-7-(pyrrolidin-1-ylmethyl)quinolin-8-ol BDBM39073 5-(methoxymethyl)-7-(1-pyrrolidinylmethyl)-8-quinolinol MLS000107426
BDBM38979 SMR000030494 7-(morpholin-4-ylmethyl)-5-(phenylmethoxymethyl)quinolin-8-ol cid_3242810 MLS000094940 7-(4-morpholinylmethyl)-5-(phenylmethoxymethyl)-8-quinolinol 5-(benzoxymethyl)-7-(morpholinomethyl)quinolin-8-ol
MLS000094939 cid_3238417 5-(phenylmethoxymethyl)-7-(piperidin-1-ylmethyl)quinolin-8-ol 5-(phenylmethoxymethyl)-7-(1-piperidinylmethyl)-8-quinolinol SMR000030493 BDBM38963 5-(benzoxymethyl)-7-(piperidinomethyl)quinolin-8-ol
MLS000576661 BDBM61857 7-nitro-5-(1-pyrrolidinylmethyl)-8-quinolinol 7-nitro-5-(pyrrolidinomethyl)quinolin-8-ol SMR000197129 cid_690617 7-nitro-5-(pyrrolidin-1-ylmethyl)quinolin-8-ol
MLS000774606 (5E)-5-[(4-methoxyphenyl)hydrazinylidene]-8-quinolinone (5E)-5-[(4-methoxyphenyl)hydrazinylidene]quinolin-8-one (5E)-5-[(4-methoxyphenyl)hydrazono]quinolin-8-one BDBM48098 cid_5924924 SMR000372120
MLS001174936 SMR000592083 (5E)-5-[(3-methoxyphenyl)hydrazono]quinolin-8-one (5E)-5-[(3-methoxyphenyl)hydrazinylidene]-8-quinolinone (5E)-5-[(3-methoxyphenyl)hydrazinylidene]quinolin-8-one cid_6108933 BDBM54465
MLS000065722 8-(1,3-benzodioxol-5-ylcarbonyl)-1,4-dioxa-8-azaspiro[4.5]decane 1,3-benzodioxol-5-yl(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methanone BDBM62734 cid_1245606 SMR000080390
5-(1,4-dioxa-8-azaspiro[4.5]decan-8-ylsulfonyl)-2-fluoranyl-N-(2-phenylethyl)benzamide SMR000314708 5-(1,4-dioxa-8-azaspiro[4.5]decan-8-ylsulfonyl)-2-fluoro-N-(2-phenylethyl)benzamide BDBM44237 5-(1,4-dioxa-8-azaspiro[4.5]decan-8-ylsulfonyl)-2-fluoro-N-phenethyl-benzamide cid_4320873 MLS000682347 5-(1,4-dioxa-8-azaspiro[4.5]dec-8-ylsulfonyl)-2-fluoro-N-(2-phenylethyl)benzamide
MLS000095145 1,4-dioxa-8-azaspiro[4.5]decan-8-yl-[5-[(4-methylphenyl)sulfonylmethyl]furan-2-yl]methanone 1,4-dioxa-8-azaspiro[4.5]decan-8-yl-[5-(tosylmethyl)-2-furyl]methanone BDBM40040 8-(5-{[(4-methylphenyl)sulfonyl]methyl}-2-furoyl)-1,4-dioxa-8-azaspiro[4.5]decane 1,4-dioxa-8-azaspiro[4.5]decan-8-yl-[5-[(4-methylphenyl)sulfonylmethyl]-2-furanyl]methanone cid_3242839 SMR000030699
(R)-methyl 8-(3-(4-(2,2-diphenylacetamido)-5-(4-hydroxybenzylamino)-5-oxopentyl)guanidino)-8-oxooctanoate BDBM50325605 CHEMBL1223992
N-(8-hydroxyquinolin-5-yl)-2,5-dimethoxybenzenesulfonamide N-(8-hydroxy-5-quinolyl)-2,5-dimethoxy-benzenesulfonamide cid_16738611 N-(8-hydroxy-5-quinolinyl)-2,5-dimethoxybenzenesulfonamide BDBM43338 2,5-dimethoxy-N-(8-oxidanylquinolin-5-yl)benzenesulfonamide PC-0685414 PCMD-CC-PAB-252
N-(2,3-dichlorobenzyl)- 8-hydroxy-5,6,7,8-tetra hydroquinoline-5- carboxamide US11439633, Example 8 US11077100, Example 8 BDBM510148
SMR000163345 BDBM48682 8-methyl-2-(2-methyl-5-nitro-phenyl)quinoline MLS000544608 cid_624046 2-{5-nitro-2-methylphenyl}-8-methylquinoline 8-methyl-2-(2-methyl-5-nitrophenyl)quinoline
US10669265, Example 8 US10633373, Example 8 methyl 6-amino-5-{5-[({[2- fluoro-5- (trifluoromethyl)phenyl]amino} carbonyl)amino]-1- benzothien-2-yl}nicotinate BDBM364990 US9868726, Example 8
(5-chloranylquinolin-8-yl) 4-methyl-3-nitro-benzoate BDBM79992 4-methyl-3-nitro-benzoic acid (5-chloro-8-quinolyl) ester (5-chloroquinolin-8-yl) 4-methyl-3-nitrobenzoate SMR000197947 4-methyl-3-nitrobenzoic acid (5-chloro-8-quinolinyl) ester 5-chloro-8-quinolinyl 4-methyl-3-nitrobenzoate cid_887191 MLS000576307
(R)-8-(8-((2,3-dihydrobenzofuran-5-yl)thio)imidazo[1,2-c]pyrimidin-5-yl)-8-azaspiro[4.5]decan-1-amine BDBM580243 US11498930, Compound 1.1.44
BDBM527791 US11179397, Example 8 (R)-8-(8-(2- chlorophenyl)-7- methylimidazo[1,2- c]pyrimidin-5-yl)-8- azaspiro[4.5] decan-1-amine
N-[5-(1,4-dioxa-8-azaspiro[4.5]decane-8-carbonyl)-2-tosyl-phenyl]acetamide N-{5-(1,4-dioxa-8-azaspiro[4.5]dec-8-ylcarbonyl)-2-[(4-methylphenyl)sulfonyl]phenyl}acetamide N-[5-[1,4-dioxa-8-azaspiro[4.5]decan-8-yl(oxo)methyl]-2-(4-methylphenyl)sulfonylphenyl]acetamide cid_3240964 SMR000032552 N-[5-(1,4-dioxa-8-azaspiro[4.5]decan-8-ylcarbonyl)-2-(4-methylphenyl)sulfonyl-phenyl]ethanamide N-[5-(1,4-dioxa-8-azaspiro[4.5]decane-8-carbonyl)-2-(4-methylphenyl)sulfonylphenyl]acetamide BDBM90635 MLS000834137
2-(6-amino-5-(8-(5- BDBM394474 US10308614, Example 75
BDBM394450 2-(6-amino-5-(8-(5- US10308614, Example 51
BDBM50295364 (8-Bromoadenosine-5'-yl)(adenosine-5'-yl)disulfide CHEMBL560315
5-(ethylamino)quinolin-8-ol BDBM50303919 CHEMBL571660
BDBM50303920 5-(isopropylamino)quinolin-8-ol CHEMBL571661
CHEMBL3856128 CHEMBL410171 BDBM50291120 Interleukin-8 inhibitor, 5
PDE5 Inhibitor, 8 BDBM93134 PDE5 Inhibitor, 5
US11186589, Compound 5 BDBM527630 US11186589, Compound 8
US20230312476, Example 5 BDBM621654 US20230312476, Compound 8
US9321721, Example 5 US9321721, Example 8 BDBM223057
US9394282, 8-5 US9394282, 12-2 BDBM237860
BDBM578963 US11492351, Example 8-5 US11479551, Example 8-5 2-(5-(4-(aminomethyl)-1-oxo-1,2-dihydrophthalazin- 6-yl)pyridin-3-yl)-5-fluorobenzonitrile;
SMR000041455 cid_660655 8-ethoxy-10-oxido-1,2,3,4-tetrahydrophenazin-5-ium 5-oxide MLS000078137 8-ethoxy-10-oxidanidyl-1,2,3,4-tetrahydrophenazin-5-ium 5-oxide BDBM87626
BDBM163045 US9670216, 8 5-Propylamino-2-(3,3,5,5-tetramethylcyclohexyl)pyridazin-3-one US9062004, 8
US8609678, 4-(dipyrimidin-2-ylamino)-N-(8-(hydroxyamino)-8-oxooctyl)benzamide [5] BDBM109953
CHEMBL85927 BDBM50085626 2-[8-(4-Chloro-phenyl)-8-oxo-octylsulfanyl]-5-pyrimidin-5-ylmethyl-1H-pyrimidin-4-one
3-[8'(Z)-pentadecenyl]phenol 5-{8(Z)-pentadecenyl}phenol BDBM50242263 (Z)-3-(pentadec-8-enyl)phenol CHEMBL470263
BDBM55713 SMR000312047 [1-(2,4-difluorophenyl)benzimidazol-5-yl]-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methanone MLS000682690 [1-(2,4-difluorophenyl)-5-benzimidazolyl]-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methanone 8-{[1-(2,4-difluorophenyl)-1H-benzimidazol-5-yl]carbonyl}-1,4-dioxa-8-azaspiro[4.5]decane cid_3585765 [1-[2,4-bis(fluoranyl)phenyl]benzimidazol-5-yl]-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methanone
8-(2-Cyclopropyl-4-methylpyrimidin-5-yl)-N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine BDBM291693 US11207325, Example 8 US9580437, Example 8
8-ethoxy-N-[(4-methoxyphenyl)methyl]quinoline-5-sulfonamide cid_9551290 8-ethoxy-N-[(4-methoxyphenyl)methyl]-5-quinolinesulfonamide BDBM32723 8-ethoxy-N-p-anisyl-quinoline-5-sulfonamide MLS000521584 SMR000131992
SMR000077387 cid_972379 N-(1,3-benzodioxol-5-yl)-2-methyl-quinoline-8-sulfonamide N-(1,3-benzodioxol-5-yl)-2-methylquinoline-8-sulfonamide N-1,3-benzodioxol-5-yl-2-methyl-8-quinolinesulfonamide BDBM40646 MLS000064659 N-(1,3-benzodioxol-5-yl)-2-methyl-8-quinolinesulfonamide
5-(1,4-dioxa-8-azaspiro[4.5]decan-8-ylsulfonyl)-2-fluoranyl-N-(2-methoxyphenyl)benzamide SMR000031466 BDBM78859 5-(1,4-dioxa-8-azaspiro[4.5]decan-8-ylsulfonyl)-2-fluoro-N-(2-methoxyphenyl)benzamide 5-(1,4-dioxa-8-azaspiro[4.5]dec-8-ylsulfonyl)-2-fluoro-N-(2-methoxyphenyl)benzamide MLS000834072 cid_3238275
5-(4-methylphenoxy)-2-quinolin-8-ylisoindole-1,3-dione MLS000576346 5-(4-methylphenoxy)-2-(8-quinolinyl)isoindole-1,3-dione 5-(4-methylphenoxy)-2-(8-quinolyl)isoindoline-1,3-quinone 5-(4-methylphenoxy)-2-quinolin-8-yl-isoindole-1,3-dione BDBM57450 cid_1296770 SMR000197987 5-(4-methylphenoxy)-2-(8-quinolinyl)-1H-isoindole-1,3(2H)-dione
8-(2-Methyl-6-(trifluoromethyl)pyridin-4-yl)-7-(5-methylfuran-2-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine 8 US11312705, Example 8 BDBM550800
2-(3-benzyl-5-hydroxy-1H- pyrazol-1-yl)isonicotinic acid US9714230, 8 BDBM263938 US9604961, Example 8 US9908865, Example 8 US10173996, Example 8
US10875864, EX. 8-8 US10392392, Example 8-8 US9416132, 8-8 BDBM242352 US10047093, 8-8
BDBM50048754 4-[5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,5-dichloro-benzoylamino)-5-oxo-pentanoylamino]-5-phenyl-pentanoic acid CHEMBL282099
(R)-4-(8-Aza-spiro[4.5]dec-8-yl)-3-[5-(8-aza-spiro[4.5]dec-8-yl)-4-(3,5-dichloro-benzoylamino)-5-oxo-pentanoylamino]-4-oxo-butyric acid CHEMBL289008 BDBM50048769
BDBM50172813 8-Hydroxy-8-(2-pentyloxy-quinolin-3-yl)-oct-5-ynoic acid methyl ester (8a) 8-Hydroxy-8-(2-pentyloxy-quinolin-3-yl)-oct-5-ynoic acid methyl ester CHEMBL197684
BDBM48083 (5E)-5-[(2-methylphenyl)hydrazinylidene]quinolin-8-one cid_12005392 SMR000207678 (5Z)-quinoline-5,8-dione 5-[(2-methylphenyl)hydrazone] MLS000585897 (5E)-5-[(2-methylphenyl)hydrazinylidene]-8-quinolinone (5E)-5-(o-tolylhydrazono)quinolin-8-one
7,8-trans-8,8'-trans-7',8'-cis-7,7'-bis(5-methoxy-3,4-methylenedioxyphenyl)-8-acetoxymethyl-8'-hydroxymethyltetrahydrofuran CHEMBL490350 BDBM50250270
5-chloro-8-[(5-methylimidazo[1,2-a]pyridin-2-yl)methoxy]quinoline 5-chloranyl-8-[(5-methylimidazo[1,2-a]pyridin-2-yl)methoxy]quinoline SMR000375930 5-chloro-8-[(5-methyl-2-imidazo[1,2-a]pyridinyl)methoxy]quinoline cid_722284 MLS000770915 BDBM78326
BDBM50048752 [5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,5-dichloro-benzoylamino)-5-oxo-pentanoylamino]-acetic acid CHEMBL33043
CHEMBL283820 (R)-5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,5-dichloro-benzoylamino)-5-oxo-pentanoic acid BDBM50048772
CHEMBL461628 5-[(8Z)-pentadec-8-enyl]resorcinol Bilobol 5-[(8Z)-pentadec-8-en-1-yl]benzene-1,3-diol BDBM50241751
cid_671596 8-methoxy-N-(2-methoxyphenyl)-5-quinolinesulfonamide 8-methoxy-N-(2-methoxyphenyl)quinoline-5-sulfonamide BDBM45846 MLS-0111543.0001
8-fluoro-10-oxido-7-pyrrolidino-1,2,3,4-tetrahydrophenazin-5-ium 5-oxide MLS000044053 7-fluoro-8-pyrrolidin-1-yl-1,2,3,4-tetrahydrophenazine 5,10-dioxide cid_3238920 8-fluoro-10-oxido-7-pyrrolidin-1-yl-1,2,3,4-tetrahydrophenazin-5-ium 5-oxide 8-fluoranyl-10-oxidanidyl-7-pyrrolidin-1-yl-1,2,3,4-tetrahydrophenazin-5-ium 5-oxide BDBM50821 SMR000021464 8-fluoro-10-oxido-7-(1-pyrrolidinyl)-1,2,3,4-tetrahydrophenazin-5-ium 5-oxide
4-(benzotriazol-1-yl)-5-quinolin-8-yloxy-benzene-1,2-dicarbonitrile 4-(benzotriazol-1-yl)-5-quinolin-8-yloxybenzene-1,2-dicarbonitrile cid_662882 4-(benzotriazol-1-yl)-5-(8-quinolyloxy)phthalonitrile MLS000037251 SMR000036468 BDBM71687 4-(1-benzotriazolyl)-5-(8-quinolinyloxy)benzene-1,2-dicarbonitrile
5-(pyridin-2-ylmethylamino)quinazolino[2,3-a]phthalazin-8-one 5-[(2-pyridinylmethyl)amino]-8H-phthalazino[1,2-b]quinazolin-8-one MLS000662082 5-(2-pyridinylmethylamino)-8-quinazolino[2,3-a]phthalazinone cid_1186195 SMR000292747 BDBM47623 5-(2-pyridylmethylamino)quinazolino[2,3-a]phthalazin-8-one
5-[(3-Methyl-pyridin-2-ylamino)-methyl]-quinolin-8-ol 5-[[(3-methyl-2-pyridyl)amino]methyl]quinolin-8-ol BDBM49188 5-[[(3-methyl-2-pyridinyl)amino]methyl]-8-quinolinol SMR000014639 cid_654330 MLS000075485 5-[[(3-methylpyridin-2-yl)amino]methyl]quinolin-8-ol
5-bromanyl-1-methyl-quinolin-1-ium-8-olate;hydrate BDBM83932 MLS000767218 5-bromo-1-methyl-quinolin-1-ium-8-olate;hydrate cid_16682477 5-bromo-1-methyl-8-quinolin-1-iumolate;hydrate 5-bromo-1-methylquinolin-1-ium-8-olate;hydrate SMR000429549
8-amino-2-(2-chlorophenyl)-5-hydroxy-1-benzopyran-4-one BDBM68714 8-amino-2-(2-chlorophenyl)-5-hydroxychromen-4-one 8-azanyl-2-(2-chlorophenyl)-5-oxidanyl-chromen-4-one 8-amino-2-(2-chlorophenyl)-5-hydroxy-chromone cid_5314969 MLS000518334 SMR000128952
MLS000770989 benzoic acid [5-chloro-7-(4-morpholinylmethyl)-8-quinolinyl] ester cid_1534921 [5-chloranyl-7-(morpholin-4-ylmethyl)quinolin-8-yl] benzoate benzoic acid [5-chloro-7-(morpholinomethyl)-8-quinolyl] ester SMR000375977 [5-chloro-7-(morpholin-4-ylmethyl)quinolin-8-yl] benzoate BDBM65490
SMR000128956 cid_5314962 BDBM68716 8-bromanyl-2-(2-chlorophenyl)-5-oxidanyl-chromen-4-one 8-bromo-2-(2-chlorophenyl)-5-hydroxy-1-benzopyran-4-one 8-bromo-2-(2-chlorophenyl)-5-hydroxy-chromone 8-bromo-2-(2-chlorophenyl)-5-hydroxychromen-4-one MLS000518337
SMR000669628 N-(7-chloro-8-hydroxy-5-quinolinyl)-4-methylbenzenesulfonamide BDBM88241 N-(7-chloro-8-hydroxy-5-quinolyl)-4-methyl-benzenesulfonamide N-(7-chloro-8-hydroxyquinolin-5-yl)-4-methylbenzenesulfonamide cid_2140576 MLS001060650 N-(7-chloranyl-8-oxidanyl-quinolin-5-yl)-4-methyl-benzenesulfonamide
cid_16060391 5-hydroxy-2-(2-methoxyphenyl)-8-nitro-1-benzopyran-4-one PiI MLS000518626 BDBM53407 SMR000465235 5-hydroxy-2-(2-methoxyphenyl)-8-nitro-chromone 5-hydroxy-2-(2-methoxyphenyl)-8-nitrochromen-4-one 2-(2-methoxyphenyl)-8-nitro-5-oxidanyl-chromen-4-one
ethyl 8-(2,4-dimethylpyrimidin-5-yl)-5-(((5-fluoro- BDBM451064 US10676479, Example 94
US10196393, Example 8-21 US10196393, Example 8-20 US11634419, Example C-6 US10947229, Example C-6 US11453668, Example 8 BDBM333122 US10196393, Example 8-18 US10196393, Example 8-19 US10196393, Example 8-16 US10196393, Example 8-17 US10196393, Example 8-15 US10196393, Example 8-12 US10196393, Example 8-2 US10196393, Example 8-1 US10196393, Example 8-13 (S)-(3-(dimethylamino)-3-methylazetidin-1-yl)(2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-5-propyl-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridin-6-yl)methanone US10196393, Example 8-10 US10196393, Example 8-11 US10196393, Example 8 US10196393, Example 8-8 US10196393, Example 8-7 US10196393, Example 8-9 US10196393, Example 8-4 US10196393, Example 8-3 US10196393, Example 8-6 US10196393, Example 8-5 US10550118, Example 8
BDBM50172822 CHEMBL198163 Sodium; 8-hydroxy-8-(3-pentyloxy-naphthalen-2-yl)-oct-5-ynoate
BDBM658682 US11932606, Compound 8 Sodium 5-(pyridin-4-yl)benzo[h]isoquinoline-8- carboxylate
CHEMBL194698 8-Hydroxy-8-(2-pentyloxy-phenyl)-oct-5-ynoic acid methyl ester BDBM50172817
CHEMBL78740 8-(3-Chloro-phenyl)-8-aza-5-azonia-spiro[4.5]decane; bromide BDBM50005130
Sodium 8-hydroxy-8-(2-methoxy-quinolin-3-yl)-oct-5-ynoate (9b) BDBM233175
Sodium 8-hydroxy-8-(2-octyloxy-quinolin-3-yl)-oct-5-ynoate (9c) BDBM233176
Sodium; 8-hydroxy-8-(2-pentyloxy-pyridin-3-yl)-oct-5-ynoate CHEMBL199172 BDBM50172809
US9670212, 8 3-[(1,3-benzodioxol-5-yloxy)methyl]-2-(2-chlorophenyl)-8-methylquinoline BDBM195116
2-(5-(4-(aminomethyl)-1-oxo-1,2-dihydrophthalazin- 6-yl)pyridin-3-yl)-4-methoxybenzonitrile; US11479551, Example 8-8 US11492351, Example 8-8 BDBM578969
(R)-8-(8-((2-amino-5-chloropyridin-4-yl)thio)imidazo[1,2-c]pyrimidin-5-yl)-8-azaspiro[4.5]decan-1-amine US11498930, Compound 1.1.33 BDBM580228
(R)-8-(8-((4- (trifluoromethyl) pyrimidin-5- yl)thio)imidazo[1, 2-c]pyrimidin-5- yl)-8- azaspiro[4.5] decan-1-amine BDBM527837 US11179397, Example 54
BDBM32248 8-(1,3-benzodioxol-5-ylmethylamino)-1,3,7-trimethylpurine-2,6-dione 8-(1,3-benzodioxol-5-ylmethylamino)-1,3,7-trimethyl-purine-2,6-dione cid_973925 1,3,7-trimethyl-8-(piperonylamino)xanthine
BDBM50048728 CHEMBL542330 (S)-4-[5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,5-dichloro-benzoylamino)-5-oxo-pentanoylamino]-4-(quinolin-8-ylcarbamoyl)-butyric acid; hydrochloride
US11179397, Example 14 BDBM527797 (R)-8-(8-(1,4- dimethyl-1H- pyrazol-5-yl)-7- methylimidazo[1,2- c]pyrimidin-5-yl)-8- azaspiro[4.5]decan- 1-amine
US11179397, Example 16 (R)-8-(8-(2-amino-5- chloropyridin-4-yl)- 7- methylimidazo[1,2- c]pyrimidin-5-yl)-8- azaspiro[4.5]decan- 1-amine BDBM527799
BDBM323024 US10508119, Example 8 US11691978, Example 8 ((1R,2R)-N-[1-Methyl-5-(methylsulfonyl)- 1H-pyrazol-4-yl]-2-[4-(1H-pyrazol-5- yl)benzoyl]cyclohexanecarboxamide US10183947, Example 8 US11001589, Example 8
N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridin-3-yl}-3-[(3R)-3-cyanopyrrolidin-1-yl]-5-fluoroquinoline-8-carboxamide US11053215, Example 8 US9920032, Example 8 US10450296, Example 8 BDBM376674
US9944647, Example 8 4-(8-(1-methyl-1H-indazol-5-yl)-5-{[(3R)-1-methylpiperidin-3-yl]methoxy}imidazo[1,2-c]pyrimidin-7-yl)benzonitrile US11401272, Example 8 BDBM388883 US10800779, Example 8
3-bromanyl-N'-[(E)-(8-oxidanylidenequinolin-5-ylidene)methyl]benzohydrazide BDBM64691 MLS000682087 3-bromo-N'-[(E)-(8-oxoquinolin-5-ylidene)methyl]benzohydrazide 3-bromo-N'-[(E)-(8-oxo-5-quinolinylidene)methyl]benzohydrazide cid_5527691 3-bromo-N'-[(1E)-(8-hydroxyquinolin-5-yl)methylene]benzohydrazide SMR000313490 3-bromo-N'-[(E)-(8-keto-5-quinolylidene)methyl]benzohydrazide
1,4-dioxa-8-azaspiro[4.5]decan-8-yl-[2-methyl-1-(3-methylphenyl)benzimidazol-5-yl]methanone BDBM30871 1,4-dioxa-8-azaspiro[4.5]decan-8-yl-[2-methyl-1-(m-tolyl)benzimidazol-5-yl]methanone 8-{[2-methyl-1-(3-methylphenyl)-1H-benzimidazol-5-yl]carbonyl}-1,4-dioxa-8-azaspiro[4.5]decane MLS000095931 cid_3241342 1,4-dioxa-8-azaspiro[4.5]decan-8-yl-[2-methyl-1-(3-methylphenyl)-5-benzimidazolyl]methanone SMR000031479
5-(1,4-dioxa-8-azaspiro[4.5]dec-8-ylsulfonyl)-N-(4-methoxyphenyl)-3-methyl-1-benzofuran-2-carboxamide cid_3243237 MLS000046289 5-(1,4-dioxa-8-azaspiro[4.5]decan-8-ylsulfonyl)-N-(4-methoxyphenyl)-3-methyl-2-benzofurancarboxamide BDBM56099 SMR000031900 5-(1,4-dioxa-8-azaspiro[4.5]decan-8-ylsulfonyl)-N-(4-methoxyphenyl)-3-methyl-1-benzofuran-2-carboxamide 5-(1,4-dioxa-8-azaspiro[4.5]decan-8-ylsulfonyl)-N-(4-methoxyphenyl)-3-methyl-coumarilamide
8-[(1-cyclohexyl-5-tetrazolyl)methyl]-3-(4-fluorophenyl)-8-azabicyclo[3.2.1]octan-3-ol 8-(1-Cyclohexyl-1H-tetrazol-5-ylmethyl)-3-(4-fluoro-phenyl)-8-aza-bicyclo[3.2.1]octan-3-ol 8-[(1-cyclohexyl-1,2,3,4-tetrazol-5-yl)methyl]-3-(4-fluorophenyl)-8-azabicyclo[3.2.1]octan-3-ol SMR000008135 cid_646509 8-[(1-cyclohexyltetrazol-5-yl)methyl]-3-(4-fluorophenyl)-8-azabicyclo[3.2.1]octan-3-ol BDBM62058 MLS000033602
8-{[3-(3,4-dichlorophenyl)-4,5-dihydro-5-isoxazolyl]carbonyl}-1,4-dioxa-8-azaspiro[4.5]decane SMR000078269 BDBM45407 MLS000064499 cid_2962212 [3-(3,4-dichlorophenyl)-4,5-dihydro-1,2-oxazol-5-yl]-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methanone [3-(3,4-dichlorophenyl)-4,5-dihydroisoxazol-5-yl]-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methanone [3-(3,4-dichlorophenyl)-2-isoxazolin-5-yl]-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methanone
8-{[3-(3-methoxyphenyl)-4,5-dihydroisoxazol-5-yl]carbonyl}-1,4-dioxa-8-azaspiro[4.5]decane SMR000028377 1,4-dioxa-8-azaspiro[4.5]decan-8-yl-[3-(3-methoxyphenyl)-2-isoxazolin-5-yl]methanone 1,4-dioxa-8-azaspiro[4.5]decan-8-yl-[3-(3-methoxyphenyl)-4,5-dihydro-1,2-oxazol-5-yl]methanone MLS000092686 1,4-dioxa-8-azaspiro[4.5]decan-8-yl-[3-(3-methoxyphenyl)-4,5-dihydroisoxazol-5-yl]methanone BDBM51322 cid_3244043
MLS001003628 5-(3-pyridylmethylamino)quinazolino[2,3-a]phthalazin-8-one SMR000347566 5-(3-pyridinylmethylamino)-8-quinazolino[2,3-a]phthalazinone 5-(pyridin-3-ylmethylamino)quinazolino[2,3-a]phthalazin-8-one BDBM47675 cid_1189887
N-(5-tert-butyl-2-methoxyphenyl)quinoline-8-sulfonamide N-(5-tert-butyl-2-methoxy-phenyl)quinoline-8-sulfonamide N-(5-tert-butyl-2-methoxyphenyl)-8-quinolinesulfonamide BDBM69773 cid_1225847 MLS001195896 SMR000558712
2-Hex-5-enyl-5-non-8-enyl-pyrrolidine BDBM50284428 CHEMBL14599
ethyl 8-bromo-5-(((5-fluoro-2,3- BDBM451061 US10676479, Example 91
8-[5-phenyl-2-(p-tolyl)pyrazolo[1,5-a]pyrimidin-7-yl]-1,4-dioxa-8-azaspiro[4.5]decane cid_1441409 MLS000528697 SMR000121172 8-(5-Phenyl-2-p-tolyl-pyrazolo[1,5-a]pyrimidin-7-yl)-1,4-dioxa-8-aza-spiro[4.5]decane BDBM74710 8-[2-(4-methylphenyl)-5-phenyl-7-pyrazolo[1,5-a]pyrimidinyl]-1,4-dioxa-8-azaspiro[4.5]decane 8-[2-(4-methylphenyl)-5-phenyl-pyrazolo[1,5-a]pyrimidin-7-yl]-1,4-dioxa-8-azaspiro[4.5]decane 8-[2-(4-methylphenyl)-5-phenylpyrazolo[1,5-a]pyrimidin-7-yl]-1,4-dioxa-8-azaspiro[4.5]decane
MLS000528674 8-[2-(3-methylphenyl)-5-phenyl-pyrazolo[1,5-a]pyrimidin-7-yl]-1,4-dioxa-8-azaspiro[4.5]decane 8-[2-(m-tolyl)-5-phenyl-pyrazolo[1,5-a]pyrimidin-7-yl]-1,4-dioxa-8-azaspiro[4.5]decane SMR000121149 cid_1441513 8-(5-Phenyl-2-m-tolyl-pyrazolo[1,5-a]pyrimidin-7-yl)-1,4-dioxa-8-aza-spiro[4.5]decane 8-[2-(3-methylphenyl)-5-phenyl-7-pyrazolo[1,5-a]pyrimidinyl]-1,4-dioxa-8-azaspiro[4.5]decane 8-[2-(3-methylphenyl)-5-phenylpyrazolo[1,5-a]pyrimidin-7-yl]-1,4-dioxa-8-azaspiro[4.5]decane BDBM79822
N-[1,3-benzodioxol-5-yl-(5-chloro-8-hydroxy-7-quinolinyl)methyl]butanamide N-[Benzo[1,3]dioxol-5-yl-(5-chloro-8-hydroxy-quinolin-7-yl)-methyl]-butyramide MLS000548411 N-[1,3-benzodioxol-5-yl-(5-chloranyl-8-oxidanyl-quinolin-7-yl)methyl]butanamide SMR000172091 BDBM77529 cid_3138755 N-[1,3-benzodioxol-5-yl-(5-chloro-8-hydroxy-7-quinolyl)methyl]butyramide N-[1,3-benzodioxol-5-yl-(5-chloro-8-hydroxyquinolin-7-yl)methyl]butanamide
US10227346, Example 8 US9920054, Example 8 US9670201, 8 3-cyano-N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-5-methoxybenzamide BDBM189880 US10426135, Example 8
(R)-8-(8- (cyclohexylthio) imidazo[1,2-c] pyrimidin-5-yl)-8- azaspiro[4.5]decan- 1-amine BDBM527862 US11179397, Example 79
US11498930, Compound 1.1.18 (R)-8-(8-(phenylthio)imidazo[1,2-c]pyrimidin-5-yl)-8-azaspiro[4.5]decan-1-amine BDBM580208
US10072026, Example 8-8 US10947254, Example 8-8 BDBM277659 US12358931, Example 8-8
2-Allyl-1,3-dimethoxy-5-methylbenzene (8) BDBM192762
3',5'-Dichloro-[1,1'- BDBM360036 US9828339, Example 8
BDBM33413 benzo[7]annulene-8-carboxylic acid, 5
BDBM50177217 2-methyl-5-nitrosoquinolin-8-ol CHEMBL202318
BDBM50367043 CHEMBL604394 CHEMBL3251358 8-(Thioethyl)Adenosine 5'-Triphosphate
CHEMBL1650636 N-(8-Hydroxyquinolin-5-yl)benzenesulfonamide BDBM50335804
CHEMBL538665 Di(8-Phenyladenosine-5'-yl)disulfide BDBM50295367
Di(8-bromoadenosine-5'-yl)disulfide BDBM50295365 CHEMBL562056
US9346814, Cmpd No 5 Example 8 BDBM50434175 CHEMBL2385294
BDBM527871 (R)-4-((5-(1- amino-8- azaspiro[4.5]decan- 8-yl)imidazo[1,2- c]pyrimidin-8- yl)thio)quinoline-8- carbonitrile US11179397, Example 88
(3S,4S)-3-methyl- 8-(8-(quinolin-5- ylthio)imidazo[1,2- c]pyrimidin-5-yl)- 2-oxa-8- azaspiro[4.5]decan- 4-amine BDBM527912 US11179397, Example 129
(R)-8-(8-(2,2- difluorobenzo[d][1,3] dioxol-5-yl)-7- methylimidazo[1,2- c]pyrimidin-5-yl)-8- azaspiro[4.5]decan- 1-amine BDBM527857 US11179397, Example 74
BDBM527836 US11179397, Example 53 (R)-8-(8-((2-amino- 5- (trifluoromethyl) pyridin-4- yl)thio)imidazo[1,2- c]pyrimidin-5-yl)-8- azaspiro[4.5]decan- 1-amine
BDBM580345 (R)-8-(8-((2-amino-5-chloropyridin-4-yl)thio)-[1,2,4]triazolo[4,3-c]pyrimidin-5-yl)-8-azaspiro[4.5]decan-1-amine US11498930, Compound 1.2.41
BDBM683217 4-(5-(3-amino-8- azabicyclo[3.2.1] octane-8-yl)-8- (5-fluoroindole- 6-yl)imidazolo [1,2-c]pyrimidin- 7-yl)-2- fluorobenzonitrile US20240216357, Example 171
BDBM683222 5-(5-(3-amino-8- azabicyclo[3.2.1] octane-8-yl)-8- (3-fluoro-4- methoxyphenyl) imidazolo[1,2-c ] pyrimidin-7-yl) picolinonitrile hydrochloride US20240216357, Example 176
US20240299360, Example 8 (5S)-5-(3-(8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepin-3 (2H)-yl)-3-oxopropyl)-5-cyclopropylimidazolidine-2,4-dione 8 BDBM695835
2-[5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,5-dichloro-benzoylamino)-5-oxo-pentanoylamino]-hexanoic acid CHEMBL285657 BDBM50048794
2-[5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,5-dichloro-benzoylamino)-5-oxo-pentanoylamino]-propionic acid BDBM50048749 CHEMBL30764
3-[5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,5-dichloro-benzoylamino)-5-oxo-pentanoylamino]-propionic acid BDBM50048733 CHEMBL30634
5-[3-(2-methoxyethyl)-2-methyl-benzimidazol-5-yl]-1,3-dimethylpyridin-2-one US10703740, Compound 8 BDBM449851 US11365186, Compound 8
BDBM360435 methyl 3-(8-((1-phenyl-5- (trifluoromethyl)-1H-pyrazole-4- carboxamido)methyl)isoquinolin-5- yl)benzoate US9828369, Example 8
BDBM50048732 4-[5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,5-dichloro-benzoylamino)-5-oxo-pentanoylamino]-butyric acid CHEMBL30844
BDBM50048741 2-[5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,5-dichloro-benzoylamino)-5-oxo-pentanoylamino]-benzoic acid CHEMBL34797
BDBM50048753 [5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,5-dichloro-benzoylamino)-5-oxo-pentanoylamino]-phenyl-acetic acid CHEMBL33200
BDBM50048755 CHEMBL280832 4-[5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,5-dichloro-benzoylamino)-5-oxo-pentanoylamino]-benzoic acid
BDBM50093918 2-[8-(4-Chloro-phenyl)-8-oxo-octylsulfanyl]-1-ethyl-5-pyrimidin-5-ylmethyl-1H-pyrimidin-4-one CHEMBL87591
BDBM50093939 1-Benzyl-2-[8-(4-chloro-phenyl)-8-oxo-octylsulfanyl]-5-pyrimidin-5-ylmethyl-1H-pyrimidin-4-one CHEMBL85598
CHEMBL1778246 BDBM50344509 2-(6-((1S,5S)-8-(cyclopropylsulfonyl)-8-azabicyclo[3.2.1]octan-3-yloxy)-5-methylpyrimidin-4-ylamino)-5-fluorobenzonitrile
CHEMBL30575 BDBM50048796 3-[5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,5-dichloro-benzoylamino)-5-oxo-pentanoylamino]-benzoic acid
CHEMBL419668 BDBM50093945 2-[8-(4-Chloro-phenyl)-8-oxo-octylsulfanyl]-1-methyl-5-pyrimidin-5-ylmethyl-1H-pyrimidin-4-one
CHEMBL86244 2-[8-(4-Chloro-phenyl)-8-oxo-octylsulfanyl]-1-phenethyl-5-pyrimidin-5-ylmethyl-1H-pyrimidin-4-one BDBM50093954
N-(2,4-dichloro-6- methylbenzyl)-5- fluoro-8-hydroxy-8- (methoxymethyl)- 5,6,7,8-tetrahydro- quinoline-5- carboxamide US11077100, Example 39 BDBM510179
BDBM34615 5-(3,4-dihydro-2H-quinolin-1-ylmethyl)-8-quinolinol 5-(3,4-dihydroquinolin-1(2H)-ylmethyl)quinolin-8-ol SMR000020507 5-(3,4-dihydro-2H-quinolin-1-ylmethyl)quinolin-8-ol cid_3243290 MLS000085572
3,7-dibenzyl-8-(5-methyl-2-furyl)xanthine 8-(5-methylfuran-2-yl)-3,7-bis(phenylmethyl)purine-2,6-dione BDBM33193 SMR000344498 8-(5-methyl-2-furanyl)-3,7-bis(phenylmethyl)purine-2,6-dione cid_3306429 MLS000772379 3,7-dibenzyl-8-(5-methylfuran-2-yl)purine-2,6-dione
1-[(8-hydroxy-5-quinolyl)methyl]isonipecotic acid ethyl ester MLS000075476 BDBM34569 SMR000014634 cid_652581 1-[(8-hydroxy-5-quinolinyl)methyl]-4-piperidinecarboxylic acid ethyl ester 1-(8-Hydroxy-quinolin-5-ylmethyl)-piperidine-4-carboxylic acid ethyl ester ethyl 1-[(8-oxidanylquinolin-5-yl)methyl]piperidine-4-carboxylate ethyl 1-[(8-hydroxyquinolin-5-yl)methyl]piperidine-4-carboxylate
N-[(5-chloro-8-hydroxy-7-quinolinyl)(phenyl)methyl]nicotinamide SMR000194861 cid_2896518 N-[(5-chloranyl-8-oxidanyl-quinolin-7-yl)-phenyl-methyl]pyridine-3-carboxamide N-[(5-chloro-8-hydroxy-7-quinolinyl)-phenylmethyl]-3-pyridinecarboxamide N-[(5-chloro-8-hydroxyquinolin-7-yl)-phenylmethyl]pyridine-3-carboxamide MLS000573359 N-[(5-chloro-8-hydroxy-7-quinolyl)-phenyl-methyl]nicotinamide BDBM67974
cid_1242782 [5-chloro-7-(morpholin-4-ylmethyl)quinolin-8-yl] 4-fluorobenzoate [5-chloranyl-7-(morpholin-4-ylmethyl)quinolin-8-yl] 4-fluoranylbenzoate MLS000051581 SMR000080051 4-fluorobenzoic acid [5-chloro-7-(4-morpholinylmethyl)-8-quinolinyl] ester 5-chloro-7-(4-morpholinylmethyl)-8-quinolinyl 4-fluorobenzoate BDBM49277 4-fluorobenzoic acid [5-chloro-7-(morpholinomethyl)-8-quinolyl] ester
MLS000046132 8-(1,4-dioxa-8-azaspiro[4.5]dec-8-ylcarbonyl)-10-methyldibenzo[b,f][1,4]thiazepin-11(10H)-one SMR000031741 3-(1,4-dioxa-8-azaspiro[4.5]decane-8-carbonyl)-5-methyl-benzo[b][1,4]benzothiazepin-6-one cid_3240545 3-[1,4-dioxa-8-azaspiro[4.5]decan-8-yl(oxo)methyl]-5-methyl-6-benzo[b][1,4]benzothiazepinone 3-(1,4-dioxa-8-azaspiro[4.5]decane-8-carbonyl)-5-methylbenzo[b][1,4]benzothiazepin-6-one 3-(1,4-dioxa-8-azaspiro[4.5]decan-8-ylcarbonyl)-5-methyl-benzo[b][1,4]benzothiazepin-6-one BDBM62685
(2S)-5,7,3',5'-tetrahydroxy-8-[3'',8''-dimethylocta-2''(E),7''-dienyl]flavonone BDBM50339153 CHEMBL1689342
5-(4-Aminophenyl)-N-(7-(hydroxyimino)-8-(methylamino)-8-oxooctyl)isoxazole-3-carboxamide BDBM50341840 CHEMBL1767044
BDBM360459 N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)quinoline-8-carboxamide US9828369, Example 32
BDBM50172820 CHEMBL196260 Sodium; (E)-8-hydroxy-8-(2-pentyloxy-pyridin-3-yl)-oct-5-enoate
BDBM50295450 CHEMBL3084657 exo-8-[Bis(2-chlorophenyl)methyl]-3-(5-oxazolyl)-8-azabicyclo-[3.2.1]octane
BDBM50341839 5-(3-Aminophenyl)-N-(7-(hydroxyimino)-8-(methylamino)-8-oxooctyl)isoxazole-3-carboxamide CHEMBL1767043
CHEMBL1224285 endo-5-((1R,5S)-8-benzyl-8-azabicyclo[3.2.1]octan-3-yloxy)picolinamide BDBM50325874
endo-5-((1R,5S)-8-benzyl-8-azabicyclo[3.2.1]octan-3-yloxy)nicotinamide BDBM50325863 CHEMBL1224068
US10030004, Compound 8 US10501436, Compound 8 US11053216, Compound 8 4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-pyridyl]amino]-N-(2-hydroxy-1,1-dimethyl-ethyl)pyridine-3-carboxamide US11702401, Compound 8 BDBM280343
US11491140, Example 8 US10512632, Example 8 BDBM278978 US10766893, Example S8 US10034861, Example 8 US10806718, Example 8 US11634416, Example 8 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-methyltetrazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine
BDBM82524 5'-Deoxy-5'-isobutylthioadenosine 5'-ISOBUTYLTHIO-5'-DEOXYADENOSINE CAS_35899-54-8
(R)-8-(8- ([1,2,4]triazolo[4,3- a]pyridin-8- ylthio)imidazo[1,2- c]pyrimidin-5-yl)-8- azaspiro[4.5]decan-1- amine BDBM527866 US11179397, Example 83
(R)-8-(8- ([1,2,4]triazolo[4,3- a]pyridin-8- ylthio)imidazo[1,2- c]pyrimidin-5-yl)-8- azaspiro[4.5]decan-1- amine BDBM527867 US11179397, Example 84
BDBM50198370 N-(2,6-dimethyl-phenyl)-5-phenylimidazo[1,5-a]pyrazine-8-amine CHEMBL223873 N-(2,6-dimethylphenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine N-(2,6-dimethylphenyl)-5-phenylimidazo[1,5-a]pyrazine-8-amine
SMR000152513 5-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]quinolin-8-ol 5-[[4-(2-methoxyphenyl)-1-piperazinyl]methyl]-8-quinolinol 5-[[4-(2-methoxyphenyl)piperazino]methyl]quinolin-8-ol MLS000565291 BDBM34708 cid_2303849
3-(Cyclopropylmethoxy)-N-[(1R)-1-(6-methylpyridazin-3-yl)ethyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide US10174016, Example 8 US10472354, Example 8 BDBM319841 US10202369, Example 8
5-(5-(3-amino- 8-azabicyclo [3.2.1]octane-8- yl)-8-(3-fluoro-4- methoxyphenyl) imidazolo[1,2-c] pyrimidin-7-yl) pyrimidin-2- carbonitrile US20240216357, Example 180 BDBM683225
N-((8 endo)-3-(2-chloropyridin-4-yl)-3-azabicyclo[3.2.1]octan-8-yl)-8-methyl-5-(2,2,2-trifluoroethoxy)-[1,2,4]triazolo pyridin-2-amine BDBM476532 US10875854, Example 5
SMR000070205 cid_695392 N-(6-methoxy-8-quinolinyl)-1,3-benzodioxole-5-carboxamide BDBM38447 N-(6-methoxy-8-quinolyl)-piperonylamide N-(6-methoxyquinolin-8-yl)-1,3-benzodioxole-5-carboxamide MLS000061736
(R)-8-(8-(phenylthio)-[1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-8-azaspiro[4.5]decan-1-amine US11498930, Compound 1.2.79 BDBM580392
(R)-8-(8-(phenylthio)-[1,2,4]triazolo[4,3-c]pyrimidin-5-yl)-8-azaspiro[4.5]decan-1-amine BDBM580322 US11498930, Compound 1.2.25
US10343992, Example 8 US10689345, Example 8 US11066365, Example 8 3-(3-chlorophenyl)-N-(1- cyanopyrrolidin-3-yl)isoxazole-5- carboxamide BDBM404349
8-bromo-5-(((5-fluoro-2,3-dihydrobenzofuran-4- BDBM451040 US10676479, Example 70
BDBM451059 US10676479, Example 89 5-((2,4-difluoro-5-methoxybenzyl)amino)-8-(2-
BDBM451066 US10676479, Example 96 ethyl 5-((2,4-difluoro-5-methoxybenzyl)amino)-8-
BDBM451067 US10676479, Example 97 ethyl 5-((2,4-difluoro-5-methoxybenzyl)amino)-8-
CHEMBL286763 BDBM50048734 (S)-4-[5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,5-dichloro-benzoylamino)-5-oxo-pentanoylamino]-5-(octahydro-isoquinolin-2-yl)-5-oxo-pentanoic acid
US10774085, Example 8 US9676783, 8 BDBM136591 US8865698, 8 US10005783, 8 US11267818, Example 8 US10047097, 8
(5S,8S)-N- (4-chloro-2,3- difluorobenzyl)- 5-fluoro- 8-hydroxy-8- (hydroxymethyl)- 5,6,7,8- tetrahydroquinoline- 5-carboxamide US11077100, Example 322 BDBM510462
4-[(3,4-Difluoro-5-hydroxyphenyl)amino]-5-oxo-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepine-8-carbonitrile BDBM220979 US10047096, 8
5-(2-hydroxyethylamino)quinazolino[2,3-a]phthalazin-8-one 5-(2-hydroxyethylamino)-8-quinazolino[2,3-a]phthalazinone MLS000419431 SMR000320166 BDBM47672 cid_2241132
5-(8-Hydroxy-7-piperidin-1-ylmethyl-isoquinolin-5-ylmethyl)-7-piperidin-1-ylmethyl-quinolin-8-ol BDBM50071612 PD-29361 CHEMBL312381
6-Chloro-8-{5-[1-(2-methoxy-ethyl)-piperidin-4-yl]-[1,3,4]oxadiazol-2-yl}-chroman-5-ylamine BDBM325566 US9636335, 8
BDBM50048786 {[5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,5-dichloro-benzoylamino)-5-oxo-pentanoyl]-methyl-amino}-acetic acid CHEMBL30369
CHEMBL1778243 BDBM50344506 5-chloro-2-(6-((1S,5S)-8-(cyclopropylsulfonyl)-8-azabicyclo[3.2.1]octan-3-yloxy)-5-methylpyrimidin-4-yloxy)benzonitrile
CHEMBL283920 {3-[5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,5-dichloro-benzoylamino)-5-oxo-pentanoylamino]-phenyl}-acetic acid BDBM50048784
US20250026742, Example 8 3-(3-(4-((aminosulfonyl)aminomethylene)phenyl)isoxazol-5-yl)-5-(4-(isopropylsulfonyl)phenyl)pyrazin-2-amine 8 BDBM714709
2-bromobenzoic acid [5-chloro-7-(morpholinomethyl)-8-quinolyl] ester MLS000770987 cid_1534930 BDBM63739 [5-chloranyl-7-(morpholin-4-ylmethyl)quinolin-8-yl] 2-bromanylbenzoate SMR000375957 [5-chloro-7-(morpholin-4-ylmethyl)quinolin-8-yl] 2-bromobenzoate 2-bromobenzoic acid [5-chloro-7-(4-morpholinylmethyl)-8-quinolinyl] ester
2-chlorobenzoic acid [5-chloro-7-(morpholinomethyl)-8-quinolyl] ester SMR000377521 2-chlorobenzoic acid [5-chloro-7-(4-morpholinylmethyl)-8-quinolinyl] ester cid_1523424 [5-chloranyl-7-(morpholin-4-ylmethyl)quinolin-8-yl] 2-chloranylbenzoate MLS001003544 BDBM65503 [5-chloro-7-(morpholin-4-ylmethyl)quinolin-8-yl] 2-chlorobenzoate
4-[(8-hydroxy-5-quinolinyl)methyl]-1-piperazinecarboxylic acid ethyl ester SMR000277165 ethyl 4-[(8-oxidanylquinolin-5-yl)methyl]piperazine-1-carboxylate BDBM34860 MLS000715648 4-[(8-hydroxy-5-quinolyl)methyl]piperazine-1-carboxylic acid ethyl ester cid_1090305 ethyl 4-[(8-hydroxyquinolin-5-yl)methyl]piperazine-1-carboxylate
5-[ethanoyl-(6-methoxyquinolin-8-yl)amino]-2-oxidanyl-benzoic acid BDBM93548 cid_279589 5-[acetyl-(6-methoxyquinolin-8-yl)amino]-2-hydroxybenzoic acid 5-[acetyl-(6-methoxy-8-quinolyl)amino]-2-hydroxy-benzoic acid SMR001797654 MLS002920056 5-[acetyl-(6-methoxy-8-quinolinyl)amino]-2-hydroxybenzoic acid
5-bromo-2-[(E)-2-(4-methoxyphenyl)ethenyl]quinolin-8-ol SMR000556112 BDBM53153 5-bromo-2-[(E)-2-(4-methoxyphenyl)ethenyl]-8-quinolinol 5-bromanyl-2-[(E)-2-(4-methoxyphenyl)ethenyl]quinolin-8-ol cid_6019408 5-bromo-2-[(E)-2-(4-methoxyphenyl)vinyl]quinolin-8-ol MLS001196542
BDBM97023 [5-chloro-7-(morpholin-4-ylmethyl)quinolin-8-yl] 2-fluorobenzoate SMR000349875 2-fluorobenzoic acid [5-chloro-7-(4-morpholinylmethyl)-8-quinolinyl] ester 2-fluorobenzoic acid [5-chloro-7-(morpholinomethyl)-8-quinolyl] ester MLS002636037 [5-chloranyl-7-(morpholin-4-ylmethyl)quinolin-8-yl] 2-fluoranylbenzoate cid_1534928
[5-chloranyl-7-(morpholin-4-ylmethyl)quinolin-8-yl] 3,4,5-trimethoxybenzoate [5-chloro-7-(morpholin-4-ylmethyl)quinolin-8-yl] 3,4,5-trimethoxybenzoate BDBM39046 SMR000091694 cid_1534926 MLS000114281 3,4,5-trimethoxybenzoic acid [5-chloro-7-(4-morpholinylmethyl)-8-quinolinyl] ester 3,4,5-trimethoxybenzoic acid [5-chloro-7-(morpholinomethyl)-8-quinolyl] ester
[5-chloranyl-7-(morpholin-4-ylmethyl)quinolin-8-yl] 4-methoxybenzoate [5-chloro-7-(morpholin-4-ylmethyl)quinolin-8-yl] 4-methoxybenzoate BDBM49220 MLS000082013 SMR000061351 cid_1534922 4-methoxybenzoic acid [5-chloro-7-(4-morpholinylmethyl)-8-quinolinyl] ester 4-methoxybenzoic acid [5-chloro-7-(morpholinomethyl)-8-quinolyl] ester
BDBM50048730 CHEMBL433623 (S)-4-[5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,5-dichloro-benzoylamino)-5-oxo-pentanoylamino]-4-(indan-5-ylcarbamoyl)-butyric acid
US10676479, Example 8 BDBM450971 (8-(2,4-Dimethylpyrimidin-5-yl)-5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)amino)imidazo[1,5-c]pyrimidin-1-yl)methanol
US10414761, Example 8 US9920047, 8 US9487511, 8 US10053456, 8 BDBM256629 US9718814, 8
US10550118, Example 8-8 US11453668, Example 8-8 BDBM431901
5-(benzoxymethyl)-7-[(4-methylpiperazino)methyl]quinolin-8-ol SMR000030495 7-[(4-methyl-1-piperazinyl)methyl]-5-(phenylmethoxymethyl)-8-quinolinol MLS000094941 cid_3242434 BDBM49239 7-[(4-methylpiperazin-1-yl)methyl]-5-(phenylmethoxymethyl)quinolin-8-ol
5-(methoxymethyl)-7-[(4-methyl-1-piperazinyl)methyl]-8-quinolinol SMR000135541 cid_683744 5-(methoxymethyl)-7-[(4-methylpiperazin-1-yl)methyl]quinolin-8-ol MLS000530561 5-(methoxymethyl)-7-[(4-methylpiperazino)methyl]quinolin-8-ol BDBM65016
5-[[4-(2,5-dimethylphenyl)sulfonylpiperazin-1-yl]methyl]quinolin-8-ol MLS000759937 cid_2486837 SMR000370014 5-[[4-(2,5-dimethylphenyl)sulfonyl-1-piperazinyl]methyl]-8-quinolinol BDBM58006 5-[[4-(2,5-dimethylphenyl)sulfonylpiperazino]methyl]quinolin-8-ol
5-nitro-7-[(4-phenyl-1-piperazinyl)methyl]-8-quinolinol BDBM63451 cid_1251267 MLS000626648 5-nitro-7-[(4-phenylpiperazin-1-yl)methyl]quinolin-8-ol SMR000298940 5-nitro-7-[(4-phenylpiperazino)methyl]quinolin-8-ol
cid_1186757 5-(2-morpholinoethylamino)quinazolino[2,3-a]phthalazin-8-one BDBM42506 5-[2-(4-morpholinyl)ethylamino]-8-quinazolino[2,3-a]phthalazinone MLS000536642 5-(2-morpholin-4-ylethylamino)quinazolino[2,3-a]phthalazin-8-one SMR000155600
BDBM283217 US11084793, Example 8 US10328077, Example 8 US9573930, Example 8 US10207999, Example 8 US9776974, Example 8 US10548896, Example 8 4-[2-(4-amino-piperidin-1-yl)-5- (6-methoxypyridin-3-yl)-1- methyl-6-oxo-1,6-dihydro- pyrimidin-4-yl]-2-fluoro- benzonitrile US10849898, Example 8 US10960005, Example 8 US10023543, Example 8 US9771329, Example 8
cid_414096 8-[[4-(diethylamino)-1-methyl-butyl]amino]quinolin-6-ol 8-[5-(diethylamino)pentan-2-ylamino]quinolin-6-ol BDBM40739 8-[5-(diethylamino)pentan-2-ylamino]-6-quinolinol
2-[(E)-2-(5-bromo-2-methoxy-phenyl)vinyl]quinolin-8-ol 2-[(E)-2-(5-bromo-2-methoxyphenyl)ethenyl]quinolin-8-ol SMR000558475 2-[(E)-2-(5-bromanyl-2-methoxy-phenyl)ethenyl]quinolin-8-ol BDBM58382 MLS001196172 2-[(E)-2-(5-bromo-2-methoxyphenyl)ethenyl]-8-quinolinol 2-[(E)-2-(5-bromo-2-methoxyphenyl)vinyl]quinolin-8-ol cid_5731505
2-[(E)-2-(5-chloro-2-methoxy-phenyl)vinyl]quinolin-8-ol BDBM54436 SMR000556279 MLS001196391 2-[(E)-2-(5-chloro-2-methoxyphenyl)ethenyl]quinolin-8-ol 2-[(E)-2-(5-chloranyl-2-methoxy-phenyl)ethenyl]quinolin-8-ol 2-[(E)-2-(5-chloro-2-methoxyphenyl)ethenyl]-8-quinolinol 2-[(E)-2-(5-chloro-2-methoxyphenyl)vinyl]quinolin-8-ol cid_5730217
2-methyl-N-[(5-nitro-8-oxidanyl-quinolin-7-yl)-phenyl-methyl]propanamide N-[(8-hydroxy-5-nitroquinolin-7-yl)-phenylmethyl]-2-methylpropanamide SMR000207599 cid_2928413 MLS000585618 N-[(8-hydroxy-5-nitroquinolin-7-yl)(phenyl)methyl]-2-methylpropanamide N-[(8-hydroxy-5-nitro-7-quinolinyl)-phenylmethyl]-2-methylpropanamide N-[(8-hydroxy-5-nitro-7-quinolyl)-phenyl-methyl]-2-methyl-propionamide BDBM33122
5-chloro-7-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-8-quinolinol SMR000079984 5-chloro-7-{[4-(2-pyridinyl)-1-piperazinyl]methyl}-8-quinolinol 5-chloro-7-[[4-(2-pyridyl)piperazino]methyl]quinolin-8-ol cid_1093278 BDBM34620 5-chloranyl-7-[(4-pyridin-2-ylpiperazin-1-yl)methyl]quinolin-8-ol 5-chloro-7-[(4-pyridin-2-ylpiperazin-1-yl)methyl]quinolin-8-ol MLS000051547
BDBM57118 MLS000531218 SMR000136196 5-chloro-7-{[4-(4-fluorophenyl)-1-piperazinyl]methyl}-8-quinolinol cid_1263653 5-chloro-7-[[4-(4-fluorophenyl)piperazin-1-yl]methyl]quinolin-8-ol 5-chloro-7-[[4-(4-fluorophenyl)-1-piperazinyl]methyl]-8-quinolinol 5-chloranyl-7-[[4-(4-fluorophenyl)piperazin-1-yl]methyl]quinolin-8-ol 5-chloro-7-[[4-(4-fluorophenyl)piperazino]methyl]quinolin-8-ol
BDBM57734 SMR000300581 MLS000862541 cid_2966178 5-chloro-7-[3-pyridinyl-(2-pyridinylamino)methyl]-8-quinolinol 5-chloro-7-[3-pyridyl-(2-pyridylamino)methyl]quinolin-8-ol 5-chloro-7-[pyridin-3-yl-(pyridin-2-ylamino)methyl]quinolin-8-ol 5-chloranyl-7-[pyridin-3-yl-(pyridin-2-ylamino)methyl]quinolin-8-ol 5-chloro-7-[3-pyridinyl(2-pyridinylamino)methyl]-8-quinolinol
BDBM64661 cid_2976904 MLS000663390 7-[(5-chloranyl-2-methoxy-phenyl)-(pyridin-3-ylamino)methyl]quinolin-8-ol 7-[(5-chloro-2-methoxyphenyl)(3-pyridinylamino)methyl]-8-quinolinol 7-[(5-chloro-2-methoxyphenyl)-(3-pyridinylamino)methyl]-8-quinolinol SMR000300973 7-[(5-chloro-2-methoxyphenyl)-(pyridin-3-ylamino)methyl]quinolin-8-ol 7-[(5-chloro-2-methoxy-phenyl)-(3-pyridylamino)methyl]quinolin-8-ol
N-[(5-nitro-8-oxidanyl-quinolin-7-yl)-thiophen-2-yl-methyl]propanamide N-[(8-hydroxy-5-nitro-7-quinolinyl)-thiophen-2-ylmethyl]propanamide N-[(8-hydroxy-5-nitroquinolin-7-yl)-thiophen-2-ylmethyl]propanamide N-[(8-Hydroxy-5-nitro-quinolin-7-yl)-thiophen-2-yl-methyl]-propionamide BDBM64616 cid_2921716 N-[(8-hydroxy-5-nitro-7-quinolyl)-(2-thienyl)methyl]propionamide MLS000553767 SMR000172090
N-[(8-hydroxy-5-nitro-7-quinolinyl)(2-thienyl)methyl]butanamide N-[(8-hydroxy-5-nitro-7-quinolyl)-(2-thienyl)methyl]butyramide N-[(8-hydroxy-5-nitro-7-quinolinyl)-thiophen-2-ylmethyl]butanamide cid_2921187 BDBM88857 MLS000575833 N-[(8-hydroxy-5-nitroquinolin-7-yl)-thiophen-2-ylmethyl]butanamide SMR000196869 N-[(5-nitro-8-oxidanyl-quinolin-7-yl)-thiophen-2-yl-methyl]butanamide
N-[(8-hydroxy-5-nitro-7-quinolinyl)-(4-methylphenyl)methyl]acetamide SMR000230818 N-[(8-hydroxy-5-nitroquinolin-7-yl)-(4-methylphenyl)methyl]acetamide MLS000705485 N-[{8-hydroxy-5-nitro-7-quinolinyl}(4-methylphenyl)methyl]acetamide BDBM64660 cid_4139598 N-[(8-hydroxy-5-nitro-7-quinolyl)-(p-tolyl)methyl]acetamide N-[(4-methylphenyl)-(5-nitro-8-oxidanyl-quinolin-7-yl)methyl]ethanamide
SMR000172089 BDBM47734 cid_2922056 N-[(8-hydroxy-5-nitro-7-quinolinyl)-(4-methylphenyl)methyl]propanamide N-[(8-hydroxy-5-nitro-7-quinolyl)-(p-tolyl)methyl]propionamide N-[(8-hydroxy-5-nitroquinolin-7-yl)-(4-methylphenyl)methyl]propanamide N-[(4-methylphenyl)-(5-nitro-8-oxidanyl-quinolin-7-yl)methyl]propanamide N-[(8-Hydroxy-5-nitro-quinolin-7-yl)-p-tolyl-methyl]-propionamide MLS000553854
SMR000517145 BDBM64032 N-[(5-chloro-8-hydroxyquinolin-7-yl)-(4-methylphenyl)methyl]acetamide N-[(5-chloro-8-hydroxy-7-quinolinyl)-(4-methylphenyl)methyl]acetamide N-[(5-Chloro-8-hydroxy-quinolin-7-yl)-p-tolyl-methyl]-acetamide N-[(5-chloro-8-hydroxy-7-quinolyl)-(p-tolyl)methyl]acetamide cid_2920402 MLS001210777 N-[(5-chloranyl-8-oxidanyl-quinolin-7-yl)-(4-methylphenyl)methyl]ethanamide
8-Hydroxy-8-(2-octyloxy-quinolin-3-yl)-oct-5-ynoic acid methyl ester (8c) BDBM233172
8-Hydroxy-8-(2-pentyloxy-pyridin-3-yl)-oct-5-ynoic acid methyl ester BDBM50172814 CHEMBL373318
8-Hydroxy-8-(3-pentyloxy-naphthalen-2-yl)-oct-5-ynoic acid methyl ester CHEMBL198166 BDBM50172816
Asinex compound 8 (2S)-1-amino-3-[(5-nitroquinolin-8-yl)amino]propan-2-ol BDBM14821
BDBM297342 US10112955, Example 8 3-methyl-5-(pyrimidin-4-ylamino)isoindolin-1-one (Cpd. No. 8)
BDBM376370 US9914740, VII-8 methyl 5-((6H- isochromeno [3,4-c]pyridine-8- carboxamido) methyl)-2- fluorobenzoate
BDBM50322779 CHEMBL1172761 5-Chloro-7-{[8-(1,2,3,4-tetrahydroacridin-9-ylamino)octylamino]methyl}quinolin-8-ol Dihydrochloride
BDBM50325866 endo-3-((1R,5S)-8-benzyl-8-azabicyclo[3.2.1]octan-3-yloxy)-5-fluorobenzamide CHEMBL1224139
BDBM50325867 CHEMBL1224140 endo-3-((1R,5S)-8-benzyl-8-azabicyclo[3.2.1]octan-3-yloxy)-5-methylbenzamide
BDBM50341837 tert-Butyl 3-(3-(7-(Hydroxyimino)-8-(methylamino)-8-oxooctylcarbamoyl)isoxazol-5-yl)phenylcarbamate CHEMBL1767041
BDBM50341838 CHEMBL1767042 tert-Butyl 4-(3-(7-Hydroxyimino-8-(methylamino)-8-oxooctylcarbamoyl)isoxazol-5-yl)phenylcarbamate
CHEMBL317905 BDBM50138646 2-Isoxazol-5-yl-8-methyl-3-p-tolyl-8-aza-bicyclo[3.2.1]octane
Sodium 8-hydroxy-8-(2-pentyloxy-benzo[h]quinolin-3-yl)-oct-5-ynoate (27b) BDBM233184
Sodium 8-hydroxy-8-(6-methoxy-2-pentyloxy-quinolin-3-yl)-oct-5-ynoate (27a) BDBM233183
Sodium 8-hydroxy-8-[2-(3-methoxy-propoxy)-quinolin-3-yl]-oct-5-ynoate (9d) BDBM233177
Sodium 8-hydroxy-8-[2-(4,4,4-trifluoro-butoxy)-quinolin-3-yl]-oct-5-ynoate (9e) BDBM233178
US10975084, Example 8-8 BDBM492406 5-(4-fluorophenyl)[1,2,4]triazolo[1,5- a]pyrimidin-7(4H)-one
CHEMBL412108 (S)-4-[5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,5-dichloro-benzoylamino)-5-oxo-pentanoylamino]-5-(2,3-dihydro-indol-1-yl)-5-oxo-pentanoic acid BDBM50048751
(R)-8-(8-((2,3- dichlorophenyl) amino)imidazo[1,2- c]pyrimidin-5-yl)-8- azaspiro[4.5]decan- 1-amine BDBM527855 US11179397, Example 72
(R)-8-(8-((2,4-dichlorophenyl)thio)imidazo[1,2-c]pyrimidin-5-yl)-8-azaspiro[4.5]decan-1-amine BDBM580210 US11498930, Compound 1.1.20
(R)-8-(8-((2-isopropylphenyl)thio)imidazo[1,2-c]pyrimidin-5-yl)-8-azaspiro[4.5]decan-1-amine BDBM580213 US11498930, Compound 1.1.21
(R)-8-(8-(2,3- dichlorophenyl)-7- methylimidazo[1,2- c]pyrimidin-5-yl)-8- azaspiro[4.5]decan- 1-amine BDBM527792 US11179397, Example 9
(R)-8-(8-(3,4- dichlorophenyl)-7- methylimidazo[1,2- c]pyrimidin-5-yl)- 8-azaspiro[4.5] decan-1-amine BDBM527808 US11179397, Example 25
(R)-8-(8-(3- chlorophenyl)-7- methylimidazo[1,2- c]pyrimidin-5-yl)-8- azaspiro[4.5]decan- 1-amine BDBM527806 US11179397, Example 23
BDBM365324 US10533001, Example 8 US11414410, Example 8 2-(4-(4- acetylpiperazin-1- yl)phenylamino)-4- (butylamino) pyrimidine-5- carboxamide US9868729, Example 8
BDBM527809 US11179397, Example 26 (R)-8-(8-(2,4- dichlorophenyl)-7- methylimidazo[1,2- c]pyrimidin-5-yl)-8- azaspiro[4.5]decan- 1-amine
BDBM527870 (R)-8-(8- (isoquinolin-4- ylthio)imidazo [1,2-c]pyrimidin-5- yl)-8- azaspiro[4.5] decan-1-amine US11179397, Example 87
BDBM580214 US11498930, Compound 1.1.22 (R)-8-(8-((2-methoxyphenyl)thio)imidazo[1,2-c]pyrimidin-5-yl)-8-azaspiro[4.5]decan-1-amine
BDBM580244 US11498930, Compound 1.1.45 (R)-8-(8-(naphthalen-1-ylthio)imidazo[1,2-c]pyrimidin-5-yl)-8-azaspiro[4.5]decan-1-amine
US10081632, Compound 8 US10758530, Compound 8 US9771366, Compound 8 1-benzyl-N-(3-(morpholinomethyl)benzofuran-5-yl)-1H-pyrazole-4-carboxamide BDBM286081
US11498930, Compound 1.1.19 (R)-8-(8-((2-chlorophenyl)thio)imidazo[1,2-c]pyrimidin-5-yl)-8-azaspiro[4.5]decan-1-amine BDBM580209
US11498930, Compound 1.2.23 BDBM580316 (R)-8-(8-(2,3-dichlorophenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-yl)-8-azaspiro[4.5]decan-1-amine
SMR000204670 2-[[7-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-4-nitro-benzofurazan-5-yl]amino]ethanol cid_3424815 MLS000586307 2-{[7-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-4-nitro-2,1,3-benzoxadiazol-5-yl]amino}ethanol 2-[[7-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-4-nitro-2,1,3-benzoxadiazol-5-yl]amino]ethanol BDBM34781
2-[[7-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-4-nitro-2,1,3-benzoxadiazol-5-yl](methyl)amino]ethanol cid_6617289 SMR000207238 2-[[7-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-4-nitro-benzofurazan-5-yl]-methyl-amino]ethanol MLS000584853 BDBM68961 2-[[7-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-4-nitro-2,1,3-benzoxadiazol-5-yl]-methylamino]ethanol 2-[[7-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-4-nitro-2,1,3-benzoxadiazol-5-yl]-methyl-amino]ethanol
8-[2-(3-fluorophenyl)-5-phenylpyrazolo[1,5-a]pyrimidin-7-yl]-1,4-dioxa-8-azaspiro[4.5]decane MLS000528642 8-[2-(3-Fluoro-phenyl)-5-phenyl-pyrazolo[1,5-a]pyrimidin-7-yl]-1,4-dioxa-8-aza-spiro[4.5]decane 8-[2-(3-fluorophenyl)-5-phenyl-pyrazolo[1,5-a]pyrimidin-7-yl]-1,4-dioxa-8-azaspiro[4.5]decane cid_1441544 8-[2-(3-fluorophenyl)-5-phenyl-7-pyrazolo[1,5-a]pyrimidinyl]-1,4-dioxa-8-azaspiro[4.5]decane SMR000121117 BDBM44860
BDBM37361 cid_650554 MLS000035341 8-[2-(4-methoxyphenyl)-5-phenylpyrazolo[1,5-a]pyrimidin-7-yl]-1,4-dioxa-8-azaspiro[4.5]decane 8-[2-(4-Methoxy-phenyl)-5-phenyl-pyrazolo[1,5-a]pyrimidin-7-yl]-1,4-dioxa-8-aza-spiro[4.5]decane 8-[2-(4-methoxyphenyl)-5-phenyl-7-pyrazolo[1,5-a]pyrimidinyl]-1,4-dioxa-8-azaspiro[4.5]decane 8-[2-(4-methoxyphenyl)-5-phenyl-pyrazolo[1,5-a]pyrimidin-7-yl]-1,4-dioxa-8-azaspiro[4.5]decane SMR000008501
BDBM54447 (5E)-5-[[2-(trifluoromethyl)phenyl]hydrazinylidene]quinolin-8-one cid_5999536 SMR000554419 (5E)-quinoline-5,8-dione 5-{[2-(trifluoromethyl)phenyl]hydrazone} MLS001195156 (5E)-5-[[2-(trifluoromethyl)phenyl]hydrazinylidene]-8-quinolinone (5E)-5-[[2-(trifluoromethyl)phenyl]hydrazono]quinolin-8-one
BDBM50048736 (S)-4-[5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,5-dichloro-benzoylamino)-5-oxo-pentanoylamino]-4-(quinolin-5-ylcarbamoyl)-butyric acid; hydrochloride CHEMBL540261
(5R)-2,6,9-humulatrien-5-ol-8-one BDBM50242095 CHEMBL469850
(8R,8'R,9'S)-5-methoxyclusin CHEMBL482233 BDBM50259849
2-(6-amino-5-(8- BDBM394449 US10308614, Example 50
2-(6-amino-5-(8- US10308614, Example 43 BDBM394442
2-(6-amino-5-(8- US10308614, Example 67 BDBM394466
2-(6-amino-5-(8- US10308614, Example 69 BDBM394468
3-5-dimethyl-8-methoxy-3,4-dihydroisocoumarin BDBM50208251 CHEMBL226463
BDBM247154 1-(5-Methylthiazol-2-yl)ethanone US9701672, 8
BDBM394470 US10308614, Example 71 2-(6-amino-5-(8-
BDBM50287542 CHEMBL54141 6-Methanesulfonyl-5-nitro-quinolin-8-ylamine
BDBM58252 5-hydroxy-2-(2-methoxyphenyl)-8-nitro-chromone
CHEMBL1269662 5-bromo-N-(quinolin-8-yl)nicotinamide BDBM50330212
CHEMBL300204 BDBM50287523 6-Benzenesulfonyl-8-methyl-5-nitro-quinoline
CHEMBL333343 BDBM50052886 6,7,8,9-Tetrahydro-5-thia-8-aza-benzocycloheptene
CHEMBL51065 6-Benzenesulfonyl-5-nitro-quinolin-8-ylamine BDBM50287539
US10308614, Example 8 2-(6-amino-5-(3- BDBM394407
US10934305, Compound HK-5 US10934305, Compound HK-8 BDBM485179
US9351965, 8 US9351965, 7 US9351965, 6 US9351965, 5 BDBM233398
WO2022098806, Compound 3-8 WO2022098806, Compound 3-5 BDBM548932
sulfonamide compound, 8 BDBM17602 2-benzenesulfonamido-5-butylbenzoic acid
SMR000206682 MLS000583496 cid_5103647 3-[5-(1,3-benzodioxol-5-ylmethylamino)-1,3,4-thiadiazol-2-yl]-8-ethoxychromen-2-one BDBM47749 8-ethoxy-3-[5-(piperonylamino)-1,3,4-thiadiazol-2-yl]coumarin 3-[5-(1,3-benzodioxol-5-ylmethylamino)-1,3,4-thiadiazol-2-yl]-8-ethoxy-chromen-2-one 3-{5-[(1,3-benzodioxol-5-ylmethyl)amino]-1,3,4-thiadiazol-2-yl}-8-ethoxy-2H-chromen-2-one 3-[5-(1,3-benzodioxol-5-ylmethylamino)-1,3,4-thiadiazol-2-yl]-8-ethoxy-1-benzopyran-2-one
US10590139, Example 8 US9227975, 8 US10011604, 8 US9795611, 8 BDBM200580
(5R,8R)-N-(2,4- dichlorobenzyl)- 5-fluoro-8- hydroxy-8- (hydroxymethyl)- 5,6,7,8- tetrahydroquinoline- 5-carboxamide US11077100, Example 302 BDBM510442 US11439633, Example 302
(5S,8R)-5-fluoro-8- hydroxy-8- (hydroxymethyl)- N-(2,3,4- trifluorobenzyl)- 5,6,7,8- tetrahydroquinoline- 5-carboxamide BDBM510449 US11439633, Example 309 US11077100, Example 309
(5S,8R)-8- (cyanomethyl)- N-(2,4- dichlorobenzyl)- 5-fluoro-8-hydroxy- 5,6,7,8- tetrahydroquinoline- 5-carboxamide BDBM510420 US11077100, Example 280 US11439633, Example 280
2-[5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,5-dichloro-benzoylamino)-5-oxo-pentanoylamino]-4-methyl-pentanoic acid BDBM50048793 CHEMBL281507
2-[8-(4-Chloro-phenyl)-8-oxo-octylsulfanyl]-1-(3-phenyl-propyl)-5-pyrimidin-5-ylmethyl-1H-pyrimidin-4-one CHEMBL87892 BDBM50093925
BDBM408104 US10336775, Example 8 -5-(4-(1-(benzo[d][1,3]dioxol-5-yl)ethyl)piperazin-1-yl)-2-iodopyrimidine US11046712, No 8
BDBM50048763 CHEMBL265740 4-{[5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,5-dichloro-benzoylamino)-5-oxo-pentanoyl]-methyl-amino}-benzoic acid
BDBM50048782 CHEMBL431692 2-{[5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,5-dichloro-benzoylamino)-5-oxo-pentanoyl]-methyl-amino}-benzoic acid
BDBM50048798 CHEMBL433621 2-[5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,5-dichloro-benzoylamino)-5-oxo-pentanoylamino]-N-benzyl-succinamic acid
BDBM50093929 2-[8-(4-Chloro-phenyl)-8-oxo-octylsulfanyl]-1-furan-2-ylmethyl-5-pyrimidin-5-ylmethyl-1H-pyrimidin-4-one CHEMBL87936
BDBM50093949 2-[8-(4-Chloro-phenyl)-8-oxo-octylsulfanyl]-1-(2-methoxy-ethyl)-5-pyrimidin-5-ylmethyl-1H-pyrimidin-4-one CHEMBL85600
BDBM510174 US11439633, Example 34 N-(2,4-dichloro-6-methylbenzyl)-5- fluoro-8-hydroxy-8-(hydroxymethyl)- 5,6,7,8-tetrahydroquinoline-5- carboxamide US11077100, Example 34
BDBM510177 US11439633, Example 37 N-(2,4-dichlorobenzyl)-5-fluoro-8-hy- droxy-8-(hydroxymethyl)-5,6,7,8-tetra- hydroquinoline-5-carboxamide US11077100, Example 37
BDBM510448 (5S,8S)-5-fluoro-8- hydroxy-8- (hydroxymethyl)- N-(2,3,4- trifluorobenzyl)- 5,6,7,8- tetrahydroquinoline- 5-carboxamide US11077100, Example 308 US11439633, Example 308
BDBM510458 (5S,8S)-N-(2,4- difluorobenzyl)-5- fluoro-8-hydroxy-8- (hydroxymethyl)- 5,6,7,8- tetrahydroquinoline- 5-carboxamide US11077100, Example 318 US11439633, Example 318
BDBM510470 US11439633, Example 330 (5S,8S)-N-(2,4- dichlorophenethyl)- 5-fluoro-8- hydroxy-8- (hydroxymethyl)- 5,6,7,8- tetrahydroquinoline- 5-carboxamide US11077100, Example 330
BDBM756223 WO2011053861, Compound 8 US2010/054853, Compound 8 (5 -2-(pyrrolidin-3 -ylamino)-4-(4-trifluoromethylamino)pyrido [4,3 -djpyrimidin- 5(6H)-one
CHEMBL289018 BDBM50048768 2-[5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,5-dichloro-benzoylamino)-5-oxo-pentanoylamino]-4-methylsulfanyl-butyric acid
CHEMBL30481 BDBM50048747 2-[5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,5-dichloro-benzoylamino)-5-oxo-pentanoylamino]-3-phenyl-propionic acid
CHEMBL30696 2-[5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,5-dichloro-benzoylamino)-5-oxo-pentanoylamino]-4-phenyl-butyric acid BDBM50048771
CHEMBL85805 BDBM50093924 2-[8-(4-Chloro-phenyl)-8-oxo-octylsulfanyl]-5-pyrimidin-5-ylmethyl-1-thiophen-2-ylmethyl-1H-pyrimidin-4-one
N-(2-chlorophenyl)-5-phenylimidazo[1,5-a]pyrazine-8-amine BDBM50246553 CHEMBL462228 N-(2-chlorophenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine
US11077100, Example 256 US11439633, Example 256 (5S,8S)-N-(2,4- dichlorobenzyl)-5- fluoro-8-hydroxy- 8-methyl-5,6,7,8- tetrahydroquinoline- 5-carboxamide BDBM510396
US11077100, Example 257 BDBM510397 US11439633, Example 257 (5S,8R)-N-(2,4- dichlorobenzyl)-5- fluoro-8-hydroxy- 8-methyl-5,6,7,8- tetrahydroquinoline- 5-carboxamide
US11077100, Example 258 BDBM510398 US11439633, Example 258 (5S,8S)-5-fluoro-8- hydroxy-8- methyl-N-(2,3,4- trifluorobenzyl)- 5,6,7,8- tetrahydroquinoline- 5-carboxamide
US11077100, Example 303 (5R,8S)-N-(2,4- dichlorobenzyl)- 5-fluoro-8- hydroxy-8- (hydroxymethyl)- 5,6,7,8- tetrahydroquinoline- 5-carboxamide US11439633, Example 303 BDBM510443
US11077100, Example 304 (5S,8S)-N-(2,4- dichlorobenzyl)- 5-fluoro-8- hydroxy-8- (hydroxymethyl)- 5,6,7,8- tetrahydroquinoline- 5-carboxamide US11439633, Example 304 BDBM510444
US11077100, Example 305 (5S,8R)-N-(2,4- dichlorobenzyl)- 5-fluoro-8- hydroxy-8- (hydroxymethyl)- 5,6,7,8- tetrahydroquinoline- 5-carboxamide BDBM510445 US11439633, Example 305
US11439633, Example 263 BDBM510403 US11077100, Example 263 (5S,8S)-N-(2,4- difluorobenzyl)-5- fluoro-8-hydroxy- 8-methyl-5,6,7,8- tetrahydroquinoline- 5-carboxamide
US11439633, Example 285 BDBM510425 (5S,8S)-N-(2,4- dichlorobenzyl)-5- fluoro-8- (fluoromethyl)-8- hydroxy-5,6,7,8- tetrahydroquinoline- 5-carboxamide US11077100, Example 285
US11439633, Example 36 BDBM510176 N-(2,3-dichlorobenzyl)-5-fluoro-8-hy- droxy-8-(hydroxymethyl)-5,6,7,8-tetra- hydroquinoline-5-carboxamide US11077100, Example 36
US20250011311, Example 52 BDBM712235 (5-Oxa-8-azaspiro [3.5]nonan-8- yl)(5-(2,4,5-trifluoro-3- hydroxyphenyl)-1,2,4- oxadiazol-3-yl)methanone
5-[(4-chloro-6-methoxy-8-quinolyl)amino]pentan-2-one BDBM32192 TG2-26-1 5-[(4-chloro-6-methoxyquinolin-8-yl)amino]pentan-2-one cid_16072276 5-[(4-chloranyl-6-methoxy-quinolin-8-yl)amino]pentan-2-one 5-[(4-chloro-6-methoxy-8-quinolinyl)amino]-2-pentanone
5-[(6-methoxy-4-phenylmethoxy-quinolin-8-yl)amino]pentan-2-one 5-[(6-methoxy-4-phenylmethoxyquinolin-8-yl)amino]pentan-2-one 5-[(6-methoxy-4-phenylmethoxy-8-quinolinyl)amino]-2-pentanone 5-[(4-benzoxy-6-methoxy-8-quinolyl)amino]pentan-2-one BDBM32152 cid_16072246 TG2-30-1
MLS000042505 8-methyl-3-methylsulfanyl-5-(phenylmethyl)-[1,2,4]triazino[5,6-b]indole 8-methyl-3-(methylthio)-5-(phenylmethyl)-[1,2,4]triazino[5,6-b]indole cid_6400963 5-benzyl-8-methyl-3-(methylthio)-[1,2,4]triazin[5,6-b]indole SMR000046397 BDBM32262 5-benzyl-8-methyl-3-methylsulfanyl-[1,2,4]triazino[5,6-b]indole
N-[(5-chloro-8-hydroxy-7-quinolinyl)-(3,4-dimethoxyphenyl)methyl]propanamide cid_2921752 N-[(5-chloro-8-hydroxy-7-quinolyl)-(3,4-dimethoxyphenyl)methyl]propionamide BDBM55745 N-[(5-chloranyl-8-oxidanyl-quinolin-7-yl)-(3,4-dimethoxyphenyl)methyl]propanamide MLS000715219 SMR000275198 N-[(5-chloro-8-hydroxyquinolin-7-yl)-(3,4-dimethoxyphenyl)methyl]propanamide
cid_3136131 N-[(5-chloro-8-hydroxyquinolin-7-yl)-(4-methoxyphenyl)methyl]propanamide SMR000274262 N-[(5-chloranyl-8-oxidanyl-quinolin-7-yl)-(4-methoxyphenyl)methyl]propanamide BDBM64665 MLS000714282 N-[(5-chloro-8-hydroxy-7-quinolinyl)-(4-methoxyphenyl)methyl]propanamide N-[(5-chloro-8-hydroxy-7-quinolyl)-(4-methoxyphenyl)methyl]propionamide
cid_3136132 N-[(5-chloranyl-8-oxidanyl-quinolin-7-yl)-(4-methylphenyl)methyl]propanamide SMR001317822 N-[(5-chloro-8-hydroxy-7-quinolyl)-(p-tolyl)methyl]propionamide N-[(5-chloro-8-hydroxyquinolin-7-yl)-(4-methylphenyl)methyl]propanamide MLS002264522 BDBM77605 N-[(5-chloro-8-hydroxy-7-quinolinyl)-(4-methylphenyl)methyl]propanamide
BDBM503309 6-amino-2-[(1R)-1-amino-3,3- difluoro-8-azaspiro[4.5]-decan-8- yl]-5-(2,3-dichloro-phenyl)- pyrimidine-4-carboxamide US11033547, Compound 8 US11696916, Compound 8
(2S,5S)-4-(1-(5-amino-4H-1,2,4-triazol-3-yl)piperidin-4-yl)-5-(4-chlorobenzyl)morpholine-2-carboxamide US9944624, Ex. 8 BDBM349918 US10208020, Example 8 US10538508, Example 8
4-(5-(3-amino-8- azabicyclo[3.2.1] octane-8-yl)-8-(5- fluoro-1H- indazole-6-yl) imidazolo[1,2-c] pyrimidin- 7-yl)-2- fluorobenzonitrile hydrochloride BDBM683219 US20240216357, Example 173
4-(5-(3-amino-8- azabicyclo[3.2.1] octane-8-yl)-8-(6- fluorobenzo[c] [1,2,5]oxadiazole- 5-yl)imidazolo [1,2-c]pyrimidin- 7-yl)-2- fluorobenzonitrile BDBM683230 US20240216357, Example 186
BDBM683064 Preparation of 4-(5-(3-amino-8-azabicyclo[3.2.1]octane-8-carbonyl)-2-(5-fluoro-3-pentylbenzo[d]isoxazol-6-yl) thiophen-3-yl)-2-fluorobenzonitrile US20240216357, Example 8
US20230381148, Compound I-8 US11578066, Compound I-8 BDBM593320 N-((5-(5-(difluoromethyl-1,3,4-oxadiazol-2- yl)thiazol-2-yl)methyl)-N-(3- (trifluoromethyl)phenyl)nicotinamide US20240269137, Compound I-8
US9216986, 8-Fluoro-2-[2-(8-methoxy-5-methyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-ethyl]-quinoline US9801878, 8-Fluoro-2-[2-(8-methoxy-5-methyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-ethyl]-quinoline BDBM197749
1H-Indazol-5-ylamine CHEMBL17551 BDBM50304148 1H-indazol-5-amine US9409868, 8 cid_88012
8-(2,4-dimethylpyrimidin-5-yl)-N-((5-fluoro-2,3- BDBM451084 US10676479, Example 114
8-(2,6-dimethylpyridin-3-yl)-5-(((5-fluoro-2,3- BDBM451045 US10676479, Example 75
8-(2-(difluoromethyl)pyridin-3-yl)-5-(((5-fluoro- BDBM451043 US10676479, Example 73
BDBM451071 8-(2,4-dimethylpyrimidin-5-yl)-N-((5-fluoro-2,3- US10676479, Example 101
US10676479, Example 14 BDBM450982 8-(2,4-dimethylpyrimidin-5-yl)-N-((5-fluoro-2,3-
US10676479, Example 15 BDBM450983 8-(2,4-dimethylpyrimidin-5-yl)-N-((5-fluoro-2,3-
ethyl 8-(2,4-dimethylpyrimidin-5-yl)-5-((2-fluoro- BDBM451068 US10676479, Example 98
ethyl 8-(2,6-dimethylpyridin-3-yl)-5-(((5-fluoro- BDBM451063 US10676479, Example 93
BDBM50048743 CHEMBL283924 (S)-4-[5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,5-dichloro-benzoylamino)-5-oxo-pentanoylamino]-5-(3,4-dihydro-2H-quinolin-1-yl)-5-oxo-pentanoic acid
BDBM50048744 CHEMBL286510 (S)-4-[5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,5-dichloro-benzoylamino)-5-oxo-pentanoylamino]-5-(3,4-dihydro-1H-isoquinolin-2-yl)-5-oxo-pentanoic acid
BDBM174777 US9102686, 8 US9540388, 8 US10053462, 8
US9089569, 8 US9695149, 8 US8952177, 8 BDBM145654
US9388176, 8 US9820989, 8 US8889870, 8 BDBM139548
(R)-8-(8-((2,4-dichlorophenyl)thio)-[1,2,4]triazolo[4,3-c]pyrimidin-5-yl)-8-azaspiro[4.5]decan-1-amine US11498930, Compound 1.2.28 BDBM580327
(R)-8-(8-((2-isopropylphenyl)thio)-[1,2,4]triazolo[4,3-c]pyrimidin-5-yl)-8-azaspiro[4.5]decan-1-amine US11498930, Compound 1.2.30 BDBM580331
(R)-8-(8-((4-chlorophenyl)thio)-[1,2,4]triazolo[4,3-c]pyrimidin-5-yl)-8-azaspiro[4.5]decan-1-amine BDBM580324 US11498930, Compound 1.2.27
(R)-8-(8-(pyridin-2-ylthio)-[1,2,4]triazolo[4,3-c]pyrimidin-5-yl)-8-azaspiro[4.5]decan-1-amine BDBM580341 US11498930, Compound 1.2.37
(R)-8-(8-(pyridin-3-ylthio)-[1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-8-azaspiro[4.5]decan-1-amine US11498930, Compound 1.2.70 BDBM580379
(R)-8-(8-(quinolin-4-ylthio)-[1,2,4]triazolo[4,3-c]pyrimidin-5-yl)-8-azaspiro[4.5]decan-1-amine BDBM580351 US11498930, Compound 1.2.47
2-(morpholin-4-yl)-4-(3-oxa-8-azabicyclo[33.2.1]oct-8-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridine BDBM268142 US9549932, 174
BDBM527794 US11179397, Example 11 (Raxial,R)-8-(8-(2,3- dichlorophenyl)-7- methylimidazo[1,2- c]pyrimidin-5-yl)-8- azaspiro[4.5]decan- 1-amine
BDBM580301 (R)-8-(8-((2,3-dichlorophenyl)thio)-[1,2,4]triazolo[4,3-c]pyrimidin-5-yl)-8-azaspiro[4.5]decan-1-amine US11498930, Compound 1.2.15
BDBM580303 US11498930, Compound 1.2.16 (S)-8-(8-((2,3-dichlorophenyl)thio)-[1,2,4]triazolo[4,3-c]pyrimidin-5-yl)-8-azaspiro[4.5]decan-1-amine
BDBM580323 (R)-8-(8-((2-chlorophenyl)thio)-[1,2,4]triazolo[4,3-c]pyrimidin-5-yl)-8-azaspiro[4.5]decan-1-amine US11498930, Compound 1.2.26
BDBM580332 US11498930, Compound 1.2.31 (R)-8-(8-((2-methoxyphenyl)thio)-[1,2,4]triazolo[4,3-c]pyrimidin-5-yl)-8-azaspiro[4.5]decan-1-amine
BDBM580335 US11498930, Compound 1.2.33 (R)-8-(8-((4-aminophenyl)thio)-[1,2,4]triazolo[4,3-c]pyrimidin-5-yl)-8-azaspiro[4.5]decan-1-amine
BDBM580350 US11498930, Compound 1.2.46 (R)-8-(8-(naphthalen-1-ylthio)-[1,2,4]triazolo[4,3-c]pyrimidin-5-yl)-8-azaspiro[4.5]decan-1-amine
US10092575, Example 8 US10376514, Example 8 BDBM289519 8-benzyl-6-(2-Chlorobenzyl)thieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5(6H)-one
US11179397, Example 69 (R)-8-(7-chloro-8- (2,3- dichlorophenyl)- imidazo[1,2- c]pyrimidin-5-yl)- 8- azaspiro[4.5]decan- 1-amine BDBM527852
US11498930, Compound 1.2.29 BDBM580330 (R)-8-(8-((2,6-dichlorophenyl)thio)-[1,2,4]triazolo[4,3-c]pyrimidin-5-yl)-8-azaspiro[4.5]decan-1-amine
US11498930, Compound 1.2.71 (R)-8-(8-((2-methoxyphenyl)thio)-[1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-8-azaspiro[4.5]decan-1-amine BDBM580380
US11498930, Compound 1.2.72 BDBM580381 (R)-8-(8((4-aminophenyl)thio)-[1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-8-azaspiro[4.5]decan-1-amine
US9856263, 8 6-Methyl-5-[2-methyl-4-(pyrazolo[1,5-a]pyrazin-4-yloxy)phenyl](8-2H) imidazo[1,2-a]pyrazine (8) BDBM364288
cid_5808003 (8E)-8-(2,3-dihydro-1,4-benzodioxin-6-ylhydrazinylidene)quinolin-5-one MLS000774822 BDBM48097 (8E)-8-(2,3-dihydro-1,4-benzodioxin-6-ylhydrazono)quinolin-5-one (8E)-8-(2,3-dihydro-1,4-benzodioxin-6-ylhydrazinylidene)-5-quinolinone SMR000365484
BDBM255797 US10092570, Example 8 1-{1-[3-(1-sec-butylazetidin-3-yl)-5-chloro-2-methoxy-4-methylphenyl]ethyl}-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine US9707233, 8 US10646492, Example 8 US11433071, Example 8 US10376513, Example 8 US9730939, Example 8 US9932341, Example 8
US10183953, Example 8 US9845333, 8 BDBM143747 US9611277, Example 8 US8969352, 8
(3S,4S)-8-(8-((8- bromoquinolin-4- yl)thio)imidazo[1,2- c]pyrimidin-5-yl)-3- methyl-2-oxa-8- azaspiro[4.5]decan- 4-amine US11179397, Example 103 BDBM527886
US11179397, Example 104 (3S,4S)-8-(8-((8- aminoquinolin-4- yl)thio)imidazo[1,2- c]pyrimidin-5-yl)-3- methyl-2-oxa-8- azaspiro[4.5]decan- 4-amine BDBM527887
8-Chloro-5-(7-chloro-1H-indazol-5-yl)-2,6-bis(trifluoromethyl)- BDBM288187 US10087185, Example 5
US11439633, Example 5 US11077100, Example 5 N-(cycloheptylmethyl)- 8-oxo-5,6,7,8-tetrahydro- quinoline-5-carboxamide BDBM510069
(E)-8-Hydroxy-8-(3-pentyloxy-naphthalen-2-yl)-oct-5-enoic acid methyl ester CHEMBL198708 BDBM50172806
8-[(2-bromo-5-methoxyphenyl)methyl]-9-butyl-9H-purin-6-amine BDBM20742 8-benzyladenine analogue, 12c
9-butyl-8-[(2-chloro-5-methoxyphenyl)methyl]-9H-purin-6-amine BDBM20741 8-benzyladenine analogue, 12b
BDBM20743 9-butyl-8-[(2-iodo-5-methoxyphenyl)methyl]-9H-purin-6-amine 8-benzyladenine analogue, 12d
BDBM50045824 8-Methyl-2-(3-methyl-[1,2,4]oxadiazol-5-yl)-3-phenyl-8-aza-bicyclo[3.2.1]octane
BDBM50076689 CHEMBL6530 5-Ethyl-8-methyl-4-trifluoromethyl-5,6,7,8-tetrahydro-1-oxa-8-aza-anthracen-2-one
BDBM50138642 CHEMBL103523 3-(4-Chloro-phenyl)-2-isoxazol-5-yl-8-methyl-8-aza-bicyclo[3.2.1]octane
BDBM50172803 CHEMBL196139 (E)-8-Hydroxy-8-(2-pentyloxy-pyridin-3-yl)-oct-5-enoic acid methyl ester
BDBM50246560 CHEMBL460107 (rel)-8-(bis(2-chlorophenyl)methyl)-5'-fluoro-8-azaspiro[bicyclo[3.2.1]octane-3,3'-indoline]
BDBM50246561 (rel)-8-(bis(2-chlorophenyl)methyl)-5'-methyl-8-azaspiro[bicyclo[3.2.1]octane-3,3'-indoline] CHEMBL518790
BDBM50253664 CHEMBL518037 endo-8-(5-Fluorobenzofur-3-ylmethyl)-3-(3,4-dichlorophenyl)-8-azabicyclo[3.2.1]octan-3-ol
BDBM50259011 CHEMBL511373 8-(bis(2-chlorophenyl)methyl)-3-(thiazol-5-yl)-8-azabicyclo[3.2.1]octan-3-ol
BDBM50295434 CHEMBL3084673 exo-8-[Bis(2-chlorophenyl)methyl]-3-(5-fluoro-2-pyridinyl)-8-azabicyclo[3.2.1]octane
BDBM50295435 CHEMBL3084656 Exo-8-[bis(2-chlorophenyl)methyl]-3-(5-bromo-2-pyridinyl)-8-azabicyclo[3.2.1]octane
BDBM50308343 CHEMBL591504 US11337935, Compound 8 US10278929, Compound 8 (Z)-5-(3,5-dibromo-4-methoxybenzylidene)thiazolidine-2,4-dione
BDBM50327244 3-Endo-(8-((5-methylthiophen-2-yl)methyl)-8-azabicyclo[3.2.1]octan-3-yloxy)benzamide CHEMBL1257578
BDBM50327245 CHEMBL1255595 endo-3-(8-((5-methylfuran-2-yl)methyl)-8-azabicyclo[3.2.1]octan-3-yloxy)benzamide
BDBM50346179 CHEMBL1783888 8-methyl-3-(pyrimidin-5-yl)-8-azabicyclo[3.2.1]oct-2-ene bis(2,2,2-trifluoroacetate)
CHEMBL3084648 BDBM50295436 Exo-8-[bis(2-chlorophenyl)methyl]-3-(5-methyl-2-pyridinyl)-8-azabicyclo[3.2.1]octane
CHEMBL462043 BDBM50253637 endo-8-(5-Methoxybenzofur-3-ylmethyl)-3-(4-chlorophenyl)-8-azabicyclo[3.2.1]octan-3-ol
CHEMBL542646 8-methyl-5'-phenylspiro[8-azabicyclo[3.2.1]octane-3,2'-pyran]-4'(3'H)-one; Hydrochloride BDBM50281449
Exo-8-[bis(2-chlorophenyl)methyl]-3-[5-(methylthio)-2-pyridinyl]-8-azabicyclo[3.2.1]octane CHEMBL3084666 BDBM50295438
N-(3-carbamoyl- benzyl)-5- methyl-5H- chromeno[3,4-c] pyridine-8- carboxamide BDBM376346 US9914740, V-8
US8598210, Table XV, 8 US8722895, 8: {[5-(4-Cyanophenyl)-3-hydroxypyridine-2- carbonyl]amino}-acetic acid BDBM107702
endo-8-(5-Fluorobenzofur-3-ylmethyl)-3-(4-chlorophenyl)-8-azabicyclo[3.2.1]octan-3-ol BDBM50253638 CHEMBL518816
BDBM164814 US10604504, Example 8 US9920031, Example 8 US9802915, Example 8 US9688629, 8 US11623921, Example 8
US10758542, Example 8 US9796724, Example 8 US8791123, 8 US9782415, Example 8 BDBM127635 US10251889, Example 8
US11667644, Example 8 US11059828, Example 8 USRE48841, Example 8 BDBM118355 US8653263, 8 US9586962, Example 8
4-Amino-N-(8-benzyl-8-aza-bicyclo[3.2.1]oct-3-yl)-5-chloro-2-methoxy-benzamide 4-Amino-N-(8-benzoyl-8-aza-bicyclo[3.2.1]oct-3-yl)-5-chloro-2-methoxy-benzamide BDBM50123807 BRL-25594 CHEMBL164919
MLS000044274 SMR000022056 N-[5-chloro-2-(trifluoromethyl)-1,3-benzodioxol-2-yl]-1,4-dioxa-8-azaspiro[4.5]decane-8-carboxamide cid_3243924 N-[5-chloranyl-2-(trifluoromethyl)-1,3-benzodioxol-2-yl]-1,4-dioxa-8-azaspiro[4.5]decane-8-carboxamide BDBM32099
4-(1,3-benzodioxol-5-yl)-5-methyl-8-propan-2-yl-3,4-dihydrochromen-2-one cid_17756871 SMR000327139 4-(1,3-benzodioxol-5-yl)-8-isopropyl-5-methyl-chroman-2-one MLS000518054 4-(1,3-benzodioxol-5-yl)-5-methyl-8-propan-2-yl-3,4-dihydro-2H-1-benzopyran-2-one BDBM91347
(5S,8R)-N-(2,4- dichlorobenzyl)-5- fluoro-8-hydroxy-8- ((methylthio)methyl)- 5,6,7,8- tetrahydroquinoline- 5-carboxamide BDBM510437 US11439633, Example 297 US11077100, Example 297
(5S,8S)-5-fluoro-8- hydroxy-8- methyl-N-((1- morpholinocyclohexyl) methyl)-5,6,7,8- tetrahydroquinoline- 5-carboxamide US11439633, Example 274 BDBM510414 US11077100, Example 274
(R)-2-[5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,5-dichloro-benzoylamino)-5-oxo-pentanoylamino]-3-cyclohexyl-propionic acid BDBM50048779 CHEMBL31093
(R)-3-[5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,5-dichloro-benzoylamino)-5-oxo-pentanoylamino]-4-phenyl-butyric acid BDBM50048770 CHEMBL30422
(R)-4-[5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,5-dichloro-benzoylamino)-5-oxo-pentanoylamino]-4-benzylcarbamoyl-butyric acid BDBM50048756 CHEMBL30335
(R)-4-[5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,5-dichloro-benzoylamino)-5-oxo-pentanoylamino]-4-phenethylcarbamoyl-butyric acid CHEMBL282639 BDBM50048799
5-Bromo-8-imidazol-1-ylmethyl-chromen-4-one 8-((1H-imidazol-1-yl)methyl)-5-bromo-4H-chromen-4-one BDBM50097371 CHEMBL161530
BDBM272072 US10065948, 8 (S)-1-(4-Chlorophenyl)-5-(3-fluoro-2-methylphenyl)- N-hydroxy-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-5- carboxamide US10457675, Example 8
BDBM50036873 CHEMBL417550 8-{5-[(5-Methoxy-chroman-3-yl)-propyl-amino]-pentyl}-8-aza-spiro[4.5]decane-7,9-dione; compound with oxalic acid
BDBM50048735 (R)-2-[5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,5-dichloro-benzoylamino)-5-oxo-pentanoylamino]-3-phenyl-propionic acid CHEMBL30875
BDBM50048764 CHEMBL30592 (S)-2-[5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,5-dichloro-benzoylamino)-5-oxo-pentanoylamino]-3-phenyl-propionic acid
BDBM50048765 CHEMBL30926 (S)-3-[5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,5-dichloro-benzoylamino)-5-oxo-pentanoylamino]-N-phenethyl-succinamic acid
BDBM50048785 (S)-3-[5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,5-dichloro-benzoylamino)-5-oxo-pentanoylamino]-4-phenyl-butyric acid CHEMBL283204
BDBM50097362 8-Imidazol-1-ylmethyl-5-nitro-chromen-4-one CHEMBL351167 8-((1H-imidazol-1-yl)methyl)-5-nitro-4H-chromen-4-one
BDBM510181 US11439633, Example 41 US11077100, Example 41 (5S*,8S*)-N-(2,4- dichlorobenzyl)- 5-fluoro-8-hydroxy- 8-(methoxymethyl)- 5,6,7,8-tetrahydro- quinoline-5- carboxamide
BDBM510185 US11439633, Example 45 US11077100, Example 45 8-(aminomethyl)- N-(2,4-dichloro-6- methylbenzyl)-5- fluoro-8-hydroxy- 5,6,7,8-tetrahydro- quinoline-5- carboxamide
BDBM510199 US11439633, Example 59 (5S*,8R*)-8-amino-N-(2,4-dichloro- benzyl)-5-fluoro-8-(hydroxymethyl)- 5,6,7,8-tetrahydroquinoline-5- carboxamide US11077100, Example 59
BDBM510415 US11439633, Example 275 US11077100, Example 275 (5S,8R)-5-fluoro-8- hydroxy-8- methyl-N-((1- morpholinocyclohexyl) methyl)-5,6,7,8- tetrahydroquinoline- 5-carboxamide
BDBM510427 US11439633, Example 287 US11077100, Example 287 (5S,8S)-N-(2,4- dichlorobenzyl)-5- fluoro-8-hydroxy-8 ((methylthio)methyl)- 5,6,7,8- tetrahydroquinoline- 5-carboxamide
BDBM510438 US11439633, Example 298 US11077100, Example 298 (5S,8S)-N-(2,4- dichlorobenzyl)-5- fluoro-8-hydroxy-8- ((methylsulfonyl) methyl)-5,6,7,8- tetrahydroquinoline- 5-carboxamide
CHEMBL33209 BDBM50048737 (S)-4-[5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,5-dichloro-benzoylamino)-5-oxo-pentanoylamino]-4-dipentylcarbamoyl-butyric acid
CHEMBL432679 (S)-4-[5-(8-Aza-spiro[4.5]dec-8-yl)-4-(3,5-dichloro-benzoylamino)-5-oxo-pentanoylamino]-4-dipropylcarbamoyl-butyric acid BDBM50048761
N-(2,4-dichloro-6-meth- ylbenzyl)-5-fluoro-8-hy- droxy-8-(methoxymeth- yl)-5,6,7,8-tetrahydro- quinoline-5- carboxamide BDBM570506 US11439633, Example 39
Preparation of 4-(3-(1H-indol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)aniline US10485800, Example 8 BDBM354731 US9814704, Example 8
US10807988, Example SC_3172 BDBM469538 cis-8-Dimethylamino-8-phenyl-3-(2-pyrimidin-5-yl-pyrimidin-5-yl)-1,3- diazaspiro[4.5]decan-2-one
US11077100, Example 278 (5R,8S)-N-(2,4- dichlorobenzyl)-5- fluoro-8-hydroxy- 8-(((2-hydroxyethyl) (methyl)amino) methyl)-5,6,7,8- tetrahydroquinoline- 5-carboxamide BDBM510418
US11077100, Example 279 BDBM510419 (5R,8S)-N-(2,4- dichlorobenzyl)-5- fluoro-8-hydroxy-8- ((3-hydroxyazetidin- 1-yl)methyl)-5,6,7,8- tetrahydroquinoline- 5-carboxamide
US11077100, Example 60 BDBM510200 (5S*,8S*)-8-amino-N-(2,4-dichloro- benzyl)-5-fluoro-8-(hydroxymethyl)- 5,6,7,8-tetrahydroquinoline-5- carboxamide US11439633, Example 60
US11439633, Example 35 US11077100, Example 35 BDBM510175 N-(2-chloro-3-(trifluoromethyl)benzyl)- 5-fluoro-8-hydroxy-8-(hydroxymethyl)- 5,6,7,8-tetrahydroquinoline-5- carboxamide
cid_2398303 MLS000564221 5-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-8-quinolinol 5-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)quinolin-8-ol SMR000151717 BDBM57224
2-thiophenecarboxylic acid [5-chloro-7-(4-morpholinylmethyl)-8-quinolinyl] ester cid_1534931 SMR000377942 thiophene-2-carboxylic acid [5-chloro-7-(morpholinomethyl)-8-quinolyl] ester [5-chloro-7-(morpholin-4-ylmethyl)quinolin-8-yl] thiophene-2-carboxylate [5-chloranyl-7-(morpholin-4-ylmethyl)quinolin-8-yl] thiophene-2-carboxylate BDBM54056 MLS001005056
4-(2-methylquinolin-8-yl)oxy-5-phenyl-thieno[2,3-d]pyrimidine 4-[(2-methyl-8-quinolyl)oxy]-5-phenyl-thieno[2,3-d]pyrimidine SMR000264228 BDBM90252 4-(2-methylquinolin-8-yl)oxy-5-phenylthieno[2,3-d]pyrimidine 4-[(2-methyl-8-quinolinyl)oxy]-5-phenylthieno[2,3-d]pyrimidine MLS000416418 cid_3843899
5-chloro-7-[1-piperidinyl(2-pyridinyl)methyl]-8-quinolinol cid_3491105 5-chloro-7-[piperidin-1-yl(pyridin-2-yl)methyl]quinolin-8-ol MLS000774847 5-chloranyl-7-[piperidin-1-yl(pyridin-2-yl)methyl]quinolin-8-ol BDBM57971 5-chloro-7-[piperidino(2-pyridyl)methyl]quinolin-8-ol SMR000365462
BDBM64651 N-[(5-chloranyl-8-oxidanyl-quinolin-7-yl)-thiophen-2-yl-methyl]propanamide MLS000714585 N-[(5-chloro-8-hydroxyquinolin-7-yl)-thiophen-2-ylmethyl]propanamide N-[(5-chloro-8-hydroxy-7-quinolinyl)-thiophen-2-ylmethyl]propanamide N-[(5-chloro-8-hydroxy-7-quinolyl)-(2-thienyl)methyl]propionamide cid_3136134 SMR000274564
BDBM64672 N-[(5-chloro-8-hydroxyquinolin-7-yl)-thiophen-2-ylmethyl]butanamide N-[(5-chloranyl-8-oxidanyl-quinolin-7-yl)-thiophen-2-yl-methyl]butanamide cid_2929884 SMR000274370 N-[(5-chloro-8-hydroxy-7-quinolyl)-(2-thienyl)methyl]butyramide MLS000714391 N-[(5-chloro-8-hydroxy-7-quinolinyl)-thiophen-2-ylmethyl]butanamide
MLS001175296 8-(5-bromanyl-2-methoxy-phenyl)-7-methyl-3-(phenylmethyl)purine-2,6-dione cid_4792884 3-benzyl-8-(5-bromo-2-methoxy-phenyl)-7-methyl-xanthine BDBM95289 SMR000596470 3-benzyl-8-(5-bromo-2-methoxyphenyl)-7-methylpurine-2,6-dione 8-(5-bromo-2-methoxyphenyl)-7-methyl-3-(phenylmethyl)purine-2,6-dione
N-[(5-chloro-8-hydroxy-7-quinolyl)-(2-furyl)methyl]butyramide cid_2930234 N-[(5-chloranyl-8-oxidanyl-quinolin-7-yl)-(furan-2-yl)methyl]butanamide BDBM57044 MLS000113782 N-[(5-chloro-8-hydroxy-7-quinolinyl)-(2-furanyl)methyl]butanamide N-[(5-chloro-8-hydroxyquinolin-7-yl)-(furan-2-yl)methyl]butanamide SMR000109674
SMR000273437 N-[(5-chloranyl-8-oxidanyl-quinolin-7-yl)-(furan-2-yl)methyl]propanamide cid_2920571 N-[(5-chloro-8-hydroxy-7-quinolinyl)-(2-furanyl)methyl]propanamide N-[(5-chloro-8-hydroxy-7-quinolyl)-(2-furyl)methyl]propionamide MLS000713956 BDBM64674 N-[(5-chloro-8-hydroxyquinolin-7-yl)-(furan-2-yl)methyl]propanamide
SMR000273955 N-[(5-chloranyl-8-oxidanyl-quinolin-7-yl)-(furan-2-yl)methyl]pentanamide N-[(5-chloro-8-hydroxy-7-quinolyl)-(2-furyl)methyl]valeramide BDBM64669 MLS000703590 N-[(5-chloro-8-hydroxyquinolin-7-yl)-(furan-2-yl)methyl]pentanamide cid_3138753 N-[(5-chloro-8-hydroxy-7-quinolinyl)-(2-furanyl)methyl]pentanamide
SMR000274504 BDBM77543 N-[(5-chloranyl-8-oxidanyl-quinolin-7-yl)-thiophen-2-yl-methyl]pentanamide N-[(5-chloro-8-hydroxyquinolin-7-yl)-thiophen-2-ylmethyl]pentanamide N-[(5-chloro-8-hydroxy-7-quinolinyl)-thiophen-2-ylmethyl]pentanamide MLS000714525 cid_2928736 N-[(5-chloro-8-hydroxy-7-quinolyl)-(2-thienyl)methyl]valeramide